8EOG

Structure of the human L-type voltage-gated calcium channel Cav1.2 complexed with L-leucine

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Membrane Protein Annotation: OPM
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: MemProtMD
Membrane Protein Annotation: mpstruc

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B [auth K]	F_UNCLASSIFIED	e8eogK2	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: F_UNCLASSIFIED	ECOD (1.6)
B [auth K]	F_UNCLASSIFIED	e8eogK5	A: alpha complex topology	X: Voltage-gated ion channels (From Topology)	H: Voltage-gated ion channels (From Topology)	T: Voltage-gated ion channels	F: F_UNCLASSIFIED	ECOD (1.6)
B [auth K]	F_UNCLASSIFIED	e8eogK3	A: extended segments	X: Voltage gated calcium channel IQ domain (From Topology)	H: Voltage gated calcium channel IQ domain (From Topology)	T: Voltage gated calcium channel IQ domain	F: F_UNCLASSIFIED	ECOD (1.6)
C	F_UNCLASSIFIED	e8eogC1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: F_UNCLASSIFIED	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B [auth K]	1.20.120.350	Mainly Alpha	Up-down Bundle	Four Helix Bundle (Hemerythrin (Met), subunit A)	Voltage-gated potassium channels. Chain C	CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth D]	PF08399	VWA N-terminal (VWA_N)	VWA N-terminal	-	Family
A [auth D]	PF00092	von Willebrand factor type A domain (VWA)	von Willebrand factor type A domain	-	Domain
A [auth D]	PF08473	Neuronal voltage-dependent calcium channel alpha 2acd (VGCC_alpha2)	Neuronal voltage-dependent calcium channel alpha 2acd	-	Family
B [auth K]	PF08763	Voltage gated calcium channel IQ domain (Ca_chan_IQ)	Voltage gated calcium channel IQ domain	Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential. The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin [1]. ...	Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential. The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin [1]. The interaction regulates two self-regulatory calcium dependent feedback mechanism, calcium dependent inactivation (CDI), and calcium-dependent facilitation (CDF).	Domain
B [auth K]	PF16905	Voltage-dependent L-type calcium channel, IQ-associated (GPHH)	Voltage-dependent L-type calcium channel, IQ-associated	-	Family
B [auth K]	PF08016	Polycystin cation channel (PKD_channel)	Polycystin cation channel	-	Family
B [auth K]	PF00520	Ion transport protein (Ion_trans)	Ion transport protein	-	Family
C	PF00625	Guanylate kinase (Guanylate_kin)	Guanylate kinase	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth D]	Voltage-dependent calcium channel subunit alpha-2/delta-1	channel regulator activity ion channel regulator activity calcium channel regulator activity molecular function regulator activity transporter regulator activity cation binding ion binding binding metal ion binding small molecule binding calcium channel activity monoatomic cation transmembrane transporter activity voltage-gated calcium channel activity gated channel activity channel regulator activity ion channel regulator activity calcium channel regulator activity molecular function regulator activity transporter regulator activity cation binding ion binding binding metal ion binding small molecule binding calcium channel activity monoatomic cation transmembrane transporter activity voltage-gated calcium channel activity gated channel activity monoatomic ion channel activity voltage-gated channel activity voltage-gated monoatomic ion channel activity voltage-gated monoatomic cation channel activity monoatomic cation channel activity passive transmembrane transporter activity calcium ion transmembrane transporter activity inorganic molecular entity transmembrane transporter activity channel activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity metal ion transmembrane transporter activity transmembrane transporter activity	import into cell calcium ion transmembrane import into cytosol transport monoatomic ion transmembrane transport import across plasma membrane inorganic ion transmembrane transport establishment of localization inorganic cation import across plasma membrane calcium ion transport metal ion transport inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization calcium ion import across plasma membrane import into cell calcium ion transmembrane import into cytosol transport monoatomic ion transmembrane transport import across plasma membrane inorganic ion transmembrane transport establishment of localization inorganic cation import across plasma membrane calcium ion transport metal ion transport inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization calcium ion import across plasma membrane inorganic ion import across plasma membrane monoatomic ion transport cellular process calcium ion import calcium ion import into cytosol monoatomic cation transport calcium ion transmembrane transport	protein-containing complex plasma membrane protein complex sarcolemma voltage-gated calcium channel complex plasma membrane membrane membrane protein complex cation channel complex transporter complex cell periphery cellular anatomical structure transmembrane transporter complex T-tubule L-type voltage-gated calcium channel complex protein-containing complex plasma membrane protein complex sarcolemma voltage-gated calcium channel complex plasma membrane membrane membrane protein complex cation channel complex transporter complex cell periphery cellular anatomical structure transmembrane transporter complex T-tubule L-type voltage-gated calcium channel complex calcium channel complex monoatomic ion channel complex
