Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
ACDC48_Ne5ftnA3 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: double psiF: CDC48_NECOD (1.6)
ACDC48e5ftnA5 A: alpha arraysX: Histone-likeH: Histone-relatedT: AAA+ ATPase lid domainF: CDC48ECOD (1.6)
AVps4_C_Ce5ftnA1 A: alpha arraysX: Histone-likeH: Histone-relatedT: AAA+ ATPase lid domainF: Vps4_C_CECOD (1.6)
ACDC48_2e5ftnA6 A: a+b two layersX: Cdc48 domain 2-like (From Topology)H: Cdc48 domain 2-like (From Topology)T: Cdc48 domain 2-likeF: CDC48_2ECOD (1.6)
ASigma54_activate5ftnA4 A: a/b three-layered sandwichesX: P-loop domains-likeH: P-loop domains-relatedT: P-loop containing nucleoside triphosphate hydrolasesF: Sigma54_activatECOD (1.6)
CCDC48_Ne5ftnC4 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: double psiF: CDC48_NECOD (1.6)
CCDC48e5ftnC3 A: alpha arraysX: Histone-likeH: Histone-relatedT: AAA+ ATPase lid domainF: CDC48ECOD (1.6)
CVps4_C_Ce5ftnC5 A: alpha arraysX: Histone-likeH: Histone-relatedT: AAA+ ATPase lid domainF: Vps4_C_CECOD (1.6)
CCDC48_2e5ftnC2 A: a+b two layersX: Cdc48 domain 2-like (From Topology)H: Cdc48 domain 2-like (From Topology)T: Cdc48 domain 2-likeF: CDC48_2ECOD (1.6)
CSigma54_activate5ftnC1 A: a/b three-layered sandwichesX: P-loop domains-likeH: P-loop domains-relatedT: P-loop containing nucleoside triphosphate hydrolasesF: Sigma54_activatECOD (1.6)
DCDC48_Ne5ftnD4 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: double psiF: CDC48_NECOD (1.6)
DCDC48e5ftnD1 A: alpha arraysX: Histone-likeH: Histone-relatedT: AAA+ ATPase lid domainF: CDC48ECOD (1.6)
DVps4_C_Ce5ftnD2 A: alpha arraysX: Histone-likeH: Histone-relatedT: AAA+ ATPase lid domainF: Vps4_C_CECOD (1.6)
DCDC48_2e5ftnD5 A: a+b two layersX: Cdc48 domain 2-like (From Topology)H: Cdc48 domain 2-like (From Topology)T: Cdc48 domain 2-likeF: CDC48_2ECOD (1.6)
DSigma54_activate5ftnD6 A: a/b three-layered sandwichesX: P-loop domains-likeH: P-loop domains-relatedT: P-loop containing nucleoside triphosphate hydrolasesF: Sigma54_activatECOD (1.6)
FCDC48_Ne5ftnF1 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: double psiF: CDC48_NECOD (1.6)
FCDC48e5ftnF5 A: alpha arraysX: Histone-likeH: Histone-relatedT: AAA+ ATPase lid domainF: CDC48ECOD (1.6)
FVps4_C_Ce5ftnF4 A: alpha arraysX: Histone-likeH: Histone-relatedT: AAA+ ATPase lid domainF: Vps4_C_CECOD (1.6)
FCDC48_2e5ftnF2 A: a+b two layersX: Cdc48 domain 2-like (From Topology)H: Cdc48 domain 2-like (From Topology)T: Cdc48 domain 2-likeF: CDC48_2ECOD (1.6)
FSigma54_activate5ftnF3 A: a/b three-layered sandwichesX: P-loop domains-likeH: P-loop domains-relatedT: P-loop containing nucleoside triphosphate hydrolasesF: Sigma54_activatECOD (1.6)
BCDC48_Ne5ftnB2 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: double psiF: CDC48_NECOD (1.6)
BCDC48e5ftnB6 A: alpha arraysX: Histone-likeH: Histone-relatedT: AAA+ ATPase lid domainF: CDC48ECOD (1.6)
BVps4_C_Ce5ftnB3 A: alpha arraysX: Histone-likeH: Histone-relatedT: AAA+ ATPase lid domainF: Vps4_C_CECOD (1.6)
