4BV2

CRYSTAL STRUCTURE OF SIR2 IN COMPLEX WITH THE INHIBITOR EX-527, 2'-O-ACETYL-ADP-RIBOSE AND DEACETYLATED P53-PEPTIDE

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	DHS-like NAD/FAD-binding domain	8042116	3001728	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	DHS-like NAD/FAD-binding domain	8042116	3001728	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	SIR2_1st	e4bv2A1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: DHS-like NAD/FAD-binding domain	F: SIR2_1st	ECOD (1.6)
A	SIR2_2nd_1	e4bv2A2	A: few secondary structure elements	X: Rubredoxin-like	H: Rubredoxin-related	T: Rubredoxin-related	F: SIR2_2nd_1	ECOD (1.6)
B	SIR2_1st	e4bv2B2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: DHS-like NAD/FAD-binding domain	F: SIR2_1st	ECOD (1.6)
B	SIR2_2nd_2	e4bv2B3	A: few secondary structure elements	X: Rubredoxin-like	H: Rubredoxin-related	T: Rubredoxin-related	F: SIR2_2nd_2	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.1220	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	TPP-binding domain	CATH (4.3.0)
A	3.30.1600.10	Alpha Beta	2-Layer Sandwich	SIR2/SIRT2 'Small Domain'	SIR2/SIRT2 'Small Domain'	CATH (4.3.0)
B	3.40.50.1220	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	TPP-binding domain	CATH (4.3.0)
B	3.30.1600.10	Alpha Beta	2-Layer Sandwich	SIR2/SIRT2 'Small Domain'	SIR2/SIRT2 'Small Domain'	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF02146	Sir2 family (SIR2)	Sir2 family	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	NAD-DEPENDENT PROTEIN DEACETYLASE	NAD+ binding NAD binding binding nucleotide binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding heterocyclic compound binding small molecule binding cation binding transition metal ion binding NAD+ binding NAD binding binding nucleotide binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding heterocyclic compound binding small molecule binding cation binding transition metal ion binding zinc ion binding metal ion binding transferase activity catalytic activity deacetylase activity protein lysine deacetylase activity catalytic activity, acting on a protein acyltransferase activity histone deacetylase activity, NAD-dependent deacylase activity NAD-dependent protein lysine deacylase activity histone deacetylase activity NAD-dependent protein lysine deacetylase activity acyltransferase activity, transferring groups other than amino-acyl groups	protein deacylation macromolecule modification metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process macromolecule deacylation protein modification process protein deacetylation	cellular anatomical structure intracellular anatomical structure cytoplasm
C [auth E], D [auth H]	CELLULAR TUMOR ANTIGEN P53	TFIID-class transcription factor complex binding transcription factor binding basal transcription machinery binding protein-containing complex binding protein binding binding basal RNA polymerase II transcription machinery binding general transcription initiation factor binding RNA polymerase II general transcription initiation factor binding histone deacetylase binding enzyme binding enzyme regulator activity molecular function regulator activity histone deacetylase regulator activity TFIID-class transcription factor complex binding transcription factor binding basal transcription machinery binding protein-containing complex binding protein binding binding basal RNA polymerase II transcription machinery binding general transcription initiation factor binding RNA polymerase II general transcription initiation factor binding histone deacetylase binding enzyme binding enzyme regulator activity molecular function regulator activity histone deacetylase regulator activity protein-folding chaperone binding chromatin binding promoter-specific chromatin binding DNA binding organic cyclic compound binding nucleic acid binding ubiquitin protein ligase binding ubiquitin-like protein ligase binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity protein phosphatase binding phosphatase binding protein phosphatase 2A binding protease binding MDM2/MDM4 family protein binding molecular function activator activity sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding double-stranded DNA binding transcription regulatory region nucleic acid binding mRNA 3'-UTR binding RNA binding mRNA binding cation binding transition metal ion binding copper ion binding ion binding metal ion binding small molecule binding core promoter sequence-specific DNA binding 14-3-3 protein binding cis-regulatory region sequence-specific DNA binding protein tyrosine kinase binding kinase binding signaling receptor binding receptor tyrosine kinase binding protein kinase binding identical protein binding p53 binding DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription repressor activity RNA polymerase II-specific DNA-binding transcription factor binding DNA-binding transcription factor binding RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding protein heterodimerization activity protein dimerization activity molecular condensate scaffold activity