8EOI | pdb_00008eoi

Structure of a human EMC:human Cav1.2 channel complex in GDN detergent


Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
CSCOP2B SuperfamilyYidC transmembrane domain-like 8101852 3002720 SCOP2B (2022-06-29)
E [auth F]SCOP2B SuperfamilyEMC6/GET2-like 8101858 3002721 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
JF_UNCLASSIFIEDe8eoiJ2 A: beta barrelsX: SH3H: SH3T: SH3F: F_UNCLASSIFIEDECOD (1.6)
JF_UNCLASSIFIEDe8eoiJ1 A: a/b three-layered sandwichesX: P-loop domains-likeH: P-loop domains-relatedT: P-loop containing nucleoside triphosphate hydrolasesF: F_UNCLASSIFIEDECOD (1.6)
F [auth G]F_UNCLASSIFIEDe8eoiG1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Prealbumin-likeF: F_UNCLASSIFIEDECOD (1.6)
G [auth H]F_UNCLASSIFIEDe8eoiH1 A: a+b three layersX: Cytidine deaminase-like (From Topology)H: Cytidine deaminase-like (From Topology)T: Cytidine deaminase-likeF: F_UNCLASSIFIEDECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF07774ER membrane protein complex subunit 1, C-terminal (EMC1_C)ER membrane protein complex subunit 1, C-terminalThis is the C-terminal domain of ER membrane protein complex subunit 1. ER membrane protein complex subunit 1 is a component of the ER membrane protein complex (EMC, composed of EMC1, EMC2, EMC3, EMC4, EMC5 and EMC6). In Saccharomyces cerevisiae, the ...Domain
PF13360PQQ-like domain (PQQ_2)PQQ-like domain- Repeat
PF00625Guanylate kinase (Guanylate_kin)Guanylate kinaseDomain
PF12052Voltage gated calcium channel subunit beta domain 4Aa N terminal (VGCC_beta4Aa_N)Voltage gated calcium channel subunit beta domain 4Aa N terminalThe beta subunit of voltage gated calcium channels is coded for by four genes 1-4. Gene 4 can produce two types of beta4A domain (beta4Aa and beta4Ab) according to how the gene splicing is carried out. This family is part of the beta4Aa N terminal do ...Domain
PF22890EMC2 TPR-like repeat domain (TPR_EMC2)EMC2 TPR-like repeat domain- Repeat
PF01956Integral membrane protein EMC3/TMCO1-like (EMC3_TMCO1)Integral membrane protein EMC3/TMCO1-like- Family
D [auth E]PF10270Membrane magnesium transporter (MMgT)Membrane magnesium transporter- Family
E [auth F]PF07019EMC6 (EMC6)EMC6- Family
F [auth G]PF09430ER membrane protein complex subunit 7, beta-sandwich domain (EMC7_beta-sandw)ER membrane protein complex subunit 7, beta-sandwich domainThis is the beta-sandwich domain found in ER membrane protein complex subunit 7 (EMC7) [1,2], which is an integral membrane component of the EMC. EMC is widely conserved and involved in membrane protein biogenesis. It mediates the insertion into endo ...Domain
G [auth H]PF03665Uncharacterised protein family (UPF0172) (UPF0172)Uncharacterised protein family (UPF0172)- Family
H [auth I]PF21203ER membrane protein complex subunit 10 (ECM10)ER membrane protein complex subunit 10- Family
I [auth K]PF16905Voltage-dependent L-type calcium channel, IQ-associated (GPHH)Voltage-dependent L-type calcium channel, IQ-associated- Family
I [auth K]PF08763Voltage gated calcium channel IQ domain (Ca_chan_IQ)Voltage gated calcium channel IQ domainVoltage gated calcium channels control cellular calcium entry in response to changes in membrane potential. The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin [1]. ...Domain
I [auth K]PF00520Ion transport protein (Ion_trans)Ion transport protein- Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
ER membrane protein complex subunit 1-
Voltage-dependent L-type calcium channel subunit beta-3
K [auth D]ER membrane protein complex subunit 4-
ER membrane protein complex subunit 2-
ER membrane protein complex subunit 3-
D [auth E]ER membrane protein complex subunit 5
E [auth F]ER membrane protein complex subunit 6-
F [auth G]ER membrane protein complex subunit 7
G [auth H]ER membrane protein complex subunit 8-
H [auth I]ER membrane protein complex subunit 10-
I [auth K]Voltage-dependent L-type calcium channel subunit alpha-1C

