8EOI

Structure of a human EMC:human Cav1.2 channel complex in GDN detergent

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Membrane Protein Annotation: OPM
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: MemProtMD
Membrane Protein Annotation: mpstruc

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
C	SCOP2B Superfamily	YidC transmembrane domain-like	8101852	3002720	SCOP2B (2022-06-29)
E [auth F]	SCOP2B Superfamily	EMC6/GET2-like	8101858	3002721	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
F [auth G]	F_UNCLASSIFIED	e8eoiG1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Prealbumin-like	F: F_UNCLASSIFIED	ECOD (1.6)
G [auth H]	F_UNCLASSIFIED	e8eoiH1	A: a+b three layers	X: Cytidine deaminase-like (From Topology)	H: Cytidine deaminase-like (From Topology)	T: Cytidine deaminase-like	F: F_UNCLASSIFIED	ECOD (1.6)
J	F_UNCLASSIFIED	e8eoiJ2	A: beta barrels	X: SH3	H: SH3	T: SH3	F: F_UNCLASSIFIED	ECOD (1.6)
J	F_UNCLASSIFIED	e8eoiJ1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: F_UNCLASSIFIED	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
I [auth K]	1.20.120.350	Mainly Alpha	Up-down Bundle	Four Helix Bundle (Hemerythrin (Met), subunit A)	Voltage-gated potassium channels. Chain C	CATH (utative)
J	2.30.30.40	Mainly Beta	Roll	SH3 type barrels.	SH3 Domains	CATH (utative)
J	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF07774	ER membrane protein complex subunit 1, C-terminal (EMC1_C)	ER membrane protein complex subunit 1, C-terminal	This is the C-terminal domain of ER membrane protein complex subunit 1. ER membrane protein complex subunit 1 is a component of the ER membrane protein complex (EMC, composed of EMC1, EMC2, EMC3, EMC4, EMC5 and EMC6). In Saccharomyces cerevisiae, the ...	This is the C-terminal domain of ER membrane protein complex subunit 1. ER membrane protein complex subunit 1 is a component of the ER membrane protein complex (EMC, composed of EMC1, EMC2, EMC3, EMC4, EMC5 and EMC6). In Saccharomyces cerevisiae, the EMC seems to be required for efficient folding of proteins in the endoplasmic reticulum (ER) [1].	Domain
A	PF13360	PQQ-like domain (PQQ_2)	PQQ-like domain	-	Repeat
B	PF22890	EMC2 TPR-like repeat domain (TPR_EMC2)	EMC2 TPR-like repeat domain	-	Repeat
C	PF01956	Integral membrane protein EMC3/TMCO1-like (EMC3_TMCO1)	Integral membrane protein EMC3/TMCO1-like	-	Family
D [auth E]	PF10270	Membrane magnesium transporter (MMgT)	Membrane magnesium transporter	-	Family
E [auth F]	PF07019	EMC6 (EMC6)	EMC6	-	Family
F [auth G]	PF09430	ER membrane protein complex subunit 7, beta-sandwich domain (EMC7_beta-sandw)	ER membrane protein complex subunit 7, beta-sandwich domain	This is the beta-sandwich domain found in ER membrane protein complex subunit 7 (EMC7) [1,2], which is an integral membrane component of the EMC. EMC is widely conserved and involved in membrane protein biogenesis. It mediates the insertion into endo ...	This is the beta-sandwich domain found in ER membrane protein complex subunit 7 (EMC7) [1,2], which is an integral membrane component of the EMC. EMC is widely conserved and involved in membrane protein biogenesis. It mediates the insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins in an energy-independent manner, both post-translational insertions of tail-anchored proteins and co-translational insertion of multipass membrane proteins [3,4]. This entry includes UPF0620 protein C83.10 from S. pombe, an orthologue of animal EMC7. This domain is also found in nodal modulators, which have been identified as part of a protein complex that participates in the nodal signalling pathway during vertebrate development [5].	Domain
G [auth H]	PF03665	Uncharacterised protein family (UPF0172) (UPF0172)	Uncharacterised protein family (UPF0172)	-	Family
H [auth I]	PF21203	ER membrane protein complex subunit 10 (ECM10)	ER membrane protein complex subunit 10	-	Family
I [auth K]	PF16905	Voltage-dependent L-type calcium channel, IQ-associated (GPHH)	Voltage-dependent L-type calcium channel, IQ-associated	-	Family
I [auth K]	PF08763	Voltage gated calcium channel IQ domain (Ca_chan_IQ)	Voltage gated calcium channel IQ domain	Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential. The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin [1]. ...	Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential. The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin [1]. The interaction regulates two self-regulatory calcium dependent feedback mechanism, calcium dependent inactivation (CDI), and calcium-dependent facilitation (CDF).	Domain
I [auth K]	PF00520	Ion transport protein (Ion_trans)	Ion transport protein	-	Family
J	PF00625	Guanylate kinase (Guanylate_kin)	Guanylate kinase	-	Domain
J	PF12052	Voltage gated calcium channel subunit beta domain 4Aa N terminal (VGCC_beta4Aa_N)	Voltage gated calcium channel subunit beta domain 4Aa N terminal	The beta subunit of voltage gated calcium channels is coded for by four genes 1-4. Gene 4 can produce two types of beta4A domain (beta4Aa and beta4Ab) according to how the gene splicing is carried out. This family is part of the beta4Aa N terminal do ...	