CLY

CLINDAMYCIN

Find entries where: CLY

is present as a standalone ligand in 6 entries

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Chemical Component Summary
Name	CLINDAMYCIN
Identifiers	(1R,2S,4R)-N-[(1S,2S)-2-chloro-1-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-methylsulfanyl-oxan-2-yl]propyl]-1-methyl-4-propyl-pyrrolidine-2-carboxamide
Formula	C₁₈ H₃₃ Cl N₂ O₅ S
Molecular Weight	424.983
Type	NON-POLYMER
Isomeric SMILES	CCC[C@@H]1C[C@H]([N@@](C1)C)C(=O)N[C@@H]([C@@H]2[C@@H]([C@@H]([C@H]([C@H](O2)SC)O)O)O)[C@H](C)Cl
InChI	InChI=1S/C18H33ClN2O5S/c1-5-6-10-7-11(21(3)8-10)17(25)20-12(9(2)19)16-14(23)13(22)15(24)18(26-16)27-4/h9-16,18,22-24H,5-8H2,1-4H3,(H,20,25)/t9-,10+,11-,12+,13-,14+,15+,16+,18+/m0/s1
InChIKey	KDLRVYVGXIQJDK-AWPVFWJPSA-N

Chemical Details
Formal Charge	0
Atom Count	60
Chiral Atom Count	9
Bond Count	61
Aromatic Bond Count	0

