EZL

6-ethoxy-1,3-benzothiazole-2-sulfonamide

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is present as a standalone ligand in 9 entries

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Chemical Component Summary
Name	6-ethoxy-1,3-benzothiazole-2-sulfonamide
Synonyms	Ethoxzolamide
Identifiers	6-ethoxy-1,3-benzothiazole-2-sulfonamide
Formula	C₉ H₁₀ N₂ O₃ S₂
Molecular Weight	258.317
Type	NON-POLYMER
Isomeric SMILES	CCOc1ccc2c(c1)sc(n2)S(=O)(=O)N
InChI	InChI=1S/C9H10N2O3S2/c1-2-14-6-3-4-7-8(5-6)15-9(11-7)16(10,12)13/h3-5H,2H2,1H3,(H2,10,12,13)
InChIKey	OUZWUKMCLIBBOG-UHFFFAOYSA-N

Chemical Details
Formal Charge	0
Atom Count	26
Chiral Atom Count	0
Bond Count	27
Aromatic Bond Count	10

Drug Info: DrugBank

DrugBank ID	DB00311
Name	Ethoxzolamide
Groups	withdrawn
Description	Ethoxzolamide is a sulfonamide used as diuretic and in glaucoma. It inhibits carbonic anhydrase activity in proximal renal tubules to decrease reabsorption of water, sodium, potassium, bicarbonate. Its pharmacological activity thus confers the risk for hypokalemia.
Synonyms	Ethoxazolamide 6-Ethoxy-1,3-benzothiazole-2-sulfonamide Ethoxyzolamide Ethoxzolamide
Indication	For use in the treatment of duodenal ulcers, as a diuretic, and in the treatment of glaucoma, and may also be useful in the treatment of seizures associated with epilepsy.
Categories	Amides Benzothiazoles Carbonic Anhydrase Inhibitors Diuretics Enzyme Inhibitors Heterocyclic Compounds, Fused-Ring Natriuretic Agents OAT1/SLC22A6 inhibitors Sulfonamides Sulfones Sulfur Compounds Thiazoles
CAS number	452-35-7

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Carbonic anhydrase 2	MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVS...	unknown	inhibitor
Carbonic anhydrase 4	MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDR...	unknown	inhibitor
Carbonic anhydrase 7	MTGHHGWGYGQDDGPSHWHKLYPIAQGDRQSPINIISSQAVYSPSLQPLE...	unknown	inhibitor
Carbonic anhydrase 1	MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISV...	unknown	inhibitor
Carbonic anhydrase 3	MAKEWGYASHNGPDHWHELFPNAKGENQSPVELHTKDIRHDPSLQPWSVS...	unknown	inhibitor
Solute carrier family 22 member 6	MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCR...	unknown	inhibitor
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682