The beta subunit of voltage gated calcium channels is coded for by four genes 1-4. Gene 4 can produce two types of beta4A domain (beta4Aa and beta4Ab) according to how the gene splicing is carried out. This family is part of the beta4Aa N terminal domain. It is made up of an alpha helix and a beta strand. It is thought to regulate the channel properties through protein-protein interactions with non Ca channel proteins. [1]	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	ER membrane protein complex subunit 1	-	protein localization membrane organization cellular localization establishment of protein localization establishment of protein localization to membrane localization within membrane tail-anchored membrane protein insertion into ER membrane protein localization to membrane endoplasmic reticulum organization establishment of localization cellular component organization localization organelle organization protein localization to organelle cellular macromolecule localization protein localization membrane organization cellular localization establishment of protein localization establishment of protein localization to membrane localization within membrane tail-anchored membrane protein insertion into ER membrane protein localization to membrane endoplasmic reticulum organization establishment of localization cellular component organization localization organelle organization protein localization to organelle cellular macromolecule localization macromolecule localization cellular process cellular component organization or biogenesis protein insertion into membrane protein insertion into ER membrane endomembrane system organization protein insertion into ER membrane by stop-transfer membrane-anchor sequence	membrane-bounded organelle protein-containing complex intracellular anatomical structure EMC complex organelle subcompartment membrane membrane protein complex intracellular membrane-bounded organelle endomembrane system endoplasmic reticulum subcompartment intracellular organelle cellular anatomical structure organelle nuclear outer membrane-endoplasmic reticulum membrane network membrane-bounded organelle protein-containing complex intracellular anatomical structure EMC complex organelle subcompartment membrane membrane protein complex intracellular membrane-bounded organelle endomembrane system endoplasmic reticulum subcompartment intracellular organelle cellular anatomical structure organelle nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum cytoplasm organelle membrane endoplasmic reticulum protein-containing complex endoplasmic reticulum membrane
B	ER membrane protein complex subunit 2	-	protein localization membrane organization cellular localization establishment of protein localization establishment of protein localization to membrane localization within membrane tail-anchored membrane protein insertion into ER membrane protein localization to membrane endoplasmic reticulum organization establishment of localization cellular component organization localization organelle organization protein localization to organelle cellular macromolecule localization protein localization membrane organization cellular localization establishment of protein localization establishment of protein localization to membrane localization within membrane tail-anchored membrane protein insertion into ER membrane protein localization to membrane endoplasmic reticulum organization establishment of localization cellular component organization localization organelle organization protein localization to organelle cellular macromolecule localization macromolecule localization cellular process cellular component organization or biogenesis protein insertion into membrane protein insertion into ER membrane endomembrane system organization protein insertion into ER membrane by stop-transfer membrane-anchor sequence	membrane-bounded organelle protein-containing complex intracellular anatomical structure EMC complex organelle subcompartment membrane membrane protein complex intracellular membrane-bounded organelle endomembrane system endoplasmic reticulum subcompartment intracellular organelle cellular anatomical structure organelle nuclear outer membrane-endoplasmic reticulum membrane network membrane-bounded organelle protein-containing complex intracellular anatomical structure EMC complex organelle subcompartment membrane membrane protein complex intracellular membrane-bounded organelle endomembrane system endoplasmic reticulum subcompartment intracellular organelle cellular anatomical structure organelle nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum cytoplasm organelle membrane endoplasmic reticulum protein-containing complex endoplasmic reticulum membrane extrinsic component of organelle membrane extrinsic component of endoplasmic reticulum membrane extrinsic component of membrane
C	ER membrane protein complex subunit 3	-	protein localization membrane organization cellular localization establishment of protein localization establishment of protein localization to membrane localization within membrane tail-anchored membrane protein insertion into ER membrane protein localization to membrane endoplasmic reticulum organization establishment of localization cellular component organization localization organelle organization protein localization to organelle cellular macromolecule localization protein localization membrane organization cellular localization establishment of protein localization establishment of protein localization to membrane localization within membrane tail-anchored membrane protein insertion into ER membrane protein localization to membrane endoplasmic reticulum organization establishment of localization cellular component organization localization organelle organization protein localization to organelle cellular macromolecule localization macromolecule localization cellular process cellular component organization or biogenesis protein insertion into membrane protein insertion into ER membrane endomembrane system organization protein insertion into ER membrane by stop-transfer membrane-anchor sequence	membrane-bounded organelle protein-containing complex intracellular anatomical structure EMC complex organelle subcompartment membrane membrane protein complex intracellular membrane-bounded organelle endomembrane system endoplasmic reticulum subcompartment intracellular organelle cellular anatomical structure organelle nuclear outer membrane-endoplasmic reticulum membrane network membrane-bounded organelle protein-containing complex intracellular anatomical structure EMC complex organelle subcompartment membrane membrane protein complex intracellular membrane-bounded organelle endomembrane system endoplasmic reticulum subcompartment intracellular organelle cellular anatomical structure organelle nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum cytoplasm organelle membrane endoplasmic reticulum protein-containing complex endoplasmic reticulum membrane
