3AKZ

Crystal structure of Thermotoga maritima nondiscriminating glutamyl-tRNA synthetase in complex with tRNAGln and a glutamyl-AMP analog

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B [auth D]	gltX_1	e3akzD2	A: alpha arrays	X: HTH	H: An anticodon-binding domain of class I aminoacyl-tRNA synthetases (From Topology)	T: An anticodon-binding domain of class I aminoacyl-tRNA synthetases	F: gltX_1	ECOD (1.6)
B [auth D]	tRNA-synt_1c_1	e3akzD5	A: alpha bundles	X: Zn-binding domain in glutaminyl-tRNA synthetase (From Topology)	H: Zn-binding domain in glutaminyl-tRNA synthetase (From Topology)	T: Zn-binding domain in glutaminyl-tRNA synthetase	F: tRNA-synt_1c_1	ECOD (1.6)
B [auth D]	tRNA-synt_1c_1	e3akzD3	A: a/b three-layered sandwiches	X: HUP domain-like	H: HUP domains (From Topology)	T: HUP domains	F: tRNA-synt_1c_1	ECOD (1.6)
C	gltX_1	e3akzC2	A: alpha arrays	X: HTH	H: An anticodon-binding domain of class I aminoacyl-tRNA synthetases (From Topology)	T: An anticodon-binding domain of class I aminoacyl-tRNA synthetases	F: gltX_1	ECOD (1.6)
C	tRNA-synt_1c_1	e3akzC5	A: alpha bundles	X: Zn-binding domain in glutaminyl-tRNA synthetase (From Topology)	H: Zn-binding domain in glutaminyl-tRNA synthetase (From Topology)	T: Zn-binding domain in glutaminyl-tRNA synthetase	F: tRNA-synt_1c_1	ECOD (1.6)
C	tRNA-synt_1c_1	e3akzC3	A: a/b three-layered sandwiches	X: HUP domain-like	H: HUP domains (From Topology)	T: HUP domains	F: tRNA-synt_1c_1	ECOD (1.6)
D [auth A]	gltX_1	e3akzA2	A: alpha arrays	X: HTH	H: An anticodon-binding domain of class I aminoacyl-tRNA synthetases (From Topology)	T: An anticodon-binding domain of class I aminoacyl-tRNA synthetases	F: gltX_1	ECOD (1.6)
D [auth A]	tRNA-synt_1c_1	e3akzA5	A: alpha bundles	X: Zn-binding domain in glutaminyl-tRNA synthetase (From Topology)	H: Zn-binding domain in glutaminyl-tRNA synthetase (From Topology)	T: Zn-binding domain in glutaminyl-tRNA synthetase	F: tRNA-synt_1c_1	ECOD (1.6)
D [auth A]	tRNA-synt_1c_1	e3akzA3	A: a/b three-layered sandwiches	X: HUP domain-like	H: HUP domains (From Topology)	T: HUP domains	F: tRNA-synt_1c_1	ECOD (1.6)
A [auth B]	gltX_1	e3akzB2	A: alpha arrays	X: HTH	H: An anticodon-binding domain of class I aminoacyl-tRNA synthetases (From Topology)	T: An anticodon-binding domain of class I aminoacyl-tRNA synthetases	F: gltX_1	ECOD (1.6)
A [auth B]	tRNA-synt_1c_1	e3akzB5	A: alpha bundles	X: Zn-binding domain in glutaminyl-tRNA synthetase (From Topology)	H: Zn-binding domain in glutaminyl-tRNA synthetase (From Topology)	T: Zn-binding domain in glutaminyl-tRNA synthetase	F: tRNA-synt_1c_1	ECOD (1.6)
A [auth B]	tRNA-synt_1c_1	e3akzB3	A: a/b three-layered sandwiches	X: HUP domain-like	H: HUP domains (From Topology)	T: HUP domains	F: tRNA-synt_1c_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B [auth D]	3.40.50.620	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	HUPs	CATH (4.3.0)
B [auth D]	3.90.800.10	Alpha Beta	Alpha-Beta Complex	Glutamyl-tRNA Synthetase	domain 3	CATH (4.3.0)
B [auth D]	1.10.1160.10	Mainly Alpha	Orthogonal Bundle	Glutamyl-tRNA Synthetase	domain 2	CATH (4.3.0)
B [auth D]	1.10.8.70	Mainly Alpha	Orthogonal Bundle	Helicase, Ruva Protein	domain 3	CATH (4.3.0)
B [auth D]	1.10.10.350	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A		CATH (4.3.0)
C	3.40.50.620	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	HUPs	CATH (4.3.0)
C	3.90.800.10	Alpha Beta	Alpha-Beta Complex	Glutamyl-tRNA Synthetase	domain 3	CATH (4.3.0)
C	1.10.1160.10	Mainly Alpha	Orthogonal Bundle	Glutamyl-tRNA Synthetase	domain 2	CATH (4.3.0)
C	1.10.8.70	Mainly Alpha	Orthogonal Bundle	Helicase, Ruva Protein	domain 3	CATH (4.3.0)
C	1.10.10.350	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A		CATH (4.3.0)
D [auth A]	3.40.50.620	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	HUPs	CATH (4.3.0)
D [auth A]	3.90.800.10	Alpha Beta	Alpha-Beta Complex	Glutamyl-tRNA Synthetase	domain 3	CATH (4.3.0)
D [auth A]	1.10.1160.10	Mainly Alpha	Orthogonal Bundle	Glutamyl-tRNA Synthetase	domain 2	CATH (4.3.0)
D [auth A]	1.10.8.70	Mainly Alpha	Orthogonal Bundle	Helicase, Ruva Protein	domain 3	CATH (4.3.0)