Drug Info: DrugBank

DrugBank ID	DB01190
Name	Clindamycin
Groups	approved vet_approved
Description	Clindamycin is a semi-synthetic lincosamide antibiotic used in the treatment of a variety of serious infections due to susceptible microorganisms[L11599,L11596] as well as topically for acne vulgaris.[L11593] It has a relatively narrow spectrum of activity that includes anaerobic bacteria as well as gram-positive cocci and bacilli and gram-negative bacilli.[A190621] Interestingly, clindamycin appears to carry some activity against protozoans, and has been used off-label in the treatment of toxoplasmosis, malaria, and babesiosis.[A190657] Clindamycin is derived from, and has largely replaced, [lincomycin], a naturally occurring lincosamide and the eponymous member of this antibiotic class, due to its improved properties over the parent compound. The name lincomycin is derived from Lincoln, Nebraska, where it was first isolated from _Streptomyces lincolnensis_ found in a soil sample.[A190621]
Synonyms	7-CDL Clindamycin Clindamycin phosphate Clindamycin hydrochloride Clindamycin palmitate hydrochloride Clindamycinum 7(S)-Chloro-7-deoxylincomycin Clindamicina Clindamycine Methyl 7-chloro-6,7,8-trideoxy-6-(1-methyl-trans-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-L-threo-alpha-D-galacto-octopyranoside
Brand Names	Clindamycin 1% / Niacinamide 4% / Spironolactone 2% / Tretinoin 0.025% NuCaraClinPAK Clindamycin Palmitate Hydrochloride Clindoxyl Adv Gel Veltin Benzoyl Peroxide 5% / Clindamycin 1% / Niacinamide 2% / Spironolactone 2% / Tretinoin 0.025% Priva-clindamycin Truemed Group LLC Clindamycin 1% / Niacinamide 4% / Tretinoin 0.05% Dalacin Vaginal Cream Clindamycin Injection In 5% Dextrose Clindamycin Phosphate and Benzoyl Peroxide Clindets Clindamycin 1% / Sodium Sulfacetamide Monohydrate 5% / Tretinoin 0.025% Clindamycin Clindamax Clindamycin 1% / Niacinamide 4% Benzaclin Clindamycin Palmitate Hydrochloride (Pediatric) Clindamycin Injection USP M-clindamycin Clindamycin phosphate and benzoyl peroxide Biacna Topical Gel Clindamycin Phosphate Injection USP Liq Taro-clindamycin/benzoyl Peroxide Gel Cleocin Phosphate (0009-6582) (standalone) Clindamycin Phosphate and Tretinion Clindamycin Phosphate and Tretinoin Clindamycin IV Infusion Benzoyl Peroxide 2.5%, Clindamycin Phosphate 1%, Niacinamide 2% / Tretinoin 0.05% Apo-clindamycin Dalacin C Phosphate Auro-clindamycin Onexton Clinda-Derm ClindaMax Teva-clindamycin Clindamycin Phosphate 1.2% and Tretinoin 0.025% ClindaReach NuCaraRXPAK Clindacin ETZ Med-clindamycin Taro-clindamycin Neuac Clindamycin 1% / Niacinamide 4% / Tretinoin 0.025% Clindacin P Cleocin Cleocin Hydrochloride Cleocin T Ag-clindamycin Clindamycin Phosphate and Tretinoin Gel 1.2%/0.025% Cabtreo Clindacin PAC Dalacin C Flavoured Granules Clindamycin Phosphate Topical Solution USP, 1% Clindamycin 1% / Niacinamide 2% / Tazarotene 0.05% Xaciato Clindacin Clindoxyl Gel CLINDAMYCIN PALMITATE HYDROCHLORIDE (Pediatric) Clindamycin Phosphate Benzoyl Peroxide 5% / Clindamycin 1% / Niacinamide 2% / Tretinoin 0.05% Ava-clindamycin Clindap-T Mylan-clindamycin Cleocin Phosphate Benzoyl Peroxide 5% / Clindamycin 1% / Niacinamide 4% Benzoyl Peroxide 5% / Clindamycin 1% / Niacinamide 2% / Tretinoin 0.1% Clindasol Benzoyl Peroxide 5% / Clindamycin1% / Niacinamide 2% / Tretinoin 0.025% Clindamycin Palmitate Hydrochloride (pediatric) Clindamycine-300 Imiquimod 5% / Levocetirizine Dihydrochloride 1% / Tretinoin 0.05% Duac Clindagel Clindamycin 1% / Hydrocortisone 2.5% / Niacinamide 4% Clindamycin Phoaphate Topical Solution USP, 1% Dalacin C 150 mg Benzoyl Peroxide 5% / Clindamycin 1% / Niacinamide 2% / Spironolactone 2% Clindamycin Injection Sdz Riva-clindamycin PMS-clindamycin Clindavix Evoclin Adapalene 0.3% / Benzoyl Peroxide 2.5% / Clindamycin 1% Dalacin C 300 mg Nu-clindamycin Clindesse CLIN-LIDO-Single Use Kit Dalacin T 1% Clindamycin Phosphate and Benzoyl Peroxide Clindamycin Phosphate and Benzoyl Peroxide Benzoyl Peroxide 2.5% / Clindamycin 1% / Niacinamide 4% Clindamycin Hydrochloride Benzoyl Peroxide 5% / Clindamycin 1% / Niacinamide 2% / Spironolactone 2% / Tretinoin 0.05% Clindamycin Phosphate Topical Solution USP Jamp Clindamycin CLIN-Single Use Kit Ziana Clindamycin HCL Adapalene 0.1% / Benzoyl Peroxide 2.5% / Clindamycin 1% Clindamycin Injection, USP Clindamycin Phoaphate Topical USP, 1% Clindamycin and Benzoyl Peroxide Ratio-clindamycin Capsules-150mg Clindamycine-150 Clindamycin Phoaphate Topical Solution, 1% Clindamycin hydrochloride Benzoyl Peroxide 2.5% / Clindamycin 1% / Niacinamide 2% / Tretinoin 0.025% Cleocin Pediatric Ratio-clindamycin Capsules - 300mg Neuac Kit Clindamycin phosphate Taro-benzoyl Peroxide / Clindamycin Kit Clindamycin in 5 Percent Dextrose Clinda-T Acanya Clindamycin - Benzoyl Peroxide Nra-clindamycin
Indication	In oral and parenteral formulations, clindamycin is indicated for the treatment of serious infections caused by susceptible anaerobic bacteria, as well as susceptible staphylococci, streptococci, and pneumococci.[L11599,L11602] Used topically, it is indicated for the treatment of acne vulgaris[L11593,L11611,L11605] and is available in combination with [benzoyl peroxide][L11584] or [tretinoin][L11590] for this purpose, or as a triple combination therapy with benzoyl peroxide and [adapalene].[L48666] Clindamycin is also indicated as a vaginal cream[L11596], suppository[L11608], or gel[L39416] for the treatment of bacterial vaginosis in non-pregnant females. Clindamycin is used for antimicrobial prophylaxis against _Viridans_ group streptococcal infections in susceptible patients undergoing oral, dental, or upper respiratory surgery, and may be used for prophylaxis against bacterial endocarditis in penicillin-allergic patients at high risk of these infections.[L11629]
Categories	Agents that produce neuromuscular block (indirect) Anti-Acne Preparations Anti-Acne Preparations for Topical Use Anti-Bacterial Agents Anti-Infective Agents Antibacterials for Systemic Use Antibiotics for Pneumocystis Pneumonia Antiinfectives for Systemic Use Antiinfectives for Treatment of Acne Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 CYP3A4 Inhibitors (moderate) Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 CYP3A5 Substrates Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Decreased Sebaceous Gland Activity Dermatologicals Enzyme Inhibitors Genito Urinary System and Sex Hormones Glycosides Gynecological Antiinfectives and Antiseptics Lincomycins Lincosamide Antibacterial Lincosamides Macrolides Macrolides, Lincosamides and Streptogramins Neuromuscular Blockade Neurotoxic agents P-glycoprotein substrates Protein Synthesis Inhibitors Pyrrolidines
ATC-Code	D10AF01 J01FF01 D10AF51 G01AA10
CAS number	18323-44-9

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
50S ribosomal protein L1	MAKKGKKYQEAASKVDRTQHYSVEEAIKLAKETSIANFDASVEVAFRLGI...	unknown	inhibitor
Cytochrome P450 3A5	MDLIPNLAVETWLLLAVSLVLLYLYGTRTHGLFKRLGIPGPTPLPLLGNV...	unknown	substrate
Cytochrome P450 3A4	MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNI...	unknown	substrate,inhibitor
Alpha-1-acid glycoprotein 1	MALSWVLTVLSLLPLLEAQIPLCANLVPVPITNATLDQITGKWFYIASAF...	unknown	substrate
P-glycoprotein 1	MDLEGDRNGGAKKKNFFKLNNKSEKDKKEKKPTVSVFSMFRYSNWLDKLY...	unknown	substrate

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682