4XDL

Crystal structure of human two pore domain potassium ion channel TREK2 (K2P10.1) in complex with a brominated fluoxetine derivative.

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: MemProtMD
Membrane Protein Annotation: mpstruc

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Ion_trans_2_1	e4xdlA2	A: alpha complex topology	X: Voltage-gated ion channels (From Topology)	H: Voltage-gated ion channels (From Topology)	T: Voltage-gated ion channels	F: Ion_trans_2_1	ECOD (1.6)
A	Ion_trans_2	e4xdlA1	A: alpha complex topology	X: Voltage-gated ion channels (From Topology)	H: Voltage-gated ion channels (From Topology)	T: Voltage-gated ion channels	F: Ion_trans_2	ECOD (1.6)
B	Ion_trans_2_1	e4xdlB2	A: alpha complex topology	X: Voltage-gated ion channels (From Topology)	H: Voltage-gated ion channels (From Topology)	T: Voltage-gated ion channels	F: Ion_trans_2_1	ECOD (1.6)
B	Ion_trans_2	e4xdlB1	A: alpha complex topology	X: Voltage-gated ion channels (From Topology)	H: Voltage-gated ion channels (From Topology)	T: Voltage-gated ion channels	F: Ion_trans_2	ECOD (1.6)
D	Ion_trans_2_1	e4xdlD1	A: alpha complex topology	X: Voltage-gated ion channels (From Topology)	H: Voltage-gated ion channels (From Topology)	T: Voltage-gated ion channels	F: Ion_trans_2_1	ECOD (1.6)
D	Ion_trans_2	e4xdlD2	A: alpha complex topology	X: Voltage-gated ion channels (From Topology)	H: Voltage-gated ion channels (From Topology)	T: Voltage-gated ion channels	F: Ion_trans_2	ECOD (1.6)
C	Ion_trans_2_1	e4xdlC1	A: alpha complex topology	X: Voltage-gated ion channels (From Topology)	H: Voltage-gated ion channels (From Topology)	T: Voltage-gated ion channels	F: Ion_trans_2_1	ECOD (1.6)
C	Ion_trans_2	e4xdlC2	A: alpha complex topology	X: Voltage-gated ion channels (From Topology)	H: Voltage-gated ion channels (From Topology)	T: Voltage-gated ion channels	F: Ion_trans_2	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.287.70	Mainly Alpha	Orthogonal Bundle	Helix Hairpins		CATH (4.3.0)
B	1.10.287.70	Mainly Alpha	Orthogonal Bundle	Helix Hairpins		CATH (4.3.0)
D	1.10.287.70	Mainly Alpha	Orthogonal Bundle	Helix Hairpins		CATH (4.3.0)
C	1.10.287.70	Mainly Alpha	Orthogonal Bundle	Helix Hairpins		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF07885	Ion channel (Ion_trans_2)	Ion channel	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Potassium channel subfamily K member 10	monoatomic cation transmembrane transporter activity potassium ion transmembrane transporter activity monoatomic ion channel activity potassium ion leak channel activity potassium channel activity monoatomic cation channel activity passive transmembrane transporter activity narrow pore channel activity leak channel activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity channel activity monoatomic ion transmembrane transporter activity transporter activity metal ion transmembrane transporter activity monoatomic cation transmembrane transporter activity potassium ion transmembrane transporter activity monoatomic ion channel activity potassium ion leak channel activity potassium channel activity monoatomic cation channel activity passive transmembrane transporter activity narrow pore channel activity leak channel activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity channel activity monoatomic ion transmembrane transporter activity transporter activity metal ion transmembrane transporter activity transmembrane transporter activity gated channel activity mechanosensitive monoatomic cation channel activity mechanosensitive potassium channel activity mechanosensitive monoatomic ion channel activity outward rectifier potassium channel activity voltage-gated channel activity voltage-gated monoatomic ion channel activity voltage-gated monoatomic cation channel activity voltage-gated potassium channel activity	transport monoatomic ion transmembrane transport potassium ion transmembrane transport inorganic ion transmembrane transport establishment of localization metal ion transport inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport potassium ion transport cellular process monoatomic cation transport transport monoatomic ion transmembrane transport potassium ion transmembrane transport inorganic ion transmembrane transport establishment of localization metal ion transport inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport potassium ion transport cellular process monoatomic cation transport cellular response to stimulus response to lipid response to stimulus response to fatty acid response to oxygen-containing compound cellular response to arachidonate cellular response to oxygen-containing compound cellular response to fatty acid cellular response to chemical stimulus response to chemical cellular response to lipid response to arachidonate stabilization of membrane potential biological regulation regulation of biological quality regulation of membrane potential behavior multicellular organismal process system process learning or memory nervous system process cognition memory regulation of biological process regulation of cellular process signaling signal transduction cell communication	cell periphery cellular anatomical structure plasma membrane membrane protein-containing complex transmembrane transporter complex membrane protein complex transporter complex monoatomic ion channel complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR003976	Two pore domain potassium channel, TREK	Family
A, B, C, D	IPR003280	Two pore domain potassium channel	Family
A, B, C, D	IPR013099	Potassium channel domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D	Pharos: P57789	astrocytic tumor lung carcinoma malignant glioma psoriasis General anesthesia malignant colon neoplasm medulloblastoma subependymal giant cell astrocytoma large cell medulloblastoma malignant ependymoma ovarian cancer ulcerative colitis

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B, C, D	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A, B, C, D	MemProtMD	Annotated as membrane protein by MemProtMD

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A, B, C, D	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	Channels: Potassium, Sodium, & Proton Ion-Selective	Two-Pore Domain Potassium Channel K_2P10.1 (TREK-2), up state

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.