D [auth A]	1.10.10.350	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A		CATH (4.3.0)
A [auth B]	3.40.50.620	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	HUPs	CATH (4.3.0)
A [auth B]	3.90.800.10	Alpha Beta	Alpha-Beta Complex	Glutamyl-tRNA Synthetase	domain 3	CATH (4.3.0)
A [auth B]	1.10.1160.10	Mainly Alpha	Orthogonal Bundle	Glutamyl-tRNA Synthetase	domain 2	CATH (4.3.0)
A [auth B]	1.10.8.70	Mainly Alpha	Orthogonal Bundle	Helicase, Ruva Protein	domain 3	CATH (4.3.0)
A [auth B]	1.10.10.350	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth B], B [auth D], C, D [auth A]	PF19269	Anticodon binding domain (Anticodon_2)	Anticodon binding domain	This entry represents the anticodon binding domain found at the C-terminus of the class-I glutamyl tRNA synthetase enzyme.	Domain
A [auth B], B [auth D], C, D [auth A]	PF00749	tRNA synthetases class I (E and Q), catalytic domain (tRNA-synt_1c)	tRNA synthetases class I (E and Q), catalytic domain	Other tRNA synthetase sub-families are too dissimilar to be included. This family includes only glutamyl and glutaminyl tRNA synthetases. In some organisms, a single glutamyl-tRNA synthetase aminoacylates both tRNA(Glu) and tRNA(Gln).	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth B], B [auth D], C, D [auth A]	Glutamyl-tRNA synthetase 2	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding glutamate-tRNA ligase activity ligase activity, forming carbon-oxygen bonds aminoacyl-tRNA ligase activity catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid catalytic activity, acting on a tRNA catalytic activity ligase activity cation binding transition metal ion binding zinc ion binding metal ion binding RNA binding tRNA binding nucleic acid binding	amino acid activation tRNA aminoacylation RNA metabolic process primary metabolic process amino acid metabolic process translation gene expression tRNA aminoacylation for protein translation macromolecule biosynthetic process nucleic acid metabolic process tRNA metabolic process nucleobase-containing compound metabolic process biosynthetic process metabolic process amino acid activation tRNA aminoacylation RNA metabolic process primary metabolic process amino acid metabolic process translation gene expression tRNA aminoacylation for protein translation macromolecule biosynthetic process nucleic acid metabolic process tRNA metabolic process nucleobase-containing compound metabolic process biosynthetic process metabolic process cellular process macromolecule metabolic process protein metabolic process glutamyl-tRNA aminoacylation	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol
E [auth F], F [auth H], G, H [auth E]	tRNAGln	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth B], B [auth D], C, D [auth A]	IPR020751	Aminoacyl-tRNA synthetase, class I, anticodon-binding domain, subdomain 2	Homologous Superfamily
A [auth B], B [auth D], C, D [auth A]	IPR000924	Glutamyl/glutaminyl-tRNA synthetase	Family
A [auth B], B [auth D], C, D [auth A]	IPR033910	Glutamyl-tRNA synthetase	Domain
A [auth B], B [auth D], C, D [auth A]	IPR020061	Glutamine-tRNA ligase, alpha-bundle domain superfamily	Homologous Superfamily
A [auth B], B [auth D], C, D [auth A]	IPR020058	Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domain	Domain
A [auth B], B [auth D], C, D [auth A]	IPR001412	Aminoacyl-tRNA synthetase, class I, conserved site	Conserved Site
A [auth B], B [auth D], C, D [auth A]	IPR014729	Rossmann-like alpha/beta/alpha sandwich fold	Homologous Superfamily
A [auth B], B [auth D], C, D [auth A]	IPR045462	Aminoacyl-tRNA synthetase, class I, anticodon-binding	Domain
A [auth B], B [auth D], C, D [auth A]	IPR049940	Glutamyl-Q tRNA(Asp) synthetase/Glutamate--tRNA ligase	Family
A [auth B], B [auth D], C, D [auth A]	IPR004527	Glutamate-tRNA ligase, bacterial/mitochondrial	Family
A [auth B], B [auth D], C, D [auth A]	IPR020752	Glutamate-tRNA synthetase, class I, anticodon-binding domain, subdomain 1	Homologous Superfamily
A [auth B], B [auth D], C, D [auth A]	IPR008925	Aminoacyl-tRNA synthetase, class I, anticodon-binding superfamily	Homologous Superfamily