7HL6

Group deposition for crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2 -- Crystal structure of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2 in complex with Z31113727 (DNV2_NS5A-x1192)


Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF20483Flavivirus RNA-directed RNA polymerase, thumb domain (Flavi_NS5_thumb)Flavivirus RNA-directed RNA polymerase, thumb domainFlaviviruses produce a large polyprotein from the ssRNA genome, encoding structural proteins required for virus assembly and non-structural (NS1-5) proteins involved in replication of the viral genome [1,2,3]. This polyprotein is cleaved by viral and ...Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
Genome polyprotein

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
IPR000208RNA-directed RNA polymerase, fingers/palm subdomains, flavivirusDomain
IPR014756Immunoglobulin E-setHomologous Superfamily
IPR001122Capsid protein C, flavivirusDomain
IPR027287Glycoprotein E, immunoglobulin-like domain, flavivirusDomain
IPR014412Genome polyprotein, FlavivirusFamily
IPR036253Flavivirus glycoprotein, central and dimerisation domain superfamilyHomologous Superfamily
IPR027417P-loop containing nucleoside triphosphate hydrolaseHomologous Superfamily
IPR026490mRNA cap 0/1 methyltransferaseDomain
IPR009003Peptidase S1, PA clanHomologous Superfamily
IPR001650Helicase, C-terminal domain-likeDomain
IPR014001Helicase superfamily 1/2, ATP-binding domainDomain
IPR013755Flaviviral glycoprotein E, central domain, subdomain 1Homologous Superfamily
IPR000752Flavivirus non-structural protein NS2ADomain
IPR047530RNA-dependent RNA polymerase, flavivirusDomain
IPR049486Flavivridae NS3 helicase, C-terminal helical domainDomain
IPR046811RNA-directed RNA polymerase, thumb subdomain, flavivirusDomain
IPR038055Flaviviral glycoprotein E, dimerisation domainHomologous Superfamily
IPR002877Ribosomal RNA methyltransferase, FtsJ domainDomain
IPR038302Envelope glycoprotein M superfamily, flavivirusHomologous Superfamily
IPR000069Envelope glycoprotein M, flavivirusDomain
IPR011492Non-structural protein NS3-like, DEAD box helicase, flavivirusDomain
IPR038345Flavivirus envelope glycoprotein E, Stem/Anchor domain superfamilyHomologous Superfamily
IPR038688Flavivirus polyprotein propeptide superfamilyHomologous Superfamily
IPR029063S-adenosyl-L-methionine-dependent methyltransferase superfamilyHomologous Superfamily
IPR026470Flavivirus envelope glycoprotein E, Stem/Anchor domainDomain
IPR011998Envelope glycoprotein E, central and dimerisation domain, flavivirusDomain
IPR043502DNA/RNA polymerase superfamilyHomologous Superfamily
IPR037172Flavivirus capsid protein C superfamilyHomologous Superfamily
IPR000404Flavivirus non-structural protein NS4ADomain
IPR000487Non-structural protein NS2B, flavivirusDomain
IPR001528Flavivirus non-structural protein NS4BDomain
IPR001157Non-structural protein NS1, flavivirusDomain
IPR013756Flaviviral glycoprotein E, central domain, subdomain 2Homologous Superfamily
IPR001850Non-structural protein NS3, peptidase S7, flavivirusDomain
IPR000336Flavivirus/Alphavirus glycoprotein, immunoglobulin-like domain superfamilyHomologous Superfamily
IPR002535Flavivirus polyprotein propeptideDomain
IPR043504Peptidase S1, PA clan, chymotrypsin-like foldHomologous Superfamily
IPR007094RNA-directed RNA polymerase, catalytic domainDomain