protein-macromolecule adaptor activity molecular adaptor activity ATP-dependent DNA/DNA annealing activity DNA/DNA annealing activity annealing activity single-stranded DNA binding ATP-dependent activity zinc ion binding disordered domain specific binding protein domain specific binding	catabolic process regulation of cellular process macroautophagy autophagy negative regulation of biological process regulation of autophagy mitophagy negative regulation of cellular process regulation of autophagy of mitochondrion process utilizing autophagic mechanism negative regulation of catabolic process regulation of biological process negative regulation of metabolic process negative regulation of autophagy of mitochondrion catabolic process regulation of cellular process macroautophagy autophagy negative regulation of biological process regulation of autophagy mitophagy negative regulation of cellular process regulation of autophagy of mitochondrion process utilizing autophagic mechanism negative regulation of catabolic process regulation of biological process negative regulation of metabolic process negative regulation of autophagy of mitochondrion biological regulation regulation of mitophagy regulation of catabolic process negative regulation of mitophagy negative regulation of macroautophagy regulation of macroautophagy negative regulation of autophagy cellular process metabolic process regulation of metabolic process autophagy of mitochondrion regulation of protein stability regulation of biological quality protein stabilization positive regulation of biological process RNA metabolic process positive regulation of macromolecule biosynthetic process positive regulation of gene expression, epigenetic cellular component organization RNA biosynthetic process nucleobase-containing compound metabolic process positive regulation of metabolic process DNA-templated transcription nucleic acid biosynthetic process transcription by RNA polymerase II positive regulation of biosynthetic process chromatin organization chromatin remodeling positive regulation of macromolecule metabolic process cellular component organization or biogenesis positive regulation of cellular process transcription initiation at RNA polymerase II promoter regulation of biosynthetic process epigenetic regulation of gene expression primary metabolic process regulation of macromolecule metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process DNA-templated transcription initiation regulation of gene expression biosynthetic process positive regulation of gene expression transcription initiation-coupled chromatin remodeling regulation of macromolecule biosynthetic process macromolecule metabolic process membrane organization transport apoptotic mitochondrial changes cell death establishment of localization mitochondrial membrane organization localization organelle organization regulation of membrane permeability regulation of mitochondrial membrane permeability involved in apoptotic process apoptotic process regulation of mitochondrial membrane permeability programmed cell death mitochondrion organization mitochondrial transport protein localization cellular localization cellular macromolecule localization macromolecule localization cellular response to stimulus response to stimulus signaling signal transduction by p53 class mediator intracellular signal transduction cell communication apoptotic signaling pathway intrinsic apoptotic signaling pathway by p53 class mediator signal transduction intrinsic apoptotic signaling pathway multicellular organismal process cellular developmental process regulation of developmental process cell development regulation of neurogenesis regulation of cell differentiation regulation of gliogenesis negative regulation of glial cell proliferation regulation of cell development regulation of nervous system development neurogenesis multicellular organism development negative regulation of neurogenesis regulation of glial cell proliferation gliogenesis cell differentiation anatomical structure development regulation of multicellular organismal process negative regulation of nervous system development negative regulation of cell differentiation system development developmental process regulation of multicellular organismal development negative regulation of cell population proliferation cell population proliferation negative regulation of developmental process nervous system development negative regulation of gliogenesis negative regulation of cell development regulation of cell population proliferation glial cell proliferation negative regulation of multicellular organismal process response to stress response to ischemia response to chemical response to antibiotic response to X-ray response to ionizing radiation response to radiation response to abiotic stimulus replicative senescence transcription preinitiation complex assembly regulation of primary metabolic process cellular component biogenesis regulation of DNA-templated transcription initiation regulation of RNA metabolic process cellular component assembly regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of DNA-templated transcription initiation positive regulation of RNA metabolic process RNA polymerase II preinitiation complex assembly regulation of DNA-templated transcription regulation of RNA polymerase II transcription preinitiation complex assembly regulation of cellular component organization positive regulation of cellular component organization positive regulation of DNA-templated transcription protein-DNA complex organization regulation of protein-containing complex assembly positive regulation of protein-containing complex assembly protein-containing complex assembly regulation of RNA biosynthetic process positive regulation of RNA polymerase II transcription preinitiation complex assembly protein-containing complex organization positive regulation of cellular component biogenesis positive regulation of transcription initiation by RNA polymerase II protein-DNA complex assembly regulation of cellular component biogenesis positive regulation of RNA biosynthetic process regulation of transcription initiation by RNA polymerase II head development animal organ development brain development cerebellum development central nervous system development metencephalon development hindbrain development tissue remodeling regulation of tissue remodeling positive regulation of miRNA transcription positive regulation of miRNA metabolic process miRNA transcription regulation of miRNA metabolic process miRNA metabolic process regulation of miRNA transcription regulation of stem cell proliferation negative regulation of stem cell proliferation stem cell proliferation biological process involved in interspecies interaction between organisms response to type II interferon response to cytokine cytokine-mediated signaling pathway cellular response to type II interferon response to biotic stimulus interferon-mediated signaling pathway innate immune response cellular response to cytokine stimulus response to external biotic stimulus cell surface receptor signaling pathway immune response response to other organism defense response type II interferon-mediated signaling pathway defense response to symbiont response to external stimulus response to peptide immune system process defense response to other organism hemopoiesis cell activation mononuclear cell differentiation T cell lineage commitment lymphocyte activation lymphocyte differentiation leukocyte activation T cell activation T cell differentiation cell fate commitment leukocyte differentiation reactive oxygen species metabolic process negative regulation of reactive oxygen species metabolic process regulation of reactive oxygen species metabolic process fibroblast proliferation DNA metabolic process cellular response to stress nucleotide-excision repair DNA damage response DNA repair cellular response to chemical stimulus cellular response to xenobiotic stimulus response to xenobiotic stimulus cellular response to biotic stimulus ER overload response ER-nucleus signaling pathway response to endoplasmic reticulum stress negative regulation of RNA biosynthetic process negative regulation of nucleobase-containing compound metabolic process negative regulation of macromolecule metabolic process negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of RNA metabolic process multicellular organism growth developmental growth growth regulation of amide metabolic process negative regulation of small molecule metabolic process carbohydrate catabolic process carbohydrate derivative metabolic process regulation of generation of precursor metabolites and energy negative regulation of nucleotide metabolic process regulation of small molecule metabolic process regulation of phosphate metabolic process regulation of nucleotide metabolic process regulation of pentose-phosphate shunt pentose-phosphate shunt phosphate-containing compound metabolic process pyridine-containing compound metabolic process small molecule metabolic process phosphorus metabolic process pyridine nucleotide metabolic process nucleoside phosphate metabolic process nicotinamide nucleotide metabolic process regulation of carbohydrate catabolic process nucleotide metabolic process regulation of purine nucleotide metabolic process negative regulation of pentose-phosphate shunt regulation of phosphorus metabolic process negative regulation of purine nucleotide metabolic process negative regulation of phosphate metabolic process glucose 6-phosphate metabolic process purine nucleotide metabolic process nucleobase-containing small molecule metabolic process regulation of NADP metabolic process amide metabolic process regulation of carbohydrate metabolic process carbohydrate metabolic process generation of precursor metabolites and energy purine-containing compound metabolic process NADP metabolic process NADPH regeneration organophosphate metabolic process negative regulation of phosphorus metabolic process negative regulation of DNA replication DNA replication negative regulation of DNA metabolic process regulation of DNA metabolic process regulation of DNA replication response