Annotations: 7WQU

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	feoB	e7wquA1	A: alpha complex topology	X: Cytosolic helical domain in ferrous iron transport protein B (From Topology)	H: Cytosolic helical domain in ferrous iron transport protein B (From Topology)	T: Cytosolic helical domain in ferrous iron transport protein B	F: feoB	ECOD (1.6)
A	MnmE_helical_2nd	e7wquA2	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: MnmE_helical_2nd	ECOD (1.6)
B	FeoC	e7wquB1	A: alpha arrays	X: HTH	H: HTH	T: winged	F: FeoC	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF02421	Ferrous iron transport protein B (FeoB_N)	Ferrous iron transport protein B	Escherichia coli has an iron(II) transport system (feo) which may make an important contribution to the iron supply of the cell under anaerobic conditions [1]. FeoB has been identified as part of this transport system. FeoB is a large 700-800 amino a ...	Escherichia coli has an iron(II) transport system (feo) which may make an important contribution to the iron supply of the cell under anaerobic conditions [1]. FeoB has been identified as part of this transport system. FeoB is a large 700-800 amino acid integral membrane protein. The N terminus contains a P-loop motif suggesting that iron transport may be ATP dependent [1].	Domain
A	PF17910	FeoB cytosolic helical domain (FeoB_Cyto)	FeoB cytosolic helical domain	FeoB is a G-protein coupled membrane protein essential for Fe(II) uptake in prokaryotes. In the structures, a canonical G-protein domain (G domain) is followed by a helical bundle domain (S-domain) which is represented by this entry.	Domain
B	PF09012	FeoC like transcriptional regulator (FeoC)	FeoC like transcriptional regulator	This family contains several transcriptional regulators, including FeoC, which contain a HTH motif. FeoC acts as a [Fe-S] dependant transcriptional repressor [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Ferrous iron transport protein B	monoatomic cation transmembrane transporter activity inorganic molecular entity transmembrane transporter activity iron ion transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity ferrous iron transmembrane transporter activity transporter activity transition metal ion transmembrane transporter activity metal ion transmembrane transporter activity transmembrane transporter activity binding guanyl nucleotide binding GTP binding nucleotide binding monoatomic cation transmembrane transporter activity inorganic molecular entity transmembrane transporter activity iron ion transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity ferrous iron transmembrane transporter activity transporter activity transition metal ion transmembrane transporter activity metal ion transmembrane transporter activity transmembrane transporter activity binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding cation binding metal ion binding	-	cell periphery cellular anatomical structure plasma membrane membrane
B	Probable [Fe-S]-dependent transcriptional repressor	DNA binding binding nucleic acid binding iron-sulfur cluster binding metal cluster binding small molecule binding cation binding transition metal ion binding iron ion binding ion binding metal ion binding	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR050860	Fe(2+) Transporter FeoB GTPase	Family
A	IPR030389	FeoB-type guanine nucleotide-binding (G) domain	Domain
A	IPR003373	Ferrous iron transport protein B	Family
A	IPR006073	GTP binding domain	Domain
A	IPR041069	FeoB, cytosolic helical domain	Domain
A	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
B	IPR015102	Transcriptional regulator HTH-type, FeoC	Domain
B	IPR023732	Probable [Fe-S]-dependent transcriptional repressor	Family
B	IPR036388	Winged helix-like DNA-binding domain superfamily	Homologous Superfamily
B	IPR036390	Winged helix DNA-binding domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.