2BO7

DISSECTION OF MANNOSYLGLYCERATE SYNTHASE: AN ARCHETYPAL MANNOSYLTRANSFERASE

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d2bo7b_	Alpha and beta proteins (a/b)	Nucleotide-diphospho-sugar transferases	Nucleotide-diphospho-sugar transferases	MGS-like	automated matches	(Rhodothermus marinus ) [TaxId: 29549 ],	SCOPe (2.08)
F	d2bo7f_	Alpha and beta proteins (a/b)	Nucleotide-diphospho-sugar transferases	Nucleotide-diphospho-sugar transferases	MGS-like	automated matches	(Rhodothermus marinus ) [TaxId: 29549 ],	SCOPe (2.08)
G	d2bo7g_	Alpha and beta proteins (a/b)	Nucleotide-diphospho-sugar transferases	Nucleotide-diphospho-sugar transferases	MGS-like	automated matches	(Rhodothermus marinus ) [TaxId: 29549 ],	SCOPe (2.08)
I	d2bo7i_	Alpha and beta proteins (a/b)	Nucleotide-diphospho-sugar transferases	Nucleotide-diphospho-sugar transferases	MGS-like	automated matches	(Rhodothermus marinus ) [TaxId: 29549 ],	SCOPe (2.08)
A	d2bo7a_	Alpha and beta proteins (a/b)	Nucleotide-diphospho-sugar transferases	Nucleotide-diphospho-sugar transferases	MGS-like	automated matches	(Rhodothermus marinus ) [TaxId: 29549 ],	SCOPe (2.08)
C	d2bo7c_	Alpha and beta proteins (a/b)	Nucleotide-diphospho-sugar transferases	Nucleotide-diphospho-sugar transferases	MGS-like	automated matches	(Rhodothermus marinus ) [TaxId: 29549 ],	SCOPe (2.08)
D	d2bo7d_	Alpha and beta proteins (a/b)	Nucleotide-diphospho-sugar transferases	Nucleotide-diphospho-sugar transferases	MGS-like	automated matches	(Rhodothermus marinus ) [TaxId: 29549 ],	SCOPe (2.08)
E	d2bo7e_	Alpha and beta proteins (a/b)	Nucleotide-diphospho-sugar transferases	Nucleotide-diphospho-sugar transferases	MGS-like	automated matches	(Rhodothermus marinus ) [TaxId: 29549 ],	SCOPe (2.08)
H	d2bo7h_	Alpha and beta proteins (a/b)	Nucleotide-diphospho-sugar transferases	Nucleotide-diphospho-sugar transferases	MGS-like	automated matches	(Rhodothermus marinus ) [TaxId: 29549 ],	SCOPe (2.08)
J	d2bo7j_	Alpha and beta proteins (a/b)	Nucleotide-diphospho-sugar transferases	Nucleotide-diphospho-sugar transferases	MGS-like	automated matches	(Rhodothermus marinus ) [TaxId: 29549 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	Nucleotide-diphospho-sugar transferases	8038402	3000077	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Nucleotide-diphospho-sugar transferases	8038402	3000077	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	Nucleotide-diphospho-sugar transferases	8038402	3000077	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	Nucleotide-diphospho-sugar transferases	8038402	3000077	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Nucleotide-diphospho-sugar transferases	8038402	3000077	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Nucleotide-diphospho-sugar transferases	8038402	3000077	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Nucleotide-diphospho-sugar transferases	8038402	3000077	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Nucleotide-diphospho-sugar transferases	8038402	3000077	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	Nucleotide-diphospho-sugar transferases	8038402	3000077	SCOP2B (2022-06-29)
J	SCOP2B Superfamily	Nucleotide-diphospho-sugar transferases	8038402	3000077	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	Glycos_transf_2_like	e2bo7B1	A: a/b three-layered sandwiches	X: Nucleotide-diphospho-sugar transferases (From Topology)	H: Nucleotide-diphospho-sugar transferases (From Topology)	T: Nucleotide-diphospho-sugar transferases	F: Glycos_transf_2_like	ECOD (1.6)