to osmotic stress response to salt stress cellular response to growth factor stimulus cell surface receptor protein serine/threonine kinase signaling pathway cellular response to transforming growth factor beta stimulus response to endogenous stimulus cellular response to endogenous stimulus response to transforming growth factor beta transforming growth factor beta receptor signaling pathway response to growth factor transforming growth factor beta receptor superfamily signaling pathway enzyme-linked receptor protein signaling pathway DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator DNA damage response, signal transduction by p53 class mediator DNA damage response, signal transduction resulting in transcription signal transduction in response to DNA damage somitogenesis epithelium development chordate embryonic development segmentation anterior/posterior pattern specification pattern specification process embryo development tissue development regionalization anatomical structure morphogenesis embryo development ending in birth or egg hatching somite development anatomical structure formation involved in morphogenesis negative regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death negative regulation of apoptotic process fibroblast apoptotic process regulation of fibroblast apoptotic process negative regulation of ATP-dependent activity regulation of helicase activity regulation of molecular function regulation of ATP-dependent activity regulation of catalytic activity negative regulation of molecular function negative regulation of helicase activity negative regulation of catalytic activity regulation of signal transduction regulation of intrinsic apoptotic signaling pathway regulation of intracellular signal transduction regulation of signal transduction by p53 class mediator regulation of signaling regulation of response to stimulus regulation of cell communication regulation of intrinsic apoptotic signaling pathway by p53 class mediator regulation of apoptotic signaling pathway cellular response to oxygen levels cellular response to hypoxia cellular response to decreased oxygen levels response to decreased oxygen levels intrinsic apoptotic signaling pathway in response to hypoxia response to hypoxia response to oxygen levels negative regulation of proteolysis regulation of protein metabolic process regulation of proteolysis proteolysis protein metabolic process negative regulation of protein metabolic process positive regulation of cardiac muscle cell apoptotic process positive regulation of programmed cell death muscle cell apoptotic process positive regulation of striated muscle cell apoptotic process regulation of cardiac muscle cell apoptotic process regulation of muscle cell apoptotic process positive regulation of apoptotic process cardiac muscle cell apoptotic process positive regulation of muscle cell apoptotic process regulation of striated muscle cell apoptotic process striated muscle cell apoptotic process leukocyte apoptotic process positive regulation of thymocyte apoptotic process lymphocyte apoptotic process thymocyte apoptotic process regulation of T cell apoptotic process positive regulation of leukocyte apoptotic process regulation of leukocyte apoptotic process regulation of lymphocyte apoptotic process positive regulation of lymphocyte apoptotic process positive regulation of T cell apoptotic process regulation of thymocyte apoptotic process T cell apoptotic process positive regulation of reactive oxygen species metabolic process small GTPase-mediated signal transduction Ras protein signal transduction intracellular signaling cassette immune system development hematopoietic or lymphoid organ development bone marrow development skeletal system development bone development response to light stimulus cellular response to radiation response to UV cellular response to environmental stimulus cellular response to UV-C response to UV-C cellular response to light stimulus cellular response to abiotic stimulus cellular response to UV neuron apoptotic process regulation of cellular senescence cellular senescence positive regulation of cellular senescence response to gamma radiation necroptotic process programmed necrotic cell death cell activation involved in immune response leukocyte proliferation immune effector process T cell proliferation involved in immune response T cell activation involved in immune response mononuclear cell proliferation lymphocyte proliferation leukocyte activation involved in immune response lymphocyte activation involved in immune response T cell proliferation oligodendrocyte apoptotic process glial cell apoptotic process regulation of protein modification process positive regulation of phosphorylation regulation of protein phosphorylation positive regulation of protein metabolic process peptidyl-tyrosine modification positive regulation of phosphate metabolic process positive regulation of peptidyl-tyrosine phosphorylation positive regulation of protein modification process peptidyl-amino acid modification protein modification process positive