Annotations: 7MSG

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	TNF-like	8064725	3000061	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	TNF-like	8064725	3000061	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	TNF-like	8064725	3000061	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	TNF receptor-like	8034506	3000971	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	TNF receptor-like	8034508	3000971	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	TNF receptor-like	8034508	3000971	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	TNF receptor-like	8034506	3000971	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	TNF receptor-like	8034506	3000971	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	TNF receptor-like	8034508	3000971	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	TNF	e7msgA1	A: beta sandwiches	X: jelly-roll	H: TNF-like (From Topology)	T: TNF-like	F: TNF	ECOD (1.6)
B	TNF	e7msgB1	A: beta sandwiches	X: jelly-roll	H: TNF-like (From Topology)	T: TNF-like	F: TNF	ECOD (1.6)
C	TNF	e7msgC1	A: beta sandwiches	X: jelly-roll	H: TNF-like (From Topology)	T: TNF-like	F: TNF	ECOD (1.6)
D	I-set_4	e7msgD2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: I-set_4	ECOD (1.6)
D	TNFR_c6	e7msgD1	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: TNF receptor-like	F: TNFR_c6	ECOD (1.6)
D	TNFRSF14	e7msgD3	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: TNF receptor-like	F: TNFRSF14	ECOD (1.6)
E	I-set_4	e7msgE2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: I-set_4	ECOD (1.6)
E	TNFR_c6	e7msgE1	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: TNF receptor-like	F: TNFR_c6	ECOD (1.6)
E	TNFRSF14	e7msgE3	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: TNF receptor-like	F: TNFRSF14	ECOD (1.6)
F	I-set_4	e7msgF2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: I-set_4	ECOD (1.6)
F	TNFR_c6	e7msgF1	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: TNF receptor-like	F: TNFR_c6	ECOD (1.6)
F	TNFRSF14	e7msgF3	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: TNF receptor-like	F: TNFRSF14	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C	PF00229	TNF(Tumour Necrosis Factor) family (TNF)	TNF(Tumour Necrosis Factor) family	-	Domain
D, E, F	PF00020	TNFR/NGFR cysteine-rich region (TNFR_c6)	TNFR/NGFR cysteine-rich region	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C	Tumor necrosis factor ligand superfamily member 14, membrane form	enzyme regulator activity cysteine-type endopeptidase inhibitor activity involved in apoptotic process molecular function regulator activity cysteine-type endopeptidase regulator activity involved in apoptotic process protein binding binding signaling receptor binding molecular function activator activity cytokine activity signaling receptor regulator activity receptor ligand activity signaling receptor activator activity cytokine receptor binding tumor necrosis factor receptor superfamily binding enzyme regulator activity cysteine-type endopeptidase inhibitor activity involved in apoptotic process molecular function regulator activity cysteine-type endopeptidase regulator activity involved in apoptotic process protein binding binding signaling receptor binding molecular function activator activity cytokine activity signaling receptor regulator activity receptor ligand activity signaling receptor activator activity cytokine receptor binding tumor necrosis factor receptor superfamily binding tumor necrosis factor receptor binding identical protein binding	multicellular organismal process T cell activation immune system process cell activation cellular process lymphocyte activation leukocyte activation cell population proliferation leukocyte proliferation mononuclear cell proliferation lymphocyte proliferation T cell proliferation developmental process regulation of biological process multicellular organismal process T cell activation immune system process cell activation cellular process lymphocyte activation leukocyte activation cell population proliferation leukocyte proliferation mononuclear cell proliferation lymphocyte proliferation T cell proliferation developmental process regulation of biological process regulation of cellular process regulation of developmental process cellular developmental process biological regulation positive regulation of biological process regulation of cell differentiation positive regulation of myoblast differentiation muscle structure development positive regulation of developmental process positive regulation of cell differentiation cell differentiation anatomical structure development regulation of myoblast differentiation myoblast differentiation positive regulation of cellular process cellular response to stimulus response to stimulus response to mechanical stimulus response to external stimulus response to abiotic stimulus cellular response to mechanical stimulus cellular response to abiotic stimulus cellular response to external stimulus cellular response to environmental stimulus immune response positive regulation of cellular component organization regulation of cellular component organization regulation of syncytium formation by plasma membrane fusion cell-cell fusion muscle cell differentiation myotube differentiation cellular component organization cellular component organization or biogenesis syncytium formation positive regulation of myoblast fusion myoblast fusion regulation of myoblast fusion positive regulation of syncytium formation by plasma membrane fusion syncytium formation by plasma membrane fusion anatomical structure morphogenesis anatomical structure formation involved in morphogenesis striated muscle cell differentiation positive regulation of cell communication positive regulation of signal transduction signaling regulation of signal transduction regulation of non-canonical NF-kappaB signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction intracellular signaling