3HQN
Apo crystal structure of Leishmania mexicana(LmPYK)pyruvate kinase
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Chains | Type | Family Name | Domain Identifier | Family Identifier | Provenance Source (Version) |
---|---|---|---|---|---|
B [auth A] | SCOP2B Superfamily | PK C-terminal domain-like | 8044406 | 3000442 | SCOP2B (2022-06-29) |
B [auth A] | SCOP2B Superfamily | Phosphoenolpyruvate/pyruvate domain | 8043649 | 3000510 | SCOP2B (2022-06-29) |
B [auth A] | SCOP2B Superfamily | PK beta-barrel domain-like | 8042557 | 3001296 | SCOP2B (2022-06-29) |
B [auth A] | SCOP2B Superfamily | Phosphoenolpyruvate/pyruvate domain | 8043649 | 3000510 | SCOP2B (2022-06-29) |
A [auth D] | SCOP2B Superfamily | PK C-terminal domain-like | 8044406 | 3000442 | SCOP2B (2022-06-29) |
A [auth D] | SCOP2B Superfamily | PK beta-barrel domain-like | 8042557 | 3001296 | SCOP2B (2022-06-29) |
A [auth D] | SCOP2B Superfamily | Phosphoenolpyruvate/pyruvate domain | 8043649 | 3000510 | SCOP2B (2022-06-29) |
A [auth D] | SCOP2B Superfamily | Phosphoenolpyruvate/pyruvate domain | 8043649 | 3000510 | SCOP2B (2022-06-29) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
B [auth A] | PK_2nd | e3hqnA4 | A: beta barrels | X: cradle loop barrel | H: RIFT-related | T: PK beta-barrel domain-like | F: PK_2nd | ECOD (1.6) |
B [auth A] | PK_1st | e3hqnA2 | A: a/b barrels | X: TIM beta/alpha-barrel | H: TIM barrels (From Topology) | T: TIM barrels | F: PK_1st | ECOD (1.6) |
B [auth A] | PK_C | e3hqnA1 | A: a/b three-layered sandwiches | X: PK C-terminal domain-like (From Topology) | H: PK C-terminal domain-like (From Topology) | T: PK C-terminal domain-like | F: PK_C | ECOD (1.6) |
A [auth D] | PK_2nd | e3hqnD4 | A: beta barrels | X: cradle loop barrel | H: RIFT-related | T: PK beta-barrel domain-like | F: PK_2nd | ECOD (1.6) |
A [auth D] | PK_1st | e3hqnD2 | A: a/b barrels | X: TIM beta/alpha-barrel | H: TIM barrels (From Topology) | T: TIM barrels | F: PK_1st | ECOD (1.6) |
A [auth D] | PK_C | e3hqnD1 | A: a/b three-layered sandwiches | X: PK C-terminal domain-like (From Topology) | H: PK C-terminal domain-like (From Topology) | T: PK C-terminal domain-like | F: PK_C | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
B [auth A] | 3.40.1380.20 | Alpha Beta | 3-Layer(aba) Sandwich | Pyruvate Kinase | Chain: A, domain 1 | CATH (4.3.0) |
B [auth A] | 3.20.20.60 | Alpha Beta | Alpha-Beta Barrel | TIM Barrel | Phosphoenolpyruvate-binding domains | CATH (4.3.0) |
B [auth A] | 2.40.33.10 | Mainly Beta | Beta Barrel | M1 Pyruvate Kinase | Domain 3 | CATH (4.3.0) |
A [auth D] | 3.40.1380.20 | Alpha Beta | 3-Layer(aba) Sandwich | Pyruvate Kinase | Chain: A, domain 1 | CATH (4.3.0) |
A [auth D] | 3.20.20.60 | Alpha Beta | Alpha-Beta Barrel | TIM Barrel | Phosphoenolpyruvate-binding domains | CATH (4.3.0) |
A [auth D] | 2.40.33.10 | Mainly Beta | Beta Barrel | M1 Pyruvate Kinase | Domain 3 | CATH (4.3.0) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
A [auth D], B [auth A] | PF00224 | Pyruvate kinase, barrel domain (PK) | Pyruvate kinase, barrel domain | This is the barrel domain of pyruvate kinases. This domain represents the beta/alpha barrel and the small beta-barrel domain inserted within it. The active site is found in a cleft between the two domains [1,2,3,4]. | Domain |
A [auth D], B [auth A] | PF02887 | Pyruvate kinase, alpha/beta domain (PK_C) | Pyruvate kinase, alpha/beta domain | Pyruvate kinase catalyses the final step in glycolysis, the conversion of phosphoenolpyruvate to pyruvate with concomitant phosphorylation of ADP to ATP [1,2]. The structure of several pyruvate kinases from various organisms have been determined [2, ... | Domain |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
A [auth D], B [auth A] | IPR015795 | Pyruvate kinase, C-terminal | Domain |
A [auth D], B [auth A] | IPR015813 | Pyruvate/Phosphoenolpyruvate kinase-like domain superfamily | Homologous Superfamily |
A [auth D], B [auth A] | IPR011037 | Pyruvate kinase-like, insert domain superfamily | Homologous Superfamily |
A [auth D], B [auth A] | IPR015806 | Pyruvate kinase, insert domain superfamily | Homologous Superfamily |
A [auth D], B [auth A] | IPR036918 | Pyruvate kinase, C-terminal domain superfamily | Homologous Superfamily |
A [auth D], B [auth A] | IPR001697 | Pyruvate kinase | Family |
A [auth D], B [auth A] | IPR018209 | Pyruvate kinase, active site | Active Site |
A [auth D], B [auth A] | IPR040442 | Pyruvate kinase-like domain superfamily | Homologous Superfamily |
A [auth D], B [auth A] | IPR015793 | Pyruvate kinase, barrel | Domain |