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Crystal structure of Pfs25 in complex with the transmission blocking antibody 1269 External Resource: Annotation Chains Family Name Domain Identifier Architecture Possible Homology Homology Topology Family Provenance Source (Version) A [auth H] V-set_8 e6b0aH2 A: beta sandwiches X: Immunoglobulin-like beta-sandwich H: Immunoglobulin-related T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like F: V-set_8 ECOD (1.6) A [auth H] C1-set_1 e6b0aH1 A: beta sandwiches X: Immunoglobulin-like beta-sandwich H: Immunoglobulin-related T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like F: C1-set_1 ECOD (1.6) B [auth L] C1-set_4 e6b0aL1 A: beta sandwiches X: Immunoglobulin-like beta-sandwich H: Immunoglobulin-related T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like F: C1-set_4 ECOD (1.6) B [auth L] V-set e6b0aL2 A: beta sandwiches X: Immunoglobulin-like beta-sandwich H: Immunoglobulin-related T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like F: V-set ECOD (1.6) C [auth A] EGF_CA e6b0aA3 A: few secondary structure elements X: EGF-like H: EGF-related T: EGF/Laminin F: EGF_CA ECOD (1.6) C [auth A] Plasmod_Pvs28 e6b0aA1 A: few secondary structure elements X: EGF-like H: EGF-related T: EGF/Laminin F: Plasmod_Pvs28 ECOD (1.6) C [auth A] UNK_F_TYPE e6b0aA2 A: few secondary structure elements X: EGF-like H: Fibulin-4 EGF-like 1 domain (From Topology) T: Fibulin-4 EGF-like 1 domain F: UNK_F_TYPE ECOD (1.6)
Chain Protein Name Description Organism Name Gene Allele Name(s) Domain Name(s) Receptor Type Receptor Description Provenance Source A [auth H] Fab 1269 VH-CH1 Homo sapiens (human) IGHV3-23*04, IGHJ3*01, IGHG1*01, IGHG1*02, IGHG1*04, IGHG1*05 V-DOMAIN VH, C-DOMAIN CH1 IG FAB-GAMMA-1_KAPPA IMGT (202448-0) B [auth L] Fab 1269 L-KAPPA Homo sapiens (human) IGKV3-20*01, IGKJ5*01, IGKC*01 V-DOMAIN V-KAPPA, C-DOMAIN C-KAPPA IG FAB-GAMMA-1_KAPPA IMGT (202448-0)
Chain Chain Class Chain Subclass Chain Type Antigen Name(s) Provenance Source A [auth H] Heavy Chain IGHV3 - 25 kda ookinete surface antigen SAbDab (2024-12-06) B [auth L] Light Chain IGKV3 Kappa 25 kda ookinete surface antigen SAbDab (2024-12-06)
Chains Accession Name Description Comments Source C [auth A] PF06247 Pvs28 EGF domain (Plasmod_Pvs28) Pvs28 EGF domain This family consists of several ookinete surface proteins (Pvs28) from several species of Plasmodium. Pvs25 and Pvs28 are expressed on the surface of ookinetes. These proteins are potential candidates for vaccine and induce antibodies that block the ... This family consists of several ookinete surface proteins (Pvs28) from several species of Plasmodium. Pvs25 and Pvs28 are expressed on the surface of ookinetes. These proteins are potential candidates for vaccine and induce antibodies that block the infectivity of Plasmodium vivax in immunised animals [1]. The structure of this protein shows it is composed of four EGF domains [2]. Less Domain
Chains Polymer Molecular Function Biological Process Cellular Component A [auth H] 1269 antibody, heavy chain - - - B [auth L] 1269 antibody, light chain - - - C [auth A] 25 kDa ookinete surface antigen - -