5WBJ

Crystal structure of the arabidopsis thaliana Raptor in complex with the TOS peptide of human 4EBP1

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	KOG1517	e5wbjA4	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: KOG1517	ECOD (1.6)
A	Raptor_N,Arm	e5wbjA3	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: Raptor_N,Arm	ECOD (1.6)
A	Raptor_N	e5wbjA1	A: a/b three-layered sandwiches	X: Caspase-like (From Topology)	H: Caspase-like (From Topology)	T: Caspase-like	F: Raptor_N	ECOD (1.6)
A	UNK_F_TYPE	e5wbjA2	A: extended segments	X: TOR1 N-terminal extended segment (From Topology)	H: TOR1 N-terminal extended segment (From Topology)	T: TOR1 N-terminal extended segment	F: UNK_F_TYPE	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF14538	Raptor N-terminal CASPase like domain (Raptor_N)	Raptor N-terminal CASPase like domain	This domain is found at the N-terminus of the Raptor protein. It has been identified to have a CASPase like structure [1]. It conserves the characteristic cys/his dyad of the caspases suggesting it may have a peptidase activity.	Domain
A	PF00400	WD domain, G-beta repeat (WD40)	WD domain, G-beta repeat	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Regulatory-associated protein of TOR 1	protein binding binding kinase binding enzyme binding	developmental process multicellular organismal process reproductive system development reproductive process embryo development developmental process involved in reproduction multicellular organism development fruit development embryo development ending in seed dormancy seed development anatomical structure development reproductive structure development post-embryonic development system development developmental process multicellular organismal process reproductive system development reproductive process embryo development developmental process involved in reproduction multicellular organism development fruit development embryo development ending in seed dormancy seed development anatomical structure development reproductive structure development post-embryonic development system development negative regulation of catabolic process regulation of biological process catabolic process regulation of cellular process negative regulation of metabolic process autophagy biological regulation negative regulation of biological process regulation of catabolic process regulation of autophagy negative regulation of autophagy negative regulation of cellular process cellular process metabolic process process utilizing autophagic mechanism regulation of metabolic process cellular response to stimulus TOR signaling response to stimulus signaling intracellular signal transduction cell communication signal transduction maintenance of shoot apical meristem identity meristem development meristem maintenance maintenance of cell number tissue development maintenance of meristem identity stem cell population maintenance	cellular anatomical structure intracellular anatomical structure cytoplasm protein-containing complex TORC1 complex TOR complex intracellular protein-containing complex cullin-RING ubiquitin ligase complex ubiquitin ligase complex catalytic complex Cul4-RING E3 ubiquitin ligase complex transferase complex
B [auth T]	Eukaryotic translation initiation factor 4E-binding protein 1	eukaryotic initiation factor 4E binding protein binding binding translation initiation factor binding translation regulator activity translation repressor activity	regulation of cellular process negative regulation of biological process regulation of primary metabolic process post-transcriptional regulation of gene expression negative regulation of translation negative regulation of cellular process translational initiation protein metabolic process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of biological process regulation of translational initiation regulation of protein metabolic process regulation of cellular process negative regulation of biological process regulation of primary metabolic process post-transcriptional regulation of gene expression negative regulation of translation negative regulation of cellular process translational initiation protein metabolic process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of biological process regulation of translational initiation regulation of protein metabolic process negative regulation of metabolic process biological regulation negative regulation of translational initiation primary metabolic process regulation of macromolecule metabolic process gene expression translation macromolecule biosynthetic process regulation of gene expression negative regulation of gene expression biosynthetic process negative regulation of biosynthetic process regulation of translation negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process metabolic process cellular process macromolecule metabolic process regulation of metabolic process cellular response to stimulus TOR signaling response to stimulus signaling intracellular signal transduction cell communication signal transduction positive regulation of biological process positive regulation of cell cycle mitotic cell cycle regulation of mitotic cell cycle positive regulation of mitotic cell cycle cell cycle regulation of cell cycle positive regulation of cellular process mitotic cell cycle process cell cycle phase transition G1/S transition of mitotic cell cycle cell cycle G1/S phase transition mitotic cell cycle phase transition cell cycle process	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR004083	Regulatory associated protein of TOR	Family
A	IPR029347	Raptor, N-terminal CASPase-like domain	Domain
A	IPR016024	Armadillo-type fold	Homologous Superfamily
A	IPR036322	WD40-repeat-containing domain superfamily	Homologous Superfamily
A	IPR011989	Armadillo-like helical	Homologous Superfamily
A	IPR001680	WD40 repeat	Repeat
A	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily
B [auth T]	IPR008606	Eukaryotic translation initiation factor 4E binding	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
B [auth T]	Pharos: Q13541	acute myeloid leukemia mantle cell lymphoma HIV infectious disease Inflammation pancreatic ductal adenocarcinoma precancerous condition psoriasis adrenal cortex carcinoma kidney neoplasm lung cancer malignant ependymoma medulloblastoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia atypical teratoid rhabdoid tumor glioblastoma acute myeloid leukemia mantle cell lymphoma HIV infectious disease Inflammation pancreatic ductal adenocarcinoma precancerous condition psoriasis adrenal cortex carcinoma kidney neoplasm lung cancer malignant ependymoma medulloblastoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia atypical teratoid rhabdoid tumor glioblastoma large cell medulloblastoma malignant glioma malignant pancreatic neoplasm non-small cell lung carcinoma pilocytic astrocytoma primitive neuroectodermal tumor cancer kidney cancer lung adenocarcinoma malignant colon neoplasm

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.