D [auth E]	ER membrane protein complex subunit 5	cobalt ion transmembrane transporter activity monoatomic cation transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transition metal ion transmembrane transporter activity metal ion transmembrane transporter activity transmembrane transporter activity iron ion transmembrane transporter activity ferrous iron transmembrane transporter activity magnesium ion transmembrane transporter activity	protein localization membrane organization cellular localization establishment of protein localization establishment of protein localization to membrane protein insertion into ER membrane by stop-transfer membrane-anchor sequence localization within membrane protein localization to membrane endoplasmic reticulum organization establishment of localization cellular component organization localization organelle organization protein localization to organelle cellular macromolecule localization protein localization membrane organization cellular localization establishment of protein localization establishment of protein localization to membrane protein insertion into ER membrane by stop-transfer membrane-anchor sequence localization within membrane protein localization to membrane endoplasmic reticulum organization establishment of localization cellular component organization localization organelle organization protein localization to organelle cellular macromolecule localization macromolecule localization cellular process cellular component organization or biogenesis protein insertion into membrane protein insertion into ER membrane endomembrane system organization transport copper ion transport transition metal ion transport monoatomic ion transport monoatomic cation transport metal ion transport magnesium ion transport tail-anchored membrane protein insertion into ER membrane	membrane-bounded organelle intracellular anatomical structure early endosome endosome intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cellular anatomical structure cytoplasmic vesicle organelle cytoplasm vesicle membrane membrane-bounded organelle intracellular anatomical structure early endosome endosome intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cellular anatomical structure cytoplasmic vesicle organelle cytoplasm vesicle membrane Golgi apparatus Golgi membrane bounding membrane of organelle organelle membrane endosome membrane early endosome membrane cytoplasmic vesicle membrane vesicle membrane cell periphery plasma membrane protein-containing complex EMC complex organelle subcompartment membrane protein complex endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum endoplasmic reticulum protein-containing complex endoplasmic reticulum membrane
E [auth F]	ER membrane protein complex subunit 6	-	protein localization membrane organization cellular localization establishment of protein localization establishment of protein localization to membrane localization within membrane tail-anchored membrane protein insertion into ER membrane protein localization to membrane endoplasmic reticulum organization establishment of localization cellular component organization localization organelle organization protein localization to organelle cellular macromolecule localization protein localization membrane organization cellular localization establishment of protein localization establishment of protein localization to membrane localization within membrane tail-anchored membrane protein insertion into ER membrane protein localization to membrane endoplasmic reticulum organization establishment of localization cellular component organization localization organelle organization protein localization to organelle cellular macromolecule localization macromolecule localization cellular process cellular component organization or biogenesis protein insertion into membrane protein insertion into ER membrane endomembrane system organization protein insertion into ER membrane by stop-transfer membrane-anchor sequence autophagosome assembly catabolic process organelle assembly vacuole organization macroautophagy autophagy autophagosome organization cellular component biogenesis cellular component assembly metabolic process process utilizing autophagic mechanism	membrane-bounded organelle protein-containing complex intracellular anatomical structure EMC complex organelle subcompartment membrane membrane protein complex intracellular membrane-bounded organelle endomembrane system endoplasmic reticulum subcompartment intracellular organelle cellular anatomical structure organelle nuclear outer membrane-endoplasmic reticulum membrane network membrane-bounded organelle protein-containing complex intracellular anatomical structure EMC complex organelle subcompartment membrane membrane protein complex intracellular membrane-bounded organelle endomembrane system endoplasmic reticulum subcompartment intracellular organelle cellular anatomical structure organelle nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum cytoplasm organelle membrane endoplasmic reticulum protein-containing complex endoplasmic reticulum membrane omegasome membrane omegasome bounding membrane of organelle