F	Glycos_transf_2_like	e2bo7F1	A: a/b three-layered sandwiches	X: Nucleotide-diphospho-sugar transferases (From Topology)	H: Nucleotide-diphospho-sugar transferases (From Topology)	T: Nucleotide-diphospho-sugar transferases	F: Glycos_transf_2_like	ECOD (1.6)
G	Glycos_transf_2_like	e2bo7G1	A: a/b three-layered sandwiches	X: Nucleotide-diphospho-sugar transferases (From Topology)	H: Nucleotide-diphospho-sugar transferases (From Topology)	T: Nucleotide-diphospho-sugar transferases	F: Glycos_transf_2_like	ECOD (1.6)
I	Glycos_transf_2_like	e2bo7I1	A: a/b three-layered sandwiches	X: Nucleotide-diphospho-sugar transferases (From Topology)	H: Nucleotide-diphospho-sugar transferases (From Topology)	T: Nucleotide-diphospho-sugar transferases	F: Glycos_transf_2_like	ECOD (1.6)
A	Glycos_transf_2_like	e2bo7A1	A: a/b three-layered sandwiches	X: Nucleotide-diphospho-sugar transferases (From Topology)	H: Nucleotide-diphospho-sugar transferases (From Topology)	T: Nucleotide-diphospho-sugar transferases	F: Glycos_transf_2_like	ECOD (1.6)
C	Glycos_transf_2_like	e2bo7C1	A: a/b three-layered sandwiches	X: Nucleotide-diphospho-sugar transferases (From Topology)	H: Nucleotide-diphospho-sugar transferases (From Topology)	T: Nucleotide-diphospho-sugar transferases	F: Glycos_transf_2_like	ECOD (1.6)
D	Glycos_transf_2_like	e2bo7D1	A: a/b three-layered sandwiches	X: Nucleotide-diphospho-sugar transferases (From Topology)	H: Nucleotide-diphospho-sugar transferases (From Topology)	T: Nucleotide-diphospho-sugar transferases	F: Glycos_transf_2_like	ECOD (1.6)
E	Glycos_transf_2_like	e2bo7E1	A: a/b three-layered sandwiches	X: Nucleotide-diphospho-sugar transferases (From Topology)	H: Nucleotide-diphospho-sugar transferases (From Topology)	T: Nucleotide-diphospho-sugar transferases	F: Glycos_transf_2_like	ECOD (1.6)
H	Glycos_transf_2_like	e2bo7H1	A: a/b three-layered sandwiches	X: Nucleotide-diphospho-sugar transferases (From Topology)	H: Nucleotide-diphospho-sugar transferases (From Topology)	T: Nucleotide-diphospho-sugar transferases	F: Glycos_transf_2_like	ECOD (1.6)
J	Glycos_transf_2_like	e2bo7J1	A: a/b three-layered sandwiches	X: Nucleotide-diphospho-sugar transferases (From Topology)	H: Nucleotide-diphospho-sugar transferases (From Topology)	T: Nucleotide-diphospho-sugar transferases	F: Glycos_transf_2_like	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	3.90.550.10	Alpha Beta	Alpha-Beta Complex	Spore Coat Polysaccharide Biosynthesis Protein SpsA	Chain A	CATH (4.3.0)
F	3.90.550.10	Alpha Beta	Alpha-Beta Complex	Spore Coat Polysaccharide Biosynthesis Protein SpsA	Chain A	CATH (4.3.0)
G	3.90.550.10	Alpha Beta	Alpha-Beta Complex	Spore Coat Polysaccharide Biosynthesis Protein SpsA	Chain A	CATH (4.3.0)
I	3.90.550.10	Alpha Beta	Alpha-Beta Complex	Spore Coat Polysaccharide Biosynthesis Protein SpsA	Chain A	CATH (4.3.0)
A	3.90.550.10	Alpha Beta	Alpha-Beta Complex	Spore Coat Polysaccharide Biosynthesis Protein SpsA	Chain A	CATH (4.3.0)
C	3.90.550.10	Alpha Beta	Alpha-Beta Complex	Spore Coat Polysaccharide Biosynthesis Protein SpsA	Chain A	CATH (4.3.0)
D	3.90.550.10	Alpha Beta	Alpha-Beta Complex	Spore Coat Polysaccharide Biosynthesis Protein SpsA	Chain A	CATH (4.3.0)
E	3.90.550.10	Alpha Beta	Alpha-Beta Complex	Spore Coat Polysaccharide Biosynthesis Protein SpsA	Chain A	CATH (4.3.0)
H	3.90.550.10	Alpha Beta	Alpha-Beta Complex	Spore Coat Polysaccharide Biosynthesis Protein SpsA	Chain A	CATH (4.3.0)
