ALA

ALANINE

Created:	1999-07-08
Last modified:	2024-09-27

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135 entries where ALA is found as a standalone ligand59 entries where ALA is covalently linked to polymer or other heterogen groups 223,613 entries where ALA is found in a polymer sequence

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Chemical Details
Formal Charge	0
Atom Count	13
Chiral Atom Count	1
Bond Count	12
Aromatic Bond Count	0

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Chemical Component Summary
Name	ALANINE
Systematic Name (OpenEye OEToolkits)	(2S)-2-aminopropanoic acid
Formula	C₃ H₇ N O₂
Molecular Weight	89.093
Type	L-PEPTIDE LINKING

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	O=C(O)C(N)C
SMILES	CACTVS	3.341	C[CH](N)C(O)=O
SMILES	OpenEye OEToolkits	1.5.0	CC(C(=O)O)N
Canonical SMILES	CACTVS	3.341	C[C@H](N)C(O)=O
Canonical SMILES	OpenEye OEToolkits	1.5.0	C[C@@H](C(=O)O)N
InChI	InChI	1.03	InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1
InChIKey	InChI	1.03	QNAYBMKLOCPYGJ-REOHCLBHSA-N

Drug Info: DrugBank

DrugBank ID	DB00160
Name	Alanine
Groups	nutraceutical
Description	Alanine is a non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and the central nervous system.
Synonyms	L-α-alanine Alanine L-alpha-Alanine L-alanine (S)-alanine L-Alanin (2S)-2-aminopropanoic acid L-2-Aminopropionic acid Alaninum Alanina (S)-2-aminopropanoic acid
Brand Names	2.5% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose FreAmine III ProSol Travasol Aminosyn 8.5% Injection With Electrolytes 5% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Aminosyn II 7% With 10% Dextrose 2.5% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Clinimix Aminosyn 4.25% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose Travasol Amino Acid Inj 5.5% Primene Aminosyn II 8.5% Injection Periolimel 2.5% E 4.25% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Travasol Inj Without Electrolytes 5.5% Aminosyn-PF 7% Aminosyn II In Dextrose Injection Clinimix 2.5% Travasol Aa Without Electrolytes In 10% Dextrose Injec Aminosyn II and Dextrose 4.25% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Quickmix Hepatasol 4.25% Travasol Amino Acid Without Electrolytes In 5% Dextrose Quickmix Aminosyn II 5% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose 2.5% Travasol Amino Acid Injection Without Electrolytes In 10% Dextrose Quickmix Plenamine 5% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose Olimel 4.4% Smofkabiven Olimel 7.6% E Essepna Travasol Amino Acid Inj 8.5% Clinisol Synthamin Olimel 5.7% E 2.5%travasol Amino Acid InJ.W.eleC.W.25%dex Aminosyn II 10% With Electrolytes Aminosyn Sulfite Free Aminosyn II in Dextrose Aminosyn II with Electrolytes in Dextrose with Calcium Aminosyn-PF 10% Travasol Inj Without Electrolytes 8.5% 4.25% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Aminosyn 3.5% M FreAmine HBC Smofkabiven Peripheral Aminosyn II 8.5% With 50% Dextrose ProcalAmine Vamin 18 Electrolyte-free Nutrineal Pd4 Vamin N Olimel 4.4% E Aminosyn II 7% M In 10% Dextrose(dual Chamber) 4.25%travasol Amino Acid InJ.W.elecw.5%dex. Smofkabiven Extra Nitrogen Electrolyte Free Aminosyn II 8.5% M In 20% Dextrose (dual Chamber) Premasol - sulfite-free (Amino Acid) 4.25% Travasol Amino Acid Injection With Electrolytes In 5% Dextrose Quickmix Olimel 5.7% 4.25% Travasol Amino Acid Injection With Electrolytes In 25% Dextrose Aminosyn II 7% Injection Aminosyn 5% Smofkabiven Electrolyte Free 2.75% Travas. Amino Acid InJ.W.elecw.25%dex Primene 10%-liq IV Primene 10% Renamin (amino Acids) Injection 2.75% Travasol Amino Acid Injection With Electrolytes In 25% Dextrose Quickmix 4.25% Travasol Amino Acid Injection Without Electrlytes In 10% Dextrose 2.75% Travasol Amino Acid Injection With Electrolytes In 5% Dextrose Quickmix Quick Mix 2.5% Travasol Aa With Electrolytes With 25% Dextrose Injec Aminosyn 7% Perikabiven Aminosyn-PF 8.5% Freamine III 4.25%trav. Amino Acid InJ.W.O.elect.5%dext. Aminosyn II with Electrolytes Aminosyn 10% W Electrolytes Aminosyn 8.5% Clinimix E Aminosyn HF Smofkabiven Extra Nitrogen Olimel 3.3% E HepatAmine TrophAmine Olimel 7.6% 2.75%travasol Amino Acid InJ.W.eleC.W.5%dex. RenAmin Aminosyn II 7% With 50% Dextrose Clinimix 4.25% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose Kabiven 20% Prosol Novamine Travasol E 4.25% Amino Acid Injection Without Electrolytes In 20% Dextrose Quickmix Aminosyn II 5% Inj
Indication	Used for protein synthesis.
Categories	Alanine Amino Acids Amino Acids, Peptides, and Proteins Dietary Supplements Proteinogenic Amino Acids Supplements
CAS number	56-41-7