B [auth K]	Isoform 20 of Voltage-dependent L-type calcium channel subunit alpha-1C	calcium channel activity monoatomic cation transmembrane transporter activity voltage-gated calcium channel activity gated channel activity monoatomic ion channel activity voltage-gated channel activity voltage-gated monoatomic ion channel activity voltage-gated monoatomic cation channel activity monoatomic cation channel activity passive transmembrane transporter activity calcium ion transmembrane transporter activity inorganic molecular entity transmembrane transporter activity channel activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity calcium channel activity monoatomic cation transmembrane transporter activity voltage-gated calcium channel activity gated channel activity monoatomic ion channel activity voltage-gated channel activity voltage-gated monoatomic ion channel activity voltage-gated monoatomic cation channel activity monoatomic cation channel activity passive transmembrane transporter activity calcium ion transmembrane transporter activity inorganic molecular entity transmembrane transporter activity channel activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity high voltage-gated calcium channel activity transporter activity metal ion transmembrane transporter activity transmembrane transporter activity cytoskeletal protein binding protein binding binding alpha-actinin binding actinin binding voltage-gated calcium channel activity involved in cardiac muscle cell action potential calmodulin binding voltage-gated calcium channel activity involved in AV node cell action potential cation binding ion binding metal ion binding small molecule binding	membrane depolarization during action potential membrane depolarization biological regulation membrane depolarization during cardiac muscle cell action potential action potential regulation of biological quality cardiac muscle cell action potential regulation of membrane potential heart process multicellular organismal process system process cardiac muscle cell action potential involved in contraction signaling atrial cardiac muscle cell to AV node cell signaling membrane depolarization during action potential membrane depolarization biological regulation membrane depolarization during cardiac muscle cell action potential action potential regulation of biological quality cardiac muscle cell action potential regulation of membrane potential heart process multicellular organismal process system process cardiac muscle cell action potential involved in contraction signaling atrial cardiac muscle cell to AV node cell signaling regulation of heart contraction regulation of system process cell-cell signaling involved in cardiac conduction cardiac muscle contraction striated muscle contraction cell communication circulatory system process actin filament-based process regulation of multicellular organismal process atrial cardiac muscle cell to AV node cell communication cell communication involved in cardiac conduction blood circulation cardiac muscle cell contraction regulation of biological process atrial cardiac muscle cell action potential cell-cell signaling actin filament-based movement muscle contraction muscle system process regulation of blood circulation membrane depolarization during atrial cardiac muscle cell action potential cardiac conduction cellular process actin-mediated cell contraction heart contraction positive regulation of cytosolic calcium ion concentration developmental process heart development multicellular organism development anatomical structure development animal organ development circulatory system development system development calcium ion transmembrane import into cytosol transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization calcium ion transport metal ion transport inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport monoatomic cation transport calcium ion transport into cytosol calcium ion transmembrane transport immune system development immune system process cell communication by electrical coupling involved in cardiac conduction cell communication by electrical coupling limb development appendage development embryonic forelimb morphogenesis embryonic limb morphogenesis embryonic morphogenesis embryonic appendage morphogenesis embryo development anatomical structure morphogenesis forelimb morphogenesis appendage morphogenesis limb morphogenesis AV node cell action potential membrane depolarization during AV node cell action potential AV node cell to bundle of His cell signaling AV node cell to bundle of His cell communication calcium ion transmembrane transport via high voltage-gated calcium channel sensory organ development eye development visual system development camera-type eye development sensory system development regulation of actin filament-based process regulation of cellular process regulation of ventricular cardiac muscle cell action potential regulation of cardiac muscle cell action potential regulation of action potential ventricular cardiac muscle cell action potential regulation of cardiac muscle contraction regulation of muscle system process regulation of striated muscle contraction regulation of actin filament-based movement regulation of muscle contraction regulation of cardiac muscle cell contraction positive regulation of adenylate cyclase activity positive regulation of cyclase activity regulation of catalytic activity positive regulation of catalytic activity positive regulation of molecular function regulation of molecular function regulation of lyase activity regulation of adenylate cyclase activity