F [auth G]	ER membrane protein complex subunit 7	binding carbohydrate binding	protein localization membrane organization cellular localization establishment of protein localization establishment of protein localization to membrane localization within membrane tail-anchored membrane protein insertion into ER membrane protein localization to membrane endoplasmic reticulum organization establishment of localization cellular component organization localization organelle organization protein localization to organelle cellular macromolecule localization protein localization membrane organization cellular localization establishment of protein localization establishment of protein localization to membrane localization within membrane tail-anchored membrane protein insertion into ER membrane protein localization to membrane endoplasmic reticulum organization establishment of localization cellular component organization localization organelle organization protein localization to organelle cellular macromolecule localization macromolecule localization cellular process cellular component organization or biogenesis protein insertion into membrane protein insertion into ER membrane endomembrane system organization protein insertion into ER membrane by stop-transfer membrane-anchor sequence	membrane-bounded organelle protein-containing complex intracellular anatomical structure EMC complex organelle subcompartment membrane membrane protein complex intracellular membrane-bounded organelle endomembrane system endoplasmic reticulum subcompartment intracellular organelle cellular anatomical structure organelle nuclear outer membrane-endoplasmic reticulum membrane network membrane-bounded organelle protein-containing complex intracellular anatomical structure EMC complex organelle subcompartment membrane membrane protein complex intracellular membrane-bounded organelle endomembrane system endoplasmic reticulum subcompartment intracellular organelle cellular anatomical structure organelle nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum cytoplasm organelle membrane endoplasmic reticulum protein-containing complex endoplasmic reticulum membrane
G [auth H]	ER membrane protein complex subunit 8	-	protein localization membrane organization cellular localization establishment of protein localization establishment of protein localization to membrane localization within membrane tail-anchored membrane protein insertion into ER membrane protein localization to membrane endoplasmic reticulum organization establishment of localization cellular component organization localization organelle organization protein localization to organelle cellular macromolecule localization protein localization membrane organization cellular localization establishment of protein localization establishment of protein localization to membrane localization within membrane tail-anchored membrane protein insertion into ER membrane protein localization to membrane endoplasmic reticulum organization establishment of localization cellular component organization localization organelle organization protein localization to organelle cellular macromolecule localization macromolecule localization cellular process cellular component organization or biogenesis protein insertion into membrane protein insertion into ER membrane endomembrane system organization protein insertion into ER membrane by stop-transfer membrane-anchor sequence	membrane-bounded organelle protein-containing complex intracellular anatomical structure EMC complex organelle subcompartment membrane membrane protein complex intracellular membrane-bounded organelle endomembrane system endoplasmic reticulum subcompartment intracellular organelle cellular anatomical structure organelle nuclear outer membrane-endoplasmic reticulum membrane network membrane-bounded organelle protein-containing complex intracellular anatomical structure EMC complex organelle subcompartment membrane membrane protein complex intracellular membrane-bounded organelle endomembrane system endoplasmic reticulum subcompartment intracellular organelle cellular anatomical structure organelle nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum cytoplasm organelle membrane endoplasmic reticulum protein-containing complex endoplasmic reticulum membrane Golgi apparatus
H [auth I]	ER membrane protein complex subunit 10	-	protein localization membrane organization cellular localization establishment of protein localization establishment of protein localization to membrane localization within membrane tail-anchored membrane protein insertion into ER membrane protein localization to membrane endoplasmic reticulum organization establishment of localization cellular component organization localization organelle organization protein localization to organelle cellular macromolecule localization protein localization membrane organization cellular localization establishment of protein localization establishment of protein localization to membrane localization within membrane tail-anchored membrane protein insertion into ER membrane protein localization to membrane endoplasmic reticulum organization establishment of localization cellular component organization localization organelle organization protein localization to organelle cellular macromolecule localization macromolecule localization cellular process cellular component organization or biogenesis protein insertion into membrane protein insertion into ER membrane endomembrane system organization positive regulation of locomotion regulation of biological process regulation of cell motility regulation of cellular process endothelial cell migration biological regulation positive regulation of biological process positive regulation of cell migration regulation of locomotion positive regulation of endothelial cell migration positive regulation of cell motility regulation of cell migration regulation of endothelial cell migration cell migration cell motility locomotion positive regulation of cellular process cell population proliferation positive regulation of cell population proliferation endothelial cell proliferation positive regulation of epithelial cell proliferation regulation of endothelial cell proliferation regulation of cell population proliferation positive regulation of endothelial cell