HQE

benzene-1,4-diol

Find entries where: HQE

is present as a standalone ligand in 7 entries

as a non-polymer is covalently linked to polymer or other heterogen groups 4 entries

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Chemical Component Summary
Name	benzene-1,4-diol
Identifiers	benzene-1,4-diol
Formula	C₆ H₆ O₂
Molecular Weight	110.111
Type	NON-POLYMER
Isomeric SMILES	c1cc(ccc1O)O
InChI	InChI=1S/C6H6O2/c7-5-1-2-6(8)4-3-5/h1-4,7-8H
InChIKey	QIGBRXMKCJKVMJ-UHFFFAOYSA-N

Chemical Details
Formal Charge	0
Atom Count	14
Chiral Atom Count	0
Bond Count	14
Aromatic Bond Count	6

Drug Info: DrugBank

DrugBank ID	DB09526
Name	Hydroquinone
Groups	approved investigational
Description	Hydroquinone is a topical lightening product found in OTC products, and is used to correct skin discoloration associated with disorders of hyperpigmentation including melasma, post-inflammatory hyperpigmention, sunspots, and freckles. It can be used alone, but is more frequently found in combination with other agents such as alpha-hydroxy acids, corticosteroids, retinoids, or sunscreen. Hydroquinone has come under scrutiny due to several complications associated with its use, including dermal irritation, exogenous onchronosis, and carginogenicity. As a result of these concerns, hydroquinone has been banned in the EU and UK.
Synonyms	4-Hydroxyphenol 1,4-benzenediol benzene-1,4-diol p-hydroxyphenol p-Hydroquinone Hydroquinone p-Benzenediol Quinol 1,4-dihydroxybenzene
Brand Names	Pure Valley Miracle Age Spot LumaSilk Emulsion Level 03 Vividly Brilliant Perfecting Rodan & Fields Proactiv Solution: Skin Lightening Lotion Clarite 4 AMBI Fade Oily Skin Esoterica Regular Cream Nu-derm System Normal-dry Skin Transformation Trial Esoterica Daytime with Moisturizers and Sunscreen Skinprint ClearTone with 2% Hydroquinone Vivant True Tone Forte Borba Age Defying Skin Lightening Spot Treatment Ultraplus Skin Lightening Cream - 2% Advanced Dual Complex Fade Maximum Strength Plus ZO Skin Health Multi-Therapy Hydroquinone System Esoterica Facial Cream Olivia Quido Blemish Eraser SH18 Ultra Harmonie Carrot Beauty Sledgehammer Hydroquinone 6% Pharmaskincare Parfait Lightening Serum I-max Lightening 5 Hyperpigmentation Treatment Ambi Fade Normal Skin Dermaclair Skin Lightening Clear-N-Smooth PLUS Black Opal Advanced Dual Phase Fade Creme Porcelana Medicated Fade Cream - Orig. Fmla Superlightener Corrector 4 Hydroquinone 6% / Tretinoin 0.05% / Triamcinolone 0.025% Idole Natural Organic Hydrocortisone 2.5% / Hydroquinone 4% / Tretinoin 0.025%, Dark Spot Lightening Cream NU-DERM system NORMAL-oily SKIN TRANSFORMATION TRIAL Pigment SH18 Skin Lightening Hqla Hyaluronic Acid Sodium Salt 1% / Hydroquinone 6% Sunvanish Derma Lightening 141016 Hydrocortisone 0.5% / Hydroquinone 4% / Tretinoin 0.025% Eldopaque Crm 2% Hydroquinone 8% / Tretinoin 0.025% Hydroquinone 8% / Tretinoin 0.025%. ZO Skin Health Pigment Control Plus Blending Creme Hydroquinone Esoterica Sunscreen Fade Cream Light The Way Advanced Skin Lightening Serum Ultraquin 4% Hydroquinone Cream With Sunscreens Aclaro Hydroquinone 141061 Hydrocortisone 0.5% / Hydroquinone 8% / Tretinoin 0.025% Nu-derm System Normal-oily Skin Transformation Trial Crusader Ultra Skin Lightening Gold Cosmetics Bleach Cream Silver Seequin 2 Pa Plus Advanced Dark Spot Correcting Serum Condition and Enhance System Travel-size Surgical Clear Essence