GLU

GLUTAMIC ACID

Find entries where: GLU

is present as a standalone ligand in 421 entries

as a non-polymer is covalently linked to polymer or other heterogen groups 28 entries

is present in a polymer sequence 220,841 entries

Find related ligands:

Similar Ligands (Stereospecific)

Similar Ligands (Quick Screen)

Toggle Hydrogen Toggle Labels

Chemical Component Summary
Name	GLUTAMIC ACID
Identifiers	(2S)-2-azanylpentanedioic acid
Formula	C₅ H₉ N O₄
Molecular Weight	147.129
Type	L-PEPTIDE LINKING
Isomeric SMILES	C(CC(=O)O)[C@@H](C(=O)O)N
InChI	InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1
InChIKey	WHUUTDBJXJRKMK-VKHMYHEASA-N

Chemical Details
Formal Charge	0
Atom Count	19
Chiral Atom Count	1
Bond Count	18
Aromatic Bond Count	0

Drug Info: DrugBank

DrugBank ID	DB00142
Name	Glutamic acid
Groups	approved nutraceutical
Description	A peptide that is a homopolymer of glutamic acid.
Synonyms	Glutamic acid hydrochloride L-Glutaminic acid Glutamic acid (S)-2-Aminopentanedioic acid Glu L-Glutamic acid L-Glutamate (S)-Glutamic acid ácido glutámico (2S)-2-Aminopentanedioic acid
Brand Names	Premasol - sulfite-free (Amino Acid) Aminosyn-PF 10% Glutamic Acid HCl Betaine HCl W Pepsin Glutamic Acid Pepsin and Betaine Tablets Aminosyn II 8.5% Injection Aminosyn-PF Olimel 4.4% E Primene 10% Olimel 5.7% Aminosyn II and Dextrose Novamine Aminosyn II 7% M In 10% Dextrose(dual Chamber) Perikabiven Women Secret Olimel 5.7% E ProSol Vamin 18 Electrolyte-free Aminosyn II 7% Injection Aminosyn II 8.5% With 50% Dextrose Glutamic Acid Hydrochloride Nu Life Aminosyn II with Electrolytes in Dextrose with Calcium Aminosyn II 7% With 50% Dextrose Aminosyn II In Dextrose Injection Clinisol Olimel 3.3% E Aminosyn II 10% With Electrolytes Glutamic Acid HCl Cap 325mg Aminosyn II 8.5% M In 20% Dextrose (dual Chamber) Primene 10%-liq IV Aminosyn-PF 7% Aminosyn II with Electrolytes Aminosyn II 5% Inj Stomach Aid-digestive Aid Olimel 4.4% Primene Aminosyn II TrophAmine Vamin N Aminosyn II in Dextrose Women Secret Care Olimel 7.6% Olimel 7.6% E Kabiven Aminosyn II 7% With 10% Dextrose Periolimel 2.5% E 20% Prosol Plenamine
Indication	Considered to be nature's "Brain food" by improving mental capacities; helps speed the healing of ulcers; gives a "lift" from fatigue; helps control alcoholism, schizophrenia and the craving for sugar.
Categories	Acid Preparations Alimentary Tract and Metabolism Amino Acids Amino Acids, Acidic Amino Acids, Dicarboxylic Amino Acids, Peptides, and Proteins Dietary Supplements Digestives, Incl. Enzymes Excitatory Amino Acids Gastrointestinal Acidifying Agents Gastrointestinal Agents Glutamates Proteinogenic Amino Acids Supplements
ATC-Code	A09AB01
CAS number	56-86-0