proliferation regulation of epithelial cell proliferation epithelial cell proliferation protein insertion into ER membrane by stop-transfer membrane-anchor sequence developmental process multicellular organismal process blood vessel morphogenesis tube development angiogenesis vasculature development circulatory system development multicellular organism development anatomical structure morphogenesis tube morphogenesis anatomical structure development anatomical structure formation involved in morphogenesis blood vessel development system development regulation of developmental process regulation of vasculature development positive regulation of developmental process regulation of multicellular organismal process regulation of anatomical structure morphogenesis regulation of multicellular organismal development positive regulation of angiogenesis positive regulation of vasculature development regulation of angiogenesis positive regulation of multicellular organismal process	membrane-bounded organelle protein-containing complex intracellular anatomical structure EMC complex organelle subcompartment membrane membrane protein complex intracellular membrane-bounded organelle endomembrane system endoplasmic reticulum subcompartment intracellular organelle cellular anatomical structure organelle nuclear outer membrane-endoplasmic reticulum membrane network membrane-bounded organelle protein-containing complex intracellular anatomical structure EMC complex organelle subcompartment membrane membrane protein complex intracellular membrane-bounded organelle endomembrane system endoplasmic reticulum subcompartment intracellular organelle cellular anatomical structure organelle nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum cytoplasm organelle membrane endoplasmic reticulum protein-containing complex endoplasmic reticulum membrane extracellular region
I [auth K]	Voltage-dependent L-type calcium channel subunit alpha-1C	calcium channel activity monoatomic cation transmembrane transporter activity voltage-gated calcium channel activity gated channel activity monoatomic ion channel activity voltage-gated channel activity voltage-gated monoatomic ion channel activity voltage-gated monoatomic cation channel activity monoatomic cation channel activity passive transmembrane transporter activity calcium ion transmembrane transporter activity inorganic molecular entity transmembrane transporter activity channel activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity calcium channel activity monoatomic cation transmembrane transporter activity voltage-gated calcium channel activity gated channel activity monoatomic ion channel activity voltage-gated channel activity voltage-gated monoatomic ion channel activity voltage-gated monoatomic cation channel activity monoatomic cation channel activity passive transmembrane transporter activity calcium ion transmembrane transporter activity inorganic molecular entity transmembrane transporter activity channel activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity high voltage-gated calcium channel activity transporter activity metal ion transmembrane transporter activity transmembrane transporter activity cytoskeletal protein binding protein binding binding alpha-actinin binding actinin binding voltage-gated calcium channel activity involved in cardiac muscle cell action potential calmodulin binding voltage-gated calcium channel activity involved in AV node cell action potential cation binding ion binding metal ion binding small molecule binding	membrane depolarization during action potential membrane depolarization biological regulation membrane depolarization during cardiac muscle cell action potential action potential regulation of biological quality cardiac muscle cell action potential regulation of membrane potential heart process multicellular organismal process system process cardiac muscle cell action potential involved in contraction signaling atrial cardiac muscle cell to AV node cell signaling membrane depolarization during action potential membrane depolarization biological regulation membrane depolarization during cardiac muscle cell action potential action potential regulation of biological quality cardiac muscle cell action potential regulation of membrane potential heart process multicellular organismal process system process cardiac muscle cell action potential involved in contraction signaling atrial cardiac muscle cell to AV node cell signaling regulation of heart contraction regulation of system process cell-cell signaling involved in cardiac conduction cardiac muscle contraction striated muscle contraction cell communication circulatory system process actin filament-based process regulation of multicellular organismal process atrial cardiac muscle cell to AV node cell communication cell communication involved in cardiac conduction blood circulation cardiac muscle cell contraction regulation of biological process atrial cardiac muscle cell action potential cell-cell signaling actin filament-based movement muscle contraction muscle system process regulation of blood circulation membrane depolarization during atrial cardiac muscle cell action potential cardiac conduction cellular process actin-mediated cell contraction heart contraction positive regulation of cytosolic calcium ion concentration developmental process heart development multicellular organism development anatomical structure development animal organ development circulatory system development system development calcium ion transmembrane import into cytosol transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization calcium ion transport metal ion transport inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport monoatomic cation transport calcium ion transport into cytosol calcium ion transmembrane transport immune system development immune system process cell communication