Skin Lightening Gel Hydroquinone 4% / Tretinoin 0.025% Advanced Lightning PCA Skin Intensive Pigment Eraser Skin Lightening Rodan Fields SH18 Caviar Beauty Olivia Quido Skincare Blemish Eraser Nadinola Skin Fade for Oily Skin Proactiv Advanced Dark Spot Correcting Serum ZO MEDICAL MELAMIN-C Skin Bleaching and Correcting with Vitamin C Hydroquinone Topiclear Skin Lightening Vivant True Tone Esoterica Unscented Essential Fade Complex Skinprint 3D Clear Peel Nuquin Hp NU-DERM System NORMAL-Oily SKIN TRANSFORMATION Porcelana Medicated Fade Crm Sunscreen Fmla Topiclear Porcelana Skin Lightening Daytime Protection Topiclear Paris eB5 Age Sport Formula Hydrocortisone 0.5% / Hydroquinone 8% / Tretinoin 0.05% Even Tone Night Treatment Movate Skin Lightening Lemon Precious Beauty Skin Lightening Artra Skin Tone for Oily Skin Palmer's Skin Success Fade Cream-normal Skin Proactiv Skin Lightening Esoterica Nighttime with Moisturizers Hydrocortisone 0.5% / Hydroquinone 4% / Tretinoin 0.025% Body Merry Lightening and Whitening Cream Idole Beauty Dermisa Skin Fade Nadinola Skin Fade for Dry Skin Dermablend Advanced Fade Cream With Sunscreen and Moisturizing Aha Nadinola Skin Disc.fade Crm for Dry Skin 2% Skin Lightening Cream Glyquin Xm Glytone Dark Spot Corrector 141030 Hydroquinone 8% Exuviance Intense Lightening Complex Body Fade Creme Maximum Strength Dual Action Skin Lightener Zarina Skin Lightening Cream With Sunscreening Filter Ambi Extra Skin Discoloration Fade Cream Dolly Intense Lightening Nova Complex HQ Porcelana 24 Hour Skin Lightening Lightening HQ Spot Differin Dark Spot Correcting Serum Image MD Lightening Rx African Formula Carrot Conditioning Gel African Formula Skin Lightening Seequin 4 Ids Unblemish Dermatologist Developed Spot Fading Toner Black Opal Advance Dual Complex Fade Gel Idole Natural Organic Skin Lightening Brighten Lightening Eldoquin Nuderm Sunfader Vantex Skin Bleaching Crm W Sunscreen 2% AMBI Skincare Oily Skin Fade Unblemish Sh18 Aclaro PD Hydroquinone Jouvence Crm 2% Obagi Ultra Glow Skin Tone Cream for Oily Skin Idole Black Ultra Glow Skin Tone Cream for Normal Skin REVERS Lightening Regimen for the Appearance of Stubborn Dark Marks, Patches and Age Spots Travel Size Artra Skin Tone for Dry Skin BEST Age Spot Remover Idole Carrot 141010 Hydroquinone 4% I-max Lightening L Othine Skin Bleach Activator Light Drula Fade Cream Medium-medicated NeoCeuticals Post Acne Fade OLIVIA QUIDO FIRM and FADE II Hydro-Q Divine Derrier Skin Bleaching cream MD Acne Medicated Dark Spot Remover Porcelana Day Skin Lightening Fade Dark Spots Daytime Treatment Balancer Gold Cosmetics Adi Clear Hydrocortisone 0.5% / Hydroquinone 6% Palmer's Skin Success Fade Cream-for Oily Sk Hydrocortisone 0.5% / Hydroquinone 6% / Tretinoin 0.025% Hydroquinone Skin Bleaching Agent Oily Skin CONDITION AND ENHANCE BLENDER Skin Lightener and Blending Skin Lightener Topiclear Cocoa Butter beauty Palmer's Skin Success Fade Cream-for Dry Skn Clear Action Dermablend Chromatone Fade Cream With Sunscreen Zo Medical Zo Multi-therapy Hydroquinone System Banishing Cream Melpaque HP Skinprint Recover Lightening Complex with 2% Hydroquinone Glytone Clarifying Esoterica Unscented Fortified W.sun Screen Obagi Nu-Derm Sunfader Black and White Skin Bleach Idole Skin Lightening Piona NU-DERM CLEAR Skin Bleaching and Corrector Glytone Skin Lightening Seequin 4 ZO Skin