6KLH | pdb_00006klh

Dimeric structure of Machupo virus polymerase bound to vRNA promoter

External Resource: Annotation

Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C	RNA-directed RNA polymerase L	RNA-directed RNA polymerase activity 5'-3' RNA polymerase activity catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid RNA polymerase activity transferase activity nucleotidyltransferase activity catalytic activity transferase activity, transferring phosphorus-containing groups binding nucleoside phosphate binding nucleotide binding heterocyclic compound binding small molecule binding RNA-directed RNA polymerase activity 5'-3' RNA polymerase activity catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid RNA polymerase activity transferase activity nucleotidyltransferase activity catalytic activity transferase activity, transferring phosphorus-containing groups binding nucleoside phosphate binding nucleotide binding heterocyclic compound binding small molecule binding hydrolase activity cation binding ion binding metal ion binding	viral gene expression cap snatching negative stranded viral RNA transcription viral process viral transcription RNA-templated viral transcription RNA metabolic process viral life cycle primary metabolic process nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process viral gene expression cap snatching negative stranded viral RNA transcription viral process viral transcription RNA-templated viral transcription RNA metabolic process viral life cycle primary metabolic process nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process nucleic acid biosynthetic process negative stranded viral RNA replication viral genome replication biosynthetic process viral RNA genome replication metabolic process cellular process macromolecule metabolic process	host cellular component cellular anatomical structure host cell virion component host intracellular part host cell cytoplasm host cell part host intracellular region
B, D	RNA (5'-R(GPCPCPUPAPGPGPAPUPCPCPAPCPUPGPUPGPCP*G)-3')	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C	IPR007099	RNA-directed RNA polymerase, negative-strand RNA virus	Domain
A, C	IPR010453	RNA polymerase, arenaviral	Family
A, C	IPR026382	RNA endonuclease, cap-snatching, arenaviral	Domain
A, C	IPR048006	RNA endonuclease, cap-snatching, bunyaviral	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.