7TVF

Crystal structure of the SHOC2-MRAS-PP1CA (SMP) complex to a resolution of 2.17 Angstrom

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A [auth F]	SCOP2B Superfamily	Metallo-dependent phosphatases	8080445	3001067	SCOP2B (2022-06-29)
B [auth C]	SCOP2B Superfamily	Metallo-dependent phosphatases	8080445	3001067	SCOP2B (2022-06-29)
C [auth E]	SCOP2B Superfamily	Ras-like P-loop GTPases	8107260	3002022	SCOP2B (2022-06-29)
D [auth B]	SCOP2B Superfamily	Ras-like P-loop GTPases	8107260	3002022	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth F]	Metallophos_2_1	e7tvfF1	A: a+b four layers	X: Carbon-nitrogen hydrolase-like	H: Metallo-dependent phosphatases (From Topology)	T: Metallo-dependent phosphatases	F: Metallophos_2_1	ECOD (1.6)
B [auth C]	Metallophos_2_1	e7tvfC1	A: a+b four layers	X: Carbon-nitrogen hydrolase-like	H: Metallo-dependent phosphatases (From Topology)	T: Metallo-dependent phosphatases	F: Metallophos_2_1	ECOD (1.6)
C [auth E]	Ras	e7tvfE1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: Ras	ECOD (1.6)
D [auth B]	Ras	e7tvfB1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: Ras	ECOD (1.6)
F [auth D]	LRR_8_3	e7tvfD1	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Leucine-rich repeats (From Topology)	T: Leucine-rich repeats	F: LRR_8_3	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth F], B [auth C]	PF00149	Calcineurin-like phosphoesterase (Metallophos)	Calcineurin-like phosphoesterase	This family includes a diverse range of phosphoesterases [1], including protein phosphoserine phosphatases, nucleotidases, sphingomyelin phosphodiesterases and 2'-3' cAMP phosphodiesterases as well as nucleases such as bacterial SbcD Swiss:P13457 or ...	This family includes a diverse range of phosphoesterases [1], including protein phosphoserine phosphatases, nucleotidases, sphingomyelin phosphodiesterases and 2'-3' cAMP phosphodiesterases as well as nucleases such as bacterial SbcD Swiss:P13457 or yeast MRE11 Swiss:P32829. The most conserved regions in this superfamily centre around the metal chelating residues.	Domain
A [auth F], B [auth C]	PF16891	Serine-threonine protein phosphatase N-terminal domain (STPPase_N)	Serine-threonine protein phosphatase N-terminal domain	-	Family
C [auth E], D [auth B]	PF00071	Ras family (Ras)	Ras family	Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See Pfam:PF00009 Pfam:PF00025, Pfam:PF00063. As regards Rab GTPases, these are important regulators of vesicle formation, motil ...	Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See Pfam:PF00009 Pfam:PF00025, Pfam:PF00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices [1].	Domain
E [auth A], F [auth D]	PF13855	Leucine rich repeat (LRR_8)	Leucine rich repeat	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth F], B [auth C]	Serine/threonine-protein phosphatase PP1-alpha catalytic subunit	phosphoric ester hydrolase activity phosphoprotein phosphatase activity protein serine/threonine phosphatase activity catalytic activity, acting on a protein hydrolase activity, acting on ester bonds phosphatase activity hydrolase activity catalytic activity cation binding transition metal ion binding ion binding binding metal ion binding small molecule binding phosphoric ester hydrolase activity phosphoprotein phosphatase activity protein serine/threonine phosphatase activity catalytic activity, acting on a protein hydrolase activity, acting on ester bonds phosphatase activity hydrolase activity catalytic activity cation binding transition metal ion binding ion binding binding metal ion binding small molecule binding cell adhesion molecule binding cadherin binding involved in cell-cell adhesion cadherin binding protein binding cell adhesion mediator activity cell-cell adhesion mediator activity ribonucleoprotein complex binding protein-containing complex binding myosin phosphatase activity protein phosphatase binding phosphatase binding protein phosphatase 1 binding enzyme binding iron ion binding	cellular response to stimulus regulation of biological process regulation of signaling regulation of cellular process cell surface receptor signaling pathway response to stimulus regulation of Wnt signaling pathway signaling regulation of canonical Wnt signaling pathway canonical Wnt signaling pathway biological regulation regulation of signal transduction cell communication regulation of response to stimulus cellular response to stimulus regulation of biological process regulation of signaling regulation of cellular process cell surface receptor signaling pathway response to stimulus regulation of Wnt signaling pathway signaling regulation of canonical Wnt signaling pathway canonical Wnt signaling pathway biological regulation regulation of signal transduction cell communication regulation of response to stimulus regulation of cell communication cellular process signal transduction Wnt signaling pathway telomere maintenance in response to DNA damage telomere organization chromosome organization primary metabolic process DNA metabolic process nucleic acid metabolic process telomere maintenance cellular component organization nucleobase-containing compound metabolic process organelle organization cellular response to stress DNA damage response response to stress metabolic process cellular component organization or biogenesis macromolecule metabolic