4IG9

Structure of NAD-dependent protein deacetylase sirtuin-1 (open state, 2.64 A)

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d4ig9a1	Alpha and beta proteins (a/b)	DHS-like NAD/FAD-binding domain	DHS-like NAD/FAD-binding domain	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d4ig9a2	Artifacts	Tags	Tags	Tags	N-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d4ig9c1	Alpha and beta proteins (a/b)	DHS-like NAD/FAD-binding domain	DHS-like NAD/FAD-binding domain	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d4ig9c2	Artifacts	Tags	Tags	Tags	N-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
E	d4ig9e1	Alpha and beta proteins (a/b)	DHS-like NAD/FAD-binding domain	DHS-like NAD/FAD-binding domain	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
E	d4ig9e2	Artifacts	Tags	Tags	Tags	N-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
G	d4ig9g1	Alpha and beta proteins (a/b)	DHS-like NAD/FAD-binding domain	DHS-like NAD/FAD-binding domain	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
G	d4ig9g2	Artifacts	Tags	Tags	Tags	N-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	DHS-like NAD/FAD-binding domain	8063730	3001728	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	DHS-like NAD/FAD-binding domain	8063730	3001728	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	DHS-like NAD/FAD-binding domain	8063730	3001728	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	DHS-like NAD/FAD-binding domain	8063730	3001728	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	SIR2_1st	e4ig9A4	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: DHS-like NAD/FAD-binding domain	F: SIR2_1st	ECOD (1.6)
A	SIR2_2nd_1	e4ig9A3	A: few secondary structure elements	X: Rubredoxin-like	H: Rubredoxin-related	T: Rubredoxin-related	F: SIR2_2nd_1	ECOD (1.6)
C	SIR2_1st	e4ig9C4	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: DHS-like NAD/FAD-binding domain	F: SIR2_1st	ECOD (1.6)
C	SIR2_2nd_1	e4ig9C3	A: few secondary structure elements	X: Rubredoxin-like	H: Rubredoxin-related	T: Rubredoxin-related	F: SIR2_2nd_1	ECOD (1.6)
E	SIR2_1st	e4ig9E4	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: DHS-like NAD/FAD-binding domain	F: SIR2_1st	ECOD (1.6)
E	SIR2_2nd_1	e4ig9E3	A: few secondary structure elements	X: Rubredoxin-like	H: Rubredoxin-related	T: Rubredoxin-related	F: SIR2_2nd_1	ECOD (1.6)
G	SIR2_1st	e4ig9G4	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: DHS-like NAD/FAD-binding domain	F: SIR2_1st	ECOD (1.6)
G	SIR2_2nd_1	e4ig9G3	A: few secondary structure elements	X: Rubredoxin-like	H: Rubredoxin-related	T: Rubredoxin-related	F: SIR2_2nd_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.1220	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	TPP-binding domain	CATH (4.3.0)
A	3.30.1600.10	Alpha Beta	2-Layer Sandwich	SIR2/SIRT2 'Small Domain'	SIR2/SIRT2 'Small Domain'	CATH (4.3.0)
C	3.40.50.1220	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	TPP-binding domain	CATH (4.3.0)
C	3.30.1600.10	Alpha Beta	2-Layer Sandwich	SIR2/SIRT2 'Small Domain'	SIR2/SIRT2 'Small Domain'	CATH (4.3.0)
E	3.40.50.1220	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	TPP-binding domain	CATH (4.3.0)
E	3.30.1600.10	Alpha Beta	2-Layer Sandwich	SIR2/SIRT2 'Small Domain'	SIR2/SIRT2 'Small Domain'	CATH (4.3.0)
G	3.40.50.1220	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	TPP-binding domain	CATH (4.3.0)
G	3.30.1600.10	Alpha Beta	2-Layer Sandwich	SIR2/SIRT2 'Small Domain'	SIR2/SIRT2 'Small Domain'	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C, E, G	PF02146	Sir2 family (SIR2)	Sir2 family	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C, E, G	NAD-dependent protein deacetylase sirtuin-1	protein binding binding histone binding catalytic activity, acting on a protein acyltransferase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides hydrolase activity transferase activity protein decrotonylase activity histone decrotonylase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds NAD-dependent protein decrotonylase activity histone modifying activity acyltransferase activity, transferring groups other than amino-acyl groups protein binding binding histone binding catalytic activity, acting on a protein acyltransferase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides hydrolase activity transferase activity protein decrotonylase activity histone decrotonylase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds NAD-dependent protein decrotonylase activity histone modifying activity acyltransferase activity, transferring groups other than amino-acyl groups NAD-dependent histone decrotonylase activity catalytic activity chromatin binding promoter-specific chromatin binding deacetylase activity protein lysine deacetylase activity deacylase activity histone deacetylase activity, NAD-dependent histone H3K14 deacetylase activity, NAD-dependent NAD-dependent protein lysine deacylase activity histone deacetylase activity histone H3K deacetylase activity NAD-dependent protein lysine deacetylase activity kinase binding enzyme binding protein kinase binding mitogen-activated protein kinase binding cation binding ion binding metal ion binding small molecule binding keratin filament binding intermediate filament binding transcription corepressor activity transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity enzyme regulator activity enzyme activator activity molecular function activator activity molecular function regulator activity histone H3K56 deacetylase activity, NAD-dependent transcription factor binding DNA-binding transcription factor binding NAD-dependent protein-lysine depropionylase activity RNA polymerase II-specific DNA-binding transcription factor binding nuclear receptor binding histone H4K16 deacetylase activity, NAD-dependent histone H4K deacetylase activity NAD-dependent protein lysine delactylase activity NAD+ binding NAD binding nucleotide binding nucleoside phosphate binding purine nucleotide binding anion binding adenyl nucleotide binding heterocyclic compound binding histone deacetylase activity, hydrolytic mechanism histone H4K12 deacetylase activity, hydrolytic mechanism histone H3K18 decrotonylase activity HLH domain binding protein domain specific binding bHLH transcription factor binding identical protein binding p53 binding histone H3K18 deacetylase activity, NAD-dependent histone H3K4 deacetylase activity, NAD-dependent DNA binding sequence-specific DNA binding double-stranded DNA binding nucleic acid binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding transcription regulatory region nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding transcription coactivator activity histone H3K9 deacetylase activity, NAD-dependent	positive regulation of cholesterol efflux regulation of localization transport positive regulation of sterol transport positive regulation of biological process regulation of lipid transport organic hydroxy compound transport localization regulation of cholesterol efflux sterol transport regulation of cholesterol transport positive regulation of cholesterol transport regulation of sterol transport regulation of biological process positive regulation of cholesterol efflux regulation of localization transport positive regulation of sterol transport positive regulation of biological process regulation of lipid transport organic hydroxy compound transport localization regulation of cholesterol efflux sterol transport regulation of cholesterol transport positive regulation of cholesterol transport regulation of sterol transport regulation of biological process regulation of transport biological regulation lipid localization lipid transport positive regulation of lipid localization establishment of localization positive regulation of lipid transport positive regulation of transport regulation of lipid localization macromolecule localization cholesterol transport cholesterol efflux developmental process fat cell differentiation regulation of cellular process cellular developmental process regulation of developmental process regulation of cell differentiation regulation of brown fat cell differentiation brown fat cell differentiation cell differentiation cellular process regulation of fat cell differentiation muscle cell apoptotic process smooth muscle cell apoptotic process regulation of apoptotic process regulation of muscle cell apoptotic process regulation of programmed cell death cell death