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
4-aminobutyrate aminotransferase, mitochondrial	MASMLLAQRLACSFQHSYRLLVPGSRHISQAAAKVDVEFDYDGPLMKTEV...	unknown	inhibitor
Alanine--glyoxylate aminotransferase	MASHKLLVTPPKALLKPLSIPNQLLLGPGPSNLPPRIMAAGGLQMIGSMS...	unknown
Alanine aminotransferase 1	MASSTGDRSQAVRHGLRAKVLTLDGMNPRVRRVEYAVRGPIVQRALELEQ...	unknown
Cysteine desulfurase	MLLRAAWRRAAVAVTAAPGPKPAAPTRGLRLRVGDRAPQSAVPADTAAAP...	unknown
Proton-coupled amino acid transporter 1	MSTQRLRNEDYHDYSSTDVSPEESPSEGLNNLSSPGSYQRFGQSNSTTWF...	unknown
Large neutral amino acids transporter small subunit 2	MEEGARHRNNTEKKHPGGGESDASPEAGSGGGGVALKKEIGLVSACGIIV...	unknown
Alanine--glyoxylate aminotransferase 2, mitochondrial	MTLIWRHLLRPLCLVTSAPRILEMHPFLSLGTSRTSVTKLSLHTKPRMPP...	unknown
Alanine--tRNA ligase, cytoplasmic	MDSTLTASEIRQRFIDFFKRNEHTYVHSSATIPLDDPTLLFANAGMNQFK...	unknown
Neutral amino acid transporter A	MEKSNETNGYLDSAQAGPAAGPGAPGTAAGRARRCAGFLRRQALVLLTVS...	unknown
Kynureninase	MEPSSLELPADTVQRIAAELKCHPTDERVALHLDEEDKLRHFRECFYIPK...	unknown
Alanine--tRNA ligase, mitochondrial	MAASVAAAARRLRRAIRRSPAWRGLSHRPLSSEPPAAKASAVRAAFLNFF...	unknown
5-phosphohydroxy-L-lysine phospho-lyase	MAADQRPKADTLALRQRLISSSCRLFFPEDPVKIVRAQGQYMYDEQGAEY...	unknown
Alanine aminotransferase 2	MQRAAALVRRGCGPRTPSSWGRSQSSAAAEASAVLKVRPERSRRERILTL...	unknown
Monocarboxylate transporter 10	MVLSQEEPDSARGTSEAQPLGPAPTGAAPPPGPGPSDSPEAAVEKVEVEL...	unknown	inhibitor
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682

Related Resource References

Resource Name	Reference
PubChem	5950, 7311724
ChEMBL	CHEMBL279597
ChEBI	CHEBI:16977, CHEBI:57972
CCDC/CSD	NAFCAB, ITUSIZ, DLALNI01, DLALNI06, IMOCAO, BOPYUB, IMEGIR16, GUQBOL, DLALNI07, CADKID01, IMEGIR12, IMEGIR14, IMEGIR13, BOQTEG, HOSLIL, IMEGIR15, DEKYEZ, IMEGIR18, DLALNI12, IMEGIR, DLALNI15, IMEGIR11, IMEGIR17, IBEGEC, DLALNI11, LOKFIA, DLALNI09, DLALNI17, DLALNI21, DLALNI16, HOSMIM, DLALNI18, DLALNI20, DLALNI10, DLALNI19, DLALNI14, CAPKEL, CADKID, AHERAG, IMEGIR06, NELPUP, DLALNI13, DLALNI05, IMEGIR05, IMEGIR09, IMEGIR08, IMEGIR04, IMEGIR03, IMEGIR07, DEKYOJ, IMEGIR02, HOSLEH, DLALNI08, IMEGIR01, KERMOJ, FITHIZ, DENVAW, ALUCAL05, ALAHCL, IWOHUA, IWOJIQ
COD	2012001, 2105146, 2105149, 2105145, 2105143, 2105151, 2105155, 2105150, 2105152, 2105154, 2105144, 2105153, 2105148, 2105147, 4501605, 7050083