BCDC48_2e5ftnB5 A: a+b two layersX: Cdc48 domain 2-like (From Topology)H: Cdc48 domain 2-like (From Topology)T: Cdc48 domain 2-likeF: CDC48_2ECOD (1.6)
BSigma54_activate5ftnB1 A: a/b three-layered sandwichesX: P-loop domains-likeH: P-loop domains-relatedT: P-loop containing nucleoside triphosphate hydrolasesF: Sigma54_activatECOD (1.6)
ECDC48_Ne5ftnE1 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: double psiF: CDC48_NECOD (1.6)
ECDC48e5ftnE5 A: alpha arraysX: Histone-likeH: Histone-relatedT: AAA+ ATPase lid domainF: CDC48ECOD (1.6)
EVps4_C_Ce5ftnE4 A: alpha arraysX: Histone-likeH: Histone-relatedT: AAA+ ATPase lid domainF: Vps4_C_CECOD (1.6)
ECDC48_2e5ftnE2 A: a+b two layersX: Cdc48 domain 2-like (From Topology)H: Cdc48 domain 2-like (From Topology)T: Cdc48 domain 2-likeF: CDC48_2ECOD (1.6)
ESigma54_activate5ftnE6 A: a/b three-layered sandwichesX: P-loop domains-likeH: P-loop domains-relatedT: P-loop containing nucleoside triphosphate hydrolasesF: Sigma54_activatECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A2.40.40.20 Mainly Beta Beta Barrel Barwin-like endoglucanases CATH (4.3.0)
A3.10.330.10 Alpha Beta Roll Vcp-like ATPase Chain A, domain 2CATH (4.3.0)
A3.40.50.300 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold P-loop containing nucleotide triphosphate hydrolasesCATH (4.3.0)
A1.10.8.60 Mainly Alpha Orthogonal Bundle Helicase, Ruva Protein domain 3CATH (4.3.0)
C2.40.40.20 Mainly Beta Beta Barrel Barwin-like endoglucanases CATH (4.3.0)
C3.10.330.10 Alpha Beta Roll Vcp-like ATPase Chain A, domain 2CATH (4.3.0)
C3.40.50.300 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold P-loop containing nucleotide triphosphate hydrolasesCATH (4.3.0)
C1.10.8.60 Mainly Alpha Orthogonal Bundle Helicase, Ruva Protein domain 3CATH (4.3.0)
D2.40.40.20 Mainly Beta Beta Barrel Barwin-like endoglucanases CATH (4.3.0)
D3.10.330.10 Alpha Beta Roll Vcp-like ATPase Chain A, domain 2CATH (4.3.0)
D3.40.50.300 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold P-loop containing nucleotide triphosphate hydrolasesCATH (4.3.0)
D1.10.8.60 Mainly Alpha Orthogonal Bundle Helicase, Ruva Protein domain 3CATH (4.3.0)
F2.40.40.20 Mainly Beta Beta Barrel Barwin-like endoglucanases CATH (4.3.0)
F3.10.330.10 Alpha Beta Roll Vcp-like ATPase Chain A, domain 2CATH (4.3.0)
F3.40.50.300 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold P-loop containing nucleotide triphosphate hydrolasesCATH (4.3.0)
F1.10.8.60 Mainly Alpha Orthogonal Bundle Helicase, Ruva Protein domain 3CATH (4.3.0)
B2.40.40.20 Mainly Beta Beta Barrel Barwin-like endoglucanases CATH (4.3.0)
B3.10.330.10 Alpha Beta Roll Vcp-like ATPase Chain A, domain 2CATH (4.3.0)
B3.40.50.300 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold P-loop containing nucleotide triphosphate hydrolasesCATH (4.3.0)
B1.10.8.60 Mainly Alpha Orthogonal Bundle Helicase, Ruva Protein domain 3CATH (4.3.0)
E2.40.40.20 Mainly Beta Beta Barrel Barwin-like endoglucanases CATH (4.3.0)
E3.10.330.10 Alpha Beta Roll Vcp-like ATPase Chain A, domain 2CATH (4.3.0)
E3.40.50.300 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold P-loop containing nucleotide triphosphate hydrolasesCATH (4.3.0)
