4HFK | pdb_00004hfk

Crystal structure of the type VI effector-immunity complex Tae4-Tai4 from Enterobacter cloacae

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	T6SS immunity proteins-like	8052373	3002110	SCOP2B (2022-06-29)
D	SCOP2 Family	T6SS immunity proteins-like	8046003	4004817	SCOP2 (2022-06-29)
D	SCOP2 Superfamily	T6SS immunity proteins-like	8052373	3002110	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Tae4	e4hfkA1	A: a+b complex topology	X: Cysteine proteinases-like	H: Cysteine proteinases (From Topology)	T: Cysteine proteinases	F: Tae4	ECOD (1.6)
C	Tae4	e4hfkC1	A: a+b complex topology	X: Cysteine proteinases-like	H: Cysteine proteinases (From Topology)	T: Cysteine proteinases	F: Tae4	ECOD (1.6)
B	Tai4_2	e4hfkB1	A: alpha bundles	X: Rap2b (SMA2266) (From Topology)	H: Rap2b (SMA2266) (From Topology)	T: Rap2b (SMA2266)	F: Tai4_2	ECOD (1.6)
D	Tai4_2	e4hfkD1	A: alpha bundles	X: Rap2b (SMA2266) (From Topology)	H: Rap2b (SMA2266) (From Topology)	T: Rap2b (SMA2266)	F: Tai4_2	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.90.1720.70	Alpha Beta	Alpha-Beta Complex	endopeptidase fold (from Nostoc punctiforme)		CATH (4.3.0)
C	3.90.1720.70	Alpha Beta	Alpha-Beta Complex	endopeptidase fold (from Nostoc punctiforme)		CATH (4.3.0)
B	1.20.120.1620	Mainly Alpha	Up-down Bundle	Four Helix Bundle (Hemerythrin (Met), subunit A)		CATH (4.3.0)
D	1.20.120.1620	Mainly Alpha	Up-down Bundle	Four Helix Bundle (Hemerythrin (Met), subunit A)		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C	PF14113	Type VI secretion system (T6SS), amidase effector protein 4 (Tae4)	Type VI secretion system (T6SS), amidase effector protein 4	Tae4 is a new form of toxin-antitoxin system protein for a type VI secretion system, T6SS. T6SS has roles in interspecies interactions, as well as higher order host-infection, by injecting effector proteins into the periplasmic compartment of the rec ...	Tae4 is a new form of toxin-antitoxin system protein for a type VI secretion system, T6SS. T6SS has roles in interspecies interactions, as well as higher order host-infection, by injecting effector proteins into the periplasmic compartment of the recipient cells of closely related species. Pseudomonas aeruginosa produces at least three effector proteins to other cells and thus has three specific cognate immunity proteins to protect itself. Tae4, or type VI amidase effector 4, in Enterobacter cloacae has a cognate Tai4 or type VI amidase immunity 4 protein [1]. The immunity protein is Tai4, Pfam:PF16695.	Domain
B, D	PF16695	Type VI secretion system (T6SS), amidase immunity protein (Tai4)	Type VI secretion system (T6SS), amidase immunity protein	Tai4 is a new form of autoimmunity protein for a type VI secretion system, T6SS. T6SS has roles in interspecies interactions, as well as higher order host-infection, by injecting effector proteins into the periplasmic compartment of the recipient cel ...	Tai4 is a new form of autoimmunity protein for a type VI secretion system, T6SS. T6SS has roles in interspecies interactions, as well as higher order host-infection, by injecting effector proteins into the periplasmic compartment of the recipient cells of closely related species. Pseudomonas aeruginosa produces at least three effector proteins to other cells and thus has three specific cognate immunity proteins to protect itself. Tae4, or type VI amidase effector 4, in Enterobacter cloacae has a cognate Tai4 or type VI amidase immunity 4 protein [1]. The effector is Tae4, Pfam:PF14113.	Domain

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C	IPR025562	Type VI secretion system (T6SS), amidase effector protein 4	Family
B, D	IPR038314	T6SS superfamily	Homologous Superfamily
B, D	IPR032032	Type VI secretion system (T6SS), amidase immunity protein	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.