5VEM

Human ectonucleotide pyrophosphatase / phosphodiesterase 5 (ENPP5, NPP5)

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	Phosphodiest_C	e5vemB1	A: a+b two layers	X: Alpha-beta plaits	H: Phosphonoacetate hydrolase insertion domain (From Topology)	T: Phosphonoacetate hydrolase insertion domain	F: Phosphodiest_C	ECOD (1.6)
B	Phosphodiest_N	e5vemB2	A: a/b three-layered sandwiches	X: Alkaline phosphatase-like (From Topology)	H: Alkaline phosphatase-like (From Topology)	T: Alkaline phosphatase-like	F: Phosphodiest_N	ECOD (1.6)
A	Phosphodiest_C	e5vemA2	A: a+b two layers	X: Alpha-beta plaits	H: Phosphonoacetate hydrolase insertion domain (From Topology)	T: Phosphonoacetate hydrolase insertion domain	F: Phosphodiest_C	ECOD (1.6)
A	Phosphodiest_N	e5vemA3	A: a/b three-layered sandwiches	X: Alkaline phosphatase-like (From Topology)	H: Alkaline phosphatase-like (From Topology)	T: Alkaline phosphatase-like	F: Phosphodiest_N	ECOD (1.6)
C	Phosphodiest_C	e5vemC1	A: a+b two layers	X: Alpha-beta plaits	H: Phosphonoacetate hydrolase insertion domain (From Topology)	T: Phosphonoacetate hydrolase insertion domain	F: Phosphodiest_C	ECOD (1.6)
C	Phosphodiest_N	e5vemC2	A: a/b three-layered sandwiches	X: Alkaline phosphatase-like (From Topology)	H: Alkaline phosphatase-like (From Topology)	T: Alkaline phosphatase-like	F: Phosphodiest_N	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C	PF01663	Type I phosphodiesterase / nucleotide pyrophosphatase (Phosphodiest)	Type I phosphodiesterase / nucleotide pyrophosphatase	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C	Ectonucleotide pyrophosphatase/phosphodiesterase family member 5	pyrophosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity NAD+ diphosphatase activity dinucleotide phosphatase activity hydrolase activity, acting on acid anhydrides catalytic activity cation binding transition metal ion binding zinc ion binding ion binding binding metal ion binding small molecule binding	cellular process cell communication	cell periphery cellular anatomical structure plasma membrane membrane extracellular region

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C	IPR002591	Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase	Family
A, B, C	IPR017850	Alkaline-phosphatase-like, core domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C	Pharos: Q9UJA9	prostate cancer Pick disease Prostatic Neoplasms tuberculosis Alzheimer disease Crohn disease gastric cancer hepatocellular carcinoma lung carcinoma medulloblastoma ovarian cancer primitive neuroectodermal tumor psoriasis type 1 diabetes mellitus astrocytic tumor prostate cancer Pick disease Prostatic Neoplasms tuberculosis Alzheimer disease Crohn disease gastric cancer hepatocellular carcinoma lung carcinoma medulloblastoma ovarian cancer primitive neuroectodermal tumor psoriasis type 1 diabetes mellitus astrocytic tumor cystic fibrosis gastric carcinoma interstitial cystitis malignant ependymoma nasopharyngeal carcinoma pancreatic intraductal papillary-mucinous carcinoma sinusitis atypical teratoid rhabdoid tumor ductal breast carcinoma in situ glioblastoma large cell medulloblastoma malignant glioma oligodendroglioma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.