7C4S

Sphingosine-1-phosphate receptor 3 with a natural ligand.

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
SAbDab Antibody Annotation
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Membrane Protein Annotation: OPM
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: MemProtMD
Membrane Protein Annotation: mpstruc

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
C [auth A]	SCOP2 Family	Class A (rhodopsin) G protein-coupled receptor-like	8103499	4001858	SCOP2 (2022-06-29)
C [auth A]	SCOP2 Superfamily	G protein-coupled receptor-like	8103500	3000473	SCOP2 (2022-06-29)
F [auth B]	SCOP2B Superfamily	G protein-coupled receptor-like	8103500	3000473	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth L]	C1-set_4	e7c4sL2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_4	ECOD (1.6)
A [auth L]	V-set	e7c4sL1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set	ECOD (1.6)
D [auth K]	C1-set_4	e7c4sK1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_4	ECOD (1.6)
D [auth K]	V-set	e7c4sK2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set	ECOD (1.6)
B [auth H]	C1-set_1	e7c4sH2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_1	ECOD (1.6)
B [auth H]	V-set_10	e7c4sH1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_10	ECOD (1.6)
E [auth J]	C1-set_1	e7c4sJ1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_1	ECOD (1.6)
E [auth J]	V-set_10	e7c4sJ2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_10	ECOD (1.6)
C [auth A]	7tm_1_2	e7c4sA1	A: alpha bundles	X: Family A G protein-coupled receptor-like (From Topology)	H: Family A G protein-coupled receptor-like (From Topology)	T: Family A G protein-coupled receptor-like	F: 7tm_1_2	ECOD (1.6)
F [auth B]	7tm_1_2	e7c4sB1	A: alpha bundles	X: Family A G protein-coupled receptor-like (From Topology)	H: Family A G protein-coupled receptor-like (From Topology)	T: Family A G protein-coupled receptor-like	F: 7tm_1_2	ECOD (1.6)

SAbDab Antibody Annotation SAbDab Database Homepage

Chain	Chain Class	Chain Subclass	Chain Type	Antigen Name(s)	Provenance Source
A [auth L], D [auth K]	Light Chain	IGKV6	Kappa	sphingosine 1-phosphate receptor 3	SAbDab (2024-12-06)
B [auth H], E [auth J]	Heavy Chain	IGHV1	-	sphingosine 1-phosphate receptor 3	SAbDab (2024-12-06)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
C [auth A], F [auth B]	PF00001	7 transmembrane receptor (rhodopsin family) (7tm_1)	7 transmembrane receptor (rhodopsin family)	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth L], D [auth K]	Antibody Fab fragment light chain	-	-	-
B [auth H], E [auth J]	Antibody Fab fragment heavy chain	-	-	-
C [auth A], F [auth B]	Sphingosine 1-phosphate receptor 3	cell adhesion molecule binding protein-containing complex binding protein binding binding integrin binding signaling receptor binding lipid binding molecular transducer activity G protein-coupled receptor activity transmembrane signaling receptor activity signaling receptor activity bioactive lipid receptor activity sphingosine-1-phosphate receptor activity	cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation adenylate cyclase-activating G protein-coupled receptor signaling pathway cell communication adenylate cyclase-modulating G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway cellular process signal transduction cell population proliferation positive regulation of cell population proliferation cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation adenylate cyclase-activating G protein-coupled receptor signaling pathway cell communication adenylate cyclase-modulating G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway cellular process signal transduction cell population proliferation positive regulation of cell population proliferation regulation of cell population proliferation positive regulation of biological process positive regulation of cellular process metabolic process regulation of metabolic process positive regulation of cytosolic calcium ion concentration regulation of biological quality multicellular organismal process regulation of establishment of endothelial barrier cellular developmental process regulation of developmental process endothelium development negative regulation of biological process cell development regulation of cell differentiation negative regulation of endothelial cell development epithelial cell differentiation regulation of cell development regulation of epithelial cell differentiation endothelial cell development multicellular organism development cell differentiation regulation of endothelial cell development anatomical structure development negative regulation of cellular process regulation of multicellular organismal process negative regulation of cell differentiation developmental process epithelium development regulation of multicellular organismal development negative regulation of epithelial cell differentiation endothelial cell differentiation regulation of endothelial cell differentiation negative regulation of developmental process negative regulation of endothelial cell differentiation tissue development negative regulation of cell development epithelial cell development establishment of endothelial barrier negative regulation of establishment of endothelial barrier adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway defense response response to stress inflammatory response regulation of biosynthetic process regulation of interleukin-1 production interleukin-1 production regulation of macromolecule metabolic process gene expression regulation of interleukin-1 beta production macromolecule biosynthetic process regulation of gene expression biosynthetic process interleukin-1 beta production regulation of cytokine production cytokine production regulation of macromolecule biosynthetic process macromolecule metabolic process cell surface receptor signaling pathway Notch signaling pathway anatomical structure morphogenesis	cell periphery cellular anatomical structure plasma membrane membrane presynapse synapse cell junction intracellular anatomical structure cytoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
C [auth A], F [auth B]	IPR004061	Sphingosine 1-phosphate receptor	Family
C [auth A], F [auth B]	IPR000276	G protein-coupled receptor, rhodopsin-like	Family
C [auth A], F [auth B]	IPR004062	EDG-3 sphingosine 1-phosphate receptor	Family
C [auth A], F [auth B]	IPR017452	GPCR, rhodopsin-like, 7TM	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
C [auth A], F [auth B]	Pharos: Q99500	primitive neuroectodermal tumor tuberculosis adrenoleukodystrophy breast cancer interstitial cystitis malignant glioma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm pilocytic astrocytoma relapsing-remitting multiple sclerosis ulcerative colitis astrocytic tumor ductal breast carcinoma in situ invasive ductal breast carcinoma malignant pancreatic neoplasm primitive neuroectodermal tumor tuberculosis adrenoleukodystrophy breast cancer interstitial cystitis malignant glioma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm pilocytic astrocytoma relapsing-remitting multiple sclerosis ulcerative colitis astrocytic tumor ductal breast carcinoma in situ invasive ductal breast carcinoma malignant pancreatic neoplasm pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia pituitary cancer Sjogren syndrome atypical teratoid rhabdoid tumor glioblastoma malignant ependymoma osteosarcoma pancreatic intraductal papillary-mucinous carcinoma Pick disease

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
C [auth A], F [auth B]	OPM	Transmembrane	Alpha-helical polytopic	Rhodopsin-like receptors and pumps	G-protein coupled receptors, family A

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
C [auth A], F [auth B]	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
C [auth A], F [auth B]	MemProtMD	Annotated as membrane protein by MemProtMD

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
C [auth A], F [auth B]	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	G Protein-Coupled Receptors: Class A	Sphingosine-1-phosphate receptor 3 (S1PR3) in complex with natural ligand

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.