regulation of smooth muscle cell apoptotic process apoptotic process programmed cell death neutral lipid metabolic process triglyceride metabolic process primary metabolic process metabolic process glycerolipid metabolic process triglyceride mobilization acylglycerol metabolic process lipid metabolic process response to stimulus immune response regulation of adaptive immune response adaptive immune response positive regulation of response to stimulus regulation of response to stimulus positive regulation of immune response immune system process regulation of immune response regulation of immune system process positive regulation of adaptive immune response positive regulation of immune system process cellular response to stimulus DNA repair-dependent chromatin remodeling cellular component organization cellular response to stress DNA damage response chromatin organization response to stress chromatin remodeling cellular component organization or biogenesis response to nutrient levels behavioral response to starvation response to starvation peptidyl-lysine acetylation peptidyl-lysine modification protein acylation protein acetylation macromolecule modification peptidyl-amino acid modification protein metabolic process macromolecule metabolic process protein modification process muscle structure development animal organ development anatomical structure development muscle organ development leukocyte apoptotic process macrophage apoptotic process positive regulation of myeloid cell apoptotic process positive regulation of macrophage apoptotic process positive regulation of leukocyte apoptotic process positive regulation of cellular process myeloid cell apoptotic process regulation of leukocyte apoptotic process positive regulation of programmed cell death positive regulation of apoptotic process regulation of macrophage apoptotic process inflammatory cell apoptotic process regulation of myeloid cell apoptotic process positive regulation of proteasomal protein catabolic process catabolic process positive regulation of protein metabolic process proteolysis involved in protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process regulation of ubiquitin-dependent protein catabolic process regulation of primary metabolic process positive regulation of metabolic process positive regulation of ubiquitin-dependent protein catabolic process regulation of proteolysis regulation of proteolysis involved in protein catabolic process modification-dependent macromolecule catabolic process proteolysis positive regulation of macromolecule metabolic process regulation of protein metabolic process proteasomal protein catabolic process regulation of macromolecule metabolic process protein catabolic process regulation of catabolic process positive regulation of protein catabolic process positive regulation of proteolysis involved in protein catabolic process positive regulation of catabolic process regulation of proteasomal ubiquitin-dependent protein catabolic process modification-dependent protein catabolic process positive regulation of proteolysis regulation of proteasomal protein catabolic process positive regulation of proteasomal ubiquitin-dependent protein catabolic process ubiquitin-dependent protein catabolic process regulation of metabolic process regulation of protein catabolic process regulation of cellular response to stress nucleobase-containing compound metabolic process positive regulation of DNA repair regulation of response to stress regulation of nucleobase-containing compound metabolic process DNA repair positive regulation of nucleobase-containing compound metabolic process DNA metabolic process nucleic acid metabolic process regulation of DNA repair positive regulation of DNA metabolic process regulation of DNA metabolic process regulation of biosynthetic process rhythmic process circadian regulation of gene expression circadian rhythm gene expression macromolecule biosynthetic process regulation of gene expression biosynthetic process regulation of macromolecule biosynthetic process cellular response to nutrient levels cellular response to starvation ovulation cycle process multicellular organismal process ovulation sexual reproduction reproductive process sex differentiation development of primary female sexual characteristics female gamete generation developmental process involved in reproduction gamete generation ovulation from ovarian follicle ovulation cycle multicellular organism development development of primary sexual characteristics reproductive structure development system development gonad development reproductive system development female gonad development multicellular organismal reproductive process female sex differentiation regulation of immune effector process positive regulation of macromolecule biosynthetic process positive regulation of biosynthetic process positive regulation of myeloid leukocyte cytokine production involved in immune response cytokine production regulation of cytokine production regulation of multicellular organismal process positive regulation of immune effector process myeloid leukocyte cytokine production cytokine production involved in immune response production of molecular mediator of immune response regulation of cytokine production involved in immune response immune effector process regulation of macrophage cytokine production positive regulation of gene expression positive regulation of cytokine production involved in immune response positive regulation of production of molecular mediator of immune response positive regulation of multicellular organismal process regulation of production of molecular mediator of immune response positive regulation of cytokine production positive regulation of macrophage cytokine production macrophage cytokine production signaling response to cytokine cytokine-mediated signaling pathway cellular response to leptin stimulus cell communication cellular response to endogenous stimulus response to hormone cellular response to cytokine stimulus response to leptin signal transduction cellular response to hormone stimulus leptin-mediated signaling pathway cell surface receptor signaling pathway response to endogenous stimulus response to peptide cellular response to chemical stimulus response to chemical response to light stimulus cellular response to environmental stimulus cellular response to light stimulus cellular response to radiation response to UV UV-damage excision repair response to radiation response to abiotic stimulus cellular response to abiotic stimulus cellular response to UV positive regulation of phosphorylation regulation of catalytic activity regulation of transferase activity positive regulation of phosphate metabolic process positive regulation of protein serine/threonine kinase activity regulation of phosphate metabolic process phosphate-containing compound metabolic process phosphorus metabolic process positive regulation of protein phosphorylation protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation regulation of molecular function positive regulation of kinase activity regulation of kinase activity regulation of protein serine/threonine kinase activity regulation of phosphorus metabolic process regulation of protein modification process regulation of protein phosphorylation positive regulation of molecular function positive regulation of protein modification process regulation of cAMP-dependent protein kinase activity positive regulation of protein kinase activity positive regulation of cAMP-dependent protein kinase activity positive regulation of transferase activity positive regulation of catalytic activity regulation of protein kinase activity regulation of phosphorylation regulation of lipid storage lipid storage nutrient storage negative regulation of biological process RNA metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process transcription by RNA polymerase II negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of metabolic process nucleobase-containing compound biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process regulation of DNA-templated transcription negative regulation of RNA metabolic process smooth muscle cell differentiation positive regulation of smooth muscle cell differentiation regulation of smooth muscle cell differentiation muscle cell differentiation positive regulation of muscle cell differentiation positive regulation of developmental