2HSZ

Crystal structure of a predicted phosphoglycolate phosphatase (hs_0176) from haemophilus somnus 129pt at 1.90 A resolution

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2hsza1	Alpha and beta proteins (a/b)	HAD-like	HAD-like	beta-Phosphoglucomutase-like	Phosphoglycolate phosphatase Gph	(Histophilus somni 129PT ) [TaxId: 205914 ],	SCOPe (2.08)
A	d2hsza2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Histophilus somni 129PT ) [TaxId: 205914 ],	SCOPe (2.08)
B	d2hszb2	Alpha and beta proteins (a/b)	HAD-like	HAD-like	beta-Phosphoglucomutase-like	automated matches	(Histophilus somni 129PT ) [TaxId: 205914 ],	SCOPe (2.08)
B	d2hszb3	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Histophilus somni 129PT ) [TaxId: 205914 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	beta-Phosphoglucomutase-like	8030040	4002304	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	HAD-like	8042419	3001890	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	HAD-like	8042419	3001890	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	HAD_2	e2hszA1	A: a/b three-layered sandwiches	X: HAD domain-like	H: HAD domain-related	T: HAD-like	F: HAD_2	ECOD (1.6)
B	HAD_2	e2hszB1	A: a/b three-layered sandwiches	X: HAD domain-like	H: HAD domain-related	T: HAD-like	F: HAD_2	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.1000	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	HAD superfamily/HAD-like	CATH (4.3.0)
A	1.10.150.240	Mainly Alpha	Orthogonal Bundle	DNA polymerase	domain 1	CATH (4.3.0)
B	3.40.50.1000	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	HAD superfamily/HAD-like	CATH (4.3.0)
B	1.10.150.240	Mainly Alpha	Orthogonal Bundle	DNA polymerase	domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF13419	Haloacid dehalogenase-like hydrolase (HAD_2)	Haloacid dehalogenase-like hydrolase	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	novel predicted phosphatase	phosphoglycolate phosphatase activity phosphoric ester hydrolase activity hydrolase activity, acting on ester bonds phosphatase activity hydrolase activity catalytic activity cation binding ion binding binding metal ion binding small molecule binding	carbohydrate metabolic process primary metabolic process metabolic process cellular process cellular response to stimulus response to stimulus DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process cellular response to stress DNA damage response response to stress macromolecule metabolic process DNA repair carbohydrate metabolic process primary metabolic process metabolic process cellular process cellular response to stimulus response to stimulus DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process cellular response to stress DNA damage response response to stress macromolecule metabolic process DNA repair dephosphorylation phosphate-containing compound metabolic process phosphorus metabolic process monocarboxylic acid biosynthetic process small molecule biosynthetic process oxoacid metabolic process organic hydroxy compound metabolic process carboxylic acid metabolic process alcohol metabolic process organic acid biosynthetic process organic acid metabolic process carboxylic acid biosynthetic process biosynthetic process organic hydroxy compound biosynthetic process alcohol biosynthetic process glycolate biosynthetic process small molecule metabolic process monocarboxylic acid metabolic process primary alcohol biosynthetic process primary alcohol metabolic process glycolate metabolic process	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR023214	HAD superfamily	Homologous Superfamily
A, B	IPR050155	HAD-like hydrolase superfamily	Family
A, B	IPR036412	HAD-like superfamily	Homologous Superfamily
A, B	IPR006439	HAD hydrolase, subfamily IA	Family
A, B	IPR037512	Phosphoglycolate phosphatase, prokaryotic	Family
A, B	IPR041492	Haloacid dehalogenase-like hydrolase	Family
A, B	IPR023198	Phosphoglycolate phosphatase-like, domain 2	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.