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Metabotropic glutamate receptor 1	MVGLLLFFFPAIFLEVSLLPRSPGRKVLLAGASSQRSVARMDGDVIIGAL...	unknown
Metabotropic glutamate receptor 4	MPGKRGLGWWWARLPLCLLLSLYGPWMPSSLGKPKGHPHMNSIRIDGDIT...	unknown
Glutamate receptor ionotropic, kainate 4	MPRVSAPLVLLPAWLVMVACSPHSLRIAAILDDPMECSRGERLSITLAKN...	unknown
Glutamate receptor ionotropic, kainate 5	MPAELLLLLIVAFASPSCQVLSSLRMAAILDDQTVCGRGERLALALAREQ...	unknown
Metabotropic glutamate receptor 7	MVQLRKLLRVLTLMKFPCCVLEVLLCALAAAARGQEMYAPHSIRIEGDVT...	unknown
Metabotropic glutamate receptor 8	MVCEGKRSASCPCFFLLTAKFYWILTMMQRTHSQEYAHSIRVDGDIILGG...	unknown
Excitatory amino acid transporter 5	MVPHAILARGRDVCRRNGLLILSVLSVIVGCLLGFFLRTRRLSPQEISYF...	unknown
5-oxoprolinase	MGSPEGRFHFAIDRGGTFTDVFAQCPGGHVRVLKLLSEDPANYADAPTEG...	unknown
Phosphoribosylformylglycinamidine synthase	MSPVLHFYVRPSGHEGAAPGHTRRKLQGKLPELQGVETELCYNVNWTAEA...	unknown
Branched-chain-amino-acid aminotransferase, mitochondrial	MAAAALGQIWARKLLSVPWLLCGPRRYASSSFKAADLQLEMTQKPHKKPG...	unknown
Glutamate receptor ionotropic, NMDA 2D	MRGAGGPRGPRGPAKMLLLLALACASPFPEEAPGPGGAGGPGGGLGGARP...	unknown
Glutaminase kidney isoform, mitochondrial	MMRLRGSGMLRDLLLRSPAGVSATLRRAQPLVTLCRRPRGGGRPAAGPAA...	unknown
Aspartate aminotransferase, mitochondrial	MALLHSGRVLPGIAAAFHPGLAAAASARASSWWTHVEMGPPDPILGVTEA...	unknown
Bifunctional glutamate/proline--tRNA ligase	MATLSLTVNSGDPPLGALLAVEHVKDDVSISVEEGKENILHVSENVIFTD...	unknown
Asparagine synthetase [glutamine-hydrolyzing]	MCGIWALFGSDDCLSVQCLSAMKIAHRGPDAFRFENVNGYTNCCFGFHRL...	unknown
Glutamine synthetase	MTTSASSHLNKGIKQVYMSLPQGEKVQAMYIWIDGTGEGLRCKTRTLDSE...	unknown
Aspartate aminotransferase, cytoplasmic	MAPPSVFAEVPQAQPVLVFKLTADFREDPDPRKVNLGVGAYRTDDCHPWV...	unknown
Tyrosine aminotransferase	MDPYMIQMSSKGNLPSILDVHVNVGGRSSVPGKMKGRKARWSVRPSDMAK...	unknown
Alanine aminotransferase 1	MASSTGDRSQAVRHGLRAKVLTLDGMNPRVRRVEYAVRGPIVQRALELEQ...	unknown
Vitamin K-dependent gamma-carboxylase	MAVSAGSARTSPSSDKVQKDKAELISGPRQDSRIGKLLGFEWTDLSSWRR...	unknown
Excitatory amino acid transporter 1	MTKSNGEEPKMGGRMERFQQGVRKRTLLAKKKVQNITKEDVKSYLFRNAF...	unknown
Excitatory amino acid transporter 2	MASTEGANNMPKQVEVRMHDSHLGSEEPKHRHLGLRLCDKLGKNLLLTLT...	unknown
Excitatory amino acid transporter 3	MGKPARKGCEWKRFLKNNWVLLSTVAAVVLGITTGVLVREHSNLSTLEKF...	unknown
Glutamate--cysteine ligase catalytic subunit	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDE...	unknown	substrate