process regulation of muscle cell differentiation positive regulation of cell differentiation response to hydrogen peroxide response to oxidative stress response to oxygen-containing compound response to reactive oxygen species cellular response to growth factor stimulus cell surface receptor protein serine/threonine kinase signaling pathway cellular response to transforming growth factor beta stimulus response to transforming growth factor beta transforming growth factor beta receptor signaling pathway response to growth factor transforming growth factor beta receptor superfamily signaling pathway enzyme-linked receptor protein signaling pathway regulation of double-strand break repair double-strand break repair positive regulation of double-strand break repair negative regulation of developmental process negative regulation of fat cell differentiation negative regulation of cell differentiation monosaccharide metabolic process gluconeogenesis regulation of small molecule metabolic process small molecule metabolic process regulation of carbohydrate metabolic process regulation of glucose metabolic process positive regulation of gluconeogenesis carbohydrate metabolic process small molecule biosynthetic process carbohydrate biosynthetic process hexose metabolic process monosaccharide biosynthetic process hexose biosynthetic process positive regulation of glucose metabolic process regulation of gluconeogenesis positive regulation of carbohydrate metabolic process regulation of carbohydrate biosynthetic process positive regulation of small molecule metabolic process glucose metabolic process negative regulation of DNA-binding transcription factor activity negative regulation of molecular function regulation of DNA-binding transcription factor activity negative regulation of programmed cell death negative regulation of apoptotic process regulation of endodeoxyribonuclease activity regulation of hydrolase activity negative regulation of signaling negative regulation of intracellular signal transduction regulation of signal transduction DNA damage response, signal transduction by p53 class mediator intracellular signal transduction negative regulation of cell communication regulation of intracellular signal transduction regulation of signal transduction by p53 class mediator negative regulation of DNA damage response, signal transduction by p53 class mediator regulation of DNA damage response, signal transduction by p53 class mediator negative regulation of signal transduction by p53 class mediator regulation of signaling negative regulation of response to stimulus signal transduction by p53 class mediator negative regulation of signal transduction regulation of cell communication signal transduction in response to DNA damage multicellular organismal-level homeostasis homeostatic process energy homeostasis sterol homeostasis chemical homeostasis cholesterol homeostasis lipid homeostasis regulation of transcription by glucose negative regulation of NF-kappaB transcription factor activity heterochromatin formation epigenetic regulation of gene expression negative regulation of gene expression constitutive heterochromatin formation DNA methylation-dependent constitutive heterochromatin formation negative regulation of gene expression, epigenetic negative regulation of phosphate metabolic process negative regulation of phosphorus metabolic process negative regulation of phosphorylation cell population proliferation positive regulation of cell population proliferation regulation of cell population proliferation cellular response to tumor necrosis factor response to tumor necrosis factor regulation of intrinsic apoptotic signaling pathway in response to DNA damage regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator negative regulation of apoptotic signaling pathway negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator intrinsic apoptotic signaling pathway in response to DNA damage intrinsic apoptotic signaling pathway negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage intrinsic apoptotic signaling pathway by p53 class mediator regulation of apoptotic signaling pathway regulation of intrinsic apoptotic signaling pathway intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator apoptotic signaling pathway negative regulation of intrinsic apoptotic signaling pathway negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator regulation of intrinsic apoptotic signaling pathway by p53 class mediator positive regulation of locomotion regulation of cell motility regulation of blood vessel endothelial cell migration endothelial cell migration positive regulation of cell migration positive regulation of blood vessel endothelial cell migration regulation of locomotion positive regulation of endothelial cell migration positive regulation of cell motility regulation of cell migration blood vessel endothelial cell migration regulation of endothelial cell migration cell migration cell motility locomotion fatty acid homeostasis myeloid leukocyte differentiation hemopoiesis macrophage differentiation cell development mononuclear cell differentiation myeloid cell differentiation leukocyte differentiation positive regulation of autophagy macroautophagy autophagy regulation of autophagy regulation of macroautophagy positive regulation of macroautophagy process utilizing autophagic mechanism regulation of cellular senescence cellular senescence positive regulation of cellular senescence response to peptide hormone response to insulin response to nitrogen compound regulation of MHC class II biosynthetic process MHC class II biosynthetic process positive regulation of MHC class II biosynthetic process negative regulation of triglyceride metabolic process neutral lipid biosynthetic process regulation of triglyceride metabolic process regulation of lipid metabolic process lipid biosynthetic process negative regulation of lipid biosynthetic process acylglycerol biosynthetic process negative regulation of triglyceride biosynthetic process triglyceride biosynthetic process regulation of triglyceride biosynthetic process glycerolipid biosynthetic process regulation of lipid biosynthetic process negative regulation of lipid metabolic process regulation of steroid biosynthetic process oxoacid metabolic process ketone metabolic process steroid metabolic process organic acid metabolic process organic acid biosynthetic process regulation of bile acid metabolic process carboxylic acid biosynthetic process steroid biosynthetic process bile acid biosynthetic process monocarboxylic acid biosynthetic process regulation of steroid metabolic process regulation of bile acid biosynthetic process carboxylic acid metabolic process regulation of ketone metabolic process bile acid metabolic process monocarboxylic acid metabolic process endothelial cell proliferation positive regulation of epithelial cell proliferation regulation of endothelial cell proliferation positive regulation of endothelial cell proliferation regulation of epithelial cell proliferation epithelial cell proliferation DNA synthesis involved in DNA repair DNA biosynthetic process negative regulation of protein modification process negative regulation of protein metabolic process negative regulation of protein acetylation regulation of protein acetylation spermatogenesis male gamete generation stress-induced premature senescence cellular homeostasis glucose homeostasis carbohydrate homeostasis intracellular chemical homeostasis intracellular glucose homeostasis establishment of organelle localization mitotic metaphase chromosome alignment negative regulation of cell cycle regulation of attachment of mitotic spindle microtubules to kinetochore establishment of localization in cell cell cycle chromosome segregation regulation of cell cycle process attachment of mitotic spindle microtubules to kinetochore sister chromatid segregation regulation of chromosome organization negative regulation of attachment of mitotic spindle microtubules to kinetochore regulation of organelle organization regulation of mitotic sister chromatid segregation mitotic cell cycle process establishment of chromosome localization negative regulation of attachment of spindle microtubules to kinetochore regulation of chromosome segregation cellular localization regulation of cellular component organization mitotic cell cycle metaphase chromosome alignment chromosome localization