by electrical coupling involved in cardiac conduction cell communication by electrical coupling limb development appendage development embryonic forelimb morphogenesis embryonic limb morphogenesis embryonic morphogenesis embryonic appendage morphogenesis embryo development anatomical structure morphogenesis forelimb morphogenesis appendage morphogenesis limb morphogenesis AV node cell action potential membrane depolarization during AV node cell action potential AV node cell to bundle of His cell signaling AV node cell to bundle of His cell communication calcium ion transmembrane transport via high voltage-gated calcium channel sensory organ development eye development visual system development camera-type eye development sensory system development regulation of actin filament-based process regulation of cellular process regulation of ventricular cardiac muscle cell action potential regulation of cardiac muscle cell action potential regulation of action potential ventricular cardiac muscle cell action potential regulation of cardiac muscle contraction regulation of muscle system process regulation of striated muscle contraction regulation of actin filament-based movement regulation of muscle contraction regulation of cardiac muscle cell contraction positive regulation of adenylate cyclase activity positive regulation of cyclase activity regulation of catalytic activity positive regulation of catalytic activity positive regulation of molecular function regulation of molecular function regulation of lyase activity regulation of adenylate cyclase activity regulation of cyclase activity positive regulation of lyase activity positive regulation of biological process positive regulation of muscle contraction positive regulation of multicellular organismal process import into cell import across plasma membrane inorganic cation import across plasma membrane calcium ion import across plasma membrane inorganic ion import across plasma membrane calcium ion import calcium ion import into cytosol cellular response to stimulus regulation of calcium ion transport regulation of localization intracellular calcium ion homeostasis response to stimulus negative regulation of biological process sarcoplasmic reticulum calcium ion transport release of sequestered calcium ion into cytosol by sarcoplasmic reticulum intracellular signal transduction intracellular signaling cassette signal transduction monoatomic cation homeostasis intracellular monoatomic ion homeostasis release of sequestered calcium ion into cytosol by endoplasmic reticulum regulation of release of sequestered calcium ion into cytosol regulation of monoatomic ion transport maintenance of location release of sequestered calcium ion into cytosol regulation of transmembrane transport chemical homeostasis calcium-mediated signaling cellular localization inorganic ion homeostasis homeostatic process calcium ion homeostasis regulation of monoatomic ion transmembrane transport negative regulation of sequestering of calcium ion regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion maintenance of location in cell regulation of calcium ion transmembrane transport intracellular monoatomic cation homeostasis monoatomic ion homeostasis negative regulation of cellular process intracellular chemical homeostasis regulation of metal ion transport regulation of sequestering of calcium ion regulation of cardiac muscle contraction by calcium ion signaling regulation of transport sequestering of calcium ion cellular homeostasis regulation of monoatomic cation transmembrane transport regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum regulation of heart rate by cardiac conduction regulation of heart rate	protein-containing complex plasma membrane protein complex sarcolemma voltage-gated calcium channel complex plasma membrane membrane membrane protein complex cation channel complex transporter complex cell periphery cellular anatomical structure transmembrane transporter complex T-tubule L-type voltage-gated calcium channel complex protein-containing complex plasma membrane protein complex sarcolemma voltage-gated calcium channel complex plasma membrane membrane membrane protein complex cation channel complex transporter complex cell periphery cellular anatomical structure transmembrane transporter complex T-tubule L-type voltage-gated calcium channel complex calcium channel complex monoatomic ion channel complex postsynaptic specialization membrane postsynaptic specialization synapse postsynaptic density membrane synaptic membrane postsynaptic density postsynapse neuron to neuron synapse organelle cell junction postsynaptic membrane asymmetric synapse plasma membrane region somatodendritic compartment cell body perikaryon neuronal cell body intracellular anatomical structure intracellular membraneless organelle Z disc sarcomere intracellular organelle I band membraneless organelle contractile muscle fiber cytoplasm supramolecular fiber myofibril supramolecular polymer supramolecular complex cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection
J	Voltage-dependent L-type calcium channel subunit beta-3	calcium channel activity monoatomic cation transmembrane transporter activity voltage-gated calcium channel activity gated channel activity monoatomic ion channel activity voltage-gated channel activity voltage-gated monoatomic ion channel activity voltage-gated monoatomic cation channel activity monoatomic cation channel activity passive transmembrane transporter activity calcium ion transmembrane transporter activity inorganic molecular entity transmembrane transporter activity channel activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity calcium channel activity monoatomic cation transmembrane transporter activity voltage-gated calcium channel activity gated channel activity monoatomic ion channel activity voltage-gated channel activity voltage-gated monoatomic ion channel activity voltage-gated monoatomic cation channel activity monoatomic cation channel activity passive transmembrane transporter activity calcium ion transmembrane transporter activity inorganic molecular entity transmembrane transporter activity channel activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity metal ion transmembrane transporter activity transmembrane transporter activity channel regulator activity ion channel regulator activity calcium channel regulator activity molecular function regulator activity transporter regulator activity	transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization calcium ion transport metal ion transport inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process calcium ion transmembrane transport via high voltage-gated calcium channel monoatomic cation transport transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization calcium ion transport metal ion transport inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process calcium ion transmembrane transport via high voltage-gated calcium channel monoatomic cation transport calcium ion transmembrane transport regulation of calcium ion transmembrane transporter activity regulation of calcium ion transport regulation of localization positive regulation of cation transmembrane transport positive regulation of calcium ion transport regulation of cellular process regulation of voltage-gated calcium channel activity positive regulation of monoatomic ion transport positive regulation of monoatomic ion transmembrane transport regulation of biological process regulation of monoatomic ion transport regulation of cation channel activity positive regulation of cation channel activity regulation of molecular function regulation of transmembrane transport positive regulation of voltage-gated calcium channel activity positive regulation of biological process regulation of transmembrane transporter activity regulation of monoatomic ion transmembrane transport regulation of transporter activity regulation of calcium ion transmembrane transport positive regulation of molecular function positive regulation of calcium ion transmembrane transporter activity positive regulation of calcium ion transmembrane transport positive regulation of transmembrane transport regulation of metal ion transport positive regulation of cellular process positive regulation of high voltage-gated calcium channel activity regulation of monoatomic ion transmembrane transporter activity regulation of high voltage-gated calcium channel activity regulation of transport biological regulation positive regulation of transport positive regulation of transporter activity positive regulation of ion transmembrane transporter activity regulation of monoatomic cation transmembrane transport	protein-containing complex plasma membrane protein complex sarcolemma voltage-gated calcium channel complex plasma membrane membrane membrane protein complex cation channel complex transporter complex cell periphery cellular anatomical structure transmembrane transporter complex T-tubule L-type voltage-gated calcium channel complex protein-containing complex plasma membrane protein complex sarcolemma voltage-gated calcium channel complex plasma membrane membrane membrane protein complex cation channel complex transporter complex cell periphery cellular anatomical structure transmembrane transporter complex T-tubule L-type voltage-gated calcium channel complex calcium channel complex monoatomic ion channel complex intracellular anatomical structure cytoplasm
K [auth D]	ER membrane protein complex subunit 4	-	protein localization membrane organization cellular localization establishment of protein localization establishment of protein localization to membrane localization within membrane tail-anchored membrane protein insertion into ER membrane protein localization to membrane endoplasmic reticulum organization establishment of localization cellular component organization localization organelle organization protein localization to organelle cellular macromolecule localization protein localization membrane organization cellular localization establishment of protein localization establishment of protein localization to membrane localization within membrane tail-anchored membrane protein insertion into ER membrane protein localization to membrane endoplasmic reticulum organization establishment of localization cellular component organization localization organelle organization protein localization to organelle cellular macromolecule localization macromolecule localization cellular process cellular component organization or biogenesis protein insertion into membrane protein insertion into ER membrane endomembrane system organization apoptotic process cell death programmed cell death protein insertion into ER membrane by stop-transfer membrane-anchor sequence	membrane-bounded organelle protein-containing complex intracellular anatomical structure EMC complex organelle subcompartment membrane membrane protein complex intracellular membrane-bounded organelle endomembrane system endoplasmic reticulum subcompartment intracellular organelle cellular anatomical structure organelle nuclear outer membrane-endoplasmic reticulum membrane network membrane-bounded organelle protein-containing complex intracellular anatomical structure EMC complex organelle subcompartment membrane membrane protein complex intracellular membrane-bounded organelle endomembrane system endoplasmic reticulum subcompartment intracellular organelle cellular anatomical structure organelle nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum cytoplasm organelle membrane endoplasmic reticulum protein-containing complex endoplasmic reticulum membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR011047	Quinoprotein alcohol dehydrogenase-like superfamily	Homologous Superfamily
