Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
A [auth B]SCOP2B SuperfamilyUBC-like 8095691 3000570 SCOP2B (2022-06-29)
B [auth F]SCOP2B SuperfamilyUBC-like 8095691 3000570 SCOP2B (2022-06-29)
C [auth D]SCOP2B SuperfamilyUBC-like 8095691 3000570 SCOP2B (2022-06-29)
D [auth H]SCOP2B SuperfamilyUBC-like 8095691 3000570 SCOP2B (2022-06-29)
E [auth A]SCOP2B SuperfamilyActivating enzymes of the ubiquitin-like proteins 8003540 3000112 SCOP2B (2022-06-29)
E [auth A]SCOP2B SuperfamilyActivating enzymes of the ubiquitin-like proteins 8017546 3000112 SCOP2B (2022-06-29)
E [auth A]SCOP2B SuperfamilyE2 binding domain-like 8003942 3000147 SCOP2B (2022-06-29)
E [auth A]SCOP2B SuperfamilySCCH domain-like 8003543 3000139 SCOP2B (2022-06-29)
E [auth A]SCOP2B SuperfamilyFCCH domain-like 8003532 3000138 SCOP2B (2022-06-29)
E [auth A]SCOP2B SuperfamilyCC (catalytic cysteine) domain-like 8003552 3000140 SCOP2B (2022-06-29)
F [auth E]SCOP2B SuperfamilyActivating enzymes of the ubiquitin-like proteins 8017546 3000112 SCOP2B (2022-06-29)
F [auth E]SCOP2B SuperfamilyCC (catalytic cysteine) domain-like 8003552 3000140 SCOP2B (2022-06-29)
F [auth E]SCOP2B SuperfamilyActivating enzymes of the ubiquitin-like proteins 8003540 3000112 SCOP2B (2022-06-29)
F [auth E]SCOP2B SuperfamilySCCH domain-like 8003543 3000139 SCOP2B (2022-06-29)
F [auth E]SCOP2B SuperfamilyE2 binding domain-like 8003942 3000147 SCOP2B (2022-06-29)
F [auth E]SCOP2B SuperfamilyFCCH domain-like 8003532 3000138 SCOP2B (2022-06-29)
G [auth C]SCOP2B SuperfamilyActivating enzymes of the ubiquitin-like proteins 8017546 3000112 SCOP2B (2022-06-29)
G [auth C]SCOP2B SuperfamilyActivating enzymes of the ubiquitin-like proteins 8003540 3000112 SCOP2B (2022-06-29)
G [auth C]SCOP2B SuperfamilyFCCH domain-like 8003532 3000138 SCOP2B (2022-06-29)
G [auth C]SCOP2B SuperfamilySCCH domain-like 8003543 3000139 SCOP2B (2022-06-29)
G [auth C]SCOP2B SuperfamilyE2 binding domain-like 8003942 3000147 SCOP2B (2022-06-29)
G [auth C]SCOP2B SuperfamilyCC (catalytic cysteine) domain-like 8003552 3000140 SCOP2B (2022-06-29)
H [auth G]SCOP2B SuperfamilyActivating enzymes of the ubiquitin-like proteins 8017546 3000112 SCOP2B (2022-06-29)
H [auth G]SCOP2B SuperfamilySCCH domain-like 8003543 3000139 SCOP2B (2022-06-29)
H [auth G]SCOP2B SuperfamilyFCCH domain-like 8003532 3000138 SCOP2B (2022-06-29)
H [auth G]SCOP2B SuperfamilyCC (catalytic cysteine) domain-like 8003552 3000140 SCOP2B (2022-06-29)
H [auth G]SCOP2B SuperfamilyActivating enzymes of the ubiquitin-like proteins 8003540 3000112 SCOP2B (2022-06-29)
H [auth G]SCOP2B SuperfamilyE2 binding domain-like 8003942 3000147 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
A [auth B]UQ_cone6zhuB1 A: a+b two layersX: UBC-likeH: UBC-like (From Topology)T: UBC-likeF: UQ_conECOD (1.6)
B [auth F]UQ_cone6zhuF1 A: a+b two layersX: UBC-likeH: UBC-like (From Topology)T: UBC-likeF: UQ_conECOD (1.6)
C [auth D]UQ_cone6zhuD1 A: a+b two layersX: UBC-likeH: UBC-like (From Topology)T: UBC-likeF: UQ_conECOD (1.6)
D [auth H]UQ_cone6zhuH1 A: a+b two layersX: UBC-likeH: UBC-like (From Topology)T: UBC-likeF: UQ_conECOD (1.6)
E [auth A]E1_FCCHe6zhuA6 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: Alanine racemase-CF: E1_FCCHECOD (1.6)
E [auth A]UBA_e1_thiolCyse6zhuA5 A: alpha arraysX: Catalytic cysteine domain in ubiquitin-activating enzyme (From Topology)H: Catalytic cysteine domain in ubiquitin-activating enzyme (From Topology)T: Catalytic cysteine domain in ubiquitin-activating enzymeF: UBA_e1_thiolCysECOD (1.6)
E [auth A]ThiF_3e6zhuA1 A: alpha arraysX: Catalytic cysteine domain in ubiquitin-activating enzyme (From Topology)H: Catalytic cysteine domain in ubiquitin-activating enzyme (From Topology)T: Catalytic cysteine domain in ubiquitin-activating enzymeF: ThiF_3ECOD (1.6)
E [auth A]E1_UFDe6zhuA2 A: a+b two layersX: beta-GraspH: E2-binding domain of E1 (From Topology)T: E2-binding domain of E1F: E1_UFDECOD (1.6)
