Annotations: 9F54

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	RNA-binding domain, RBD	8040670	3000110	SCOP2B (2022-06-29)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00076	RNA recognition motif (RRM_1)	RNA recognition motif	The RRM motif (a.k.a. RRM, RBD, or RNP domain) is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and pro ...	The RRM motif (a.k.a. RRM, RBD, or RNP domain) is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins (Swiss:P05455) have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins (Swiss:P05455) are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed	pre-mRNA binding RNA binding binding nucleic acid binding protein binding protein domain specific binding mRNA 3'-UTR binding mRNA binding single-stranded RNA binding regulatory RNA binding miRNA binding telomeric repeat-containing RNA binding DNA binding sequence-specific DNA binding pre-mRNA binding RNA binding binding nucleic acid binding protein binding protein domain specific binding mRNA 3'-UTR binding mRNA binding single-stranded RNA binding regulatory RNA binding miRNA binding telomeric repeat-containing RNA binding DNA binding sequence-specific DNA binding G-rich strand telomeric DNA binding sequence-specific single stranded DNA binding single-stranded telomeric DNA binding single-stranded DNA binding telomeric DNA binding identical protein binding	localization cellular localization import into nucleus nucleocytoplasmic transport transport nuclear transport establishment of localization in cell intracellular transport cellular process establishment of localization cellular response to stimulus cellular response to arsenic-containing substance response to stimulus response to sodium arsenite localization cellular localization import into nucleus nucleocytoplasmic transport transport nuclear transport establishment of localization in cell intracellular transport cellular process establishment of localization cellular response to stimulus cellular response to arsenic-containing substance response to stimulus response to sodium arsenite response to arsenic-containing substance cellular response to chemical stimulus response to chemical cellular response to salt cellular response to sodium arsenite response to salt RNA transport nitrogen compound transport nucleic acid transport mRNA transport establishment of RNA localization macromolecule localization RNA localization nucleobase-containing compound transport cellular response to nutrient levels response to nutrient levels cellular response to stress response to stress response to starvation cellular response to glucose starvation cellular response to starvation regulation of cellular process alternative mRNA splicing, via spliceosome RNA metabolic process regulation of mRNA splicing, via spliceosome mRNA processing regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process regulation of RNA metabolic process RNA processing regulation of nucleobase-containing compound metabolic process regulation of biosynthetic process regulation of mRNA processing RNA splicing regulation of biological process biological regulation primary metabolic process regulation of macromolecule metabolic process gene expression nucleobase-containing compound biosynthetic process regulation of RNA splicing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process regulation of gene expression biosynthetic process RNA splicing, via transesterification reactions regulation of alternative mRNA splicing, via spliceosome mRNA splicing, via spliceosome metabolic process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of mRNA metabolic process regulation of metabolic process negative regulation of telomere maintenance negative regulation of biological process telomere organization negative regulation of telomere maintenance via telomerase regulation of DNA biosynthetic process RNA-templated DNA biosynthetic process telomere maintenance via telomere lengthening negative regulation of chromosome organization negative regulation of nucleobase-containing compound metabolic process negative regulation of cellular component organization negative regulation of metabolic process DNA metabolic process regulation of chromosome organization regulation of telomere maintenance via telomere lengthening regulation of organelle organization telomere maintenance negative regulation of macromolecule biosynthetic process DNA biosynthetic process negative regulation of DNA biosynthetic process regulation of DNA metabolic process regulation of telomere maintenance regulation of cellular component organization negative regulation of telomere maintenance via telomere lengthening cellular component organization negative regulation of cellular process cellular component organization or biogenesis negative regulation of macromolecule metabolic process telomere maintenance via telomerase chromosome organization regulation of telomere maintenance via telomerase organelle organization negative regulation of organelle organization negative regulation of biosynthetic process negative regulation of DNA metabolic process RNA export from nucleus nuclear export positive regulation of organelle organization positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of telomere maintenance via telomere lengthening positive regulation of macromolecule metabolic process positive regulation of telomere maintenance positive regulation of nucleobase-containing compound metabolic process positive regulation of chromosome organization positive regulation of DNA metabolic process positive regulation of telomere maintenance via telomerase positive regulation of cellular component organization positive regulation of biological process positive regulation of biosynthetic process positive regulation of cellular process positive regulation of DNA biosynthetic process	cellular anatomical structure membrane membrane-bounded organelle catalytic step 2 spliceosome protein-containing complex intracellular anatomical structure catalytic complex nucleus nuclear protein-containing complex intracellular membrane-bounded organelle intracellular organelle spliceosomal complex organelle ribonucleoprotein complex cellular anatomical structure membrane membrane-bounded organelle catalytic step 2 spliceosome protein-containing complex intracellular anatomical structure catalytic complex nucleus nuclear protein-containing complex intracellular membrane-bounded organelle intracellular organelle spliceosomal complex organelle ribonucleoprotein complex extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle cytoplasm cytosol membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR034516	hnRNP A1/3, RNA recognition motif 2	Domain
A	IPR000504	RNA recognition motif domain	Domain
A	IPR021662	Heterogeneous nuclear ribonucleoprotein A1/A2, C-terminal	Domain
A	IPR034845	hnRNP A1, RNA recognition motif 1	Domain
A	IPR012677	Nucleotide-binding alpha-beta plait domain superfamily	Homologous Superfamily
A	IPR035979	RNA-binding domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P09651	amyotrophic lateral sclerosis amyotrophic lateral sclerosis type 20 inclusion body myopathy with early-onset Paget disease with or without frontotemporal dementia 3 sarcomatoid carcinoma inclusion body myopathy with Paget disease of bone and frontotemporal dementia Mammary Neoplasms, Experimental carcinoma lymphoplasmacytic lymphoma medulloblastoma neurodegenerative disease ovarian cancer pancreatic intraductal papillary-mucinous neoplasm primitive neuroectodermal tumor astrocytic tumor lung adenocarcinoma amyotrophic lateral sclerosis amyotrophic lateral sclerosis type 20 inclusion body myopathy with early-onset Paget disease with or without frontotemporal dementia 3 sarcomatoid carcinoma inclusion body myopathy with Paget disease of bone and frontotemporal dementia Mammary Neoplasms, Experimental carcinoma lymphoplasmacytic lymphoma medulloblastoma neurodegenerative disease ovarian cancer pancreatic intraductal papillary-mucinous neoplasm primitive neuroectodermal tumor astrocytic tumor lung adenocarcinoma malignant colon neoplasm mammary neoplasms, animal myopathy oligodendroglioma pancreatic ductal adenocarcinoma Pick disease progressive supranuclear palsy atypical teratoid rhabdoid tumor undifferentiated carcinoma glioblastoma inclusion body myopathy with Paget disease of bone and frontotemporal dementia type 1 lung cancer malignant ependymoma nasopharyngeal carcinoma osteosarcoma pancreatic intraductal papillary-mucinous carcinoma plasma cell myeloma arthrogryposis psoriasis dermatomyositis large cell medulloblastoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.