7O4B

Crystal structure of Penicillin-Binding Protein 1 (PBP1) from Staphylococcus aureus in complex with penicillin G

External Resource: Annotation


Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A,
B [auth C]		PF03717Penicillin-binding Protein dimerisation domain (PBP_dimer)Penicillin-binding Protein dimerisation domainThis domain is found at the N terminus of Class B High Molecular Weight Penicillin-Binding Proteins. Its function has not been precisely defined, but is strongly implicated in PBP polymerisation. The domain forms a largely disordered 'sugar tongs' st ...This domain is found at the N terminus of Class B High Molecular Weight Penicillin-Binding Proteins. Its function has not been precisely defined, but is strongly implicated in PBP polymerisation. The domain forms a largely disordered 'sugar tongs' structure.
Domain
A,
B [auth C]		PF00905Penicillin binding protein transpeptidase domain (Transpeptidase)Penicillin binding protein transpeptidase domainThe active site serine (residue 337 in Swiss:P14677) is conserved in all members of this family.Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A,
B [auth C]		Penicillin-binding protein 1

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
A,
B [auth C]		IPR005543PASTA domainDomain
A,
B [auth C]		IPR012338Beta-lactamase/transpeptidase-likeHomologous Superfamily
A,
B [auth C]		IPR005311Penicillin-binding protein, dimerisation domainDomain
A,
B [auth C]		IPR001460Penicillin-binding protein, transpeptidaseDomain
A,
B [auth C]		IPR050515Bacterial Transpeptidases and Beta-LactamasesFamily
A,
B [auth C]		IPR036138Penicillin-binding protein, dimerisation domain superfamilyHomologous Superfamily