regulation of protein phosphorylation protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation regulation of peptidyl-tyrosine phosphorylation macromolecule modification regulation of phosphorylation peptidyl-tyrosine phosphorylation neuroblast proliferation generation of neurons neural precursor cell proliferation cell cycle G2/M phase transition regulation of cell cycle phase transition regulation of cell cycle process regulation of cell cycle G2/M phase transition cell cycle phase transition cell cycle regulation of cell cycle cell cycle process positive regulation of mitochondrial membrane permeability positive regulation of membrane permeability B cell activation B cell lineage commitment B cell differentiation positive regulation of organelle organization regulation of release of cytochrome c from mitochondria positive regulation of release of cytochrome c from mitochondria regulation of organelle organization release of cytochrome c from mitochondria regulation of mitochondrion organization protein complex oligomerization protein tetramerization viral process cellular response to nutrient levels response to nutrient levels response to starvation cellular response to glucose starvation cellular response to starvation negative regulation of neural precursor cell proliferation regulation of neuroblast proliferation negative regulation of neuroblast proliferation regulation of neural precursor cell proliferation positive regulation of neuron apoptotic process regulation of neuron apoptotic process cellular response to ionizing radiation regulation of growth negative regulation of cell growth regulation of cell growth cell growth negative regulation of growth establishment of protein localization nitrogen compound transport nucleocytoplasmic transport nuclear transport intracellular transport protein localization to nucleus import into nucleus establishment of protein localization to organelle protein transport protein localization to organelle establishment of localization in cell protein import into nucleus intracellular protein transport DNA damage checkpoint signaling negative regulation of cell cycle regulation of cell cycle G1/S phase transition cell cycle G1/S phase transition mitotic cell cycle negative regulation of mitotic cell cycle regulation of mitotic cell cycle mitotic DNA integrity checkpoint signaling mitotic DNA damage checkpoint signaling negative regulation of cell cycle phase transition negative regulation of G1/S transition of mitotic cell cycle mitotic G1/S transition checkpoint signaling negative regulation of mitotic cell cycle phase transition negative regulation of cell cycle G1/S phase transition DNA integrity checkpoint signaling negative regulation of cell cycle process cell cycle checkpoint signaling regulation of mitotic cell cycle phase transition mitotic cell cycle checkpoint signaling mitotic G1 DNA damage checkpoint signaling mitotic cell cycle process regulation of G1/S transition of mitotic cell cycle G1/S transition of mitotic cell cycle mitotic cell cycle phase transition regulation of execution phase of apoptosis positive regulation of execution phase of apoptosis execution phase of apoptosis in utero embryonic development T cell differentiation in thymus heart development cardiac chamber morphogenesis heart morphogenesis circulatory system development cardiac septum development cardiac septum morphogenesis cardiac chamber development animal organ morphogenesis embryonic organ development mRNA transcription mRNA metabolic process negative regulation of transforming growth factor beta receptor signaling pathway negative regulation of signaling regulation of transmembrane receptor protein serine/threonine kinase signaling pathway negative regulation of cell communication regulation of transforming growth factor beta receptor signaling pathway negative regulation of response to stimulus regulation of cellular response to transforming growth factor beta stimulus regulation of cellular response to growth factor stimulus negative regulation of signal transduction negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway rhythmic process entrainment of circadian clock circadian rhythm regulation of circadian rhythm photoperiodism entrainment of circadian clock by photoperiod behavior circadian behavior rhythmic behavior rRNA transcription rRNA metabolic process regulation of fibroblast proliferation negative regulation of fibroblast proliferation positive regulation of cell communication positive regulation of signal transduction positive regulation of apoptotic signaling pathway positive regulation of response to stimulus positive regulation of intracellular signal transduction positive regulation of intrinsic apoptotic signaling pathway positive regulation of signaling cellular response to tumor necrosis factor tumor necrosis factor-mediated signaling pathway response to tumor necrosis factor regulation of programmed necrotic cell death positive regulation of programmed necrotic cell death post-transcriptional regulation of gene expression RNA processing