HCZ

6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide


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Chemical Component Summary

Name6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
Identifiers6-chloro-1,1-dioxo-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide
FormulaC7 H8 Cl N3 O4 S2
Molecular Weight297.739
TypeNON-POLYMER
Isomeric SMILESc1c2c(cc(c1Cl)S(=O)(=O)N)S(=O)(=O)NCN2
InChIInChI=1S/C7H8ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-2,10-11H,3H2,(H2,9,12,13)
InChIKeyJZUFKLXOESDKRF-UHFFFAOYSA-N

Chemical Details

Formal Charge0
Atom Count25
Chiral Atom Count0
Bond Count26
Aromatic Bond Count6

Drug Info: DrugBank

DrugBank IDDB00999 
NameHydrochlorothiazide
Groups
  • vet_approved
  • approved
DescriptionHydrochlorothiazide is the most commonly prescribed thiazide diuretic.[A185138] It is indicated to treat edema and hypertension.[A185138,L8447,L8450] Hydrochlorothiazide use is common but declining in favour of angiotensin converting enzyme inhibitors.[A185138] Many combination products are available containing hydrochlorothiazide and angiotensin converting enzyme inhibitors[L8390,L8423] or angiotensin II receptor blockers.[L7426,L7459] Hydrochlorothiazide was granted FDA approval on 12 February 1959.[L8444]
Synonyms
  • Hydrochlorothiazide
  • Hydrochlorothiazidum
  • HCTZ
  • Hidroclorotiazida
Brand Names
  • Teva-olmesartan / HCT
  • Pritorplus
  • Losartan Potassium and Hydrochlorothiazide
  • Exforge HCT
  • Nra-telmisartan Hctz
IndicationHydrochlorothiazide is indicated alone or in combination for the management of edema associated with congestive heart failure, hepatic cirrhosis, nephrotic syndrome, acute glomerulonephritis, chronic renal failure, and corticosteroid and estrogen therapy.[L8447,L8450] Hydrochlorothiazide is also indicated alone or in combination for the management of hypertension.[A185138,L8447,L8450,L45663]
Categories
  • Amides
  • Antihypertensive Agents
  • Antihypertensive Agents Indicated for Hypertension
  • Benzothiadiazines
  • Cardiovascular Agents
ATC-Code
  • C09BX03
  • C03AX01
  • C03AB03
  • C09DX03
  • C03EA01
CAS number58-93-5

Drug Targets

NameTarget SequencePharmacological ActionActions
Solute carrier family 12 member 3MAELPTTETPGDATLCSGRFTISTLLSSDEPSPPAAYDSSHPSHLTHSST...unknowninhibitor
Calcium-activated potassium channel subunit alpha-1MANGGGGGGGSSGGGGGGGGSSLRMSSNIHANHLSLDASSSSSSSSSSSS...unknowninhibitor
Serum albuminMKWVTFISLLFLFSSAYSRGVFRRDAHKSEVAHRFKDLGEENFKALVLIA...unknownbinder
Solute carrier family 22 member 6MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCR...unknownsubstrate,inhibitor
Solute carrier family 22 member 8MTFSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHCR...unknownsubstrate
View More
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682

Related Resource References

Resource NameReference
Pharos CHEMBL435
PubChem 3639
ChEMBL CHEMBL435
ChEBI CHEBI:5778
CCDC/CSD KASMOH, HCSBTZ01, HCSBTZ02, LOLZOE, HCSBTZ08, DADNEE, PIRYAS, HCSBTZ04, DADMUT, HCSBTZ05, CASCAB, NOLCAV, LOLZEU, CASMAL, PIRXUL, EGENIP02, MUPPIX, HCSBTZ03, NOLCEZ, PIRXOF, HCSBTZ06, HCSBTZ07, ODATIX, ODEFEJ, VITWIE, BANPAK, PIRLUZ, EGENOV, SIZZUZ, DADMED, DADMIH, EGENIP, DADMED01, EGENIP01, DADNAA, HCSBTZ, EGENUB, NOLBOI, NOLBOI01, SOBBAP, REZXEZ, EGEPAJ, OBAFIK, HCSBTZ09
COD 2211088, 2206412, 2206455, 2206674, 2206702, 2103079, 4502543, 7216244, 7216241, 7217346, 7217349, 2105753, 2105754, 2105755, 2105756, 2208938, 2209149, 1551861, 1551862, 1551863, 1551864