Health Pigment Control plus Brightening Creme Hydroquinone plus Vitamin C Drula Fade Cream Normal-medicated Neostrata Hq Plus Lightening Cream Corrector 2 Restoration Serum Epione Obagi-C Rx System Normal-oily Skin Intervention eB5 Age Spot Formula Esoterica Daytime with Sunscreen Meditowel Illuminating Skin Brightening Metasol Medicated Fade Creme with Sunscreen Clear-N-Smooth UltraMax Scarlight MD LumaSilk Emulsion Level 02 NU-DERM SUNFADER Skin Lightener with Sunscreen (SPF 15) PABA FREE Multi Complex Fade Hydroquinone with sunscreens Gold Cosmetics Bleach Cream Forte Nadinola Skin Disc.fade Crm for Oily Skin 2% Ultra Glow Fade Triderma AGELESS Total Skin Bleaching Serum Ambi Fade Oily Skin Clear-N-Smooth Crusader Skin Lightening NeoStrata HQ Skin Lightening Exence White Obagi - C Hydrocortisone 0.5% / Hydroquinone 8% / Tretinoin 0.025% Desoximetasone 0.05% / Hydroquinone 6% / Tretinoin 0.05% Tri-luma Clear-N-Smooth SuperMax Phaze 13 Light N' Block Pigment Cream SH 18 Whitening Idole Intense African Formula Black MELAMIN Skin Bleaching and Correcting Hydroquinone ELASTIDERM DECOLLETAGE SKIN LIGHTENING COMPLEX Chest and Neck Clairissime Clear Complexion Lotion Skin Lightening Treatment Dr. Lightening Ultra-Potent Facial SLMD Skincare by Sandra Lee, M.D. - Dark Spot Fix Alumier MD Lightening Drula Fade Cream Extra-medicated Lightener Dr. Throwers Skin Lightening Moisturizing 141017 Hydrocortisone 0.5% / Hydroquinone 6% / Tretinoin 0.025% Erfa Hydroquinone Medisilke Night Caro Light Hydroquinone Time Release Recover Lightening Complex with 4% Hydroquinone Fade Dark Spots Nighttime Treatment Continuum Unifying Lotion I Hydrocortisone 1% / Hydroquinone 8% / Tretinoin 0.05% 141011 Hydroquinone 6% CONDITION AND ENHANCE CLEAR Skin Bleaching and Corrector Hydroquinone 8% OBAGI-C RX System NORMAL-DRY SKIN INTERVENTION Miracle Fade NU-DERM BLENDER Skin Lightener and Blending Rejuvaderm medispa fading Nu-derm System Normal-dry Skin Transformation Unblemish Regimen for Acne and Post Acne Marks Hot Movate Hydroquinone 4% / Tretinoin 0.025% / Triamcinolone Acetonide 0.025% REVERSE Lightening Regimen for the Appearance of Stubborn Dark Marks, Patches and Age Spots Nadinola Skin FadeExtra EB5 Age Spot Treatment SYMBA Skin Lightening Nadinola Skin Fade for Normal Skin Movate Lemon Nu-derm Travel Set Normal/dry Skin Transformation System Rodan and Fields Skin Lightening Treatment Fade Away Extra Care Obagi-C Rx system C-Therapy Night Skin Lightening with Vitamins C and E Cenovia Ultra-Potent Brightening Serum Dermisa Skin Fade Vitamin C infused Drula Fade Cream Superforte Medicated Hydroquinone 8%. AMBI Fade Normal Skin Creme Blanchissante - Crm 2% PLEXADERM Dark Spot Fade Gel Movate Skin Lightening Clear Essence Advance Complex Fade Gel Top White Skin Lightening Lumipearl Dark Mark Corrector Nu-derm Starter Set Normal-dry Skin Transformation System Porcelana Skin Lightening Nighttime Hydration Eldopaque Forte Crm 4% Skin Lightening Complex Fading Fluid OBAGI-C RX system NORMAL-oily SKIN INTERVENTION Clear-N-Smooth Ultimate Hydroquinone Proactiv Solution Dark Spot Corrector Topiclear Cocoa Butter Artra Skin Tone for Normal Skin Double White Hydroquinone 4% African Gold Skin Discoloration Fade Crm 2% Top White Hydroquinone 6% /tretinoin 0.05% Solaquin Forte Obagi Medical - Nu-Derm System - Normal to Dry - Skin Transformation Trial Kit Eldoquin Forte Obagi