Excitatory amino acid transporter 4	MSSHGNSLFLRESGQRLGRVGWLQRLQESLQQRALRTRLRLQTMTLEHVL...	unknown
Glutamate dehydrogenase 2, mitochondrial	MYRYLAKALLPSRAGPAALGSAANHSAALLGRGRGQPAAASQPGLALAAR...	unknown	substrate
GMP synthase [glutamine-hydrolyzing]	MALCNGDSKLENAGGDLKDGHHHYEGAVVILDAGAQYGKVIDRRVRELFV...	unknown
Branched-chain-amino-acid aminotransferase, cytosolic	MKDCSNGCSAECTGEGGSKEVVGTFKAKDLIVTPATILKEKPDPNNLVFG...	unknown
4-aminobutyrate aminotransferase, mitochondrial	MASMLLAQRLACSFQHSYRLLVPGSRHISQAAAKVDVEFDYDGPLMKTEV...	unknown
Glutamate receptor ionotropic, NMDA 1	MSTMRLLTLALLFSCSVARAACDPKIVNIGAVLSTRKHEQMFREAVNQAN...	unknown
Folylpolyglutamate synthase, mitochondrial	MSRARSHLRAALFLAAASARGITTQVAARRGLSAWPVPQEPSMEYQDAVR...	unknown
Glutamyl aminopeptidase	MNFAEREGSKRYCIQTKHVAILCAVVVGVGLIVGLAVGLTRSCDSSGDGG...	unknown
Glutamate receptor ionotropic, NMDA 2A	MGRVGYWTLLVLPALLVWRGPAPSAAAEKGPPALNIAVMLGHSHDVTERE...	unknown
Glutamate receptor ionotropic, NMDA 2B	MKPRAECCSPKFWLVLAVLAVSGSRARSQKSPPSIGIAVILVGTSDEVAI...	unknown
Glutamate receptor ionotropic, NMDA 2C	MGGALGPALLLTSLFGAWAGLGPGQGEQGMTVAVVFSSSGPPQAQFRARL...	unknown
Probable glutamate--tRNA ligase, mitochondrial	MAALLRRLLQRERPSAASGRPVGRREANLGTDAGVAVRVRFAPSPTGFLH...	unknown
Glutamine-dependent NAD(+) synthetase	MGRKVTVATCALNQWALDFEGNLQRILKSIEIAKNRGARYRLGPELEICG...	unknown	product of
N-acetylglutamate synthase, mitochondrial	MATALMAVVLRAAAVAPRLRGRGGTGGARRLSCGARRRAARGTSPGRRLS...	unknown
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial	MNYARFITAASAARNPSPIRTMTDILSRGPKSMISLAGGLPNPNMFPFKT...	unknown
Glutamate receptor ionotropic, NMDA 3A	MRRLSLWWLLSRVCLLLPPPCALVLAGVPSSSSHPQPCQILKRIGHAVRV...	unknown
Alanine aminotransferase 2	MQRAAALVRRGCGPRTPSSWGRSQSSAAAEASAVLKVRPERSRRERILTL...	unknown	substrate,product of
Alpha-aminoadipic semialdehyde synthase, mitochondrial	MLQVHRTGLGRLGVSLSKGLHHKAVLAVRREDVNAWERRAPLAPKHIKGI...	unknown
Glutaminase liver isoform, mitochondrial	MRSMKALQKALSRAGSHCGRGGWGHPSRSPLLGGGVRHHLSEAAAQGRET...	unknown
Aspartyl aminopeptidase	MQVAMNGKARKEAVQTAAKELLKFVNRSPSPFHAVAECRNRLLQAGFSEL...	unknown
Cystine/glutamate transporter	MVRKPVVSTISKGGYLQGNVNGRLPSLGNKEPPGQEKVQLKRKVTLLRGV...	unknown
Carboxypeptidase Q	MKFLIFAFFGGVHLLSLCSGKAICKNGISKRTFEEIKEEIASCGDVAKAI...	unknown
Phosphoserine aminotransferase	MDAPRQVVNFGPGPAKLPHSVLLEIQKELLDYKGVGISVLEMSHRSSDFA...	unknown
