3ELA
Crystal structure of active site inhibited coagulation factor VIIA mutant in complex with soluble tissue factor
External Resource: Annotation
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Chains | Domain Info | Class | Fold | Superfamily | Family | Domain | Species | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A [auth L] | d3elal1 | Small proteins | Knottins (small inhibitors, toxins, lectins) | EGF/Laminin | EGF-type module | Coagulation factor VIIa | human (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
B [auth H] | d3elah_ | All beta proteins | Trypsin-like serine proteases | Trypsin-like serine proteases | Eukaryotic proteases | Coagulation factor VIIa | human (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Chains | Type | Family Name | Domain Identifier | Family Identifier | Provenance Source (Version) |
---|---|---|---|---|---|
A [auth L] | SCOP2B Superfamily | EGF/Laminin-like | 8039292 | 3000412 | SCOP2B (2022-06-29) |
A [auth L] | SCOP2B Superfamily | EGF/Laminin-like | 8039297 | 3000412 | SCOP2B (2022-06-29) |
B [auth H] | SCOP2B Superfamily | Trypsin-like serine proteases | 8003776 | 3000114 | SCOP2B (2022-06-29) |
C [auth T] | SCOP2B Superfamily | Fibronectin type III | 8055493 | 3002063 | SCOP2B (2022-06-29) |
C [auth T] | SCOP2B Superfamily | Fibronectin type III | 8055099 | 3002063 | SCOP2B (2022-06-29) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A [auth L] | FXa_inhibition | e3elaL2 | A: few secondary structure elements | X: EGF-like | H: EGF-related | T: EGF/Laminin | F: FXa_inhibition | ECOD (1.6) |
A [auth L] | hEGF_3 | e3elaL1 | A: few secondary structure elements | X: EGF-like | H: EGF-related | T: EGF/Laminin | F: hEGF_3 | ECOD (1.6) |
B [auth H] | Trypsin_1 | e3elaH1 | A: beta barrels | X: cradle loop barrel | H: RIFT-related | T: FMN-binding split barrel 2 | F: Trypsin_1 | ECOD (1.6) |
C [auth T] | Tissue_fac | e3elaT4 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: Tissue_fac | ECOD (1.6) |
C [auth T] | Interfer-bind_2 | e3elaT3 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: Interfer-bind_2 | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
A [auth L] | 2.10.25.10 | Mainly Beta | Ribbon | Laminin | Laminin | CATH (4.3.0) |
B [auth H] | 2.40.10.10 | Mainly Beta | Beta Barrel | Thrombin, subunit H | Trypsin-like serine proteases | CATH (4.3.0) |
C [auth T] | 2.60.40.10 | Mainly Beta | Sandwich | Immunoglobulin-like | Immunoglobulins | CATH (4.3.0) |
IMGT Antibody Annotation IMGT Database Homepage
Chain | Protein Name | Description | Organism Name | Gene Allele Name(s) | Domain Name(s) | Receptor Type | Receptor Description | Provenance Source |
---|---|---|---|---|---|---|---|---|
C [auth T] | F3 Tissue factor | 2F-DOMAIN | Homo sapiens (human) | F3*01 | F-LIKE-DOMAIN F-DOMAIN | RPI | 2F-DOMAIN | IMGT (202447-0) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
A [auth L] | PF00008 | EGF-like domain (EGF) | EGF-like domain | There is no clear separation between noise and signal. Pfam:PF00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is t ... | Domain |
A [auth L] | PF14670 | Coagulation Factor Xa inhibitory site (FXa_inhibition) | Coagulation Factor Xa inhibitory site | This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442 [1]. | Domain |
B [auth H] | PF00089 | Trypsin (Trypsin) | Trypsin | - | Domain |
C [auth T] | PF09294 | Interferon-alpha/beta receptor, fibronectin type III (Interfer-bind) | Interferon-alpha/beta receptor, fibronectin type III | Members of this family adopt a secondary structure consisting of seven beta-strands arranged in an immunoglobulin-like beta-sandwich, in a Greek-key topology. They are required for binding to interferon-alpha [1]. | Domain |