Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
BSCOP2B SuperfamilyTrypsin-like serine proteases 8042154 3000114 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyTrypsin-like serine proteases 8042154 3000114 SCOP2B (2022-06-29)
FSCOP2B SuperfamilyTrypsin-like serine proteases 8042154 3000114 SCOP2B (2022-06-29)
G [auth X]SCOP2B SuperfamilyEGF/Laminin-like 8038334 3000412 SCOP2B (2022-06-29)
G [auth X]SCOP2B SuperfamilyEGF/Laminin-like 8038333 3000412 SCOP2B (2022-06-29)
G [auth X]SCOP2B SuperfamilyEGF/Laminin-like 8038335 3000412 SCOP2B (2022-06-29)
H [auth Y]SCOP2B SuperfamilyEGF/Laminin-like 8038333 3000412 SCOP2B (2022-06-29)
H [auth Y]SCOP2B SuperfamilyEGF/Laminin-like 8038335 3000412 SCOP2B (2022-06-29)
H [auth Y]SCOP2B SuperfamilyEGF/Laminin-like 8038334 3000412 SCOP2B (2022-06-29)
I [auth Z]SCOP2B SuperfamilyEGF/Laminin-like 8038335 3000412 SCOP2B (2022-06-29)
I [auth Z]SCOP2B SuperfamilyEGF/Laminin-like 8038334 3000412 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
G [auth X]Tme5_EGF_likee3gisX2 A: few secondary structure elementsX: EGF-likeH: EGF-relatedT: EGF/LamininF: Tme5_EGF_likeECOD (1.6)
G [auth X]EGF_CAe3gisX3 A: few secondary structure elementsX: EGF-likeH: EGF-relatedT: EGF/LamininF: EGF_CAECOD (1.6)
H [auth Y]Tme5_EGF_likee3gisY5 A: few secondary structure elementsX: EGF-likeH: EGF-relatedT: EGF/LamininF: Tme5_EGF_likeECOD (1.6)
H [auth Y]EGF_CAe3gisY4 A: few secondary structure elementsX: EGF-likeH: EGF-relatedT: EGF/LamininF: EGF_CAECOD (1.6)
I [auth Z]Tme5_EGF_likee3gisZ5 A: few secondary structure elementsX: EGF-likeH: EGF-relatedT: EGF/LamininF: Tme5_EGF_likeECOD (1.6)
I [auth Z]EGF_CAe3gisZ4 A: few secondary structure elementsX: EGF-likeH: EGF-relatedT: EGF/LamininF: EGF_CAECOD (1.6)
I [auth Z]UNK_F_TYPEe3gisZ1 A: few secondary structure elementsX: EGF-likeH: EGF-relatedT: EGF/LamininF: UNK_F_TYPEECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
B, D, F
PF00089Trypsin (Trypsin)TrypsinDomain
G [auth X],
H [auth Y],
I [auth Z]
PF12662Complement Clr-like EGF-like (cEGF)Complement Clr-like EGF-likecEGF, or complement Clr-like EGF, domains have six conserved cysteine residues disulfide-bonded into the characteristic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL recepto ...Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, C, E
Prothrombin
B, D, F
Prothrombin
G [auth X],
H [auth Y],
I [auth Z]
Thrombomodulin

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
A, C, E
IPR018992Thrombin light chainDomain
A, C, E
IPR037111Thrombin light chain domain superfamilyHomologous Superfamily
A, C, E
IPR003966Prothrombin/thrombinFamily
A, C, E
IPR018114Serine proteases, trypsin family, histidine active siteActive Site
A, C, E
IPR009003Peptidase S1, PA clanHomologous Superfamily
A, C, E
IPR033116Serine proteases, trypsin family, serine active siteActive Site
A, C, E
IPR001254Serine proteases, trypsin domainDomain
A, C, E
IPR035972Gamma-carboxyglutamic acid-rich (GLA) domain superfamilyHomologous Superfamily
A, C, E
IPR000001KringleDomain
A, C, E
IPR000294Gamma-carboxyglutamic acid-rich (GLA) domainDomain
A, C, E
IPR051659Serine Protease S1 Domain-Containing ProteinFamily
A, C, E
IPR018056Kringle, conserved siteConserved Site
A, C, E
IPR013806Kringle-like foldHomologous Superfamily
A, C, E
IPR038178Kringle superfamilyHomologous Superfamily
A, C, E
IPR001314Peptidase S1A, chymotrypsin familyFamily
A, C, E
IPR043504Peptidase S1, PA clan, chymotrypsin-like foldHomologous Superfamily
B, D, F
IPR018992Thrombin light chainDomain
B, D, F
IPR037111Thrombin light chain domain superfamilyHomologous Superfamily
B, D, F
IPR003966Prothrombin/thrombinFamily
B, D, F
IPR018114Serine proteases, trypsin family, histidine active siteActive Site
B, D, F
IPR009003Peptidase S1, PA clanHomologous Superfamily
B, D, F
IPR033116Serine proteases, trypsin family, serine active siteActive Site
B, D, F
IPR001254Serine proteases, trypsin domainDomain
B, D, F
IPR035972Gamma-carboxyglutamic acid-rich (GLA) domain superfamilyHomologous Superfamily
B, D, F
IPR000001KringleDomain
B, D, F
IPR000294Gamma-carboxyglutamic acid-rich (GLA) domainDomain
B, D, F
IPR051659Serine Protease S1 Domain-Containing ProteinFamily
B, D, F
IPR018056Kringle, conserved siteConserved Site
B, D, F
IPR013806Kringle-like foldHomologous Superfamily
B, D, F
IPR038178Kringle superfamilyHomologous Superfamily
B, D, F
IPR001314Peptidase S1A, chymotrypsin familyFamily
B, D, F
IPR043504Peptidase S1, PA clan, chymotrypsin-like foldHomologous Superfamily
G [auth X],
H [auth Y],
I [auth Z]
IPR052126Spindle_Organization_and_ThrombomodulinFamily
G [auth X],
H [auth Y],
I [auth Z]
IPR016187C-type lectin foldHomologous Superfamily
G [auth X],
H [auth Y],
I [auth Z]
IPR018097EGF-like calcium-binding, conserved siteConserved Site
G [auth X],
H [auth Y],
I [auth Z]
IPR026823Complement Clr-like EGF domainDomain
G [auth X],
H [auth Y],
I [auth Z]
IPR001304C-type lectin-likeDomain
G [auth X],
H [auth Y],
I [auth Z]
IPR016186C-type lectin-like/link domain superfamilyHomologous Superfamily
G [auth X],
H [auth Y],
I [auth Z]
IPR000742EGF-like domainDomain
G [auth X],
H [auth Y],
I [auth Z]
IPR049883NOTCH1 EGF-like calcium-binding domainDomain
G [auth X],
H [auth Y],
I [auth Z]
IPR015149Thrombomodulin-like, EGF-likeDomain
G [auth X],
H [auth Y],
I [auth Z]
IPR009030Growth factor receptor cysteine-rich domain superfamilyHomologous Superfamily
G [auth X],
H [auth Y],
I [auth Z]
IPR001881EGF-like calcium-binding domainDomain
G [auth X],
H [auth Y],
I [auth Z]
IPR000152EGF-type aspartate/asparagine hydroxylation sitePTM

Pharos: Disease Associations Pharos Homepage Annotation

ChainsDrug Target  Associated Disease
A, C, E
PharosP00734
B, D, F
PharosP00734
G [auth X],
H [auth Y],
I [auth Z]
PharosP07204