regulation of miRNA processing miRNA-mediated post-transcriptional gene silencing negative regulation of gene expression negative regulation of miRNA-mediated gene silencing post-transcriptional gene silencing miRNA processing negative regulation of post-transcriptional gene silencing regulation of miRNA-mediated gene silencing negative regulation of post-transcriptional gene silencing by regulatory ncRNA regulation of regulatory ncRNA processing regulation of gene silencing by regulatory ncRNA regulation of post-transcriptional gene silencing by regulatory ncRNA negative regulation of miRNA processing negative regulation of gene silencing by regulatory ncRNA regulatory ncRNA-mediated post-transcriptional gene silencing regulatory ncRNA processing regulatory ncRNA-mediated gene silencing regulation of post-transcriptional gene silencing negative regulation of G1 to G0 transition regulation of G1 to G0 transition G1 to G0 transition cellular response to nitrogen compound response to oxygen-containing compound response to nitrogen compound response to actinomycin D cellular response to oxygen-containing compound cellular response to actinomycin D cellular response to antibiotic cellular response to oxidative stress cellular response to chemical stress oxidative stress-induced premature senescence response to oxidative stress stress-induced premature senescence cellular response to gamma radiation chromosome organization embryonic morphogenesis gastrulation regulation of cellular response to stress regulation of response to stress regulation of DNA damage response, signal transduction by p53 class mediator negative regulation of telomere maintenance telomere organization negative regulation of telomere maintenance via telomerase regulation of DNA biosynthetic process RNA-templated DNA biosynthetic process telomere maintenance via telomere lengthening negative regulation of chromosome organization negative regulation of cellular component organization regulation of chromosome organization regulation of telomere maintenance via telomere lengthening telomere maintenance DNA biosynthetic process negative regulation of DNA biosynthetic process regulation of telomere maintenance negative regulation of telomere maintenance via telomere lengthening telomere maintenance via telomerase regulation of telomere maintenance via telomerase negative regulation of organelle organization glucose catabolic process to lactate via pyruvate oxoacid metabolic process organic acid metabolic process lactate metabolic process glycolytic fermentation negative regulation of carbohydrate metabolic process hexose catabolic process hexose metabolic process glucose catabolic process monocarboxylic acid metabolic process glucose catabolic process to lactate monosaccharide catabolic process small molecule catabolic process monosaccharide metabolic process energy derivation by oxidation of organic compounds negative regulation of fermentation organic hydroxy compound metabolic process fermentation regulation of glucose catabolic process to lactate via pyruvate regulation of glucose metabolic process carboxylic acid metabolic process negative regulation of glucose catabolic process to lactate via pyruvate regulation of fermentation glucose metabolic process determination of adult lifespan stem cell differentiation hematopoietic stem cell differentiation hematopoietic progenitor cell differentiation DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress mitochondrial genome maintenance mitochondrial DNA metabolic process mitochondrial DNA repair intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator intrinsic apoptotic signaling pathway in response to DNA damage double-strand break repair	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle membraneless organelle nuclear lumen germ cell nucleus protein-containing complex replication fork chromosome site of double-strand break site of DNA damage mitochondrion mitochondrial matrix transcription regulator complex chromatin nuclear periphery nuclear matrix centrosome microtubule organizing center cytoskeleton microtubule cytoskeleton nucleoplasm transcription repressor complex endoplasmic reticulum endomembrane system nuclear body PML body

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR026591	Sirtuin, catalytic core small domain superfamily	Homologous Superfamily
A, B	IPR003000	Sirtuin family	Family
A, B	IPR026590	Sirtuin family, catalytic core domain	Domain
A, B	IPR050134	NAD-dependent sirtuin protein deacylases	Family
A, B	IPR029035	DHS-like NAD/FAD-binding domain superfamily	Homologous Superfamily
A, B	IPR028628	Sirtuin, class U	Family
C [auth E], D [auth H]	IPR012346	p53/RUNT-type transcription factor, DNA-binding domain superfamily	Homologous Superfamily
C [auth E], D [auth H]	IPR002117	p53 tumour suppressor family	Family
C [auth E], D [auth H]	IPR013872	p53 transactivation domain	Domain
C [auth E], D [auth H]	IPR036674	p53-like tetramerisation domain superfamily	Homologous Superfamily
C [auth E], D [auth H]	IPR011615	p53, DNA-binding domain	Domain
