1VLB

STRUCTURE REFINEMENT OF THE ALDEHYDE OXIDOREDUCTASE FROM DESULFOVIBRIO GIGAS AT 1.28 A

External Resource: Annotation


Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
Ad1vlba1 All alpha proteins CO dehydrogenase ISP C-domain like CO dehydrogenase ISP C-domain like CO dehydrogenase ISP C-domain like Aldehyde oxidoreductase, domain 2 (Megalodesulfovibrio gigas ) [TaxId: 879 ], SCOPe (2.08)
Ad1vlba2 Alpha and beta proteins (a+b) beta-Grasp (ubiquitin-like) 2Fe-2S ferredoxin-like 2Fe-2S ferredoxin domains from multidomain proteins Aldehyde oxidoreductase, N-terminal domain (Megalodesulfovibrio gigas ) [TaxId: 879 ], SCOPe (2.08)
Ad1vlba3 Alpha and beta proteins (a+b) alpha/beta-Hammerhead CO dehydrogenase molybdoprotein N-domain-like CO dehydrogenase molybdoprotein N-domain-like Aldehyde oxidoreductase, domain 3 (Megalodesulfovibrio gigas ) [TaxId: 879 ], SCOPe (2.08)
Ad1vlba4 Alpha and beta proteins (a+b) Molybdenum cofactor-binding domain Molybdenum cofactor-binding domain Molybdenum cofactor-binding domain Aldehyde oxidoreductase (Megalodesulfovibrio gigas ) [TaxId: 879 ], SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2 FamilyCO dehydrogenase ISP C-domain like 8029062 4001010 SCOP2 (2022-06-29)
ASCOP2 Family2Fe-2S ferredoxin domains from multidomain proteins 8029063 4000241 SCOP2 (2022-06-29)
ASCOP2 FamilyCO dehydrogenase molybdoprotein N-domain-like 8029064 4001129 SCOP2 (2022-06-29)
ASCOP2 FamilyMolybdenum cofactor-binding domain 8029066 4001972 SCOP2 (2022-06-29)
ASCOP2 SuperfamilyCO dehydrogenase ISP C-domain like 8041441 3000439 SCOP2 (2022-06-29)
ASCOP2 Superfamily2Fe-2S ferredoxin-like 8041442 3000113 SCOP2 (2022-06-29)
ASCOP2 SuperfamilyCO dehydrogenase molybdoprotein N-domain-like 8041443 3000847 SCOP2 (2022-06-29)
ASCOP2 SuperfamilyMolybdenum cofactor-binding domain 8041445 3000625 SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AFer2_2e1vlbA1 A: alpha bundlesX: CO dehydrogenase ISP C-domain like (From Topology)H: CO dehydrogenase ISP C-domain like (From Topology)T: CO dehydrogenase ISP C-domain likeF: Fer2_2ECOD (1.6)
AFer2e1vlbA3 A: a+b two layersX: beta-GraspH: Ubiquitin-relatedT: Ubiquitin-likeF: Fer2ECOD (1.6)
AAld_Xan_dh_C2e1vlbA5 A: a+b two layersX: MocoBD/DmpA-related (From Homology)H: MocoBD/DmpA-relatedT: Molybdenum cofactor-binding domainF: Ald_Xan_dh_C2ECOD (1.6)
AAld_Xan_dh_Ce1vlbA4 A: a+b complex topologyX: alpha/beta-Hammerhead/Barrel-sandwich hybridH: alpha/beta-Hammerhead/Barrel-sandwich hybridT: CO dehydrogenase molybdoprotein N-domain-likeF: Ald_Xan_dh_CECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A3.10.20.30 Alpha Beta Roll Ubiquitin-like (UB roll) Beta-grasp domainCATH (4.3.0)
A1.10.150.120 Mainly Alpha Orthogonal Bundle DNA polymerase domain 1CATH (4.3.0)
A3.90.1170.50 Alpha Beta Alpha-Beta Complex Aldehyde Oxidoreductase domain 3CATH (4.3.0)
A3.30.365.10 Alpha Beta 2-Layer Sandwich Aldehyde Oxidoreductase domain 4CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF01315Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain (Ald_Xan_dh_C)Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain- Domain
PF01799[2Fe-2S] binding domain (Fer2_2)[2Fe-2S] binding domain- Domain
PF20256Molybdopterin cofactor-binding domain (MoCoBD_2)Molybdopterin cofactor-binding domain- Domain
PF02738Molybdopterin cofactor-binding domain (MoCoBD_1)Molybdopterin cofactor-binding domain- Domain
PF001112Fe-2S iron-sulfur cluster binding domain (Fer2)2Fe-2S iron-sulfur cluster binding domain- Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
ALDEHYDE OXIDOREDUCTASE - -

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
IPR054705Molybdopterin-dependent aldehyde oxidoreductaseFamily
IPR0360102Fe-2S ferredoxin-like superfamilyHomologous Superfamily
IPR000674Aldehyde oxidase/xanthine dehydrogenase, a/b hammerheadDomain
IPR0010412Fe-2S ferredoxin-type iron-sulfur binding domainDomain
IPR0060582Fe-2S ferredoxin, iron-sulphur binding siteBinding Site
IPR036856Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead superfamilyHomologous Superfamily
IPR037165Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain superfamilyHomologous Superfamily
IPR046867Aldehyde oxidase/xanthine dehydrogenase, second molybdopterin binding domainDomain
IPR002888[2Fe-2S]-bindingDomain
IPR036884[2Fe-2S]-binding domain superfamilyHomologous Superfamily
IPR016208Aldehyde oxidase/xanthine dehydrogenase-likeFamily
IPR012675Beta-grasp domain superfamilyHomologous Superfamily
IPR008274Aldehyde oxidase/xanthine dehydrogenase, first molybdopterin binding domainDomain

Structure Motif Annotation: Mechanism and Catalytic Site Atlas M-CSA Database Homepage

ChainsEnzyme NameDescriptionCatalytic Residues
aldehyde dehydrogenase (FAD-independent)  M-CSA #105

The sulfate-reducing bacteria Desulfovibrio gigas synthesises a xanthine oxidase-related molybdenum-iron protein aldehyde oxidoreductase (Mop) which catalyses the oxidation of aldehydes to carboxylic acids. Mop contains two separate [2Fe-2S] clusters, and an Mo ion held by a pterin derivative called molybdopterin cytosine dinucleotide (together called the molybedenum cofactor, Mo-co).

Defined by 1 residue: GLU:A-869
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Explore in 3D: M-CSA Motif Definition
At least 2 residues must be present to support Structure Motif searching.
EC: 1.2.3.1 (PDB Primary Data)
EC: 1.2.99.7 (UniProt)