cassette signal transduction regulation of signaling non-canonical NF-kappaB signal transduction positive regulation of intracellular signal transduction regulation of response to stimulus regulation of cell communication positive regulation of non-canonical NF-kappaB signal transduction positive regulation of signaling positive regulation of locomotion regulation of cell motility positive regulation of T cell chemotaxis positive regulation of chemotaxis positive regulation of cell migration regulation of lymphocyte chemotaxis taxis cell migration regulation of immune system process regulation of mononuclear cell migration positive regulation of immune system process chemotaxis regulation of leukocyte chemotaxis positive regulation of lymphocyte migration regulation of leukocyte migration lymphocyte migration positive regulation of leukocyte chemotaxis leukocyte migration regulation of locomotion response to chemical regulation of T cell migration regulation of T cell chemotaxis regulation of response to external stimulus lymphocyte chemotaxis regulation of lymphocyte migration positive regulation of lymphocyte chemotaxis positive regulation of response to external stimulus positive regulation of cell motility regulation of cell migration positive regulation of mononuclear cell migration T cell chemotaxis cell motility locomotion cell chemotaxis positive regulation of T cell migration positive regulation of leukocyte migration regulation of chemotaxis cellular response to chemical stimulus mononuclear cell migration T cell migration leukocyte chemotaxis apoptotic process cell death programmed cell death regulation of leukocyte activation regulation of cell activation positive regulation of leukocyte cell-cell adhesion leukocyte cell-cell adhesion positive regulation of cell-cell adhesion positive regulation of lymphocyte activation positive regulation of cell activation cell adhesion cell-cell adhesion positive regulation of leukocyte activation regulation of multicellular organismal process regulation of cell-cell adhesion positive regulation of T cell activation positive regulation of cell adhesion regulation of cell adhesion regulation of T cell activation lymphocyte costimulation regulation of leukocyte cell-cell adhesion positive regulation of multicellular organismal process T cell costimulation regulation of lymphocyte activation multicellular organismal-level homeostasis leukocyte homeostasis T cell homeostasis homeostatic process homeostasis of number of cells lymphocyte homeostasis	cell periphery cellular anatomical structure plasma membrane membrane intracellular anatomical structure cytoplasm extracellular region extracellular space
D, E, F	CD160 antigen, soluble form,Tumor necrosis factor receptor superfamily member 14	MHC class Ib receptor activity molecular transducer activity transmembrane signaling receptor activity signaling receptor activity immune receptor activity protein binding binding signaling receptor binding MHC class I receptor activity activating MHC class I receptor activity protein-containing complex binding MHC protein complex binding MHC class I protein complex binding kinase binding MHC class Ib receptor activity molecular transducer activity transmembrane signaling receptor activity signaling receptor activity immune receptor activity protein binding binding signaling receptor binding MHC class I receptor activity activating MHC class I receptor activity protein-containing complex binding MHC protein complex binding MHC class I protein complex binding kinase binding enzyme binding cytokine binding virus receptor activity exogenous protein binding tumor necrosis factor receptor activity death receptor activity ubiquitin protein ligase binding ubiquitin-like protein ligase binding	regulation of immune effector process lymphocyte mediated immunity positive regulation of leukocyte mediated immunity positive regulation of response to biotic stimulus regulation of cellular process response to stimulus response to biotic stimulus positive regulation of leukocyte mediated cytotoxicity positive regulation of immune response positive regulation of natural killer cell mediated immunity leukocyte mediated immunity regulation of immune system process natural killer cell mediated immunity positive regulation of immune system process regulation of immune effector process lymphocyte mediated immunity positive regulation of leukocyte mediated immunity positive regulation of response to biotic stimulus regulation of cellular process response to stimulus response to biotic stimulus positive regulation of leukocyte mediated cytotoxicity positive regulation of immune response positive regulation of natural killer cell mediated immunity leukocyte mediated immunity regulation of immune system process natural killer cell mediated immunity positive regulation of immune system process regulation of biological process regulation of natural killer cell mediated immunity immune response response to other organism regulation of innate immune response response to external stimulus leukocyte mediated cytotoxicity immune effector process regulation of leukocyte mediated immunity regulation of response to stimulus defense response to other organism positive regulation of defense response natural killer cell mediated cytotoxicity regulation of immune response positive regulation of natural killer cell mediated cytotoxicity regulation of cell killing positive regulation of cell killing regulation of defense response regulation of response to biotic stimulus regulation of natural killer cell mediated cytotoxicity biological process involved in interspecies interaction between organisms regulation of response to external stimulus positive regulation of lymphocyte mediated immunity positive regulation of biological process positive regulation of response to stimulus positive regulation of response to external stimulus response to stress regulation