organelle localization mitotic sister chromatid segregation regulation of attachment of spindle microtubules to kinetochore regulation of cell cycle cell cycle process mitotic nuclear division attachment of spindle microtubules to kinetochore organelle fission chromosome organization negative regulation of cell cycle process organelle organization nuclear division negative regulation of chromosome segregation regulation of sister chromatid segregation nuclear chromosome segregation regulation of metaphase plate congression protein destabilization regulation of protein stability regulation of biological quality cellular response to glucose starvation response to decreased oxygen levels cellular response to oxygen levels cellular response to hypoxia cellular response to decreased oxygen levels response to hypoxia response to oxygen levels microtubule organizing center organization regulation of centrosome cycle microtubule cytoskeleton organization regulation of microtubule-based process centrosome duplication centrosome cycle regulation of centrosome duplication microtubule-based process cytoskeleton organization response to ionizing radiation cellular response to ionizing radiation protein ubiquitination post-translational protein modification protein modification by small protein conjugation protein modification by small protein conjugation or removal nucleus localization maintenance of organelle location maintenance of nucleus location maintenance of location in cell maintenance of location triglyceride homeostasis acylglycerol homeostasis intracellular triglyceride homeostasis cellular response to nitrogen compound positive regulation of cell communication positive regulation of signal transduction insulin receptor signaling pathway regulation of cellular response to insulin stimulus cell surface receptor protein tyrosine kinase signaling pathway positive regulation of cellular response to insulin stimulus regulation of insulin receptor signaling pathway positive regulation of insulin receptor signaling pathway cellular response to peptide hormone stimulus cellular response to oxygen-containing compound cellular response to insulin stimulus positive regulation of signaling negative regulation of transforming growth factor beta receptor signaling pathway regulation of transmembrane receptor protein serine/threonine kinase signaling pathway regulation of transforming growth factor beta receptor signaling pathway regulation of cellular response to transforming growth factor beta stimulus regulation of cellular response to growth factor stimulus negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway hippo signaling negative regulation of hippo signaling regulation of hippo signaling negative regulation of TOR signaling TOR signaling regulation of TOR signaling protein deacylation macromolecule deacylation protein deacetylation regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction intracellular signaling cassette phosphatidylinositol 3-kinase/protein kinase B signal transduction cellular response to testosterone stimulus response to ketone response to lipid negative regulation of cellular response to testosterone stimulus response to testosterone regulation of cellular response to testosterone stimulus cellular response to lipid cellular response to ketone positive regulation of DNA-templated transcription positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process cellular response to heat regulation of cellular response to heat response to heat response to temperature stimulus white fat cell differentiation regulation of mitotic cell cycle blood vessel morphogenesis tube development angiogenesis vasculature development circulatory system development anatomical structure morphogenesis tube morphogenesis anatomical structure formation involved in morphogenesis blood vessel development connective tissue development adipose tissue development positive regulation of adipose tissue development tissue development regulation of adipose tissue development negative regulation of canonical NF-kappaB signal transduction canonical NF-kappaB signal transduction regulation of canonical NF-kappaB signal transduction intracellular receptor signaling pathway peroxisome proliferator activated receptor signaling pathway regulation of peroxisome proliferator activated receptor signaling pathway nuclear receptor-mediated signaling pathway positive regulation of intracellular signal transduction positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction neuron apoptotic process negative regulation of neuron apoptotic process regulation of neuron apoptotic process regulation of response to endoplasmic reticulum stress intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress positive regulation of apoptotic signaling pathway regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway positive regulation of response to endoplasmic reticulum stress response to endoplasmic reticulum stress positive regulation of intrinsic apoptotic signaling pathway positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway cellular response to oxidative stress cellular response to chemical stress cellular response to hydrogen peroxide cellular response to reactive oxygen species intrinsic apoptotic signaling pathway in response to oxidative stress regulation of oxidative stress-induced intrinsic apoptotic signaling pathway negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway single strand break repair regulation of vasculature development regulation of anatomical structure morphogenesis regulation of multicellular organismal development positive regulation of angiogenesis positive regulation of vasculature development regulation of angiogenesis negative regulation of cellular senescence negative regulation of peptidyl-lysine acetylation regulation of peptidyl-lysine acetylation prostaglandin metabolic process negative regulation of small molecule metabolic process unsaturated fatty acid metabolic process prostaglandin biosynthetic process regulation of fatty acid metabolic process regulation of fatty acid biosynthetic process regulation of prostaglandin biosynthetic process icosanoid metabolic process regulation of unsaturated fatty acid biosynthetic process negative regulation of prostaglandin biosynthetic process prostanoid metabolic process icosanoid biosynthetic process negative regulation of fatty acid biosynthetic process prostanoid biosynthetic process fatty acid metabolic process negative regulation of fatty acid metabolic process fatty acid biosynthetic process unsaturated fatty acid biosynthetic process hormone-mediated signaling pathway negative regulation of intracellular steroid hormone receptor signaling pathway response to steroid hormone regulation of intracellular steroid hormone receptor signaling pathway androgen receptor signaling pathway nuclear receptor-mediated steroid hormone signaling pathway cellular response to steroid hormone stimulus steroid hormone receptor signaling pathway regulation of androgen receptor signaling pathway negative regulation of androgen receptor signaling pathway nucleotide-excision repair pyrimidine dimer repair pyrimidine dimer repair by nucleotide-excision repair nucleolar chromatin organization rDNA heterochromatin formation nucleus organization nucleolus organization facultative heterochromatin formation protein depropionylation response to leukemia inhibitory factor cellular response to leukemia inhibitory factor	membrane-bounded organelle intracellular organelle organelle envelope cellular anatomical structure intracellular anatomical structure organelle nuclear envelope nucleus intracellular membrane-bounded organelle endomembrane system cytoplasm cytosol membrane-enclosed lumen intracellular membraneless organelle membrane-bounded organelle intracellular organelle organelle envelope cellular anatomical structure intracellular anatomical structure organelle nuclear envelope nucleus intracellular membrane-bounded organelle endomembrane system cytoplasm cytosol membrane-enclosed lumen intracellular membraneless organelle nucleolus intracellular organelle lumen organelle lumen membraneless organelle nuclear lumen protein-containing complex chromatin silencing complex nuclear protein-containing complex rDNA heterochromatin chromatin chromosome heterochromatin fibrillar center euchromatin eNoSc complex organelle inner membrane nuclear membrane membrane nuclear inner membrane organelle membrane mitochondrion nucleoplasm nuclear body PML body
