Annotations: 4YAS

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d4yasa_	Alpha and beta proteins (a/b)	alpha/beta-Hydrolases	alpha/beta-Hydrolases	Hydroxynitrile lyase-like	Hydroxynitrile lyase	(Hevea brasiliensis ) [TaxId: 3981 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	alpha/beta-Hydrolases	8039822	3000102	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Hydrolase_4_1	e4yasA1	A: a/b three-layered sandwiches	X: alpha/beta-Hydrolases (From Topology)	H: alpha/beta-Hydrolases (From Topology)	T: alpha/beta-Hydrolases	F: Hydrolase_4_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.1820	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Alpha/Beta hydrolase fold, catalytic domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00561	alpha/beta hydrolase fold (Abhydrolase_1)	alpha/beta hydrolase fold	This catalytic domain is found in a very wide range of enzymes.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	PROTEIN (HYDROXYNITRILE LYASE)	aliphatic (S)-hydroxynitrile lyase activity lyase activity catalytic activity carbon-carbon lyase activity (S)-hydroxynitrile lyase activity aldehyde-lyase activity aromatic (S)-hydroxynitrile lyase activity hydrolase activity, acting on ester bonds carboxylic ester hydrolase activity hydrolase activity methyl jasmonate esterase activity methyl salicylate esterase activity methyl indole-3-acetate esterase activity	benzene-containing compound metabolic process oxoacid metabolic process organic hydroxy compound metabolic process carboxylic acid metabolic process salicylic acid metabolic process organic acid metabolic process phenol-containing compound metabolic process metabolic process cellular process small molecule metabolic process monocarboxylic acid metabolic process fatty acid metabolic process long-chain fatty acid metabolic process jasmonic acid metabolic process benzene-containing compound metabolic process oxoacid metabolic process organic hydroxy compound metabolic process carboxylic acid metabolic process salicylic acid metabolic process organic acid metabolic process phenol-containing compound metabolic process metabolic process cellular process small molecule metabolic process monocarboxylic acid metabolic process fatty acid metabolic process long-chain fatty acid metabolic process jasmonic acid metabolic process primary metabolic process lipid metabolic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR000073	Alpha/beta hydrolase fold-1	Domain
A	IPR045889	Methylesterase/Alpha-hydroxynitrile lyase	Family
A	IPR029058	Alpha/Beta hydrolase fold	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.