A	IPR011678	ER membrane protein complex subunit 1, C-terminal	Domain
A	IPR002372	Pyrrolo-quinoline quinone repeat	Repeat
A	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily
A	IPR026895	ER membrane protein complex subunit 1	Family
B	IPR039856	ER membrane protein complex subunit 2-like	Family
B	IPR011990	Tetratricopeptide-like helical domain superfamily	Homologous Superfamily
B	IPR055217	EMC2, TPR-like domain	Domain
B	IPR019734	Tetratricopeptide repeat	Repeat
C	IPR008568	ER membrane protein complex subunit 3	Family
C	IPR002809	Integral membrane protein EMC3/TMCO1-like	Family
D [auth E]	IPR018937	Membrane magnesium transporter	Family
E [auth F]	IPR008504	ER membrane protein complex subunit 6	Family
E [auth F]	IPR029008	ER membrane protein complex subunit 6-like	Family
F [auth G]	IPR013784	Carbohydrate-binding-like fold	Homologous Superfamily
F [auth G]	IPR019008	ER membrane protein complex subunit 7, beta-sandwich domain	Domain
F [auth G]	IPR039163	ER membrane protein complex subunit 7	Family
G [auth H]	IPR037518	MPN domain	Domain
G [auth H]	IPR005366	ER membrane protein complex subunit 8/9	Family
H [auth I]	IPR051754	Chromatin and ER Membrane Complex Protein	Family
I [auth K]	IPR014873	Voltage-dependent calcium channel, alpha-1 subunit, IQ domain	Domain
I [auth K]	IPR002077	Voltage-dependent calcium channel, alpha-1 subunit	Family
I [auth K]	IPR031649	Voltage-dependent L-type calcium channel, IQ-associated domain	Domain
I [auth K]	IPR005451	Voltage-dependent calcium channel, L-type, alpha-1C subunit	Family
I [auth K]	IPR005821	Ion transport domain	Domain
I [auth K]	IPR005446	Voltage-dependent calcium channel, L-type, alpha-1 subunit	Family
I [auth K]	IPR050599	Voltage-dependent calcium channel alpha-1 subunit	Family
I [auth K]	IPR031688	Voltage-gated calcium channel subunit alpha, C-terminal	Domain
I [auth K]	IPR027359	Voltage-dependent channel domain superfamily	Homologous Superfamily
J	IPR008145	Guanylate kinase/L-type calcium channel beta subunit	Domain
J	IPR001452	SH3 domain	Domain
J	IPR036028	SH3-like domain superfamily	Homologous Superfamily
J	IPR035760	Voltage-dependent L-type calcium channel subunit beta-3, SH3 domain	Domain
J	IPR046937	Voltage-dependent L-type calcium channel subunit beta-1-4, N-terminal A domain	Domain
J	IPR008079	Voltage-dependent calcium channel, L-type, beta-3 subunit	Family
J	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
J	IPR000584	Voltage-dependent calcium channel, L-type, beta subunit	Family
K [auth D]	IPR009445	ER membrane protein complex subunit 4	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q8N766	cerebellar atrophy, visual impairment, and psychomotor retardation; astrocytic tumor glioblastoma malignant ependymoma neurodegenerative disease osteosarcoma large cell medulloblastoma malignant mesothelioma non-small cell lung carcinoma ovarian cancer diabetes mellitus lung cancer medulloblastoma oligodendroglioma psoriasis
B	Pharos: Q15006	androgenetic alopecia large cell medulloblastoma ovarian cancer dermatomyositis lung cancer progressive supranuclear palsy Down syndrome medulloblastoma
C	Pharos: Q9P0I2	astrocytic tumor glioblastoma malignant glioma osteosarcoma plasma cell myeloma atypical teratoid rhabdoid tumor large cell medulloblastoma medulloblastoma ovarian cancer primitive neuroectodermal tumor breast cancer malignant ependymoma oligodendroglioma pancreatic ductal adenocarcinoma
D [auth E]	Pharos: Q8N4V1	ovarian cancer
E [auth F]	Pharos: Q9BV81	ovarian cancer
F [auth G]	Pharos: Q9NPA0	breast cancer pancreatic ductal adenocarcinoma dermatomyositis plasma cell myeloma ovarian cancer
G [auth H]	Pharos: O43402	B-cell chronic lymphocytic leukemia ovarian cancer breast cancer Sjogren syndrome lung cancer
H [auth I]	Pharos: Q5UCC4	atypical teratoid rhabdoid tumor malignant ependymoma primary biliary cholangitis glioblastoma osteosarcoma psoriasis lung carcinoma pilocytic astrocytoma
I [auth K]	Pharos: Q13936	Timothy syndrome Brugada syndrome Brugada syndrome 3 hypertensive disorder long QT syndrome bipolar disorder primary immunodeficiency disease Limb Deformities, Congenital hypoglycemia schizophrenia depressive disorder heart disease intellectual disability major depressive disorder acute coronary syndrome Timothy syndrome Brugada syndrome Brugada syndrome 3 hypertensive disorder long QT syndrome bipolar disorder primary immunodeficiency disease Limb Deformities, Congenital hypoglycemia schizophrenia depressive disorder heart disease intellectual disability major depressive disorder acute coronary syndrome anorexia nervosa atrial fibrillation autism spectrum disorder short QT syndrome bipolar I disorder endogenous depression attention deficit hyperactivity disorder, inattentive type ventricular fibrillation, paroxysmal familial, type 1 cardiomyopathy autism Prinzmetal angina
K [auth D]	Pharos: Q5J8M3	breast cancer breast carcinoma ovarian cancer

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B, C, D [auth E], E [auth F] A, B, C, D [auth E], E [auth F], F [auth G], G [auth H], H [auth I], I [auth K], K [auth D]	OPM	Transmembrane	Alpha-helical polytopic	Ion channel (VIC) superfamily	Voltage-sensitive calcium channel

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B, C, D [auth E], E [auth F] A, B, C, D [auth E], E [auth F], F [auth G], G [auth H], H [auth I], I [auth K], K [auth D]	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A, B, C, D [auth E], E [auth F] A, B, C, D [auth E], E [auth F], F [auth G], G [auth H], H [auth I], I [auth K], K [auth D]	MemProtMD	Annotated as membrane protein by MemProtMD

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A, B, C, D [auth E], E [auth F] A, B, C, D [auth E], E [auth F], F [auth G], G [auth H], H [auth I], I [auth K], K [auth D]	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	Sec, Translocase, and Insertase Proteins	ER membrane protein complex (EMC) in complex with Ca_V1.2 and Ca_Vβ₃