B, D, F, H	NAD-dependent protein deacetylase sirtuin-1	protein binding binding histone binding catalytic activity, acting on a protein acyltransferase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides hydrolase activity transferase activity protein decrotonylase activity histone decrotonylase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds NAD-dependent protein decrotonylase activity histone modifying activity acyltransferase activity, transferring groups other than amino-acyl groups protein binding binding histone binding catalytic activity, acting on a protein acyltransferase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides hydrolase activity transferase activity protein decrotonylase activity histone decrotonylase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds NAD-dependent protein decrotonylase activity histone modifying activity acyltransferase activity, transferring groups other than amino-acyl groups NAD-dependent histone decrotonylase activity catalytic activity chromatin binding promoter-specific chromatin binding deacetylase activity protein lysine deacetylase activity deacylase activity histone deacetylase activity, NAD-dependent histone H3K14 deacetylase activity, NAD-dependent NAD-dependent protein lysine deacylase activity histone deacetylase activity histone H3K deacetylase activity NAD-dependent protein lysine deacetylase activity kinase binding enzyme binding protein kinase binding mitogen-activated protein kinase binding cation binding ion binding metal ion binding small molecule binding keratin filament binding intermediate filament binding transcription corepressor activity transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity enzyme regulator activity enzyme activator activity molecular function activator activity molecular function regulator activity histone H3K56 deacetylase activity, NAD-dependent transcription factor binding DNA-binding transcription factor binding NAD-dependent protein-lysine depropionylase activity RNA polymerase II-specific DNA-binding transcription factor binding nuclear receptor binding histone H4K16 deacetylase activity, NAD-dependent histone H4K deacetylase activity NAD-dependent protein lysine delactylase activity NAD+ binding NAD binding nucleotide binding nucleoside phosphate binding purine nucleotide binding anion binding adenyl nucleotide binding heterocyclic compound binding histone deacetylase activity, hydrolytic mechanism histone H4K12 deacetylase activity, hydrolytic mechanism histone H3K18 decrotonylase activity HLH domain binding protein domain specific binding bHLH transcription factor binding identical protein binding p53 binding histone H3K18 deacetylase activity, NAD-dependent histone H3K4 deacetylase activity, NAD-dependent DNA binding sequence-specific DNA binding double-stranded DNA binding nucleic acid binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding transcription regulatory region nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding transcription coactivator activity histone H3K9 deacetylase activity, NAD-dependent	positive regulation of cholesterol efflux regulation of localization transport positive regulation of sterol transport positive regulation of biological process regulation of lipid transport organic hydroxy compound transport localization regulation of cholesterol efflux sterol transport regulation of cholesterol transport positive regulation of cholesterol transport regulation of sterol transport regulation of biological process positive regulation of cholesterol efflux regulation of localization transport positive regulation of sterol transport positive regulation of biological process regulation of lipid transport organic hydroxy compound transport localization regulation of cholesterol efflux sterol transport regulation of cholesterol transport positive regulation of cholesterol transport regulation of sterol transport regulation of biological process regulation of transport biological regulation lipid localization lipid transport positive regulation of lipid localization establishment of localization positive regulation of lipid transport positive regulation of transport regulation of lipid localization macromolecule localization cholesterol transport cholesterol efflux developmental process fat cell differentiation regulation of cellular process cellular developmental process regulation of developmental process regulation of cell differentiation regulation of brown fat cell differentiation brown fat cell differentiation cell differentiation cellular process regulation of fat cell differentiation muscle cell apoptotic process smooth muscle cell apoptotic process regulation of apoptotic process regulation of muscle cell apoptotic process regulation of programmed cell death cell death regulation of smooth muscle cell apoptotic process apoptotic process programmed cell death neutral lipid metabolic process triglyceride metabolic process primary metabolic process metabolic process glycerolipid metabolic process triglyceride mobilization acylglycerol metabolic process lipid metabolic process response to stimulus immune response regulation of adaptive immune response adaptive immune response positive regulation of response to stimulus regulation of response to stimulus positive regulation of immune response immune system process regulation of immune response regulation of immune system process positive regulation of adaptive immune response positive regulation of immune system process cellular response to stimulus DNA repair-dependent chromatin remodeling cellular component organization cellular response to stress DNA damage response chromatin organization response to stress chromatin remodeling cellular component organization or biogenesis response to nutrient levels behavioral response to starvation response to starvation peptidyl-lysine acetylation peptidyl-lysine modification protein acylation protein acetylation macromolecule modification peptidyl-amino acid modification protein metabolic process macromolecule metabolic process protein modification process muscle structure development animal organ development anatomical structure development muscle organ development leukocyte apoptotic process macrophage apoptotic process positive regulation of myeloid cell apoptotic process positive regulation of macrophage apoptotic process positive regulation of leukocyte apoptotic process positive regulation of cellular process myeloid cell apoptotic process regulation of leukocyte apoptotic process positive regulation of programmed cell death positive regulation of apoptotic process regulation of macrophage apoptotic process inflammatory cell apoptotic process regulation of myeloid cell apoptotic process positive regulation of proteasomal protein catabolic process catabolic process positive regulation of protein metabolic process proteolysis involved in protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process regulation of ubiquitin-dependent protein catabolic process regulation of primary metabolic process positive regulation of metabolic process positive regulation of ubiquitin-dependent protein catabolic process regulation of proteolysis regulation of proteolysis involved in protein catabolic process modification-dependent macromolecule catabolic process proteolysis positive regulation of macromolecule metabolic process regulation of protein metabolic process proteasomal protein catabolic process regulation of macromolecule metabolic process protein catabolic process regulation of catabolic process positive regulation of protein catabolic process positive regulation of proteolysis involved in protein catabolic process positive regulation of catabolic process regulation of proteasomal ubiquitin-dependent protein catabolic process modification-dependent protein catabolic process positive regulation of proteolysis regulation of proteasomal protein catabolic process positive regulation of proteasomal ubiquitin-dependent protein catabolic process ubiquitin-dependent protein catabolic process regulation of metabolic process regulation of protein catabolic process regulation of cellular response to stress nucleobase-containing compound metabolic process positive regulation of DNA repair regulation of response to stress regulation of nucleobase-containing