FLP

FLURBIPROFEN

Created:	1999-07-08
Last modified:	2011-06-04

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11 entries where FLP is found as a standalone ligand

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Chemical Details
Formal Charge	0
Atom Count	31
Chiral Atom Count	1
Bond Count	32
Aromatic Bond Count	13

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Chemical Component Summary
Name	FLURBIPROFEN
Systematic Name (OpenEye OEToolkits)	(2S)-2-(3-fluoro-4-phenyl-phenyl)propanoic acid
Formula	C₁₅ H₁₃ F O₂
Molecular Weight	244.261
Type	NON-POLYMER

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	Fc2cc(ccc2c1ccccc1)C(C(=O)O)C
SMILES	CACTVS	3.341	C[CH](C(O)=O)c1ccc(c(F)c1)c2ccccc2
SMILES	OpenEye OEToolkits	1.5.0	CC(c1ccc(c(c1)F)c2ccccc2)C(=O)O
Canonical SMILES	CACTVS	3.341	C[C@H](C(O)=O)c1ccc(c(F)c1)c2ccccc2
Canonical SMILES	OpenEye OEToolkits	1.5.0	C[C@@H](c1ccc(c(c1)F)c2ccccc2)C(=O)O
InChI	InChI	1.03	InChI=1S/C15H13FO2/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18)/t10-/m0/s1
InChIKey	InChI	1.03	SYTBZMRGLBWNTM-JTQLQIEISA-N

Drug Info: DrugBank

DrugBank ID	DB16159
Name	Esflurbiprofen
Groups	investigational
Description	Esflurbiprofen is under investigation in clinical trial NCT03434197 (Safety and Efficacy of SFPP in Knee Osteoarthritis).
Synonyms	Flurbiprofen, (s)- Esflurbiprofen
Categories	Antiinflammatory Preparations, Non-Steroids for Topical Use Musculo-Skeletal System Topical Products for Joint and Muscular Pain
ATC-Code	M02AA29
CAS number	51543-39-6

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Gamma-secretase subunit APH-1B	MTAAVFFGCAFIAFGPALALYVFTIATEPLRIIFLIAGAFFWLVSLLISS...	unknown	inhibitor
Nicastrin	MATAGGGSGADPGSRGLLRLLSFCVLLAGLCRGNSVERKIYIPLNKTAPC...	unknown	inhibitor
Gamma-secretase subunit APH-1A	MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGAFFWLVSLLLAS...	unknown	inhibitor
Gamma-secretase subunit PEN-2	MNLERVSNEEKLNLCRKYYLGGFAFLPFLWLVNIFWFFREAFLVPAYTEQ...	unknown	inhibitor
Presenilin-1	MTELPAPLSYFQNAQMSEDNHLSNTVRSQNDNRERQEHNDRRSLGHPEPL...	unknown	inhibitor
Presenilin-2	MLTFMASDSEEEVCDERTSLMSAESPTPRSCQEGRQGPEDGENTAQWRSQ...	unknown	inhibitor
Prostaglandin G/H synthase 2	MLARALLLCAVLALSHTANPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFY...	unknown	inhibitor
Prostaglandin G/H synthase 1	MSRSLLLWFLLFLLLLPPLPVLLADPGAPTPVNPCCYYPCQHQGICVRFG...	unknown	inhibitor
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682