3MCY

Crystal structure of FimH lectin domain bound to biphenyl mannoside meta-methyl ester.

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3mcya_	All beta proteins	Common fold of diphtheria toxin/transcription factors/cytochrome f	Bacterial adhesins	Pilus subunits	Mannose-specific adhesin FimH, N-terminal domain	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
C [auth B]	d3mcyb_	All beta proteins	Common fold of diphtheria toxin/transcription factors/cytochrome f	Bacterial adhesins	Pilus subunits	Mannose-specific adhesin FimH, N-terminal domain	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
D [auth C]	d3mcyc_	All beta proteins	Common fold of diphtheria toxin/transcription factors/cytochrome f	Bacterial adhesins	Pilus subunits	Mannose-specific adhesin FimH, N-terminal domain	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
B [auth D]	d3mcyd_	All beta proteins	Common fold of diphtheria toxin/transcription factors/cytochrome f	Bacterial adhesins	Pilus subunits	Mannose-specific adhesin FimH, N-terminal domain	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Bacterial adhesin-like	8100642	3000723	SCOP2B (2022-06-29)
C [auth B]	SCOP2 Family	Pilus subunits	8100641	4002034	SCOP2 (2022-06-29)
C [auth B]	SCOP2 Superfamily	Bacterial adhesin-like	8100642	3000723	SCOP2 (2022-06-29)
D [auth C]	SCOP2B Superfamily	Bacterial adhesin-like	8100642	3000723	SCOP2B (2022-06-29)
B [auth D]	SCOP2B Superfamily	Bacterial adhesin-like	8100642	3000723	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	FimH_man-bind	e3mcyA1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Common fold of diphtheria toxin/transcription factors/cytochrome f	F: FimH_man-bind	ECOD (1.6)
C [auth B]	FimH_man-bind	e3mcyB1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Common fold of diphtheria toxin/transcription factors/cytochrome f	F: FimH_man-bind	ECOD (1.6)
D [auth C]	FimH_man-bind	e3mcyC1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Common fold of diphtheria toxin/transcription factors/cytochrome f	F: FimH_man-bind	ECOD (1.6)
B [auth D]	FimH_man-bind	e3mcyD1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Common fold of diphtheria toxin/transcription factors/cytochrome f	F: FimH_man-bind	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.40.1090	Mainly Beta	Sandwich	Immunoglobulin-like	Fimbrial-type adhesion domain	CATH (4.3.0)
C [auth B]	2.60.40.1090	Mainly Beta	Sandwich	Immunoglobulin-like	Fimbrial-type adhesion domain	CATH (4.3.0)
D [auth C]	2.60.40.1090	Mainly Beta	Sandwich	Immunoglobulin-like	Fimbrial-type adhesion domain	CATH (4.3.0)
B [auth D]	2.60.40.1090	Mainly Beta	Sandwich	Immunoglobulin-like	Fimbrial-type adhesion domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B [auth D], C [auth B], D [auth C]	PF09160	FimH, mannose binding (FimH_man-bind)	FimH, mannose binding	Members of this family adopt a secondary structure consisting of a beta sandwich, with nine strands arranged in two sheets in a Greek key topology. They are predominantly found in bacterial mannose-specific adhesins, since they are capable of binding ...	Members of this family adopt a secondary structure consisting of a beta sandwich, with nine strands arranged in two sheets in a Greek key topology. They are predominantly found in bacterial mannose-specific adhesins, since they are capable of binding to D-mannose [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B [auth D], C [auth B], D [auth C]	FimH	cation binding ion binding binding metal ion binding small molecule binding	cell adhesion involved in biofilm formation cell aggregation biofilm formation biological process involved in intraspecies interaction between organisms cell-substrate adhesion single-species biofilm formation aggregation of unicellular organisms submerged biofilm formation cell adhesion involved in single-species biofilm formation cell adhesion cellular process single-species submerged biofilm formation	pilus cell projection cellular anatomical structure

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B [auth D], C [auth B], D [auth C]	IPR000259	Fimbrial-type adhesion domain	Domain
A, B [auth D], C [auth B], D [auth C]	IPR036937	Fimbrial-type adhesion domain superfamily	Homologous Superfamily
A, B [auth D], C [auth B], D [auth C]	IPR015243	FimH, mannose-binding domain	Domain
A, B [auth D], C [auth B], D [auth C]	IPR050263	Bacterial Fimbrial Adherence	Family
A, B [auth D], C [auth B], D [auth C]	IPR008966	Adhesion domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.