compound metabolic process DNA repair positive regulation of nucleobase-containing compound metabolic process DNA metabolic process nucleic acid metabolic process regulation of DNA repair positive regulation of DNA metabolic process regulation of DNA metabolic process regulation of biosynthetic process rhythmic process circadian regulation of gene expression circadian rhythm gene expression macromolecule biosynthetic process regulation of gene expression biosynthetic process regulation of macromolecule biosynthetic process cellular response to nutrient levels cellular response to starvation ovulation cycle process multicellular organismal process ovulation sexual reproduction reproductive process sex differentiation development of primary female sexual characteristics female gamete generation developmental process involved in reproduction gamete generation ovulation from ovarian follicle ovulation cycle multicellular organism development development of primary sexual characteristics reproductive structure development system development gonad development reproductive system development female gonad development multicellular organismal reproductive process female sex differentiation regulation of immune effector process positive regulation of macromolecule biosynthetic process positive regulation of biosynthetic process positive regulation of myeloid leukocyte cytokine production involved in immune response cytokine production regulation of cytokine production regulation of multicellular organismal process positive regulation of immune effector process myeloid leukocyte cytokine production cytokine production involved in immune response production of molecular mediator of immune response regulation of cytokine production involved in immune response immune effector process regulation of macrophage cytokine production positive regulation of gene expression positive regulation of cytokine production involved in immune response positive regulation of production of molecular mediator of immune response positive regulation of multicellular organismal process regulation of production of molecular mediator of immune response positive regulation of cytokine production positive regulation of macrophage cytokine production macrophage cytokine production signaling response to cytokine cytokine-mediated signaling pathway cellular response to leptin stimulus cell communication cellular response to endogenous stimulus response to hormone cellular response to cytokine stimulus response to leptin signal transduction cellular response to hormone stimulus leptin-mediated signaling pathway cell surface receptor signaling pathway response to endogenous stimulus response to peptide cellular response to chemical stimulus response to chemical response to light stimulus cellular response to environmental stimulus cellular response to light stimulus cellular response to radiation response to UV UV-damage excision repair response to radiation response to abiotic stimulus cellular response to abiotic stimulus cellular response to UV positive regulation of phosphorylation regulation of catalytic activity regulation of transferase activity positive regulation of phosphate metabolic process positive regulation of protein serine/threonine kinase activity regulation of phosphate metabolic process phosphate-containing compound metabolic process phosphorus metabolic process positive regulation of protein phosphorylation protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation regulation of molecular function positive regulation of kinase activity regulation of kinase activity regulation of protein serine/threonine kinase activity regulation of phosphorus metabolic process regulation of protein modification process regulation of protein phosphorylation positive regulation of molecular function positive regulation of protein modification process regulation of cAMP-dependent protein kinase activity positive regulation of protein kinase activity positive regulation of cAMP-dependent protein kinase activity positive regulation of transferase activity positive regulation of catalytic activity regulation of protein kinase activity regulation of phosphorylation regulation of lipid storage lipid storage nutrient storage negative regulation of biological process RNA metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process transcription by RNA polymerase II negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of metabolic process nucleobase-containing compound biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process regulation of DNA-templated transcription negative regulation of RNA metabolic process smooth muscle cell differentiation positive regulation of smooth muscle cell differentiation regulation of smooth muscle cell differentiation muscle cell differentiation positive regulation of muscle cell differentiation positive regulation of developmental process regulation of muscle cell differentiation positive regulation of cell differentiation response to hydrogen peroxide response to oxidative stress response to oxygen-containing compound response to reactive oxygen species cellular response to growth factor stimulus cell surface receptor protein serine/threonine kinase signaling pathway cellular response to transforming growth factor beta stimulus response to transforming growth factor beta transforming growth factor beta receptor signaling pathway response to growth factor transforming growth factor beta receptor superfamily signaling pathway enzyme-linked receptor protein signaling pathway regulation of double-strand break repair double-strand break repair positive regulation of double-strand break repair negative regulation of developmental process negative regulation of fat cell differentiation negative regulation of cell differentiation monosaccharide metabolic process gluconeogenesis regulation of small molecule metabolic process small molecule metabolic process regulation of carbohydrate metabolic process regulation of glucose metabolic process positive regulation of gluconeogenesis carbohydrate metabolic process small molecule biosynthetic process carbohydrate biosynthetic process hexose metabolic process monosaccharide biosynthetic process hexose biosynthetic process positive regulation of glucose metabolic process regulation of gluconeogenesis positive regulation of carbohydrate metabolic process regulation of carbohydrate biosynthetic process positive regulation of small molecule metabolic process glucose metabolic process negative regulation of DNA-binding transcription factor activity negative regulation of molecular function regulation of DNA-binding transcription factor activity negative regulation of programmed cell death negative regulation of apoptotic process regulation of endodeoxyribonuclease activity regulation of hydrolase activity negative regulation of signaling negative regulation of intracellular signal transduction regulation of signal transduction DNA damage response, signal transduction by p53 class mediator intracellular signal transduction negative regulation of cell communication regulation of intracellular signal transduction regulation of signal transduction by p53 class mediator negative regulation of DNA damage response, signal transduction by p53 class mediator regulation of DNA damage response, signal transduction by p53 class mediator negative regulation of signal transduction by p53 class mediator regulation of signaling negative regulation of response to stimulus signal transduction by p53 class mediator negative regulation of signal transduction regulation of cell communication signal transduction in response to DNA damage multicellular organismal-level homeostasis homeostatic process energy homeostasis sterol homeostasis chemical homeostasis cholesterol homeostasis lipid homeostasis regulation of transcription by glucose negative regulation of NF-kappaB transcription factor activity heterochromatin formation epigenetic regulation of gene expression negative regulation of gene expression constitutive heterochromatin formation DNA methylation-dependent constitutive heterochromatin formation negative regulation of gene expression, epigenetic negative regulation of phosphate metabolic process negative regulation of phosphorus metabolic process negative regulation of phosphorylation cell population proliferation positive regulation of cell population proliferation