of response to stress innate immune response positive regulation of immune effector process response to external biotic stimulus positive regulation of cellular process positive regulation of innate immune response defense response regulation of leukocyte mediated cytotoxicity biological regulation defense response to symbiont regulation of lymphocyte mediated immunity immune system process cellular process cell killing multicellular organismal process regulation of natural killer cell cytokine production positive regulation of macromolecule biosynthetic process positive regulation of metabolic process cytokine production positive regulation of macromolecule metabolic process regulation of cytokine production involved in immune response regulation of gene expression biosynthetic process positive regulation of production of molecular mediator of immune response positive regulation of multicellular organismal process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of production of molecular mediator of immune response positive regulation of cytokine production regulation of metabolic process natural killer cell cytokine production positive regulation of biosynthetic process regulation of cytokine production regulation of multicellular organismal process cytokine production involved in immune response production of molecular mediator of immune response regulation of biosynthetic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process positive regulation of natural killer cell cytokine production positive regulation of gene expression positive regulation of cytokine production involved in immune response adaptive immune response developmental process blood vessel morphogenesis tube development angiogenesis vasculature development circulatory system development multicellular organism development anatomical structure morphogenesis tube morphogenesis anatomical structure development anatomical structure formation involved in morphogenesis blood vessel development system development cellular response to stimulus signaling intracellular signal transduction cell communication intracellular signaling cassette signal transduction phosphatidylinositol 3-kinase/protein kinase B signal transduction adaptive immune memory response regulation of adaptive immune response negative regulation of response to stimulus negative regulation of immune response negative regulation of biological process negative regulation of adaptive immune response negative regulation of adaptive immune memory response regulation of adaptive immune memory response negative regulation of immune system process immunological memory process regulation of leukocyte activation regulation of alpha-beta T cell activation regulation of cell activation positive regulation of cell activation T cell activation positive regulation of leukocyte activation negative regulation of T cell costimulation alpha-beta T cell activation positive regulation of T cell activation regulation of T cell costimulation positive regulation of alpha-beta T cell activation regulation of leukocyte cell-cell adhesion CD4-positive, alpha-beta T cell costimulation T cell costimulation positive regulation of leukocyte cell-cell adhesion lymphocyte activation leukocyte cell-cell adhesion leukocyte activation positive regulation of cell-cell adhesion positive regulation of lymphocyte activation positive regulation of CD4-positive, alpha-beta T cell activation cell adhesion cell-cell adhesion CD4-positive, alpha-beta T cell activation regulation of cell-cell adhesion negative regulation of CD4-positive, alpha-beta T cell costimulation positive regulation of cell adhesion regulation of cell adhesion cell activation regulation of T cell activation regulation of CD4-positive, alpha-beta T cell costimulation regulation of CD4-positive, alpha-beta T cell activation lymphocyte costimulation regulation of lymphocyte activation immune response-regulating cell surface receptor signaling pathway negative regulation of signaling regulation of signal transduction regulation of antigen receptor-mediated signaling pathway negative regulation of antigen receptor-mediated signaling pathway negative regulation of cell communication immune response-activating signaling pathway immune response-regulating signaling pathway negative regulation of cellular process regulation of signaling cell surface receptor signaling pathway immune response-activating cell surface receptor signaling pathway regulation of T cell receptor signaling pathway T cell receptor signaling pathway negative regulation of signal transduction negative regulation of T cell receptor signaling pathway regulation of cell communication antigen receptor-mediated signaling pathway activation of immune response regulation of localization regulated exocytosis cell activation involved in immune response leukocyte degranulation vesicle-mediated transport localization positive regulation of leukocyte degranulation positive regulation of regulated secretory pathway establishment of localization in cell natural killer cell activation establishment of localization regulation of secretion positive regulation of natural killer cell degranulation regulation of natural killer cell degranulation exocytosis natural killer cell degranulation cellular localization transport positive regulation of secretion by cell positive regulation of exocytosis regulation of regulated secretory pathway secretion by cell regulation of secretion by cell positive regulation of secretion natural killer cell activation involved in immune response leukocyte activation involved in immune response regulation of leukocyte degranulation lymphocyte activation involved in immune response secretion regulation of transport export from cell regulation of vesicle-mediated transport positive regulation of transport regulation of exocytosis mucosal immune response organ or tissue specific immune response positive