7D8E

Crystal Structure of double mutant Y115E Y117E human Secretory Glutaminyl Cyclase in complex with LSB-09

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Zn-dependent exopeptidases	8036989	3000662	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Zn-dependent exopeptidases	8036989	3000662	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Zn-dependent exopeptidases	8036989	3000662	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Peptidase_M28	e7d8eA1	A: a/b three-layered sandwiches	X: Phosphorylase/hydrolase-like	H: Zn-dependent exopeptidases (From Topology)	T: Zn-dependent exopeptidases	F: Peptidase_M28	ECOD (1.6)
B	Peptidase_M28	e7d8eB1	A: a/b three-layered sandwiches	X: Phosphorylase/hydrolase-like	H: Zn-dependent exopeptidases (From Topology)	T: Zn-dependent exopeptidases	F: Peptidase_M28	ECOD (1.6)
C	Peptidase_M28	e7d8eC1	A: a/b three-layered sandwiches	X: Phosphorylase/hydrolase-like	H: Zn-dependent exopeptidases (From Topology)	T: Zn-dependent exopeptidases	F: Peptidase_M28	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C	PF04389	Peptidase family M28 (Peptidase_M28)	Peptidase family M28	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C	Glutaminyl-peptide cyclotransferase	aminoacyltransferase activity glutaminyl-peptide cyclotransferase activity catalytic activity, acting on a protein acyltransferase activity transferase activity catalytic activity cation binding transition metal ion binding zinc ion binding ion binding binding metal ion binding small molecule binding	peptidyl-glutamine modification macromolecule modification peptidyl-amino acid modification metabolic process cellular process primary metabolic process peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase protein metabolic process macromolecule metabolic process protein modification process	membrane-bounded organelle vesicle lumen intracellular anatomical structure intracellular vesicle membrane-enclosed lumen cytoplasmic vesicle lumen intracellular membrane-bounded organelle secretory granule lumen endomembrane system intracellular organelle lumen intracellular organelle cellular anatomical structure cytoplasmic vesicle organelle lumen membrane-bounded organelle vesicle lumen intracellular anatomical structure intracellular vesicle membrane-enclosed lumen cytoplasmic vesicle lumen intracellular membrane-bounded organelle secretory granule lumen endomembrane system intracellular organelle lumen intracellular organelle cellular anatomical structure cytoplasmic vesicle organelle lumen organelle specific granule lumen secretory granule secretory vesicle cytoplasm vesicle specific granule tertiary granule lumen tertiary granule extracellular region ficolin-1-rich granule ficolin-1-rich granule lumen extracellular exosome extracellular vesicle extracellular organelle extracellular space extracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C	IPR007484	Peptidase M28	Domain
A, B, C	IPR040234	Glutaminyl-peptide cyclotransferase-like	Family
A, B, C	IPR037457	M28 Zn-Peptidase Glutaminyl Cyclase	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C	Pharos: Q16769	B-cell chronic lymphocytic leukemia melanoma allergic contact dermatitis breast cancer large cell medulloblastoma malignant ependymoma sarcoidosis astrocytic tumor cutaneous melanoma lung adenocarcinoma MALT lymphoma oligodendroglioma ulcerative colitis gastric carcinoma lung cancer B-cell chronic lymphocytic leukemia melanoma allergic contact dermatitis breast cancer large cell medulloblastoma malignant ependymoma sarcoidosis astrocytic tumor cutaneous melanoma lung adenocarcinoma MALT lymphoma oligodendroglioma ulcerative colitis gastric carcinoma lung cancer medulloblastoma psoriasis

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.