process developmental process multicellular organismal process epithelium development tube development branching morphogenesis of an epithelial tube morphogenesis of an epithelium tissue development tissue morphogenesis anatomical structure morphogenesis multicellular organism development tube morphogenesis morphogenesis of a branching structure anatomical structure development epithelial tube morphogenesis morphogenesis of a branching epithelium rhythmic process circadian rhythm regulation of circadian rhythm cell division positive regulation of cell communication positive regulation of signal transduction signal transduction in absence of ligand positive regulation of biological process regulation of programmed cell death positive regulation of extrinsic apoptotic signaling pathway in absence of ligand extrinsic apoptotic signaling pathway positive regulation of apoptotic signaling pathway positive regulation of response to stimulus extrinsic apoptotic signaling pathway in absence of ligand positive regulation of cellular process positive regulation of programmed cell death regulation of apoptotic process positive regulation of extrinsic apoptotic signaling pathway cell death positive regulation of apoptotic process regulation of extrinsic apoptotic signaling pathway apoptotic signaling pathway regulation of extrinsic apoptotic signaling pathway in absence of ligand apoptotic process programmed cell death regulation of apoptotic signaling pathway positive regulation of signaling regulation of generation of precursor metabolites and energy positive regulation of macromolecule biosynthetic process regulation of primary metabolic process positive regulation of glycogen metabolic process positive regulation of metabolic process regulation of small molecule metabolic process small molecule metabolic process positive regulation of macromolecule metabolic process carbohydrate biosynthetic process hexose metabolic process positive regulation of glucose metabolic process positive regulation of glycogen biosynthetic process biosynthetic process energy reserve metabolic process regulation of macromolecule biosynthetic process positive regulation of carbohydrate metabolic process regulation of glycogen metabolic process regulation of metabolic process monosaccharide metabolic process regulation of glycogen biosynthetic process glucan biosynthetic process energy derivation by oxidation of organic compounds regulation of glucan biosynthetic process regulation of polysaccharide metabolic process polysaccharide metabolic process glucan metabolic process positive regulation of biosynthetic process regulation of carbohydrate metabolic process regulation of glucose metabolic process regulation of biosynthetic process carbohydrate metabolic process polysaccharide biosynthetic process glycogen metabolic process generation of precursor metabolites and energy regulation of macromolecule metabolic process glycogen biosynthetic process macromolecule biosynthetic process regulation of polysaccharide biosynthetic process regulation of carbohydrate biosynthetic process positive regulation of small molecule metabolic process glucose metabolic process protein dephosphorylation dephosphorylation macromolecule modification phosphate-containing compound metabolic process protein metabolic process protein modification process phosphorus metabolic process post-transcriptional regulation of gene expression regulation of translation in response to stress translational initiation regulation of translational initiation regulation of protein metabolic process gene expression translation regulation of gene expression regulation of translation regulation of translational initiation in response to stress animal organ development respiratory tube development lung development respiratory system development system development catabolic process carbohydrate catabolic process macromolecule catabolic process regulation of glycogen catabolic process glycogen catabolic process regulation of carbohydrate catabolic process glucan catabolic process regulation of catabolic process polysaccharide catabolic process circadian regulation of gene expression response to light stimulus entrainment of circadian clock response to external stimulus photoperiodism response to radiation response to abiotic stimulus entrainment of circadian clock by photoperiod response to metal ion response to chemical response to lead ion	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle membraneless organelle nuclear lumen membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle membraneless organelle nuclear lumen somatodendritic compartment cell body perikaryon neuronal cell body phosphatase complex protein-containing complex protein phosphatase type 1 complex catalytic complex cytoplasm protein serine/threonine phosphatase complex PTW/PP1 phosphatase complex extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle cytosol cell periphery plasma membrane membrane presynapse synapse cell junction nucleoplasm glutamatergic synapse cell-cell junction adherens junction anchoring junction glycogen granule neuron spine neuron projection dendritic spine plasma membrane bounded cell projection cell projection postsynapse dendrite dendritic tree