Medical - Nu-Derm System - Normal to Dry - Skin Transformation Kit Condition and Enhance System Full-size Non-surgical Ultra Glow Skin Tone Cream Oily Skin Aloe Vera Topiclear Xtra lemon beauty Neostrata Canada Hq Plus Cream HQ Plus Brightening Cream VI Derm Nu-derm System Normal-oily Skin Transformation Neova Complex HQ Plus Skinprint ClearTone with 8% Hydroquinone Skin Beautifying Milk Continuum Unifying Lotion II Dermisa Skin Fade Cream Total White Brightening Daily Fade Maximum Strength SPF15 ZO Skin Health Pigment Control Program Plus Hydroquinone Viquin Forte With Moisturizing Aha - Crm Solaquin Ultra Glow Skin Tone Cream Normal Skin Aloe Vera gloTriple Action Serum Enlighten Me Idole Lemon Ambi Skincare Normal Skin Fade Topiclear Paris Beauty Perrigo Hydroquinone with sunscreens Ultra Glow Fade with Aloe Vera Advanced Skin Lightening Cream Clear Essence Medicated Fade Cream Epiquin Micro Condition and Enhance System Travel-size Non-surgical NEXT GENERATION Correct Brightening Serum EpiQuin Micro Obagi Protocols Clear Cicatricure Skin Lightening Active 4 Clear Essence Skin Lightening Milk 141067 Hydroquinone 8% Melquin Hp Hydroquinone 5% / Tretinoin 0.025% / Triamcinolone Acetonide 0.025% Esoterica Scented-fortified With Sunscreen Obagi-C Rx System Normal-dry Skin Intervention MELAMIX Skin Lightener and Blending OBAGI-C Rx system C-CLARIFYING SERUM NORMAL TO oily SKIN LIGHTENING SERUM WITH VITAMIN C 141060 Hydrocortisone 0.5% / Hydroquinone 4% / Tretinoin 0.025% Hydroquinone cream Lustra Gold Cosmetics Bleach Cream Hqra-otc Glytone Clarifying SunVanish with Sunscreen Topiclear Xtra beauty Hydroquinone Skin Bleaching Agent Normal Skin Nu-derm Starter Set Normal-oily Skin Transformation System Melquin 3 New York Fair and Lovely Dr. Throwers Pbc No. 1 Movate Carrot Accelerated Dark Spot Corrector Pharmaskincare Serum Skin Lightening Ultra Glow Skin Tone Cream Dry Skin Aloe Vera ZO Skin Health Pigment Control Creme Hydroquinone Sunbalance Teatrical Skin Lightening Skin Lightener Hydrocortisone 0.5% / Hydroquinone 6% / Tretinoin 0.05% Topiclear Lemon Lustra-AF MELAMIN Skin Bleaching and Correcting Alphaquin HP Metasol Skin Lightening Glytone skin bleaching fading Fair and White Bright Malika and Khadija Brightening Spot Treatment Lustra AF 141055 Hydroquinone 6% Celazome Fade Shades Lightening Cream w/ Glycolic Acid Topiclear Carrot Clear-N-Smooth Super-Ultimate OBAGI C RX system C CLARIFYING SERUM Meaningful Beauty Dark Spot Correcting Treatment Teatrical Pro-Aclarant Skin Lightening Corrector Light Hyaluronic Acid Sodium Salt 0.5% / Hydroquinone 4% / Tretinoin 0.05% OLIVIA QUIDO FIRM and FADE I Porcelana Night Skin Lightening Glytone SunVanish Skin Lightening Spotfade Dark Spot Wand Nadinola Skin Discoloration Fade Cream-S.C.f Skin Lightening Accelerator Pack NU-DERM system NORMAL-DRY SKIN TRANSFORMATION TRIAL Obagi Nu-Derm
Indication	Hydroquinone is used as an OTC topical lightening agent for disorders of hyperpigmentation including melasma, post-inflammatory hyperpigmention, sunspots and freckles.
Categories	Antioxidants Benzene Derivatives Biological Factors Compounds used in a research, industrial, or household setting Depigmenting Agents Dermatologicals Melanin Synthesis Inhibitor Melanin Synthesis Inhibitors Mutagens Noxae Phenols Protective Agents Radiation-Protective Agents Toxic Actions
ATC-Code	D11AX11
CAS number	123-31-9

