8ZP9 | pdb_00008zp9

Cryo-EM structure of Cas5-HNH Cascade bound with sDNA, Conf2

External Resource: Annotation

Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B [auth F], C [auth H], D [auth I], E [auth J], F [auth K], B [auth F], C [auth H], D [auth I], E [auth J], F [auth K], G	PF09344	CT1975-like protein (Cas_CT1975)	CT1975-like protein	-	Family
H [auth B]	PF09704	CRISPR-associated protein (Cas_Cas5) (Cas_Cas5d)	CRISPR-associated protein (Cas_Cas5)	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	RNA (61-MER)	-	-	-
B [auth F], C [auth H], D [auth I], E [auth J], F [auth K], B [auth F], C [auth H], D [auth I], E [auth J], F [auth K], G	CRISPR system Cascade subunit CasC	-	-	-
H [auth B]	CRISPR system Cascade subunit CasD	endonuclease activity nuclease activity hydrolase activity, acting on ester bonds hydrolase activity catalytic activity cation binding transition metal ion binding zinc ion binding ion binding binding metal ion binding small molecule binding RNA binding nucleic acid binding	biological process involved in interspecies interaction between organisms response to stimulus response to other organism defense response response to external stimulus response to biotic stimulus defense response to virus defense response to other organism response to stress response to external biotic stimulus response to virus maintenance of CRISPR repeat elements chromosome organization primary metabolic process biological process involved in interspecies interaction between organisms response to stimulus response to other organism defense response response to external stimulus response to biotic stimulus defense response to virus defense response to other organism response to stress response to external biotic stimulus response to virus maintenance of CRISPR repeat elements chromosome organization primary metabolic process DNA metabolic process maintenance of DNA repeat elements nucleic acid metabolic process cellular component organization nucleobase-containing compound metabolic process organelle organization cellular process metabolic process cellular component organization or biogenesis macromolecule metabolic process	-
I [auth M]	DNA (60-MER)	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
B [auth F], C [auth H], D [auth I], E [auth J], F [auth K], B [auth F], C [auth H], D [auth I], E [auth J], F [auth K], G	IPR010148	CRISPR-associated protein, CT1975	Family
H [auth B]	IPR010147	CRISPR-associated protein, CasD	Family
H [auth B]	IPR021124	CRISPR-associated protein, Cas5	Family
H [auth B]	IPR003615	HNH nuclease	Domain
H [auth B]	IPR002711	HNH endonuclease	Domain
H [auth B]	IPR013422	CRISPR-associated protein Cas5, N-terminal	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.