regulation of cell population proliferation cellular response to tumor necrosis factor response to tumor necrosis factor regulation of intrinsic apoptotic signaling pathway in response to DNA damage regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator negative regulation of apoptotic signaling pathway negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator intrinsic apoptotic signaling pathway in response to DNA damage intrinsic apoptotic signaling pathway negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage intrinsic apoptotic signaling pathway by p53 class mediator regulation of apoptotic signaling pathway regulation of intrinsic apoptotic signaling pathway intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator apoptotic signaling pathway negative regulation of intrinsic apoptotic signaling pathway negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator regulation of intrinsic apoptotic signaling pathway by p53 class mediator positive regulation of locomotion regulation of cell motility regulation of blood vessel endothelial cell migration endothelial cell migration positive regulation of cell migration positive regulation of blood vessel endothelial cell migration regulation of locomotion positive regulation of endothelial cell migration positive regulation of cell motility regulation of cell migration blood vessel endothelial cell migration regulation of endothelial cell migration cell migration cell motility locomotion fatty acid homeostasis myeloid leukocyte differentiation hemopoiesis macrophage differentiation cell development mononuclear cell differentiation myeloid cell differentiation leukocyte differentiation positive regulation of autophagy macroautophagy autophagy regulation of autophagy regulation of macroautophagy positive regulation of macroautophagy process utilizing autophagic mechanism regulation of cellular senescence cellular senescence positive regulation of cellular senescence response to peptide hormone response to insulin response to nitrogen compound regulation of MHC class II biosynthetic process MHC class II biosynthetic process positive regulation of MHC class II biosynthetic process negative regulation of triglyceride metabolic process neutral lipid biosynthetic process regulation of triglyceride metabolic process regulation of lipid metabolic process lipid biosynthetic process negative regulation of lipid biosynthetic process acylglycerol biosynthetic process negative regulation of triglyceride biosynthetic process triglyceride biosynthetic process regulation of triglyceride biosynthetic process glycerolipid biosynthetic process regulation of lipid biosynthetic process negative regulation of lipid metabolic process regulation of steroid biosynthetic process oxoacid metabolic process ketone metabolic process steroid metabolic process organic acid metabolic process organic acid biosynthetic process regulation of bile acid metabolic process carboxylic acid biosynthetic process steroid biosynthetic process bile acid biosynthetic process monocarboxylic acid biosynthetic process regulation of steroid metabolic process regulation of bile acid biosynthetic process carboxylic acid metabolic process regulation of ketone metabolic process bile acid metabolic process monocarboxylic acid metabolic process endothelial cell proliferation positive regulation of epithelial cell proliferation regulation of endothelial cell proliferation positive regulation of endothelial cell proliferation regulation of epithelial cell proliferation epithelial cell proliferation DNA synthesis involved in DNA repair DNA biosynthetic process negative regulation of protein modification process negative regulation of protein metabolic process negative regulation of protein acetylation regulation of protein acetylation spermatogenesis male gamete generation stress-induced premature senescence cellular homeostasis glucose homeostasis carbohydrate homeostasis intracellular chemical homeostasis intracellular glucose homeostasis establishment of organelle localization mitotic metaphase chromosome alignment negative regulation of cell cycle regulation of attachment of mitotic spindle microtubules to kinetochore establishment of localization in cell cell cycle chromosome segregation regulation of cell cycle process attachment of mitotic spindle microtubules to kinetochore sister chromatid segregation regulation of chromosome organization negative regulation of attachment of mitotic spindle microtubules to kinetochore regulation of organelle organization regulation of mitotic sister chromatid segregation mitotic cell cycle process establishment of chromosome localization negative regulation of attachment of spindle microtubules to kinetochore regulation of chromosome segregation cellular localization regulation of cellular component organization mitotic cell cycle metaphase chromosome alignment chromosome localization organelle localization mitotic sister chromatid segregation regulation of attachment of spindle microtubules to kinetochore regulation of cell cycle cell cycle process mitotic nuclear division attachment of spindle microtubules to kinetochore organelle fission chromosome organization negative regulation of cell cycle process organelle organization nuclear division negative regulation of chromosome segregation regulation of sister chromatid segregation nuclear chromosome segregation regulation of metaphase plate congression protein destabilization regulation of protein stability regulation of biological quality cellular response to glucose starvation response to decreased oxygen levels cellular response to oxygen levels cellular response to hypoxia cellular response to decreased oxygen levels response to hypoxia response to oxygen levels microtubule organizing center organization regulation of centrosome cycle microtubule cytoskeleton organization regulation of microtubule-based process centrosome duplication centrosome cycle regulation of centrosome duplication microtubule-based process cytoskeleton organization response to ionizing radiation cellular response to ionizing radiation protein ubiquitination post-translational protein modification protein modification by small protein conjugation protein modification by small protein conjugation or removal nucleus localization maintenance of organelle location maintenance of nucleus location maintenance of location in cell maintenance of location triglyceride homeostasis acylglycerol homeostasis intracellular triglyceride homeostasis cellular response to nitrogen compound positive regulation of cell communication positive regulation of signal transduction insulin receptor signaling pathway regulation of cellular response to insulin stimulus cell surface receptor protein tyrosine kinase signaling pathway positive regulation of cellular response to insulin stimulus regulation of insulin receptor signaling pathway positive regulation of insulin receptor signaling pathway cellular response to peptide hormone stimulus cellular response to oxygen-containing compound cellular response to insulin stimulus positive regulation of signaling negative regulation of transforming growth factor beta receptor signaling pathway regulation of transmembrane receptor protein serine/threonine kinase signaling pathway regulation of transforming growth factor beta receptor signaling pathway regulation of cellular response to transforming growth factor beta stimulus regulation of cellular response to growth factor stimulus negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway hippo signaling negative regulation of hippo signaling regulation of hippo signaling negative regulation of TOR signaling TOR signaling regulation of TOR signaling protein deacylation macromolecule deacylation protein deacetylation regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction intracellular signaling cassette phosphatidylinositol 3-kinase/protein kinase B signal transduction cellular response to testosterone stimulus response to ketone response to lipid negative regulation of cellular response to testosterone stimulus response to testosterone regulation of cellular response to testosterone stimulus cellular response to lipid cellular response to ketone positive regulation of DNA-templated transcription positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process cellular response to heat regulation of cellular response to heat response