Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
A [auth K]SCOP2B SuperfamilyPhosphoenolpyruvate/pyruvate domain 8043649 3000510 SCOP2B (2022-06-29)
A [auth K]SCOP2B SuperfamilyPhosphoenolpyruvate/pyruvate domain 8043649 3000510 SCOP2B (2022-06-29)
A [auth K]SCOP2B SuperfamilyPK beta-barrel domain-like 8042557 3001296 SCOP2B (2022-06-29)
A [auth K]SCOP2B SuperfamilyPK C-terminal domain-like 8044406 3000442 SCOP2B (2022-06-29)
B [auth A]SCOP2B SuperfamilyPK beta-barrel domain-like 8042557 3001296 SCOP2B (2022-06-29)
B [auth A]SCOP2B SuperfamilyPhosphoenolpyruvate/pyruvate domain 8043649 3000510 SCOP2B (2022-06-29)
B [auth A]SCOP2B SuperfamilyPK C-terminal domain-like 8044406 3000442 SCOP2B (2022-06-29)
B [auth A]SCOP2B SuperfamilyPhosphoenolpyruvate/pyruvate domain 8043649 3000510 SCOP2B (2022-06-29)
C [auth B]SCOP2B SuperfamilyPK C-terminal domain-like 8044406 3000442 SCOP2B (2022-06-29)
C [auth B]SCOP2B SuperfamilyPhosphoenolpyruvate/pyruvate domain 8043649 3000510 SCOP2B (2022-06-29)
C [auth B]SCOP2B SuperfamilyPhosphoenolpyruvate/pyruvate domain 8043649 3000510 SCOP2B (2022-06-29)
C [auth B]SCOP2B SuperfamilyPK beta-barrel domain-like 8042557 3001296 SCOP2B (2022-06-29)
D [auth C]SCOP2B SuperfamilyPhosphoenolpyruvate/pyruvate domain 8043649 3000510 SCOP2B (2022-06-29)
D [auth C]SCOP2B SuperfamilyPK beta-barrel domain-like 8042557 3001296 SCOP2B (2022-06-29)
D [auth C]SCOP2B SuperfamilyPhosphoenolpyruvate/pyruvate domain 8043649 3000510 SCOP2B (2022-06-29)
D [auth C]SCOP2B SuperfamilyPK C-terminal domain-like 8044406 3000442 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
A [auth K]PK_2nde3hqoK4 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: PK beta-barrel domain-likeF: PK_2ndECOD (1.6)
A [auth K]PK_1ste3hqoK2 A: a/b barrelsX: TIM beta/alpha-barrelH: TIM barrels (From Topology)T: TIM barrelsF: PK_1stECOD (1.6)
A [auth K]PK_Ce3hqoK1 A: a/b three-layered sandwichesX: PK C-terminal domain-like (From Topology)H: PK C-terminal domain-like (From Topology)T: PK C-terminal domain-likeF: PK_CECOD (1.6)
B [auth A]PK_2nde3hqoA4 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: PK beta-barrel domain-likeF: PK_2ndECOD (1.6)
B [auth A]PK_1ste3hqoA2 A: a/b barrelsX: TIM beta/alpha-barrelH: TIM barrels (From Topology)T: TIM barrelsF: PK_1stECOD (1.6)
B [auth A]PK_Ce3hqoA1 A: a/b three-layered sandwichesX: PK C-terminal domain-like (From Topology)H: PK C-terminal domain-like (From Topology)T: PK C-terminal domain-likeF: PK_CECOD (1.6)
C [auth B]PK_2nde3hqoB4 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: PK beta-barrel domain-likeF: PK_2ndECOD (1.6)
C [auth B]PK_1ste3hqoB2 A: a/b barrelsX: TIM beta/alpha-barrelH: TIM barrels (From Topology)T: TIM barrelsF: PK_1stECOD (1.6)
C [auth B]PK_Ce3hqoB1 A: a/b three-layered sandwichesX: PK C-terminal domain-like (From Topology)H: PK C-terminal domain-like (From Topology)T: PK C-terminal domain-likeF: PK_CECOD (1.6)
D [auth C]PK_2nde3hqoC4 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: PK beta-barrel domain-likeF: PK_2ndECOD (1.6)
D [auth C]PK_1ste3hqoC2 A: a/b barrelsX: TIM beta/alpha-barrelH: TIM barrels (From Topology)T: TIM barrelsF: PK_1stECOD (1.6)
D [auth C]PK_Ce3hqoC1 A: a/b three-layered sandwichesX: PK C-terminal domain-like (From Topology)H: PK C-terminal domain-like (From Topology)T: PK C-terminal domain-likeF: PK_CECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A [auth K],
B [auth A],
C [auth B],
D [auth C]
PF00224Pyruvate kinase, barrel domain (PK)Pyruvate kinase, barrel domainThis is the barrel domain of pyruvate kinases. This domain represents the beta/alpha barrel and the small beta-barrel domain inserted within it. The active site is found in a cleft between the two domains [1,2,3,4].Domain
A [auth K],
B [auth A],
C [auth B],
D [auth C]
PF02887Pyruvate kinase, alpha/beta domain (PK_C)Pyruvate kinase, alpha/beta domainPyruvate kinase catalyses the final step in glycolysis, the conversion of phosphoenolpyruvate to pyruvate with concomitant phosphorylation of ADP to ATP [1,2]. The structure of several pyruvate kinases from various organisms have been determined [2, ...Pyruvate kinase catalyses the final step in glycolysis, the conversion of phosphoenolpyruvate to pyruvate with concomitant phosphorylation of ADP to ATP [1,2]. The structure of several pyruvate kinases from various organisms have been determined [2, 3,4]. The protein comprises three-four domains: a small N-terminal helical domain (absent in bacterial PK), a beta/alpha barrel domain, a beta-barrel domain (inserted within the beta/alpha-barrel domain), and a 3-layer alpha/beta/alpha sandwich domain (represented in this entry). This domain is at the C-terminal of pyruvate kinases and contains the FBP (fructose 1,6-bisphosphate) binding site [2,4,5].
Domain