E1.10.8.60 Mainly Alpha Orthogonal Bundle Helicase, Ruva Protein domain 3CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B, C, D, E
PF02933Cell division protein 48 (CDC48), domain 2 (CDC48_2)Cell division protein 48 (CDC48), domain 2This domain has a double psi-beta barrel fold and includes VCP-like ATPase and N-ethylmaleimide sensitive fusion protein N-terminal domains. Both the VAT and NSF N-terminal functional domains consist of two structural domains of which this is at t ...This domain has a double psi-beta barrel fold and includes VCP-like ATPase and N-ethylmaleimide sensitive fusion protein N-terminal domains. Both the VAT and NSF N-terminal functional domains consist of two structural domains of which this is at the C-terminus. The VAT-N domain found in AAA ATPases Pfam:PF00004 is a substrate 185-residue recognition domain [1].
Domain
A, B, C, D, E
PF17862AAA+ lid domain (AAA_lid_3)AAA+ lid domainThis entry represents the alpha helical AAA+ lid domain that is found to the C-terminus of AAA domains.Domain
A, B, C, D, E
PF00004ATPase family associated with various cellular activities (AAA) (AAA)ATPase family associated with various cellular activities (AAA)AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes [2].Domain
A, B, C, D, E
PF02359Cell division protein 48 (CDC48), N-terminal domain (CDC48_N)Cell division protein 48 (CDC48), N-terminal domainThis domain has a double psi-beta barrel fold and includes VCP-like ATPase and N-ethylmaleimide sensitive fusion protein N-terminal domains. Both the VAT and NSF N-terminal functional domains consist of two structural domains of which this is at t ...This domain has a double psi-beta barrel fold and includes VCP-like ATPase and N-ethylmaleimide sensitive fusion protein N-terminal domains. Both the VAT and NSF N-terminal functional domains consist of two structural domains of which this is at the N-terminus. The VAT-N domain found in AAA ATPases Pfam:PF00004 is a substrate 185-residue recognition domain [1].
Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, B, C, D, E
TRANSITIONAL ENDOPLASMIC RETICULUM ATPASE

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
A, B, C, D, E
IPR003959ATPase, AAA-type, coreDomain
A, B, C, D, E
IPR005938AAA ATPase, CDC48 familyFamily
A, B, C, D, E
IPR027417P-loop containing nucleoside triphosphate hydrolaseHomologous Superfamily
A, B, C, D, E
IPR029067CDC48 domain 2-like superfamilyHomologous Superfamily
A, B, C, D, E
IPR003338CDC48, N-terminal subdomainDomain
A, B, C, D, E
IPR004201CDC48, domain 2Domain
A, B, C, D, E
IPR009010Aspartate decarboxylase-like domain superfamilyHomologous Superfamily
A, B, C, D, E
IPR003593AAA+ ATPase domainDomain
A, B, C, D, E
IPR041569AAA ATPase, AAA+ lid domainDomain
A, B, C, D, E
IPR050168AAA ATPase domain-containing proteinFamily
A, B, C, D, E
IPR003960ATPase, AAA-type, conserved siteConserved Site

Pharos: Disease Associations Pharos Homepage Annotation

ChainsDrug Target  Associated Disease
A, B, C, D, E
PharosP55072