1ZKP | pdb_00001zkp

1.5A Resolution Crystal Structure of a Metallo Beta Lactamase Family Protein, the ELAC Homolgue of Bacillus anthracis, a Putative Ribonuclease

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1zkpa1	Alpha and beta proteins (a+b)	Metallo-hydrolase/oxidoreductase	Metallo-hydrolase/oxidoreductase	YhfI-like	Hypothetical protein BA1088 (BAS1016)	(Bacillus anthracis str. Ames ) [TaxId: 198094 ],	SCOPe (2.08)
A	d1zkpa2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Bacillus anthracis str. Ames ) [TaxId: 198094 ],	SCOPe (2.08)
B	d1zkpb2	Alpha and beta proteins (a+b)	Metallo-hydrolase/oxidoreductase	Metallo-hydrolase/oxidoreductase	YhfI-like	Hypothetical protein BA1088 (BAS1016)	(Bacillus anthracis str. Ames ) [TaxId: 198094 ],	SCOPe (2.08)
B	d1zkpb3	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Bacillus anthracis str. Ames ) [TaxId: 198094 ],	SCOPe (2.08)
C	d1zkpc2	Alpha and beta proteins (a+b)	Metallo-hydrolase/oxidoreductase	Metallo-hydrolase/oxidoreductase	YhfI-like	Hypothetical protein BA1088 (BAS1016)	(Bacillus anthracis str. Ames ) [TaxId: 198094 ],	SCOPe (2.08)
C	d1zkpc3	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Bacillus anthracis str. Ames ) [TaxId: 198094 ],	SCOPe (2.08)
D	d1zkpd2	Alpha and beta proteins (a+b)	Metallo-hydrolase/oxidoreductase	Metallo-hydrolase/oxidoreductase	YhfI-like	Hypothetical protein BA1088 (BAS1016)	(Bacillus anthracis str. Ames ) [TaxId: 198094 ],	SCOPe (2.08)
D	d1zkpd3	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Bacillus anthracis str. Ames ) [TaxId: 198094 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	YhfI-like	8023421	4000431	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Metallo-hydrolase/oxidoreductase	8035801	3001057	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Metallo-hydrolase/oxidoreductase	8035801	3001057	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Metallo-hydrolase/oxidoreductase	8035801	3001057	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Metallo-hydrolase/oxidoreductase	8035801	3001057	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Lactamase_B_2	e1zkpA1	A: a+b four layers	X: Metallo-hydrolase/oxidoreductase (From Topology)	H: Metallo-hydrolase/oxidoreductase (From Topology)	T: Metallo-hydrolase/oxidoreductase	F: Lactamase_B_2	ECOD (1.6)
B	Lactamase_B_2	e1zkpB1	A: a+b four layers	X: Metallo-hydrolase/oxidoreductase (From Topology)	H: Metallo-hydrolase/oxidoreductase (From Topology)	T: Metallo-hydrolase/oxidoreductase	F: Lactamase_B_2	ECOD (1.6)
C	Lactamase_B_2	e1zkpC1	A: a+b four layers	X: Metallo-hydrolase/oxidoreductase (From Topology)	H: Metallo-hydrolase/oxidoreductase (From Topology)	T: Metallo-hydrolase/oxidoreductase	F: Lactamase_B_2	ECOD (1.6)
D	Lactamase_B_2	e1zkpD1	A: a+b four layers	X: Metallo-hydrolase/oxidoreductase (From Topology)	H: Metallo-hydrolase/oxidoreductase (From Topology)	T: Metallo-hydrolase/oxidoreductase	F: Lactamase_B_2	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.60.15.10	Alpha Beta	4-Layer Sandwich	Metallo-beta-lactamase	Chain A	CATH (4.3.0)
B	3.60.15.10	Alpha Beta	4-Layer Sandwich	Metallo-beta-lactamase	Chain A	CATH (4.3.0)
C	3.60.15.10	Alpha Beta	4-Layer Sandwich	Metallo-beta-lactamase	Chain A	CATH (4.3.0)
D	3.60.15.10	Alpha Beta	4-Layer Sandwich	Metallo-beta-lactamase	Chain A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF12706	Beta-lactamase superfamily domain (Lactamase_B_2)	Beta-lactamase superfamily domain	This family is part of the beta-lactamase superfamily and is related to Pfam:PF00753.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	hypothetical protein BA1088	tRNA-specific ribonuclease activity endonuclease activity RNA endonuclease activity, producing 5'-phosphomonoesters catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid RNA nuclease activity hydrolase activity catalytic activity, acting on a tRNA nuclease activity hydrolase activity, acting on ester bonds RNA endonuclease activity 3'-tRNA processing endoribonuclease activity catalytic activity cation binding tRNA-specific ribonuclease activity endonuclease activity RNA endonuclease activity, producing 5'-phosphomonoesters catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid RNA nuclease activity hydrolase activity catalytic activity, acting on a tRNA nuclease activity hydrolase activity, acting on ester bonds RNA endonuclease activity 3'-tRNA processing endoribonuclease activity catalytic activity cation binding ion binding binding metal ion binding small molecule binding	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR036866	Ribonuclease Z/Hydroxyacylglutathione hydrolase-like	Homologous Superfamily
A, B, C, D	IPR001279	Metallo-beta-lactamase	Domain
A, B, C, D	IPR050094	Zinc_phosphodiesterase_ELAC	Unknown

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.