regulation of cyclase activity positive regulation of lyase activity positive regulation of biological process positive regulation of muscle contraction positive regulation of multicellular organismal process import into cell import across plasma membrane inorganic cation import across plasma membrane calcium ion import across plasma membrane inorganic ion import across plasma membrane calcium ion import calcium ion import into cytosol cellular response to stimulus regulation of calcium ion transport regulation of localization intracellular calcium ion homeostasis response to stimulus negative regulation of biological process sarcoplasmic reticulum calcium ion transport release of sequestered calcium ion into cytosol by sarcoplasmic reticulum intracellular signal transduction intracellular signaling cassette signal transduction monoatomic cation homeostasis intracellular monoatomic ion homeostasis release of sequestered calcium ion into cytosol by endoplasmic reticulum regulation of release of sequestered calcium ion into cytosol regulation of monoatomic ion transport maintenance of location release of sequestered calcium ion into cytosol regulation of transmembrane transport chemical homeostasis calcium-mediated signaling cellular localization inorganic ion homeostasis homeostatic process calcium ion homeostasis regulation of monoatomic ion transmembrane transport negative regulation of sequestering of calcium ion regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion maintenance of location in cell regulation of calcium ion transmembrane transport intracellular monoatomic cation homeostasis monoatomic ion homeostasis negative regulation of cellular process intracellular chemical homeostasis regulation of metal ion transport regulation of sequestering of calcium ion regulation of cardiac muscle contraction by calcium ion signaling regulation of transport sequestering of calcium ion cellular homeostasis regulation of monoatomic cation transmembrane transport regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum regulation of heart rate by cardiac conduction regulation of heart rate	protein-containing complex plasma membrane protein complex sarcolemma voltage-gated calcium channel complex plasma membrane membrane membrane protein complex cation channel complex transporter complex cell periphery cellular anatomical structure transmembrane transporter complex T-tubule L-type voltage-gated calcium channel complex protein-containing complex plasma membrane protein complex sarcolemma voltage-gated calcium channel complex plasma membrane membrane membrane protein complex cation channel complex transporter complex cell periphery cellular anatomical structure transmembrane transporter complex T-tubule L-type voltage-gated calcium channel complex calcium channel complex monoatomic ion channel complex postsynaptic specialization membrane postsynaptic specialization synapse postsynaptic density membrane synaptic membrane postsynaptic density postsynapse neuron to neuron synapse organelle cell junction postsynaptic membrane asymmetric synapse plasma membrane region somatodendritic compartment cell body perikaryon neuronal cell body intracellular anatomical structure intracellular membraneless organelle Z disc sarcomere intracellular organelle I band membraneless organelle contractile muscle fiber cytoplasm supramolecular fiber myofibril supramolecular polymer supramolecular complex cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection
C	Voltage-dependent L-type calcium channel subunit beta-3	calcium channel activity monoatomic cation transmembrane transporter activity voltage-gated calcium channel activity gated channel activity monoatomic ion channel activity voltage-gated channel activity voltage-gated monoatomic ion channel activity voltage-gated monoatomic cation channel activity monoatomic cation channel activity passive transmembrane transporter activity calcium ion transmembrane transporter activity inorganic molecular entity transmembrane transporter activity channel activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity calcium channel activity monoatomic cation transmembrane transporter activity voltage-gated calcium channel activity gated channel activity monoatomic ion channel activity voltage-gated channel activity voltage-gated monoatomic ion channel activity voltage-gated monoatomic cation channel activity monoatomic cation channel activity passive transmembrane transporter activity calcium ion transmembrane transporter activity inorganic molecular entity transmembrane transporter activity channel activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity metal ion transmembrane transporter activity transmembrane transporter activity channel regulator activity ion channel regulator activity calcium channel regulator activity molecular function regulator activity transporter regulator activity	transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization calcium ion transport metal ion transport inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process calcium ion transmembrane transport via high voltage-gated calcium channel monoatomic cation transport transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization calcium ion transport metal ion transport inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process calcium ion transmembrane transport via high voltage-gated calcium channel monoatomic cation transport calcium ion transmembrane transport regulation of calcium ion transmembrane transporter activity regulation of calcium ion transport regulation of