CLW

CHLORZOXAZONE

Created:	2002-07-26
Last modified:	2020-06-05

Find Related PDB Entry
6 entries where CLW is found as a standalone ligand

Help Find related ligands:
Similar Ligands (Stereospecific) Similar Ligands (including Stereoisomers) Similar Ligands (Quick Screen) Similar Ligands (Substructure Stereospecific) Similar Ligands (Substructure including Stereoisomers)

Help

Find related ligands:

Similar Ligands (Stereospecific) Similar Ligands (including Stereoisomers) Similar Ligands (Quick Screen) Similar Ligands (Substructure Stereospecific) Similar Ligands (Substructure including Stereoisomers)

Chemical Details
Formal Charge	0
Atom Count	15
Chiral Atom Count	0
Bond Count	16
Aromatic Bond Count	10

Toggle Hydrogen Toggle Labels

Chemical Component Summary
Name	CHLORZOXAZONE
Synonyms	5-CHLORO-2-BENZOXAZOLONE
Systematic Name (OpenEye OEToolkits)	5-chloro-3H-1,3-benzoxazol-2-one
Formula	C₇ H₄ Cl N O₂
Molecular Weight	169.565
Type	NON-POLYMER

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	Clc2cc1c(OC(=O)N1)cc2
SMILES	CACTVS	3.341	Clc1ccc2OC(=O)Nc2c1
SMILES	OpenEye OEToolkits	1.5.0	c1cc2c(cc1Cl)NC(=O)O2
Canonical SMILES	CACTVS	3.341	Clc1ccc2OC(=O)Nc2c1
Canonical SMILES	OpenEye OEToolkits	1.5.0	c1cc2c(cc1Cl)NC(=O)O2
InChI	InChI	1.03	InChI=1S/C7H4ClNO2/c8-4-1-2-6-5(3-4)9-7(10)11-6/h1-3H,(H,9,10)
InChIKey	InChI	1.03	TZFWDZFKRBELIQ-UHFFFAOYSA-N

Drug Info: DrugBank

DrugBank ID	DB00356
Name	Chlorzoxazone
Groups	approved
Description	A centrally acting central muscle relaxant with sedative properties. It is claimed to inhibit muscle spasm by exerting an effect primarily at the level of the spinal cord and subcortical areas of the brain. (From Martindale, The Extra Pharmacopoea, 30th ed, p1202)
Synonyms	Chlorzoxazon 5-chlorobenzoxazolin-2-one 5-chloro-2-benzoxazolinone 5-chloro-2(3H)-benzoxazolone Chlorzoxazona Clorzoxazona Chlorzoxazone Clorzoxazone 5-chloro-2-hydroxybenzoxazole Chlorzoxazonum 5-chloro-2-benzoxazolol 5-chlorobenzoxazolidone 2-hydroxy-5-chlorobenzoxazole Chlorzoxane 5-chloro-3H-benzooxazol-2-one 5-chloro-2-benzoxazolone
Brand Names	Parafon Forte DSC Chlorzoxazone Lorzone Parafon Forte C8 W Codeine Tab Extra Strength Tylenol Aches and Strains Back-aid Forte - Tab Acetazone Forte Parafon Forte Parafon DSC Parafon Forte Tablets Acetazone Forte C8 Gin Pain Pills - Tab
Indication	For the relief of discomfort associated with acute painful musculoskeletal conditions.
Categories	Benzoxazoles and derivatives Central Nervous System Agents Central Nervous System Depressants Centrally-mediated Muscle Relaxation Cytochrome P-450 CYP1A2 Substrates Cytochrome P-450 CYP2A6 Substrates Cytochrome P-450 CYP2D6 Substrates Cytochrome P-450 CYP2E1 Inhibitors Cytochrome P-450 CYP2E1 Inhibitors (strength unknown) Cytochrome P-450 CYP2E1 Substrates Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 CYP3A4 Inhibitors (weak) Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Drugs that are Mainly Renally Excreted Heterocyclic Compounds, Fused-Ring Muscle Relaxants Muscle Relaxants, Centrally Acting Agents Musculo-Skeletal System Oxazol, Thiazine, and Triazine Derivatives Peripheral Nervous System Agents
ATC-Code	M03BB03 M03BB53 M03BB73
CAS number	95-25-0

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Calcium-activated potassium channel subunit alpha-1	MANGGGGGGGSSGGGGGGGGSSLRMSSNIHANHLSLDASSSSSSSSSSSS...	unknown	inhibitor
Cytochrome P450 2E1	MSALGVTVALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLEL...	unknown	substrate,inhibitor
Cytochrome P450 1A1	MLFPISMSATEFLLASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIG...	unknown	substrate
Cytochrome P450 1A2	MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPL...	unknown	substrate
Cytochrome P450 2A6	MLASGMLLVALLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQLN...	unknown	substrate
Cytochrome P450 3A4	MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNI...	unknown	substrate,inhibitor
Cytochrome P450 2D6	MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVD...	unknown	substrate
View More

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682