Annotations: 5M45

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
D	Hydantoinase_B_3rd	e5m45D3	A: beta sandwiches	X: Apc (acetophenone carboxylase) beta subunit C-terminal domain (From Topology)	H: Apc (acetophenone carboxylase) beta subunit C-terminal domain (From Topology)	T: Apc (acetophenone carboxylase) beta subunit C-terminal domain	F: Hydantoinase_B_3rd	ECOD (1.6)
D	Hydantoinase_B_2nd	e5m45D1	A: a+b two layers	X: MocoBD/DmpA-related (From Homology)	H: MocoBD/DmpA-related	T: Apc (acetophenone carboxylase) beta subunit middle domain	F: Hydantoinase_B_2nd	ECOD (1.6)
D	Hydantoinase_B_1st	e5m45D2	A: a+b three layers	X: Profilin-like	H: N-terminal domain of Apc beta-subunit (From Topology)	T: N-terminal domain of Apc beta-subunit	F: Hydantoinase_B_1st	ECOD (1.6)
J	Hydantoinase_B_3rd	e5m45J2	A: beta sandwiches	X: Apc (acetophenone carboxylase) beta subunit C-terminal domain (From Topology)	H: Apc (acetophenone carboxylase) beta subunit C-terminal domain (From Topology)	T: Apc (acetophenone carboxylase) beta subunit C-terminal domain	F: Hydantoinase_B_3rd	ECOD (1.6)
J	Hydantoinase_B_2nd	e5m45J3	A: a+b two layers	X: MocoBD/DmpA-related (From Homology)	H: MocoBD/DmpA-related	T: Apc (acetophenone carboxylase) beta subunit middle domain	F: Hydantoinase_B_2nd	ECOD (1.6)
J	Hydantoinase_B_1st	e5m45J1	A: a+b three layers	X: Profilin-like	H: N-terminal domain of Apc beta-subunit (From Topology)	T: N-terminal domain of Apc beta-subunit	F: Hydantoinase_B_1st	ECOD (1.6)
A	Hydantoinase_B_3rd	e5m45A1	A: beta sandwiches	X: Apc (acetophenone carboxylase) beta subunit C-terminal domain (From Topology)	H: Apc (acetophenone carboxylase) beta subunit C-terminal domain (From Topology)	T: Apc (acetophenone carboxylase) beta subunit C-terminal domain	F: Hydantoinase_B_3rd	ECOD (1.6)
A	Hydantoinase_B_2nd	e5m45A2	A: a+b two layers	X: MocoBD/DmpA-related (From Homology)	H: MocoBD/DmpA-related	T: Apc (acetophenone carboxylase) beta subunit middle domain	F: Hydantoinase_B_2nd	ECOD (1.6)
A	Hydantoinase_B_1st	e5m45A3	A: a+b three layers	X: Profilin-like	H: N-terminal domain of Apc beta-subunit (From Topology)	T: N-terminal domain of Apc beta-subunit	F: Hydantoinase_B_1st	ECOD (1.6)
G	Hydantoinase_B_3rd	e5m45G2	A: beta sandwiches	X: Apc (acetophenone carboxylase) beta subunit C-terminal domain (From Topology)	H: Apc (acetophenone carboxylase) beta subunit C-terminal domain (From Topology)	T: Apc (acetophenone carboxylase) beta subunit C-terminal domain	F: Hydantoinase_B_3rd	ECOD (1.6)
G	Hydantoinase_B_2nd	e5m45G3	A: a+b two layers	X: MocoBD/DmpA-related (From Homology)	H: MocoBD/DmpA-related	T: Apc (acetophenone carboxylase) beta subunit middle domain	F: Hydantoinase_B_2nd	ECOD (1.6)
G	Hydantoinase_B_1st	e5m45G1	A: a+b three layers	X: Profilin-like	H: N-terminal domain of Apc beta-subunit (From Topology)	T: N-terminal domain of Apc beta-subunit	F: Hydantoinase_B_1st	ECOD (1.6)
H	HyuA	e5m45H3	A: beta sandwiches	X: beta sandwich domain in acetophenone carboxylase (Apc) alpha subunit (From Topology)	H: beta sandwich domain in acetophenone carboxylase (Apc) alpha subunit (From Topology)	T: beta sandwich domain in acetophenone carboxylase (Apc) alpha subunit	F: HyuA	ECOD (1.6)
H	EUF08328	e5m45H5	A: a+b two layers	X: Reverse ferredoxin	H: a+b domain in Acetophenone carboxylase (Apc) alpha subunit (From Topology)	T: a+b domain in Acetophenone carboxylase (Apc) alpha subunit	F: EUF08328	ECOD (1.6)
H	Hydant_A_N_C	e5m45H4	A: a/b three-layered sandwiches	X: a/b domain in Acetophenone carboxylase (Apc) alpha subunit (From Topology)	H: a/b domain in Acetophenone carboxylase (Apc) alpha subunit (From Topology)	T: a/b domain in Acetophenone carboxylase (Apc) alpha subunit	F: Hydant_A_N_C	ECOD (1.6)
H	Hydantoinase_A_C	e5m45H1	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Ribonuclease H-like (From Topology)	T: Ribonuclease H-like	F: Hydantoinase_A_C	ECOD (1.6)
H	Hydant_A_N_N	e5m45H2	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Ribonuclease H-like (From Topology)	T: Ribonuclease H-like	F: Hydant_A_N_N	ECOD (1.6)