C [auth E], D [auth B]	Ras-related protein M-Ras	guanyl nucleotide binding binding nucleotide binding GDP binding guanyl ribonucleotide binding purine ribonucleotide binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding guanyl nucleotide binding binding nucleotide binding GDP binding guanyl ribonucleotide binding purine ribonucleotide binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding GTP-dependent protein binding protein binding pyrophosphatase activity GTPase activity G protein activity ribonucleoside triphosphate phosphatase activity molecular function regulator activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity GTP binding purine ribonucleoside triphosphate binding	cellular component organization organelle organization actin cytoskeleton organization actin filament-based process cellular process cellular component organization or biogenesis cytoskeleton organization response to peptide response to stimulus response to chemical response to cytokine response to leukemia inhibitory factor cellular response to cytokine stimulus cellular response to leukemia inhibitory factor cellular component organization organelle organization actin cytoskeleton organization actin filament-based process cellular process cellular component organization or biogenesis cytoskeleton organization response to peptide response to stimulus response to chemical response to cytokine response to leukemia inhibitory factor cellular response to cytokine stimulus cellular response to leukemia inhibitory factor cellular response to stimulus regulation of biological process small GTPase-mediated signal transduction regulation of cellular process signaling Ras protein signal transduction biological regulation intracellular signal transduction cell communication intracellular signaling cassette signal transduction	cell periphery cellular anatomical structure plasma membrane membrane
E [auth A], F [auth D]	Leucine-rich repeat protein SHOC-2	protein phosphatase binding phosphatase binding protein phosphatase 1 binding protein binding binding enzyme binding enzyme regulator activity phosphatase regulator activity molecular function regulator activity protein phosphatase regulator activity	multicellular organismal process regulation of cellular process cellular developmental process regulation of developmental process negative regulation of biological process regulation of cell differentiation neurogenesis multicellular organism development neuron differentiation cell differentiation anatomical structure development negative regulation of cellular process negative regulation of cell differentiation system development multicellular organismal process regulation of cellular process cellular developmental process regulation of developmental process negative regulation of biological process regulation of cell differentiation neurogenesis multicellular organism development neuron differentiation cell differentiation anatomical structure development negative regulation of cellular process negative regulation of cell differentiation system development developmental process regulation of biological process negative regulation of developmental process biological regulation nervous system development generation of neurons cellular process negative regulation of neuron differentiation regulation of neuron differentiation regulation of neuron projection development regulation of cellular component organization positive regulation of cellular component organization cell projection organization positive regulation of biological process cell development neuron projection development cellular component organization positive regulation of neuron projection development positive regulation of cell projection organization cellular component organization or biogenesis positive regulation of cellular process plasma membrane bounded cell projection organization regulation of cell projection organization neuron development regulation of plasma membrane bounded cell projection organization cellular response to stimulus cellular response to growth factor stimulus response to stimulus cell surface receptor signaling pathway signaling response to endogenous stimulus cellular response to nerve growth factor stimulus cell communication cellular response to endogenous stimulus nerve growth factor signaling pathway neurotrophin signaling pathway response to nerve growth factor response to growth factor signal transduction positive regulation of neuron differentiation positive regulation of developmental process positive regulation of cell differentiation response to fibroblast growth factor cell surface receptor protein tyrosine kinase signaling pathway fibroblast growth factor receptor signaling pathway cellular response to fibroblast growth factor stimulus enzyme-linked receptor protein signaling pathway import into cell nitrogen compound transport guanine nucleotide transmembrane transport organic anion transport nucleotide transport transport purine ribonucleotide transport import across plasma membrane carbohydrate derivative transport establishment of localization purine nucleotide transport transmembrane transport adenine nucleotide transport localization nucleotide transmembrane transport cyclic-GMP-AMP transmembrane import across plasma membrane guanine nucleotide transport cyclic nucleotide transport nucleobase-containing compound transport organophosphate ester transport