Purine biosynthesis transcriptional repressor PurR

UniProtKB accession:  P37551

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UniProtKB description:  DNA-binding transcriptional repressor that controls the expression of a number of genes involved in the synthesis, metabolism and transport of purines (PubMed:10919400, PubMed:11591660, PubMed:34967415, PubMed:7638212). In response to a signal of excess adenine, represses the transcription of the pur operon, which encodes enzymes of the purine biosynthetic pathway (PubMed:10919400, PubMed:7638212). It also represses the expression of the purA and purR genes (PubMed:16163456, PubMed:7638212). In addition, controls the expression of several other genes or operons, which encode enzymes or transporters playing a role in purine nucleotide metabolism (PubMed:11591660, PubMed:34967415). Acts by binding directly to specific DNA sequences, named PurBoxes, in the upstream control regions of affected genes (PubMed:10919400, PubMed:11591660, PubMed:12837784, PubMed:16163456, PubMed:34967415, PubMed:7638212, PubMed:9393704). Two PurBoxes are required for high-affinity PurR binding (PubMed:12837784, PubMed:16163456). Also responds to amino acid starvation via (p)ppGpp, which strongly increases PurR activity and repression of purine nucleotide biosynthesis genes (PubMed:34967415).