8S1Z

Crystal structure of glycosylated human primary amine oxidase AOC3

External Resource: Annotation

Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Protein Modification Annotation

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Membrane primary amine oxidase	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding protein heterodimerization activity protein binding protein dimerization activity transition metal ion binding copper ion binding aliphatic amine oxidase activity oxidoreductase activity, acting on the CH-NH2 group of donors oxidoreductase activity cation binding ion binding binding calcium ion binding metal ion binding small molecule binding protein heterodimerization activity protein binding protein dimerization activity transition metal ion binding copper ion binding aliphatic amine oxidase activity oxidoreductase activity, acting on the CH-NH2 group of donors oxidoreductase activity oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor catalytic activity aliphatic amine dehydrogenase activity quinone binding primary methylamine oxidase activity identical protein binding	response to stimulus response to chemical response to antibiotic amine metabolic process metabolic process cellular process cell adhesion defense response response to stress inflammatory response	cellular anatomical structure membrane cell surface cell periphery plasma membrane intracellular anatomical structure cytoplasm membrane-bounded organelle early endosome endosome intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cellular anatomical structure membrane cell surface cell periphery plasma membrane intracellular anatomical structure cytoplasm membrane-bounded organelle early endosome endosome intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle organelle vesicle Golgi apparatus cell projection actin-based cell projection microvillus plasma membrane bounded cell projection endoplasmic reticulum

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR036460	Copper amine oxidase, catalytic domain superfamily	Homologous Superfamily
A, B, C, D	IPR015798	Copper amine oxidase, catalytic domain	Domain
A, B, C, D	IPR015802	Copper amine oxidase, N3-terminal	Domain
A, B, C, D	IPR000269	Copper amine oxidase	Family
A, B, C, D	IPR049947	Copper amine oxidase, copper-binding site	Conserved Site
A, B, C, D	IPR016182	Copper amine oxidase, N-terminal	Homologous Superfamily
A, B, C, D	IPR049948	Copper amine oxidase, TPQ-binding site	Conserved Site
A, B, C, D	IPR015800	Copper amine oxidase, N2-terminal	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D	Pharos: Q16853	diabetes mellitus hypertensive disorder paratuberculosis Diabetes Mellitus, Experimental malignant colon neoplasm non-small cell lung carcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia Sjogren syndrome acute myeloid leukemia breast carcinoma lung cancer malignant mesothelioma pancreatic intraductal papillary-mucinous carcinoma adenoma breast fibroadenoma diabetes mellitus hypertensive disorder paratuberculosis Diabetes Mellitus, Experimental malignant colon neoplasm non-small cell lung carcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia Sjogren syndrome acute myeloid leukemia breast carcinoma lung cancer malignant mesothelioma pancreatic intraductal papillary-mucinous carcinoma adenoma breast fibroadenoma chronic renal failure syndrome ductal breast carcinoma in situ invasive ductal breast carcinoma lung carcinoma pancreatic intraductal papillary-mucinous neoplasm psoriasis depressive disorder diabetic kidney disease Emery-Dreifuss muscular dystrophy lung adenocarcinoma

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
A, B, C, D	TPQ	Parent Component: TYR RESID: AA0147 PSI-MOD : oxidation of tyrosine to L-2',4',5'-topaquinone MOD:00156

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.