purine-containing compound transmembrane transport negative regulation of cell population proliferation negative regulation of neural precursor cell proliferation cell population proliferation regulation of cell population proliferation neural precursor cell proliferation regulation of neural precursor cell proliferation cellular response to nitrogen compound response to peptide hormone cellular response to peptide hormone stimulus response to oxygen-containing compound response to nitrogen compound cellular response to growth hormone stimulus cellular response to oxygen-containing compound response to growth hormone cellular response to chemical stimulus response to hormone response to chemical cellular response to hormone stimulus positive regulation of cell communication small GTPase-mediated signal transduction positive regulation of signal transduction regulation of small GTPase mediated signal transduction regulation of signal transduction intracellular signal transduction positive regulation of response to stimulus regulation of intracellular signal transduction regulation of Ras protein signal transduction intracellular signaling cassette positive regulation of Ras protein signal transduction regulation of signaling Ras protein signal transduction positive regulation of intracellular signal transduction regulation of response to stimulus regulation of cell communication positive regulation of small GTPase mediated signal transduction positive regulation of signaling	phosphatase complex protein-containing complex protein phosphatase type 1 complex cellular anatomical structure intracellular anatomical structure catalytic complex cytoplasm protein serine/threonine phosphatase complex cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen phosphatase complex protein-containing complex protein phosphatase type 1 complex cellular anatomical structure intracellular anatomical structure catalytic complex cytoplasm protein serine/threonine phosphatase complex cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth F], B [auth C]	IPR050341	Serine/threonine-protein phosphatase PP1 catalytic subunit	Family
A [auth F], B [auth C]	IPR004843	Calcineurin-like phosphoesterase domain, ApaH type	Domain
A [auth F], B [auth C]	IPR031675	Serine-threonine protein phosphatase, N-terminal	Domain
A [auth F], B [auth C]	IPR029052	Metallo-dependent phosphatase-like	Homologous Superfamily
A [auth F], B [auth C]	IPR006186	Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase	Domain
C [auth E], D [auth B]	IPR005225	Small GTP-binding domain	Domain
C [auth E], D [auth B]	IPR020849	Small GTPase, Ras-type	Family
C [auth E], D [auth B]	IPR001806	Small GTPase	Family
C [auth E], D [auth B]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
E [auth A], F [auth D]	IPR001611	Leucine-rich repeat	Repeat
E [auth A], F [auth D]	IPR003591	Leucine-rich repeat, typical subtype	Repeat
E [auth A], F [auth D]	IPR050216	Leucine-rich repeat domain-containing protein	Family
E [auth A], F [auth D]	IPR032675	Leucine-rich repeat domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A [auth F], B [auth C]	Pharos: P62136	lung adenocarcinoma osteosarcoma severe acute respiratory syndrome lymphoplasmacytic lymphoma ovarian cancer Middle East respiratory syndrome plasma cell myeloma
C [auth E], D [auth B]	Pharos: O14807	carotid artery disease coronary artery disease malignant ependymoma medulloblastoma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia adrenal cortex carcinoma atypical teratoid rhabdoid tumor Carotid Atherosclerosis Hodgkins lymphoma large cell medulloblastoma malignant glioma myocardial infarction pancreatic intraductal papillary-mucinous carcinoma primitive neuroectodermal tumor carotid artery disease coronary artery disease malignant ependymoma medulloblastoma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia adrenal cortex carcinoma atypical teratoid rhabdoid tumor Carotid Atherosclerosis Hodgkins lymphoma large cell medulloblastoma malignant glioma myocardial infarction pancreatic intraductal papillary-mucinous carcinoma primitive neuroectodermal tumor amyotrophic lateral sclerosis breast cancer glioblastoma lung carcinoma malignant mesothelioma myopathy pancreatic intraductal papillary-mucinous neoplasm type 2 diabetes mellitus ductal breast carcinoma in situ heart disease invasive ductal breast carcinoma
E [auth A], F [auth D]	Pharos: Q9UQ13	Noonan syndrome Noonan syndrome-like disorder with loose anagen hair 1 disease of pilosebaceous unit cardiofaciocutaneous syndrome Female Pseudo-Turner Syndrome intellectual disability malignant glioma Noonan syndrome-like disorder with loose anagen hair plasma cell myeloma Costello syndrome hydrops fetalis large cell medulloblastoma hypertrophic cardiomyopathy lymphoplasmacytic lymphoma Noonan syndrome with multiple lentigines Noonan syndrome Noonan syndrome-like disorder with loose anagen hair 1 disease of pilosebaceous unit cardiofaciocutaneous syndrome Female Pseudo-Turner Syndrome intellectual disability malignant glioma Noonan syndrome-like disorder with loose anagen hair plasma cell myeloma Costello syndrome hydrops fetalis large cell medulloblastoma hypertrophic cardiomyopathy lymphoplasmacytic lymphoma Noonan syndrome with multiple lentigines ovarian cancer

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.