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
IPR011047Quinoprotein alcohol dehydrogenase-like superfamilyHomologous Superfamily
IPR011678ER membrane protein complex subunit 1, C-terminalDomain
IPR002372Pyrrolo-quinoline quinone repeatRepeat
IPR015943WD40/YVTN repeat-like-containing domain superfamilyHomologous Superfamily
IPR026895ER membrane protein complex subunit 1Family
IPR008145Guanylate kinase/L-type calcium channel beta subunitDomain
IPR001452SH3 domainDomain
IPR036028SH3-like domain superfamilyHomologous Superfamily
IPR035760Voltage-dependent L-type calcium channel subunit beta-3, SH3 domainDomain
IPR046937Voltage-dependent L-type calcium channel subunit beta-1-4, N-terminal A domainDomain
IPR008079Voltage-dependent calcium channel, L-type, beta-3 subunitFamily
IPR027417P-loop containing nucleoside triphosphate hydrolaseHomologous Superfamily
IPR000584Voltage-dependent calcium channel, L-type, beta subunitFamily
K [auth D]IPR009445ER membrane protein complex subunit 4Family
IPR039856ER membrane protein complex subunit 2-likeFamily
IPR011990Tetratricopeptide-like helical domain superfamilyHomologous Superfamily
IPR055217EMC2, TPR-like domainDomain
IPR019734Tetratricopeptide repeatRepeat
IPR008568ER membrane protein complex subunit 3Family
IPR002809Integral membrane protein EMC3/TMCO1-likeFamily
D [auth E]IPR018937Membrane magnesium transporterFamily
E [auth F]IPR008504ER membrane protein complex subunit 6Family
E [auth F]IPR029008ER membrane protein complex subunit 6-likeFamily
F [auth G]IPR013784Carbohydrate-binding-like foldHomologous Superfamily
F [auth G]IPR019008ER membrane protein complex subunit 7, beta-sandwich domainDomain
F [auth G]IPR039163ER membrane protein complex subunit 7Family
G [auth H]IPR037518MPN domainDomain
G [auth H]IPR005366ER membrane protein complex subunit 8/9Family
H [auth I]IPR051754Chrom_ER_Complex_ProteinUnknown
I [auth K]IPR014873Voltage-dependent calcium channel, alpha-1 subunit, IQ domainDomain
I [auth K]IPR002077Voltage-dependent calcium channel, alpha-1 subunitFamily
I [auth K]IPR031649Voltage-dependent L-type calcium channel, IQ-associated domainDomain
I [auth K]IPR005451Voltage-dependent calcium channel, L-type, alpha-1C subunitFamily
I [auth K]IPR005821Ion transport domainDomain
I [auth K]IPR005446Voltage-dependent calcium channel, L-type, alpha-1 subunitFamily
I [auth K]IPR050599Voltage-dependent calcium channel alpha-1 subunitFamily
I [auth K]IPR031688Voltage-gated calcium channel subunit alpha, C-terminalDomain
I [auth K]IPR027359Voltage-dependent channel domain superfamilyHomologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

ChainsDrug Target  Associated Disease
PharosQ8N766
K [auth D]PharosQ5J8M3
PharosQ15006
PharosQ9P0I2
D [auth E]PharosQ8N4V1
E [auth F]PharosQ9BV81
F [auth G]PharosQ9NPA0
G [auth H]PharosO43402
H [auth I]PharosQ5UCC4
I [auth K]PharosQ13936