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Tyrosinase	MLLAVLYCLLWSFQTSAGHFPRACVSSKNLMEKECCPPWSGDRSPCGQLS...	unknown	inhibitor
Cysteinyl leukotriene receptor 1	MDETGNLTVSSATCHDTIDDFRNQVYSTLYSMISVVGFFGNGFVLYVLIK...	unknown	activator
Lysosomal alpha-glucosidase	MGVRHPPCSHRLLAVCALVSLATAALLGHILLHDFLLVPRELSGSSPVLE...	unknown	product of
Serum albumin	MKWVTFISLLFLFSSAYSRGVFRRDAHKSEVAHRFKDLGEENFKALVLIA...	unknown

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682

Related Resource References

Resource Name	Reference
Pharos	CHEMBL537
PubChem	785
ChEMBL	CHEMBL537
ChEBI	CHEBI:17594
CCDC/CSD	BATRET, CPFEHQ, CIRWEG, AXILUQ, EBILUX, BOKHUG, CEFDOG, COHWIF01, CISCOW, CAKZEV, DOMBEN, BIRQUO, EDAYUG, COZZIB, EDAYEQ, BAVKOA, CABWAD, COHWIF03, ABORAM, COZZOH, BAMZUN01, ACESIL, BAMZUN, AVEKER, EBIMEI, COHWIF02, BUSPAG, BZMETD, EKESIY04, EKESIY05, DIZCEV, DAMPOZ, DAMPOZ01, EKESIY01, EKESIY02, BAMZUN02, EKESIY03, EKESIY06, EKESAQ02, EKESAQ01, ABOQUF, BACRAB, CIPLES, CARWUP, BAMZUN03, COHWIF, CARWUP02, CARWUP01, AVEKIY
COD	2100714, 2100715, 2100716, 2100717, 2211791, 2103388, 2204577, 2100228, 2100231

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.

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HQE

benzene-1,4-diol

Chemical Component Summary

Chemical Details

Drug Info: DrugBank

Drug Targets

Related Resource References