C [auth E], D [auth H]	IPR008967	p53-like transcription factor, DNA-binding domain superfamily	Homologous Superfamily
C [auth E], D [auth H]	IPR010991	p53, tetramerisation domain	Domain
C [auth E], D [auth H]	IPR040926	Cellular tumor antigen p53, transactivation domain 2	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
C [auth E], D [auth H]	Pharos: P04637	Li-Fraumeni syndrome melanoma cholangiocarcinoma choroid plexus papilloma angiosarcoma B-cell chronic lymphocytic leukemia adrenal cortex carcinoma esophageal cancer adrenocortical carcinoma, hereditary malignant glioma renal cell carcinoma urinary bladder cancer skin basal cell carcinoma squamous cell carcinoma psoriasis Li-Fraumeni syndrome melanoma cholangiocarcinoma choroid plexus papilloma angiosarcoma B-cell chronic lymphocytic leukemia adrenal cortex carcinoma esophageal cancer adrenocortical carcinoma, hereditary malignant glioma renal cell carcinoma urinary bladder cancer skin basal cell carcinoma squamous cell carcinoma psoriasis osteosarcoma head and neck squamous cell carcinoma esophageal squamous cell carcinoma small cell lung carcinoma nasopharyngeal carcinoma hypertensive disorder amyotrophic lateral sclerosis T-cell non-Hodgkin lymphoma adenoma Balkan nephropathy choroid plexus carcinoma hypertrophic cardiomyopathy colorectal cancer glioblastoma kidney Wilms tumor skin neoplasm thymoma cancer gallbladder cancer malignant mesothelioma transitional cell carcinoma non-small cell lung carcinoma cutaneous melanoma esophageal adenocarcinoma breast adenocarcinoma primary cutaneous T-cell non-Hodgkin lymphoma Neoplasm Metastasis male infertility thyroid gland carcinoma keratosis giant cell glioblastoma carotid artery disease salivary gland adenoid cystic carcinoma astrocytic tumor central nervous system cancer ovarian cancer sarcomatoid carcinoma Li-Fraumeni syndrome 1 Sezary syndrome papillary renal cell carcinoma liver cancer small cell carcinoma microcystic adenoma hepatocellular carcinoma essential thrombocythemia spindle cell sarcoma brain ischemia breast cancer clear cell adenocarcinoma familial pancreatic carcinoma thymic carcinoma collecting duct carcinoma follicular thyroid adenoma thyroid adenoma carcinoma gastric cancer tubular adenocarcinoma gliosarcoma demyelinating disease sarcomatoid renal cell carcinoma penile neoplasm adrenal gland cancer mixed glioma polyploidy lung cancer exocrine pancreatic carcinoma myelodysplastic syndrome breast carcinoma prostate cancer female infertility intrahepatic cholangiocarcinoma malignant colon neoplasm vulvar lichen sclerosus adenocarcinoma sarcoma granular cell carcinoma adenoid cystic carcinoma schizophrenia papillary adenoma skin cancer chromophobe renal cell carcinoma mouth disease lung carcinoma brain glioma chronic obstructive pulmonary disease eye disease breast disease prostate disease thymus neoplasm colorectal adenocarcinoma pulmonary emphysema malignant ependymoma gallbladder neoplasm neuroblastoma acute kidney failure renal carcinoma uterine corpus leiomyoma triple-negative breast carcinoma oligodendroglioma acute megakaryoblastic leukemia cribriform carcinoma glioma susceptibility 1 undifferentiated carcinoma granulomatous slack skin disease urinary bladder neoplasm ovarian neoplasm head and neck carcinoma childhood acute lymphoblastic leukemia skin disease benign neoplasm of pancreas medulloblastoma penile cancer bile duct cancer polycystic ovary syndrome lung benign neoplasm bone osteosarcoma hereditary breast ovarian cancer syndrome lung disease nasopharyngeal carcinoma, susceptibility to, 1 primitive neuroectodermal tumor lymphatic system disease subependymal giant cell astrocytoma Burkitt lymphoma neoplasm of esophagus intestinal disease ischemic disease neurodegenerative disease congenital anemia uterine disease oral cavity neoplasm acute myeloid leukemia cribriform carcinoma of breast SAPHO syndrome atypical teratoid rhabdoid tumor ovarian carcinoma Hantavirus hemorrhagic fever with renal syndrome, Puumala virus type urogenital neoplasm cervical cancer pancreatic neoplasm Li-Fraumeni syndrome 2 basal cell carcinoma, susceptibility to, 7 malignant pancreatic neoplasm head and neck neoplasm uterine cervix carcinoma in situ papilloma epithelioid sarcoma benign urinary system neoplasm hematopoietic and lymphoid system neoplasm liver neoplasm esophageal disease bone disease chromosome 17p deletion adult hepatocellular carcinoma brain disease hereditary diffuse gastric adenocarcinoma stomach disease nasopharyngeal neoplasm IgA glomerulonephritis clear cell renal carcinoma colonic neoplasm anemia thyroid cancer colorectal carcinoma pustulosis palmaris et plantaris gastric neoplasm kidney disease rheumatoid arthritis glioma large cell medulloblastoma autoimmune disease urinary bladder disease ovarian disease head and neck cancer cervical carcinoma endometriosis benign colon neoplasm choroid plexus cancer adrenal carcinoma liver disease skin pigmented basal cell carcinoma metabolic syndrome X hepatoblastoma pilocytic astrocytoma bone marrow disease

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.