E [auth A]ThiF_1e6zhuA4 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: Activating enzymes of the ubiquitin-like proteinsF: ThiF_1ECOD (1.6)
E [auth A]ThiF_3e6zhuA3 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: Activating enzymes of the ubiquitin-like proteinsF: ThiF_3ECOD (1.6)
F [auth E]E1_FCCHe6zhuE5 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: Alanine racemase-CF: E1_FCCHECOD (1.6)
F [auth E]UBA_e1_thiolCyse6zhuE4 A: alpha arraysX: Catalytic cysteine domain in ubiquitin-activating enzyme (From Topology)H: Catalytic cysteine domain in ubiquitin-activating enzyme (From Topology)T: Catalytic cysteine domain in ubiquitin-activating enzymeF: UBA_e1_thiolCysECOD (1.6)
F [auth E]ThiF_3e6zhuE3 A: alpha arraysX: Catalytic cysteine domain in ubiquitin-activating enzyme (From Topology)H: Catalytic cysteine domain in ubiquitin-activating enzyme (From Topology)T: Catalytic cysteine domain in ubiquitin-activating enzymeF: ThiF_3ECOD (1.6)
F [auth E]E1_UFDe6zhuE2 A: a+b two layersX: beta-GraspH: E2-binding domain of E1 (From Topology)T: E2-binding domain of E1F: E1_UFDECOD (1.6)
F [auth E]ThiF_1e6zhuE6 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: Activating enzymes of the ubiquitin-like proteinsF: ThiF_1ECOD (1.6)
F [auth E]ThiF_3e6zhuE1 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: Activating enzymes of the ubiquitin-like proteinsF: ThiF_3ECOD (1.6)
G [auth C]E1_FCCHe6zhuC3 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: Alanine racemase-CF: E1_FCCHECOD (1.6)
G [auth C]UBA_e1_thiolCyse6zhuC1 A: alpha arraysX: Catalytic cysteine domain in ubiquitin-activating enzyme (From Topology)H: Catalytic cysteine domain in ubiquitin-activating enzyme (From Topology)T: Catalytic cysteine domain in ubiquitin-activating enzymeF: UBA_e1_thiolCysECOD (1.6)
G [auth C]ThiF_3e6zhuC2 A: alpha arraysX: Catalytic cysteine domain in ubiquitin-activating enzyme (From Topology)H: Catalytic cysteine domain in ubiquitin-activating enzyme (From Topology)T: Catalytic cysteine domain in ubiquitin-activating enzymeF: ThiF_3ECOD (1.6)
G [auth C]E1_UFDe6zhuC6 A: a+b two layersX: beta-GraspH: E2-binding domain of E1 (From Topology)T: E2-binding domain of E1F: E1_UFDECOD (1.6)
G [auth C]ThiF_1e6zhuC5 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: Activating enzymes of the ubiquitin-like proteinsF: ThiF_1ECOD (1.6)
G [auth C]ThiF_3e6zhuC4 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: Activating enzymes of the ubiquitin-like proteinsF: ThiF_3ECOD (1.6)
H [auth G]E1_FCCHe6zhuG1 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: Alanine racemase-CF: E1_FCCHECOD (1.6)
H [auth G]UBA_e1_thiolCyse6zhuG3 A: alpha arraysX: Catalytic cysteine domain in ubiquitin-activating enzyme (From Topology)H: Catalytic cysteine domain in ubiquitin-activating enzyme (From Topology)T: Catalytic cysteine domain in ubiquitin-activating enzymeF: UBA_e1_thiolCysECOD (1.6)
H [auth G]ThiF_3e6zhuG5 A: alpha arraysX: Catalytic cysteine domain in ubiquitin-activating enzyme (From Topology)H: Catalytic cysteine domain in ubiquitin-activating enzyme (From Topology)T: Catalytic cysteine domain in ubiquitin-activating enzymeF: ThiF_3ECOD (1.6)
H [auth G]E1_UFDe6zhuG6 A: a+b two layersX: beta-GraspH: E2-binding domain of E1 (From Topology)T: E2-binding domain of E1F: E1_UFDECOD (1.6)
H [auth G]ThiF_1e6zhuG2 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: Activating enzymes of the ubiquitin-like proteinsF: ThiF_1ECOD (1.6)
H [auth G]ThiF_3e6zhuG4 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: Activating enzymes of the ubiquitin-like proteinsF: ThiF_3ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A [auth B],
B [auth F],
C [auth D],
D [auth H]