B	HyuA	e5m45B4	A: beta sandwiches	X: beta sandwich domain in acetophenone carboxylase (Apc) alpha subunit (From Topology)	H: beta sandwich domain in acetophenone carboxylase (Apc) alpha subunit (From Topology)	T: beta sandwich domain in acetophenone carboxylase (Apc) alpha subunit	F: HyuA	ECOD (1.6)
B	EUF08328	e5m45B5	A: a+b two layers	X: Reverse ferredoxin	H: a+b domain in Acetophenone carboxylase (Apc) alpha subunit (From Topology)	T: a+b domain in Acetophenone carboxylase (Apc) alpha subunit	F: EUF08328	ECOD (1.6)
B	Hydant_A_N_C	e5m45B2	A: a/b three-layered sandwiches	X: a/b domain in Acetophenone carboxylase (Apc) alpha subunit (From Topology)	H: a/b domain in Acetophenone carboxylase (Apc) alpha subunit (From Topology)	T: a/b domain in Acetophenone carboxylase (Apc) alpha subunit	F: Hydant_A_N_C	ECOD (1.6)
B	Hydantoinase_A_C	e5m45B3	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Ribonuclease H-like (From Topology)	T: Ribonuclease H-like	F: Hydantoinase_A_C	ECOD (1.6)
B	Hydant_A_N_N	e5m45B1	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Ribonuclease H-like (From Topology)	T: Ribonuclease H-like	F: Hydant_A_N_N	ECOD (1.6)
E	HyuA	e5m45E4	A: beta sandwiches	X: beta sandwich domain in acetophenone carboxylase (Apc) alpha subunit (From Topology)	H: beta sandwich domain in acetophenone carboxylase (Apc) alpha subunit (From Topology)	T: beta sandwich domain in acetophenone carboxylase (Apc) alpha subunit	F: HyuA	ECOD (1.6)
E	EUF08328	e5m45E5	A: a+b two layers	X: Reverse ferredoxin	H: a+b domain in Acetophenone carboxylase (Apc) alpha subunit (From Topology)	T: a+b domain in Acetophenone carboxylase (Apc) alpha subunit	F: EUF08328	ECOD (1.6)
E	Hydant_A_N_C	e5m45E1	A: a/b three-layered sandwiches	X: a/b domain in Acetophenone carboxylase (Apc) alpha subunit (From Topology)	H: a/b domain in Acetophenone carboxylase (Apc) alpha subunit (From Topology)	T: a/b domain in Acetophenone carboxylase (Apc) alpha subunit	F: Hydant_A_N_C	ECOD (1.6)
E	Hydantoinase_A_C	e5m45E2	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Ribonuclease H-like (From Topology)	T: Ribonuclease H-like	F: Hydantoinase_A_C	ECOD (1.6)
E	Hydant_A_N_N	e5m45E3	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Ribonuclease H-like (From Topology)	T: Ribonuclease H-like	F: Hydant_A_N_N	ECOD (1.6)
K	HyuA	e5m45K1	A: beta sandwiches	X: beta sandwich domain in acetophenone carboxylase (Apc) alpha subunit (From Topology)	H: beta sandwich domain in acetophenone carboxylase (Apc) alpha subunit (From Topology)	T: beta sandwich domain in acetophenone carboxylase (Apc) alpha subunit	F: HyuA	ECOD (1.6)
K	EUF08328	e5m45K4	A: a+b two layers	X: Reverse ferredoxin	H: a+b domain in Acetophenone carboxylase (Apc) alpha subunit (From Topology)	T: a+b domain in Acetophenone carboxylase (Apc) alpha subunit	F: EUF08328	ECOD (1.6)
K	Hydant_A_N_C	e5m45K5	A: a/b three-layered sandwiches	X: a/b domain in Acetophenone carboxylase (Apc) alpha subunit (From Topology)	H: a/b domain in Acetophenone carboxylase (Apc) alpha subunit (From Topology)	T: a/b domain in Acetophenone carboxylase (Apc) alpha subunit	F: Hydant_A_N_C	ECOD (1.6)
K	Hydantoinase_A_C	e5m45K3	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Ribonuclease H-like (From Topology)	T: Ribonuclease H-like	F: Hydantoinase_A_C	ECOD (1.6)
K	Hydant_A_N_N	e5m45K2	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Ribonuclease H-like (From Topology)	T: Ribonuclease H-like	F: Hydant_A_N_N	ECOD (1.6)
C	Acetone_carb_G	e5m45C1	A: few secondary structure elements	X: Rubredoxin-like	H: Rubredoxin-related	T: Rubredoxin-related	F: Acetone_carb_G	ECOD (1.6)
F	Acetone_carb_G	e5m45F1	A: few secondary structure elements	X: Rubredoxin-like	H: Rubredoxin-related	T: Rubredoxin-related	F: Acetone_carb_G	ECOD (1.6)
I	Acetone_carb_G	e5m45I1	A: few secondary structure elements	X: Rubredoxin-like	H: Rubredoxin-related	T: Rubredoxin-related	F: Acetone_carb_G	ECOD (1.6)
L	Acetone_carb_G	e5m45L1	A: few secondary structure elements	X: Rubredoxin-like	H: Rubredoxin-related	T: Rubredoxin-related	F: Acetone_carb_G	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, D, G, J	PF02538	Hydantoinase B/oxoprolinase (Hydantoinase_B)	Hydantoinase B/oxoprolinase	-	Family
B, E, H, K	PF01968	Hydantoinase/oxoprolinase (Hydantoinase_A)	Hydantoinase/oxoprolinase	-	Family
