5CUI

Crystal structure of Human Defensin-5 R28A mutant.

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Defensin_1	e5cuiA1	A: few secondary structure elements	X: Defensin-like	H: Defensin-related	T: Defensin-related	F: Defensin_1	ECOD (1.6)
C	Defensin_1	e5cuiC1	A: few secondary structure elements	X: Defensin-like	H: Defensin-related	T: Defensin-related	F: Defensin_1	ECOD (1.6)
E	Defensin_1	e5cuiE1	A: few secondary structure elements	X: Defensin-like	H: Defensin-related	T: Defensin-related	F: Defensin_1	ECOD (1.6)
F	Defensin_1	e5cuiF1	A: few secondary structure elements	X: Defensin-like	H: Defensin-related	T: Defensin-related	F: Defensin_1	ECOD (1.6)
B	Defensin_1	e5cuiB1	A: few secondary structure elements	X: Defensin-like	H: Defensin-related	T: Defensin-related	F: Defensin_1	ECOD (1.6)
D	Defensin_1	e5cuiD1	A: few secondary structure elements	X: Defensin-like	H: Defensin-related	T: Defensin-related	F: Defensin_1	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F	PF00323	Mammalian defensin (Defensin_1)	Mammalian defensin	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F	Defensin-5	identical protein binding protein binding binding protein homodimerization activity protein dimerization activity	biological regulation regulation of membrane permeability positive regulation of membrane permeability regulation of biological quality protein-containing complex organization protein homotetramerization cellular component organization cellular component biogenesis cellular component assembly protein complex oligomerization protein tetramerization protein-containing complex assembly protein homooligomerization cellular process biological regulation regulation of membrane permeability positive regulation of membrane permeability regulation of biological quality protein-containing complex organization protein homotetramerization cellular component organization cellular component biogenesis cellular component assembly protein complex oligomerization protein tetramerization protein-containing complex assembly protein homooligomerization cellular process cellular component organization or biogenesis humoral immune response biological process involved in interspecies interaction between organisms response to stimulus response to other organism defense response immune response antibacterial humoral response defense response to symbiont response to external stimulus antimicrobial humoral response response to biotic stimulus defense response to bacterium defense response to other organism response to stress immune system process response to bacterium response to external biotic stimulus innate immune response cellular response to stimulus response to lipid cellular response to lipopolysaccharide response to oxygen-containing compound cellular response to molecule of bacterial origin response to lipopolysaccharide cellular response to oxygen-containing compound cellular response to biotic stimulus cellular response to chemical stimulus response to chemical cellular response to lipid response to molecule of bacterial origin disruption of cellular anatomical structure in another organism disruption of anatomical structure in another organism disruption of plasma membrane integrity in another organism multicellular organismal process regulation of cellular process positive regulation of interleukin-8 production positive regulation of biological process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of biosynthetic process cytokine production regulation of cytokine production regulation of multicellular organismal process positive regulation of macromolecule metabolic process positive regulation of cellular process regulation of biosynthetic process regulation of biological process interleukin-8 production regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of gene expression biosynthetic process positive regulation of gene expression positive regulation of multicellular organismal process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process positive regulation of cytokine production regulation of metabolic process regulation of interleukin-8 production disruption of cell in another organism biological process involved in symbiotic interaction killing by host of symbiont cells biological process involved in interaction with symbiont killing of cells of another organism cell killing innate immune response in mucosa mucosal immune response organ or tissue specific immune response antimicrobial humoral immune response mediated by antimicrobial peptide defense response to fungus response to fungus defense response to Gram-negative bacterium defense response to Gram-positive bacterium	midbody cellular anatomical structure membrane-bounded organelle intracellular organelle intracellular anatomical structure organelle intracellular membrane-bounded organelle intracellular vesicle endomembrane system cytoplasmic vesicle secretory granule secretory vesicle cytoplasm vesicle midbody cellular anatomical structure membrane-bounded organelle intracellular organelle intracellular anatomical structure organelle intracellular membrane-bounded organelle intracellular vesicle endomembrane system cytoplasmic vesicle secretory granule secretory vesicle cytoplasm vesicle transport vesicle Golgi apparatus membrane-enclosed lumen intracellular organelle lumen Golgi lumen organelle lumen extracellular region vesicle lumen cytoplasmic vesicle lumen secretory granule lumen extracellular space

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F	IPR016327	Alpha-defensin	Family
A, B, C, D, E A, B, C, D, E, F	IPR006081	Alpha-defensin, C-terminal	Domain
A, B, C, D, E A, B, C, D, E, F	IPR006080	Beta/alpha-defensin, C-terminal	Domain
A, B, C, D, E A, B, C, D, E, F	IPR002366	Alpha-defensin, N-terminal	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D, E A, B, C, D, E, F	Pharos: Q01523	ulcerative colitis IgA glomerulonephritis Peutz-Jeghers syndrome Adenomatous Polyps malignant colon neoplasm inflammatory bowel disease Crohn disease lung cancer benign colon neoplasm colonic neoplasm

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.