Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
CSCOP2B SuperfamilyTrypsin-like serine proteases 8003776 3000114 SCOP2B (2022-06-29)
HSCOP2B SuperfamilyTrypsin-like serine proteases 8003776 3000114 SCOP2B (2022-06-29)
MSCOP2B SuperfamilyTrypsin-like serine proteases 8003776 3000114 SCOP2B (2022-06-29)
RSCOP2B SuperfamilyTrypsin-like serine proteases 8003776 3000114 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyEGF/Laminin-like 8039297 3000412 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyEGF/Laminin-like 8039292 3000412 SCOP2B (2022-06-29)
ISCOP2B SuperfamilyEGF/Laminin-like 8039292 3000412 SCOP2B (2022-06-29)
ISCOP2B SuperfamilyEGF/Laminin-like 8039297 3000412 SCOP2B (2022-06-29)
NSCOP2B SuperfamilyEGF/Laminin-like 8039292 3000412 SCOP2B (2022-06-29)
NSCOP2B SuperfamilyEGF/Laminin-like 8039297 3000412 SCOP2B (2022-06-29)
SSCOP2B SuperfamilyEGF/Laminin-like 8039292 3000412 SCOP2B (2022-06-29)
SSCOP2B SuperfamilyEGF/Laminin-like 8039297 3000412 SCOP2B (2022-06-29)
ESCOP2B SuperfamilyFibronectin type III 8055099 3002063 SCOP2B (2022-06-29)
ESCOP2B SuperfamilyFibronectin type III 8055493 3002063 SCOP2B (2022-06-29)
JSCOP2B SuperfamilyFibronectin type III 8055493 3002063 SCOP2B (2022-06-29)
JSCOP2B SuperfamilyFibronectin type III 8055099 3002063 SCOP2B (2022-06-29)
OSCOP2B SuperfamilyFibronectin type III 8055099 3002063 SCOP2B (2022-06-29)
TSCOP2B SuperfamilyFibronectin type III 8055099 3002063 SCOP2B (2022-06-29)

SAbDab Antibody Annotation SAbDab Database Homepage

ChainChain ClassChain SubclassChain TypeAntigen Name(s) Provenance Source
A, F, K, P
Light ChainIGKV3 Kappacoagulation factor vii | coagulation factor viiSAbDab (2024-12-06)
B, G, L, Q
Heavy ChainIGHV4 -coagulation factor vii | coagulation factor viiSAbDab (2024-12-06)

Thera-SAbDab Antibody Annotation Thera-SAbDab Database Homepage

ChainNameTargetProvenance Source
A, F, K, P
Sutacimig F7a/F7A/FVIIa/FVIIA, TREML1/GLTL1825/PRO3438/TLT-1/TLT1Therapeutic SAbDab (2024-12-06)
B, G, L, Q
Sutacimig F7a/F7A/FVIIa/FVIIA, TREML1/GLTL1825/PRO3438/TLT-1/TLT1Therapeutic SAbDab (2024-12-06)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
C, H, M, R
PF00089Trypsin (Trypsin)Trypsin- Domain
D, I, N, S
PF00008EGF-like domain (EGF)EGF-like domainThere is no clear separation between noise and signal. Pfam:PF00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is t ...There is no clear separation between noise and signal. Pfam:PF00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.
Domain
D, I, N, S
PF14670Coagulation Factor Xa inhibitory site (FXa_inhibition)Coagulation Factor Xa inhibitory siteThis short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442 [1].Domain
E, J, O, T
PF09294Interferon-alpha/beta receptor, fibronectin type III (Interfer-bind)Interferon-alpha/beta receptor, fibronectin type IIIMembers of this family adopt a secondary structure consisting of seven beta-strands arranged in an immunoglobulin-like beta-sandwich, in a Greek-key topology. They are required for binding to interferon-alpha [1].Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, F, K, P
Fab light chain---
B, G, L, Q
Fab heavy chain---
C, H, M, R
Coagulation factor VII
D, I, N, S
Coagulation factor VII
E, J, O, T
Tissue factor

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
C, H, M, R
IPR018097EGF-like calcium-binding, conserved siteConserved Site
C, H, M, R
IPR018114Serine proteases, trypsin family, histidine active siteActive Site
C, H, M, R
IPR009003Peptidase S1, PA clanHomologous Superfamily
C, H, M, R
IPR033116Serine proteases, trypsin family, serine active siteActive Site
C, H, M, R
IPR001254Serine proteases, trypsin domainDomain
C, H, M, R
IPR035972Gamma-carboxyglutamic acid-rich (GLA) domain superfamilyHomologous Superfamily
C, H, M, R
IPR001881EGF-like calcium-binding domainDomain
C, H, M, R
IPR012224Peptidase S1A, coagulation factor VII/IX/X/C/ZFamily
C, H, M, R
IPR000294Gamma-carboxyglutamic acid-rich (GLA) domainDomain
C, H, M, R
IPR000742EGF-like domainDomain
C, H, M, R
IPR050442Peptidase S1 family, coagulation factorsFamily
C, H, M, R
IPR017857Coagulation factor-like, Gla domain superfamilyHomologous Superfamily
C, H, M, R
IPR001314Peptidase S1A, chymotrypsin familyFamily
C, H, M, R
IPR043504Peptidase S1, PA clan, chymotrypsin-like foldHomologous Superfamily
C, H, M, R
IPR000152EGF-type aspartate/asparagine hydroxylation sitePTM
D, I, N, S
IPR018097EGF-like calcium-binding, conserved siteConserved Site
D, I, N, S
IPR018114Serine proteases, trypsin family, histidine active siteActive Site
D, I, N, S
IPR009003Peptidase S1, PA clanHomologous Superfamily
D, I, N, S
IPR033116Serine proteases, trypsin family, serine active siteActive Site
D, I, N, S
IPR001254Serine proteases, trypsin domainDomain
D, I, N, S
IPR035972Gamma-carboxyglutamic acid-rich (GLA) domain superfamilyHomologous Superfamily
D, I, N, S
IPR001881EGF-like calcium-binding domainDomain
D, I, N, S
IPR012224Peptidase S1A, coagulation factor VII/IX/X/C/ZFamily
D, I, N, S
IPR000294Gamma-carboxyglutamic acid-rich (GLA) domainDomain
D, I, N, S
IPR000742EGF-like domainDomain
D, I, N, S
IPR050442Peptidase S1 family, coagulation factorsFamily
D, I, N, S
IPR017857Coagulation factor-like, Gla domain superfamilyHomologous Superfamily
D, I, N, S
IPR001314Peptidase S1A, chymotrypsin familyFamily
D, I, N, S
IPR043504Peptidase S1, PA clan, chymotrypsin-like foldHomologous Superfamily
D, I, N, S
IPR000152EGF-type aspartate/asparagine hydroxylation sitePTM
E, J, O, T
IPR001187Tissue factorFamily
E, J, O, T
IPR003961Fibronectin type IIIDomain
E, J, O, T
IPR015373Interferon/interleukin receptor domainDomain
E, J, O, T
IPR013783Immunoglobulin-like foldHomologous Superfamily
E, J, O, T
IPR050650Type II Cytokine and Tissue Factor ReceptorsFamily
E, J, O, T
IPR036116Fibronectin type III superfamilyHomologous Superfamily
E, J, O, T
IPR030472Tissue factor, conserved siteConserved Site

Pharos: Disease Associations Pharos Homepage Annotation

ChainsDrug Target  Associated Disease
C, H, M, R
PharosP08709
D, I, N, S
PharosP08709
E, J, O, T
PharosP13726