AIC

(2S,5R,6R)-6-{[(2R)-2-AMINO-2-PHENYLETHANOYL]AMINO}-3,3-DIMETHYL-7-OXO-4-THIA-1-AZABICYCLO[3.2.0]HEPTANE-2-CARBOXYLIC ACID

Find entries where: AIC

is present as a standalone ligand in 8 entries

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Chemical Component Summary
Name	(2S,5R,6R)-6-{[(2R)-2-AMINO-2-PHENYLETHANOYL]AMINO}-3,3-DIMETHYL-7-OXO-4-THIA-1-AZABICYCLO[3.2.0]HEPTANE-2-CARBOXYLIC ACID
Synonyms	AMPICILLIN; D(-)-ALPHA-AMINOBENZYLPENICILLIN; 6-[D(-)-ALPHA-AMINOPHENYLLACETAMIDO]PENICILLANIC ACID
Identifiers	(2S,5R,6R)-6-[[(2R)-2-amino-2-phenyl-ethanoyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
Formula	C₁₆ H₁₉ N₃ O₄ S
Molecular Weight	349.405
Type	NON-POLYMER
Isomeric SMILES	CC1([C@@H](N2[C@H](S1)[C@@H](C2=O)NC(=O)[C@@H](c3ccccc3)N)C(=O)O)C
InChI	InChI=1S/C16H19N3O4S/c1-16(2)11(15(22)23)19-13(21)10(14(19)24-16)18-12(20)9(17)8-6-4-3-5-7-8/h3-7,9-11,14H,17H2,1-2H3,(H,18,20)(H,22,23)/t9-,10-,11+,14-/m1/s1
InChIKey	AVKUERGKIZMTKX-NJBDSQKTSA-N

Chemical Details
Formal Charge	0
Atom Count	43
Chiral Atom Count	4
Bond Count	45
Aromatic Bond Count	6

Drug Info: DrugBank

DrugBank ID	DB00415
Name	Ampicillin
Groups	vet_approved approved
Description	Ampicillin is a semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic.
Synonyms	Ampicillin sodium Ampicillin anhydrous Ampicillin acid Ampicillin, anhydrous Anhydrous ampicillin Aminobenzylpenicillin Ampicilline AP Ampicillin D-(−)-6-(α-aminophenylacetamido)penicillanic acid D-(−)-ampicillin Ampicillinum Ampicilina Ampicillin (anhydrous) Ampicillin trihydrate ABPC
Brand Names	Ampicillin Sodium Apo Ampi Capsules 500mg Nu-ampi Sus 125mg/5ml Apo Ampi Liq 250mg/5ml Novo-ampicillin Pws 500mg/5ml Unasyn Jaa Amp Tab 125mg Penbritin-1000 Pws 1000mg/vial Ampicillin for Injection, USP Sterile Ampicillin Sodium 250mg USP Penbritin Cap 250mg Taro-ampicillin Cap 500mg Ampicin for Injection 250mg Ampicin Inj 1gm Penbritin-125 Pws 125mg/vial Ampicillin Trihydrate Ampicin Inj 500mg Ampicillin sodium Ampicillin and Sulbactam Penbritin Pws 250mg/5ml Ampicin Inj 125mg/vial Novo-ampicillin Sus 125mg/5ml Nu-ampi Suspension 250mg/5ml Penbritin Inj 250mg Pro Ampi 500 Cap 500mg Pro Ampi 250 Cap 250mg Apo Ampi Capsules 250mg Taro-ampicillin Cap 250mg Penbritin Cap 500mg Ampicillin Sodium for Injection, USP Ampicillin Sodium for Injection BP Novo-ampicillin Sus 250mg/5ml Nu-ampi Capsules 250mg Ampicillin Ampicin Inj 2000mg Ampicillin for Injection AMPICILLIN and SULBACTAM Pro Biosan Kit Ampicillin Sodium for Injection, BP Penbritin Inj 1000mg Penbritin Inj 500mg Penbritin-250 Pws Im/iv 250mg/vial Ampicillin Sodium and Sulbactam Sodium Nu-ampi Capsules 500mg Teva-ampicillin Penbritin Inj 2000mg Apo Ampi Liq 125mg/5ml
Indication	For treatment of infection (Respiratory, GI, UTI and meningitis) due to E. coli, P. mirabilis, enterococci, Shigella, S. typhosa and other Salmonella, nonpenicillinase-producing N. gononhoeae, H. influenzae, staphylococci, streptococci including streptoc
Categories	Amides Aminopenicillins Anti-Bacterial Agents Anti-Infective Agents Antibacterials for Systemic Use Antiinfectives for Systemic Use Beta-Lactam Antibacterials beta-Lactams Drugs that are Mainly Renally Excreted Heterocyclic Compounds, Fused-Ring Lactams Ophthalmologicals Penicillin G Penicillins Penicillins With Extended Spectrum Sensory Organs Sulfur Compounds
ATC-Code	J01CR50 J01CA51 J01CA01 S01AA19
CAS number	69-53-4

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Penicillin-binding protein 2a	MKLDKLFEKFLSLFKKETSELEDSDSTILRRSRSDRKKLAQVGPIRKFWR...	unknown	inhibitor
Penicillin-binding protein 1b	MQNQLNELKRKMLEFFQQKQKNKKSARPGKKGSSTKKSKTLDKSAIFPAI...	unknown	inhibitor
Penicillin-binding protein 3	MKKIFLTLLTVSLLGGASTAVAQDFTIAAKHAIAVEANTGKILYEKDATQ...	unknown	inhibitor
Penicillin-binding protein 1A	MNKPTILRLIKYLSISFLSLVIAAIVLGGGVFFYYVSKAPSLSESKLVAT...	unknown	inhibitor
Penicillin-binding protein 2B	MRKFNSHSIPIRLNLLFSIVILLFMTIIGRLLYMQVLNKDFYEKKLASAS...	unknown	inhibitor
Solute carrier family 15 member 1	MGMSKSHSFFGYPLSIFFIVVNEFCERFSYYGMRAILILYFTNFISWDDN...	unknown
Solute carrier family 15 member 2	MNPFQKNESKETLFSPVSIEEVPPRPPSPPKKPSPTICGSNYPLSIAFIV...	unknown
Angiopoietin-1 receptor	MDSLASLVLCGVSLLLSGTVEGAMDLILINSLPLVSDAETSLTCIASGWR...	unknown
Serum albumin	MKWVTFISLLFLFSSAYSRGVFRRDAHKSEVAHRFKDLGEENFKALVLIA...	unknown	other/unknown
Solute carrier family 22 member 5	MRDYDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRC...	unknown	inhibitor
Solute carrier family 15 member 1	MGMSKSHSFFGYPLSIFFIVVNEFCERFSYYGMRAILILYFTNFISWDDN...	unknown	inhibitor
Solute carrier family 15 member 2	MNPFQKNESKETLFSPVSIEEVPPRPPSPPKKPSPTICGSNYPLSIAFIV...	unknown	inhibitor
Monocarboxylate transporter 1	MPPAVGGPVGYTPPDGGWGWAVVIGAFISIGFSYAFPKSITVFFKEIEGI...	unknown
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682