B, E, H, K	PF19278	Hydantoinase/oxoprolinase C-terminal domain (Hydant_A_C)	Hydantoinase/oxoprolinase C-terminal domain	This domain is found at the C-terminus of acetophenone carboxylase alpha subunit [1]. According to ECOD this domain adopts a reverse ferredoxin fold. This domain is found at the C-terminus of a wide range of related enzymes subunits.	Domain
B, E, H, K	PF05378	Hydantoinase/oxoprolinase N-terminal region (Hydant_A_N)	Hydantoinase/oxoprolinase N-terminal region	-	Family
C, F, I, L	PF08882	Acetone carboxylase gamma subunit (Acetone_carb_G)	Acetone carboxylase gamma subunit	Acetone carboxylase is the key enzyme of bacterial acetone metabolism, catalysing the condensation of acetone and CO(2) to form acetoacetate.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, D, G, J	Acetone carboxylase alpha subunit	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding acetone carboxylase activity ligase activity, forming carbon-carbon bonds catalytic activity ligase activity hydrolase activity 5-oxoprolinase (ATP-hydrolyzing) activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	cellular response to stimulus cellular detoxification cellular response to chemical stimulus response to stimulus response to chemical detoxification cellular process cellular detoxification of acetone cellular response to toxic substance response to toxic substance glutathione metabolic process modified amino acid metabolic process metabolic process sulfur compound metabolic process cellular response to stimulus cellular detoxification cellular response to chemical stimulus response to stimulus response to chemical detoxification cellular process cellular detoxification of acetone cellular response to toxic substance response to toxic substance glutathione metabolic process modified amino acid metabolic process metabolic process sulfur compound metabolic process amide metabolic process	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol
B, E, H, K	Acetone carboxylase beta subunit	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding acetone carboxylase activity ligase activity, forming carbon-carbon bonds catalytic activity ligase activity hydrolase activity 5-oxoprolinase (ATP-hydrolyzing) activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	cellular response to stimulus cellular detoxification cellular response to chemical stimulus response to stimulus response to chemical detoxification cellular process cellular detoxification of acetone cellular response to toxic substance response to toxic substance glutathione metabolic process modified amino acid metabolic process metabolic process sulfur compound metabolic process cellular response to stimulus cellular detoxification cellular response to chemical stimulus response to stimulus response to chemical detoxification cellular process cellular detoxification of acetone cellular response to toxic substance response to toxic substance glutathione metabolic process modified amino acid metabolic process metabolic process sulfur compound metabolic process amide metabolic process	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol
C, F, I, L	Acetone carboxylase gamma subunit	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding acetone carboxylase activity ligase activity, forming carbon-carbon bonds catalytic activity ligase activity	cellular response to stimulus cellular detoxification cellular response to chemical stimulus response to stimulus response to chemical detoxification cellular process cellular detoxification of acetone cellular response to toxic substance response to toxic substance	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, D, G, J	IPR045079	Oxoprolinase-like	Family
A, D, G, J	IPR003692	Hydantoinase B/oxoprolinase	Domain
B, E, H, K	IPR045079	Oxoprolinase-like	Family
B, E, H, K	IPR049517	Acetophenone carboxylase-like, C-terminal domain	Domain
B, E, H, K	IPR043129	ATPase, nucleotide binding domain	Homologous Superfamily
B, E, H, K	IPR002821	Hydantoinase A/oxoprolinase	Domain
B, E, H, K	IPR008040	Hydantoinase/oxoprolinase, N-terminal	Domain
C, F, I, L	IPR016750	Acetophenone carboxylase beta subunit/Acetone carboxylase gamma subunit	Family