7CNA

Crystal structure of Spindlin1/C11orf84 complex bound to histone H3K4me3K9me3 peptide

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Protein Modification Annotation

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Tudor/PWWP/MBT domain-like	8052900	3000404	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Tudor/PWWP/MBT domain-like	8052902	3000404	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Tudor/PWWP/MBT domain-like	8052901	3000404	SCOP2B (2022-06-29)
C [auth D]	SCOP2B Superfamily	Tudor/PWWP/MBT domain-like	8052900	3000404	SCOP2B (2022-06-29)
C [auth D]	SCOP2B Superfamily	Tudor/PWWP/MBT domain-like	8052901	3000404	SCOP2B (2022-06-29)
C [auth D]	SCOP2B Superfamily	Tudor/PWWP/MBT domain-like	8052902	3000404	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Spin-Ssty_1	e7cnaA3	A: beta barrels	X: SH3	H: SH3	T: SH3	F: Spin-Ssty_1	ECOD (1.6)
A	Spin-Ssty_2	e7cnaA2	A: beta barrels	X: SH3	H: SH3	T: SH3	F: Spin-Ssty_2	ECOD (1.6)
A	Spin-Ssty	e7cnaA1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: Spin-Ssty	ECOD (1.6)
C [auth D]	Spin-Ssty_1	e7cnaD1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: Spin-Ssty_1	ECOD (1.6)
C [auth D]	Spin-Ssty_2	e7cnaD2	A: beta barrels	X: SH3	H: SH3	T: SH3	F: Spin-Ssty_2	ECOD (1.6)
C [auth D]	Spin-Ssty	e7cnaD3	A: beta barrels	X: SH3	H: SH3	T: SH3	F: Spin-Ssty	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C [auth D]	PF02513	Spin/Ssty Family (Spin-Ssty)	Spin/Ssty Family	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C [auth D]	Spindlin-1	methylated histone binding protein binding binding modification-dependent protein binding histone binding methylation-dependent protein binding	cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction cell communication positive regulation of response to stimulus positive regulation of Wnt signaling pathway signal transduction Wnt signaling pathway positive regulation of cellular process cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction cell communication positive regulation of response to stimulus positive regulation of Wnt signaling pathway signal transduction Wnt signaling pathway positive regulation of cellular process regulation of biological process regulation of signaling cell surface receptor signaling pathway regulation of Wnt signaling pathway biological regulation regulation of response to stimulus regulation of cell communication cellular process positive regulation of signaling RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process primary metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of gene expression biosynthetic process metabolic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription macromolecule metabolic process regulation of metabolic process sexual reproduction reproductive process multicellular organismal reproductive process gamete generation rRNA transcription rRNA metabolic process positive regulation of DNA-templated transcription positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process meiotic cell cycle cell cycle cellular component organization chromatin organization cellular component organization or biogenesis	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle membraneless organelle nuclear lumen membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle membraneless organelle nuclear lumen nuclear membrane membrane endomembrane system organelle envelope nuclear envelope organelle membrane cytoplasm cytosol cytoskeleton spindle microtubule cytoskeleton nucleoplasm
B, D [auth E]	Spindlin interactor and repressor of chromatin-binding protein	-	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process regulation of cellular process negative regulation of biological process RNA metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process regulation of cellular process negative regulation of biological process RNA metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process negative regulation of DNA-templated transcription regulation of biological process negative regulation of metabolic process biological regulation primary metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process regulation of molecular function regulation of catalytic activity regulation of transferase activity regulation of protein ADP-ribosylation	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure organelle nucleus intracellular membrane-bounded organelle membraneless organelle site of DNA damage intracellular membraneless organelle chromosome
E [auth C]	ALA-ARG-THR-M3L-GLN-THR-ALA-ARG-M3L-SER-THR	-	-	-
F	ALA-ARG-THR-M3L-GLN-THR-ALA-ARG-M3L-SER-GLY	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C [auth D]	IPR042567	Spindlin/spermiogenesis-specific domain superfamily	Homologous Superfamily
A, C [auth D]	IPR003671	Spindlin/spermiogenesis-specific protein	Family
B, D [auth E]	IPR040647	SPIN-DOC-like, zinc-finger	Domain
B, D [auth E]	IPR052675	Zinc finger translocation-associated & Spindlin interactor	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, C [auth D]	Pharos: Q9Y657	acute myeloid leukemia cystic fibrosis glioblastoma malignant ependymoma myopathy pancreatic ductal adenocarcinoma amyotrophic lateral sclerosis Duchenne muscular dystrophy juvenile dermatomyositis malignant pancreatic neoplasm osteosarcoma pancreatic intraductal papillary-mucinous neoplasm Becker muscular dystrophy Emery-Dreifuss muscular dystrophy limb-girdle muscular dystrophy acute myeloid leukemia cystic fibrosis glioblastoma malignant ependymoma myopathy pancreatic ductal adenocarcinoma amyotrophic lateral sclerosis Duchenne muscular dystrophy juvenile dermatomyositis malignant pancreatic neoplasm osteosarcoma pancreatic intraductal papillary-mucinous neoplasm Becker muscular dystrophy Emery-Dreifuss muscular dystrophy limb-girdle muscular dystrophy medulloblastoma ovarian cancer sinusitis
B, D [auth E]	Pharos: Q9BUA3	bipolar disorder endogenous depression

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
E [auth C]	M3L	Parent Component: LYS RESID: AA0074 PSI-MOD : N6,N6,N6-trimethyl-L-lysine MOD:00083
F	M3L	Parent Component: LYS RESID: AA0074 , AA0074 PSI-MOD : N6,N6,N6-trimethyl-L-lysine MOD:00083 , N6,N6,N6-trimethyl-L-lysine MOD:00083

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.