Glutamate dehydrogenase 1, mitochondrial	MYRYLGEALLLSRAGPAALGSASADSAALLGWARGQPAAAPQPGLALAAR...	unknown
Glutamate receptor ionotropic, kainate 1	MEHGTLLAQPGLWTRDTSWALLYFLCYILPQTAPQVLRIGGIFETVENEP...	unknown
Glutamate receptor 1	MQHIFAFFCTGFLGAVVGANFPNNIQIGGLFPNQQSQEHAAFRFALSQLT...	unknown
Glutamate--cysteine ligase regulatory subunit	MGTDSRAAKALLARARTLHLQTGNLLNWGRLRKKCPSTHSEELHDCIQKT...	unknown
Glutamate carboxypeptidase 2	MWNLLHETDSAVATARRPRWLCAGALVLAGGFFLLGFLFGWFIKSSNEAT...	unknown
Glutamate decarboxylase 2	MASPGSGFWSFGSEDGSGDSENPGTARAWCQVAQKFTGGIGNKLCALLYG...	unknown
Glutamate decarboxylase 1	MASSTPSSSATSSNAGADPNTTNLRPTTYDTWCGVAHGCTRKLGLKICGF...	unknown
Formimidoyltransferase-cyclodeaminase	MSQLVECVPNFSEGKNQEVIDAISGAITQTPGCVLLDVDAGPSTNRTVYT...	unknown
Glutamate receptor 2	MQKIMHISVLLSPVLWGLIFGVSSNSIQIGGLFPRGADQEYSAFRVGMVQ...	unknown
Glutamate receptor 3	MARQKKMGQSVLRAVFFLVLGLLGHSHGGFPNTISIGGLFMRNTVQEHSA...	unknown
Glutamate receptor 4	MRIISRQIVLLFSGFWGLAMGAFPSSVQIGGLFIRNTDQEYTAFRLAIFL...	unknown
Delta-1-pyrroline-5-carboxylate synthase	MLSQVYRCGFQPFNQHLLPWVKCTTVFRSHCIQPSVIRHVRSWSNIPFIT...	unknown
Glutamate receptor ionotropic, kainate 2	MKIIFPILSNPVFRRTVKLLLCLLWIGYSQGTTHVLRFGGIFEYVESGPM...	unknown
Glutamate receptor ionotropic, kainate 3	MTAPWRRLRSLVWEYWAGLLVCAFWIPDSRGMPHVIRIGGIFEYADGPNA...	unknown
Aspartate aminotransferase	MAPPSVFAEVPQAQPVLVFKLTADFREDPDPRKVNLGVGAYRTDDCHPWV...	unknown	substrate
Monocarboxylate transporter 10	MVLSQEEPDSARGTSEAQPLGPAPTGAAPPPGPGPSDSPEAAVEKVEVEL...	unknown	substrate,inhibitor
Monocarboxylate transporter 1	MPPAVGGPVGYTPPDGGWGWAVVIGAFISIGFSYAFPKSITVFFKEIEGI...	unknown	substrate
Mitochondrial glutamate carrier 2	MTHQDLSITAKLINGGVAGLVGVTCVFPIDLAKTRLQNQHGKAMYKGMID...	unknown
Mitochondrial glutamate carrier 1	MADKQISLPAKLINGGIAGLIGVTCVFPIDLAKTRLQNQQNGQRVYTSMS...	unknown
View More

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682

Related Resource References

Resource Name	Reference
Pharos	CHEMBL575060
PubChem	88747398, 33032, 44272391
ChEMBL	CHEMBL575060
ChEBI	CHEBI:53374, CHEBI:16015
CCDC/CSD	LGLUTA02, LGLUTA03, ZZZBUS01, JOGLOJ, FACXIR, ZARBOM, JEJVIE, BEZQEE, UCAJEN, LGLUTA, DUSMAF, GUHLUR, JEMNOF

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.

Prepare Data

Validate Data

Deposit Data

Help and Resources

GLU

GLUTAMIC ACID

Chemical Component Summary

Chemical Details

Drug Info: DrugBank

Drug Targets

Related Resource References