to heat response to temperature stimulus white fat cell differentiation regulation of mitotic cell cycle blood vessel morphogenesis tube development angiogenesis vasculature development circulatory system development anatomical structure morphogenesis tube morphogenesis anatomical structure formation involved in morphogenesis blood vessel development connective tissue development adipose tissue development positive regulation of adipose tissue development tissue development regulation of adipose tissue development negative regulation of canonical NF-kappaB signal transduction canonical NF-kappaB signal transduction regulation of canonical NF-kappaB signal transduction intracellular receptor signaling pathway peroxisome proliferator activated receptor signaling pathway regulation of peroxisome proliferator activated receptor signaling pathway nuclear receptor-mediated signaling pathway positive regulation of intracellular signal transduction positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction neuron apoptotic process negative regulation of neuron apoptotic process regulation of neuron apoptotic process regulation of response to endoplasmic reticulum stress intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress positive regulation of apoptotic signaling pathway regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway positive regulation of response to endoplasmic reticulum stress response to endoplasmic reticulum stress positive regulation of intrinsic apoptotic signaling pathway positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway cellular response to oxidative stress cellular response to chemical stress cellular response to hydrogen peroxide cellular response to reactive oxygen species intrinsic apoptotic signaling pathway in response to oxidative stress regulation of oxidative stress-induced intrinsic apoptotic signaling pathway negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway single strand break repair regulation of vasculature development regulation of anatomical structure morphogenesis regulation of multicellular organismal development positive regulation of angiogenesis positive regulation of vasculature development regulation of angiogenesis negative regulation of cellular senescence negative regulation of peptidyl-lysine acetylation regulation of peptidyl-lysine acetylation prostaglandin metabolic process negative regulation of small molecule metabolic process unsaturated fatty acid metabolic process prostaglandin biosynthetic process regulation of fatty acid metabolic process regulation of fatty acid biosynthetic process regulation of prostaglandin biosynthetic process icosanoid metabolic process regulation of unsaturated fatty acid biosynthetic process negative regulation of prostaglandin biosynthetic process prostanoid metabolic process icosanoid biosynthetic process negative regulation of fatty acid biosynthetic process prostanoid biosynthetic process fatty acid metabolic process negative regulation of fatty acid metabolic process fatty acid biosynthetic process unsaturated fatty acid biosynthetic process hormone-mediated signaling pathway negative regulation of intracellular steroid hormone receptor signaling pathway response to steroid hormone regulation of intracellular steroid hormone receptor signaling pathway androgen receptor signaling pathway nuclear receptor-mediated steroid hormone signaling pathway cellular response to steroid hormone stimulus steroid hormone receptor signaling pathway regulation of androgen receptor signaling pathway negative regulation of androgen receptor signaling pathway nucleotide-excision repair pyrimidine dimer repair pyrimidine dimer repair by nucleotide-excision repair nucleolar chromatin organization rDNA heterochromatin formation nucleus organization nucleolus organization facultative heterochromatin formation protein depropionylation response to leukemia inhibitory factor cellular response to leukemia inhibitory factor	membrane-bounded organelle intracellular organelle organelle envelope cellular anatomical structure intracellular anatomical structure organelle nuclear envelope nucleus intracellular membrane-bounded organelle endomembrane system cytoplasm cytosol membrane-enclosed lumen intracellular membraneless organelle membrane-bounded organelle intracellular organelle organelle envelope cellular anatomical structure intracellular anatomical structure organelle nuclear envelope nucleus intracellular membrane-bounded organelle endomembrane system cytoplasm cytosol membrane-enclosed lumen intracellular membraneless organelle nucleolus intracellular organelle lumen organelle lumen membraneless organelle nuclear lumen protein-containing complex chromatin silencing complex nuclear protein-containing complex rDNA heterochromatin chromatin chromosome heterochromatin fibrillar center euchromatin eNoSc complex organelle inner membrane nuclear membrane membrane nuclear inner membrane organelle membrane mitochondrion nucleoplasm nuclear body PML body

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C, E, G	IPR003000	Sirtuin family	Family
A, C, E, G	IPR026590	Sirtuin family, catalytic core domain	Domain
A, C, E, G	IPR026591	Sirtuin, catalytic core small domain superfamily	Homologous Superfamily
A, C, E, G	IPR029035	DHS-like NAD/FAD-binding domain superfamily	Homologous Superfamily
A, C, E, G	IPR050134	NAD-dependent sirtuin protein deacylases	Family
B, D, F, H	IPR003000	Sirtuin family	Family
B, D, F, H	IPR026590	Sirtuin family, catalytic core domain	Domain
B, D, F, H	IPR026591	Sirtuin, catalytic core small domain superfamily	Homologous Superfamily
B, D, F, H	IPR029035	DHS-like NAD/FAD-binding domain superfamily	Homologous Superfamily
B, D, F, H	IPR050134	NAD-dependent sirtuin protein deacylases	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, C, E, G	Pharos: Q96EB6	metabolic syndrome X diabetic retinopathy atherosclerosis type 2 diabetes mellitus obesity disorder Ceroid lipofuscinosis, neuronal 1, infantile streptococcal pneumonia experimental autoimmune encephalomyelitis non-alcoholic fatty liver disease autoimmune disease glucose intolerance osteosarcoma HIV infectious disease breast carcinoma colitis metabolic syndrome X diabetic retinopathy atherosclerosis type 2 diabetes mellitus obesity disorder Ceroid lipofuscinosis, neuronal 1, infantile streptococcal pneumonia experimental autoimmune encephalomyelitis non-alcoholic fatty liver disease autoimmune disease glucose intolerance osteosarcoma HIV infectious disease breast carcinoma colitis diabetes mellitus Wallerian degeneration neurodegenerative disease brain infarction pneumonia prostate cancer retinal disease congestive heart failure demyelinating disease atrial fibrillation heart disease pneumonitis breast cancer hyperglycemia schizophrenia acute kidney failure systemic sclerosis adrenal cortex carcinoma fatty liver disease brain cancer heart failure liver disease alcohol abuse ovarian cancer human African trypanosomiasis cancer maturity-onset diabetes of the young thrombotic disease arteriosclerosis disorder bipolar disorder palsy
B, D, F, H	Pharos: Q96EB6	metabolic syndrome X diabetic retinopathy atherosclerosis type 2 diabetes mellitus obesity disorder Ceroid lipofuscinosis, neuronal 1, infantile streptococcal pneumonia experimental autoimmune encephalomyelitis non-alcoholic fatty liver disease autoimmune disease glucose intolerance osteosarcoma HIV infectious disease breast carcinoma colitis metabolic syndrome X diabetic retinopathy atherosclerosis type 2 diabetes mellitus obesity disorder Ceroid lipofuscinosis, neuronal 1, infantile streptococcal pneumonia experimental autoimmune encephalomyelitis non-alcoholic fatty liver disease autoimmune disease glucose intolerance osteosarcoma HIV infectious disease breast carcinoma colitis diabetes mellitus Wallerian degeneration neurodegenerative disease brain infarction pneumonia prostate cancer retinal disease congestive heart failure demyelinating disease atrial fibrillation heart disease pneumonitis breast cancer hyperglycemia schizophrenia acute kidney failure systemic sclerosis adrenal cortex carcinoma fatty liver disease brain cancer heart failure liver disease alcohol abuse ovarian cancer human African trypanosomiasis cancer maturity-onset diabetes of the young thrombotic disease arteriosclerosis disorder bipolar disorder palsy

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.