regulation of endothelial cell apoptotic process positive regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death cell death positive regulation of apoptotic process endothelial cell apoptotic process apoptotic process programmed cell death regulation of endothelial cell apoptotic process defense response to Gram-negative bacterium defense response to bacterium response to bacterium immune response to tumor cell regulation of natural killer cell mediated immune response to tumor cell positive regulation of immune response to tumor cell natural killer cell mediated immune response to tumor cell positive regulation of response to tumor cell positive regulation of natural killer cell mediated immune response to tumor cell regulation of response to tumor cell response to tumor cell regulation of immune response to tumor cell regulation of developmental process regulation of vasculature development regulation of anatomical structure morphogenesis regulation of multicellular organismal development negative regulation of blood vessel morphogenesis negative regulation of developmental process negative regulation of angiogenesis negative regulation of vasculature development regulation of angiogenesis negative regulation of multicellular organismal process regulation of type II interferon production type II interferon production positive regulation of type II interferon production positive regulation of locomotion regulation of cell motility regulation of lymphocyte migration positive regulation of cell migration positive regulation of cell motility regulation of cell migration positive regulation of mononuclear cell migration cell migration cell motility regulation of mononuclear cell migration locomotion positive regulation of lymphocyte migration regulation of leukocyte migration positive regulation of T cell migration lymphocyte migration positive regulation of leukocyte migration leukocyte migration regulation of locomotion regulation of T cell migration mononuclear cell migration T cell migration negative regulation of lymphocyte proliferation negative regulation of T cell proliferation negative regulation of cell adhesion negative regulation of leukocyte proliferation alpha-beta T cell proliferation lymphocyte proliferation regulation of leukocyte proliferation cell population proliferation negative regulation of T cell activation negative regulation of leukocyte cell-cell adhesion regulation of cell population proliferation mononuclear cell proliferation negative regulation of cell-cell adhesion negative regulation of leukocyte activation negative regulation of lymphocyte activation leukocyte proliferation negative regulation of mononuclear cell proliferation regulation of alpha-beta T cell proliferation T cell proliferation regulation of lymphocyte proliferation negative regulation of cell population proliferation negative regulation of cell activation regulation of T cell proliferation negative regulation of alpha-beta T cell proliferation regulation of mononuclear cell proliferation negative regulation of alpha-beta T cell activation defense response to Gram-positive bacterium regulation of protein modification process positive regulation of phosphorylation regulation of protein phosphorylation positive regulation of protein metabolic process peptidyl-tyrosine modification positive regulation of phosphate metabolic process regulation of primary metabolic process positive regulation of peptidyl-tyrosine phosphorylation positive regulation of protein modification process regulation of phosphate metabolic process peptidyl-amino acid modification phosphate-containing compound metabolic process protein metabolic process protein modification process phosphorus metabolic process positive regulation of protein phosphorylation protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation regulation of protein metabolic process regulation of peptidyl-tyrosine phosphorylation primary metabolic process macromolecule modification regulation of phosphorylation regulation of phosphorus metabolic process peptidyl-tyrosine phosphorylation	cell periphery cellular anatomical structure plasma membrane membrane side of membrane extracellular region cell surface external side of plasma membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C	IPR008983	Tumour necrosis factor-like domain superfamily	Homologous Superfamily
A, B, C	IPR006052	Tumour necrosis factor domain	Domain
A, B, C	IPR006053	Tumour necrosis factor	Family
D, E, F	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
D, E, F	IPR042385	CD160 ANTIGEN	Family
D, E, F	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
D, E, F	IPR022332	Tumour necrosis factor receptor 14	Family
D, E, F	IPR001368	TNFR/NGFR cysteine-rich region	Domain
D, E, F	IPR034031	Tumor necrosis factor receptor 14/UL144, N-terminal	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C	Pharos: O43557	rheumatoid arthritis multiple sclerosis age-related macular degeneration malignant mesothelioma non-small cell lung carcinoma head and neck cancer osteosarcoma tuberculosis interstitial cystitis Multiple Sclerosis, Acute Fulminating ovarian cancer wet macular degeneration
D, E, F	Pharos: Q92956	breast carcinoma tuberculosis Crohn disease type 1 diabetes mellitus osteosarcoma rheumatoid arthritis celiac disease allergic rhinitis Brain Injuries, Focal Hashimoto thyroiditis large cell medulloblastoma primary biliary cholangitis ulcerative colitis azoospermia brain injury breast carcinoma tuberculosis Crohn disease type 1 diabetes mellitus osteosarcoma rheumatoid arthritis celiac disease allergic rhinitis Brain Injuries, Focal Hashimoto thyroiditis large cell medulloblastoma primary biliary cholangitis ulcerative colitis azoospermia brain injury diffuse large B-cell lymphoma hypothyroidism osteosarcoma follicular lymphoma pancreatic ductal adenocarcinoma sclerosing cholangitis

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.