8BAY
Crystal Structure of IDH1 variant R132C S280F in complex with NADPH, Ca2+ and 3-butyl-2-oxoglutarate
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Chains | Type | Family Name | Domain Identifier | Family Identifier | Provenance Source (Version) |
---|---|---|---|---|---|
B | SCOP2B Superfamily | Isocitrate/Isopropylmalate dehydrogenase-like | 8039863 | 3001375 | SCOP2B (2022-06-29) |
A | SCOP2B Superfamily | Isocitrate/Isopropylmalate dehydrogenase-like | 8039863 | 3001375 | SCOP2B (2022-06-29) |
C | SCOP2B Superfamily | Isocitrate/Isopropylmalate dehydrogenase-like | 8039863 | 3001375 | SCOP2B (2022-06-29) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
B | Iso_dh | e8bayB1 | A: a/b three-layered sandwiches | X: Isocitrate/Isopropylmalate dehydrogenase-like (From Topology) | H: Isocitrate/Isopropylmalate dehydrogenase-like (From Topology) | T: Isocitrate/Isopropylmalate dehydrogenase-like | F: Iso_dh | ECOD (1.6) |
A | Iso_dh | e8bayA2 | A: a/b three-layered sandwiches | X: Isocitrate/Isopropylmalate dehydrogenase-like (From Topology) | H: Isocitrate/Isopropylmalate dehydrogenase-like (From Topology) | T: Isocitrate/Isopropylmalate dehydrogenase-like | F: Iso_dh | ECOD (1.6) |
C | Iso_dh | e8bayC2 | A: a/b three-layered sandwiches | X: Isocitrate/Isopropylmalate dehydrogenase-like (From Topology) | H: Isocitrate/Isopropylmalate dehydrogenase-like (From Topology) | T: Isocitrate/Isopropylmalate dehydrogenase-like | F: Iso_dh | ECOD (1.6) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF00180 | Isocitrate/isopropylmalate dehydrogenase (Iso_dh) | Isocitrate/isopropylmalate dehydrogenase | - | Domain |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
IPR024084 | Isopropylmalate dehydrogenase-like domain | Domain | |
IPR004790 | Isocitrate dehydrogenase NADP-dependent | Family | |
IPR019818 | Isocitrate/isopropylmalate dehydrogenase, conserved site | Conserved Site |