PF00179Ubiquitin-conjugating enzyme (UQ_con)Ubiquitin-conjugating enzymeProteins destined for proteasome-mediated degradation may be ubiquitinated. Ubiquitination follows conjugation of ubiquitin to a conserved cysteine residue of UBC homologues. TSG101 is one of several UBC homologues that lacks this active site cystein ...Domain
E [auth A],
F [auth E],
G [auth C],
H [auth G]
PF00899ThiF family (ThiF)ThiF familyThis domain is found in ubiquitin activating E1 family and members of the bacterial ThiF/MoeB/HesA family. It is repeated in Ubiquitin-activating enzyme E1 [1-3]. Domain
E [auth A],
F [auth E],
G [auth C],
H [auth G]
PF09358Ubiquitin fold domain (E1_UFD)Ubiquitin fold domainThe ubiquitin fold domain is found at the C-terminus of ubiquitin-activating E1 family enzymes. This domain binds to E2 enzymes [1]. Domain
E [auth A],
F [auth E],
G [auth C],
H [auth G]
PF10585Ubiquitin-activating enzyme, SCCH domain (UBA_E1_SCCH)Ubiquitin-activating enzyme, SCCH domainUbiquitin-activating enzyme (E1 enzyme) activates ubiquitin by first adenylating with ATP its C-terminal glycine residue and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding an ubiquitin-E1 thiolester and free A ...Domain
E [auth A],
F [auth E],
G [auth C],
H [auth G]
PF16190Ubiquitin-activating enzyme E1 FCCH domain (E1_FCCH)Ubiquitin-activating enzyme E1 FCCH domainThis domain is found in the ubiquitin-activating E1 family enzymes [1]. Domain
E [auth A],
F [auth E],
G [auth C],
H [auth G]
PF16191Ubiquitin-activating enzyme E1 four-helix bundle (E1_4HB)Ubiquitin-activating enzyme E1 four-helix bundleThis domain is found in the ubiquitin-activating E1 family enzymes [1]. Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A [auth B],
B [auth F],
C [auth D],
D [auth H]
Ubiquitin-conjugating enzyme E2-34 kDa
E [auth A],
F [auth E],
G [auth C],
H [auth G]
Ubiquitin-activating enzyme E1 1

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
A [auth B],
B [auth F],
C [auth D],
D [auth H]
IPR050113Ubiquitin-conjugating enzymeFamily
A [auth B],
B [auth F],
C [auth D],
D [auth H]
IPR016135Ubiquitin-conjugating enzyme/RWD-likeHomologous Superfamily
A [auth B],
B [auth F],
C [auth D],
D [auth H]
IPR023313Ubiquitin-conjugating enzyme, active siteActive Site
A [auth B],
B [auth F],
C [auth D],
D [auth H]
IPR000608Ubiquitin-conjugating enzyme E2, catalytic core domainDomain
E [auth A],
F [auth E],
G [auth C],
H [auth G]
IPR042302Ubiquitin-activating enzyme E1, FCCH domain superfamilyHomologous Superfamily
E [auth A],
F [auth E],
G [auth C],
H [auth G]
IPR000011Ubiquitin/SUMO-activating enzyme E1-likeFamily
E [auth A],
F [auth E],
G [auth C],
H [auth G]
IPR045886ThiF/MoeB/HesA familyFamily
E [auth A],
F [auth E],
G [auth C],
H [auth G]
IPR042449Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1Homologous Superfamily
E [auth A],
F [auth E],
G [auth C],
H [auth G]
IPR019572Ubiquitin-activating enzyme, SCCH domainDomain
E [auth A],
F [auth E],
G [auth C],
H [auth G]
IPR042063Ubiquitin-activating enzyme E1, SCCH domainHomologous Superfamily
E [auth A],
F [auth E],
G [auth C],
H [auth G]
IPR000594THIF-type NAD/FAD binding foldDomain
E [auth A],
F [auth E],
G [auth C],
H [auth G]
IPR032420Ubiquitin-activating enzyme E1, four-helix bundleDomain
E [auth A],
F [auth E],
G [auth C],
H [auth G]
IPR018075Ubiquitin-activating enzyme E1Family
E [auth A],
F [auth E],
G [auth C],
H [auth G]
IPR032418Ubiquitin-activating enzyme E1, FCCH domainDomain
E [auth A],
F [auth E],
G [auth C],
H [auth G]
IPR018965Ubiquitin-activating enzyme E1, C-terminalDomain
E [auth A],
F [auth E],
G [auth C],
H [auth G]
IPR035985Ubiquitin-activating enzymeHomologous Superfamily
E [auth A],
F [auth E],
G [auth C],
H [auth G]
IPR033127Ubiquitin-activating enzyme E1, Cys active siteActive Site
E [auth A],
F [auth E],
G [auth C],
H [auth G]
IPR038252Ubiquitin-activating enzyme E1, C-terminal domain superfamilyHomologous Superfamily
E [auth A],
F [auth E],
G [auth C],
H [auth G]
IPR018074Ubiquitin-activating enzyme E1, conserved siteConserved Site