J	3.90.550.10	Alpha Beta	Alpha-Beta Complex	Spore Coat Polysaccharide Biosynthesis Protein SpsA	Chain A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	PF21967	Mannosylglycerate synthase C-terminal domain (MGS_C)	Mannosylglycerate synthase C-terminal domain	Mannosylglycerate synthase catalyses the formation of the stress protectant 2-O-alpha-D-mannosyl glycerate [1]. It consists of a GT-like domain at the N-terminal and a C-terminal helical domain, represented in this entry, that is apparently involved ...	Mannosylglycerate synthase catalyses the formation of the stress protectant 2-O-alpha-D-mannosyl glycerate [1]. It consists of a GT-like domain at the N-terminal and a C-terminal helical domain, represented in this entry, that is apparently involved in protein oligomerization [1].	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	PF21969	Mannosylglycerate synthase, GT domain (MGS_GT)	Mannosylglycerate synthase, GT domain	Mannosylglycerate synthase catalyses the formation of the stress protectant 2-O-alpha-D-mannosyl glycerate [1]. It consists of a GT-like domain at the N-terminal and a C-terminal helical domain [1]. This entry represents the N-terminal glycosyltransf ...	Mannosylglycerate synthase catalyses the formation of the stress protectant 2-O-alpha-D-mannosyl glycerate [1]. It consists of a GT-like domain at the N-terminal and a C-terminal helical domain [1]. This entry represents the N-terminal glycosyltransferase domain (GT) which, at the sequence level, is most similar to family-GT2 inverting GTs, however, MGS is a retaining GT [1,2].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	MANNOSYLGLYCERATE SYNTHASE	mannosylglycerate synthase activity glycosyltransferase activity transferase activity hexosyltransferase activity catalytic activity cation binding ion binding binding metal ion binding small molecule binding identical protein binding protein binding	carbohydrate derivative biosynthetic process carbohydrate metabolic process glycosyl compound metabolic process glycosyl compound biosynthetic process small molecule biosynthetic process oxoacid metabolic process glycoside metabolic process carbohydrate biosynthetic process carboxylic acid metabolic process carbohydrate derivative metabolic process primary metabolic process organic acid biosynthetic process organic acid metabolic process carboxylic acid biosynthetic process glycoside biosynthetic process carbohydrate derivative biosynthetic process carbohydrate metabolic process glycosyl compound metabolic process glycosyl compound biosynthetic process small molecule biosynthetic process oxoacid metabolic process glycoside metabolic process carbohydrate biosynthetic process carboxylic acid metabolic process carbohydrate derivative metabolic process primary metabolic process organic acid biosynthetic process organic acid metabolic process carboxylic acid biosynthetic process glycoside biosynthetic process mannosylglycerate biosynthetic process biosynthetic process small molecule metabolic process metabolic process cellular process mannosylglycerate metabolic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	IPR054145	Mannosylglycerate synthase, GT domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	IPR054143	Mannosylglycerate synthase, C-terminal domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	IPR029044	Nucleotide-diphospho-sugar transferases	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.