6FTQ | pdb_00006ftq

Crystal structure of human beta-ureidopropionase (beta-alanine synthase) - mutant T299C

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Protein Modification Annotation

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	CN_hydrolase	e6ftqA1	A: a+b four layers	X: Carbon-nitrogen hydrolase-like	H: Carbon-nitrogen hydrolase (From Topology)	T: Carbon-nitrogen hydrolase	F: CN_hydrolase	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.60.110.10	Alpha Beta	4-Layer Sandwich	Nitrilase/N-carbamoyl-D-aminoacid amidohydrolase	Carbon-nitrogen hydrolase	CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00795	Carbon-nitrogen hydrolase (CN_hydrolase)	Carbon-nitrogen hydrolase	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Beta-ureidopropionase	identical protein binding protein binding binding protein homodimerization activity protein dimerization activity beta-ureidopropionase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides hydrolase activity catalytic activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	developmental process multicellular organism development multicellular organismal process hepaticobiliary system development gland development animal organ development anatomical structure development liver development system development pyrimidine ribonucleotide catabolic process ribose phosphate metabolic process ribonucleotide catabolic process pyrimidine ribonucleoside monophosphate catabolic process CMP catabolic process developmental process multicellular organism development multicellular organismal process hepaticobiliary system development gland development animal organ development anatomical structure development liver development system development pyrimidine ribonucleotide catabolic process ribose phosphate metabolic process ribonucleotide catabolic process pyrimidine ribonucleoside monophosphate catabolic process CMP catabolic process catabolic process pyrimidine-containing compound catabolic process organophosphate catabolic process carbohydrate derivative metabolic process nucleoside phosphate catabolic process pyrimidine nucleotide metabolic process nucleobase-containing compound metabolic process pyrimidine nucleotide catabolic process ribonucleotide metabolic process ribonucleoside monophosphate metabolic process nucleobase-containing small molecule metabolic process phosphate-containing compound metabolic process small molecule metabolic process ribonucleoside monophosphate catabolic process phosphorus metabolic process nucleoside monophosphate metabolic process pyrimidine ribonucleotide metabolic process nucleotide catabolic process pyrimidine nucleoside monophosphate catabolic process nucleoside phosphate metabolic process pyrimidine nucleoside monophosphate metabolic process carbohydrate derivative catabolic process pyrimidine-containing compound metabolic process pyrimidine ribonucleoside monophosphate metabolic process nucleoside monophosphate catabolic process primary metabolic process nucleotide metabolic process nucleobase-containing compound catabolic process CMP metabolic process organophosphate metabolic process metabolic process cellular process glycosyl compound metabolic process pyrimidine nucleoside catabolic process glycosyl compound catabolic process pyrimidine nucleoside metabolic process nucleoside metabolic process nucleobase-containing small molecule catabolic process nucleoside catabolic process small molecule catabolic process pyrimidine deoxyribonucleotide catabolic process pyrimidine deoxyribonucleoside monophosphate catabolic process deoxyribonucleoside monophosphate catabolic process deoxyribonucleotide catabolic process pyrimidine deoxyribonucleotide metabolic process deoxyribose phosphate catabolic process pyrimidine deoxyribonucleoside monophosphate metabolic process deoxyribonucleotide metabolic process dUMP catabolic process 2'-deoxyribonucleotide metabolic process deoxyribose phosphate metabolic process deoxyribonucleoside monophosphate metabolic process dUMP metabolic process dCMP catabolic process dCMP metabolic process protein-containing complex organization protein homotetramerization cellular component organization cellular component biogenesis cellular component assembly protein complex oligomerization protein tetramerization protein-containing complex assembly protein homooligomerization cellular component organization or biogenesis beta-alanine metabolic process oxoacid metabolic process small molecule biosynthetic process carboxylic acid metabolic process amino acid metabolic process organic acid metabolic process organic acid biosynthetic process beta-alanine biosynthetic process beta-alanine biosynthetic process via 3-ureidopropionate carboxylic acid biosynthetic process non-proteinogenic amino acid metabolic process amino acid biosynthetic process biosynthetic process non-proteinogenic amino acid biosynthetic process embryo development ending in birth or egg hatching chordate embryonic development embryo development in utero embryonic development UMP metabolic process UMP catabolic process	extracellular exosome membrane-bounded organelle extracellular vesicle cellular anatomical structure extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR050345	Aliphatic Amidase/Beta-Ureidopropionase	Family
A	IPR003010	Carbon-nitrogen hydrolase	Domain
A	IPR036526	Carbon-nitrogen hydrolase superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q9UBR1	beta-ureidopropionase deficiency metabolic disease West syndrome developmental and epileptic encephalopathy Symptomatic Infantile Spasms acne medulloblastoma ovarian cancer tuberculosis autism intellectual disability non-alcoholic fatty liver disease psoriasis Spasmus nutans nephrosclerosis beta-ureidopropionase deficiency metabolic disease West syndrome developmental and epileptic encephalopathy Symptomatic Infantile Spasms acne medulloblastoma ovarian cancer tuberculosis autism intellectual disability non-alcoholic fatty liver disease psoriasis Spasmus nutans nephrosclerosis osteosarcoma

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
A	CSD	Parent Component: CYS RESID: AA0262 PSI-MOD : L-cysteine sulfinic acid MOD:00267

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.