localization positive regulation of cation transmembrane transport positive regulation of calcium ion transport regulation of cellular process regulation of voltage-gated calcium channel activity positive regulation of monoatomic ion transport positive regulation of monoatomic ion transmembrane transport regulation of biological process regulation of monoatomic ion transport regulation of cation channel activity positive regulation of cation channel activity regulation of molecular function regulation of transmembrane transport positive regulation of voltage-gated calcium channel activity positive regulation of biological process regulation of transmembrane transporter activity regulation of monoatomic ion transmembrane transport regulation of transporter activity regulation of calcium ion transmembrane transport positive regulation of molecular function positive regulation of calcium ion transmembrane transporter activity positive regulation of calcium ion transmembrane transport positive regulation of transmembrane transport regulation of metal ion transport positive regulation of cellular process positive regulation of high voltage-gated calcium channel activity regulation of monoatomic ion transmembrane transporter activity regulation of high voltage-gated calcium channel activity regulation of transport biological regulation positive regulation of transport positive regulation of transporter activity positive regulation of ion transmembrane transporter activity regulation of monoatomic cation transmembrane transport	protein-containing complex plasma membrane protein complex sarcolemma voltage-gated calcium channel complex plasma membrane membrane membrane protein complex cation channel complex transporter complex cell periphery cellular anatomical structure transmembrane transporter complex T-tubule L-type voltage-gated calcium channel complex protein-containing complex plasma membrane protein complex sarcolemma voltage-gated calcium channel complex plasma membrane membrane membrane protein complex cation channel complex transporter complex cell periphery cellular anatomical structure transmembrane transporter complex T-tubule L-type voltage-gated calcium channel complex calcium channel complex monoatomic ion channel complex intracellular anatomical structure cytoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth D]	IPR051173	Voltage-dependent calcium channel subunit alpha-2/delta	Family
A [auth D]	IPR013680	Voltage-dependent calcium channel, alpha-2/delta subunit, conserved region	Domain
A [auth D]	IPR013608	VWA N-terminal	Domain
A [auth D]	IPR002035	von Willebrand factor, type A	Domain
A [auth D]	IPR036465	von Willebrand factor A-like domain superfamily	Homologous Superfamily
B [auth K]	IPR014873	Voltage-dependent calcium channel, alpha-1 subunit, IQ domain	Domain
B [auth K]	IPR002077	Voltage-dependent calcium channel, alpha-1 subunit	Family
B [auth K]	IPR031649	Voltage-dependent L-type calcium channel, IQ-associated domain	Domain
B [auth K]	IPR005451	Voltage-dependent calcium channel, L-type, alpha-1C subunit	Family
B [auth K]	IPR005821	Ion transport domain	Domain
B [auth K]	IPR005446	Voltage-dependent calcium channel, L-type, alpha-1 subunit	Family
B [auth K]	IPR050599	Voltage-dependent calcium channel alpha-1 subunit	Family
B [auth K]	IPR031688	Voltage-gated calcium channel subunit alpha, C-terminal	Domain
B [auth K]	IPR027359	Voltage-dependent channel domain superfamily	Homologous Superfamily
C	IPR008145	Guanylate kinase/L-type calcium channel beta subunit	Domain
C	IPR001452	SH3 domain	Domain
C	IPR036028	SH3-like domain superfamily	Homologous Superfamily
C	IPR035760	Voltage-dependent L-type calcium channel subunit beta-3, SH3 domain	Domain
C	IPR046937	Voltage-dependent L-type calcium channel subunit beta-1-4, N-terminal A domain	Domain
C	IPR008079	Voltage-dependent calcium channel, L-type, beta-3 subunit	Family
C	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
C	IPR000584	Voltage-dependent calcium channel, L-type, beta subunit	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
B [auth K]	Pharos: Q13936	Timothy syndrome Brugada syndrome Brugada syndrome 3 hypertensive disorder long QT syndrome bipolar disorder primary immunodeficiency disease Limb Deformities, Congenital hypoglycemia schizophrenia depressive disorder heart disease intellectual disability major depressive disorder acute coronary syndrome Timothy syndrome Brugada syndrome Brugada syndrome 3 hypertensive disorder long QT syndrome bipolar disorder primary immunodeficiency disease Limb Deformities, Congenital hypoglycemia schizophrenia depressive disorder heart disease intellectual disability major depressive disorder acute coronary syndrome anorexia nervosa atrial fibrillation autism spectrum disorder short QT syndrome bipolar I disorder endogenous depression attention deficit hyperactivity disorder, inattentive type ventricular fibrillation, paroxysmal familial, type 1 cardiomyopathy autism Prinzmetal angina

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A [auth D], B [auth K]	OPM	Transmembrane	Alpha-helical polytopic	Ion channel (VIC) superfamily	Voltage-sensitive calcium channel

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A [auth D], B [auth K]	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A [auth D], B [auth K]	MemProtMD	Annotated as membrane protein by MemProtMD

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A [auth D], B [auth K]	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	Channels: Calcium Ion-Selective	Ca_v1.2 L-type voltage-gated calcium channel in complex with L-leucine