Annotations: 1V1C

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	SH3_1	e1v1cA1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: SH3_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.30.30.40	Mainly Beta	Roll	SH3 type barrels.	SH3 Domains	CATH (4.3.0)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	OBSCURIN	cytoskeletal protein binding titin binding protein binding binding protein serine/threonine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups histone H2AS121 kinase activity histone modifying activity histone H2A kinase activity cytoskeletal protein binding titin binding protein binding binding protein serine/threonine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups histone H2AS121 kinase activity histone modifying activity histone H2A kinase activity catalytic activity histone kinase activity AMP-activated protein kinase activity structural molecule activity structural constituent of muscle ankyrin binding DNA-dependent protein kinase activity histone H3T45 kinase activity histone H3 kinase activity eukaryotic translation initiation factor 2alpha kinase activity adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding phosphatidylinositol-3,4-bisphosphate binding calmodulin binding phosphatidylinositol-5-phosphate binding phospholipid binding lipid binding phosphatidylinositol phosphate binding phosphatidylinositol binding histone H3T6 kinase activity histone H3T3 kinase activity cation binding metal ion binding histone H2BS14 kinase activity histone H2B kinase activity histone H3S57 kinase activity Rho-dependent protein serine/threonine kinase activity histone H2AT120 kinase activity histone H2AXS139 kinase activity histone H2AX kinase activity histone H4S1 kinase activity histone H4 kinase activity protein serine kinase activity phosphatidylinositol-4,5-bisphosphate binding phosphatidylinositol bisphosphate binding enzyme regulator activity guanyl nucleotide binding GTP binding hydrolase activity guanyl ribonucleotide binding GDP binding ribonucleoside triphosphate phosphatase activity molecular function regulator activity hydrolase activity, acting on acid anhydrides pyrophosphatase activity GTPase activity nucleoside-triphosphatase regulator activity GTPase regulator activity guanyl-nucleotide exchange factor activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides phosphatidylinositol-3,4,5-trisphosphate binding histone H3T11 kinase activity phosphatidylinositol-4-phosphate binding histone H3S28 kinase activity 3-phosphoinositide-dependent protein kinase activity histone H2BS36 kinase activity phosphatidylinositol-3-phosphate binding histone H2AS1 kinase activity ribosomal protein S6 kinase activity histone H3S10 kinase activity	cellular response to stimulus regulation of biological process regulation of signaling regulation of cellular process small GTPase-mediated signal transduction response to stimulus signaling regulation of small GTPase mediated signal transduction biological regulation regulation of signal transduction intracellular signal transduction cell communication regulation of intracellular signal transduction regulation of response to stimulus intracellular signaling cassette cellular response to stimulus regulation of biological process regulation of signaling regulation of cellular process small GTPase-mediated signal transduction response to stimulus signaling regulation of small GTPase mediated signal transduction biological regulation regulation of signal transduction intracellular signal transduction cell communication regulation of intracellular signal transduction regulation of response to stimulus intracellular signaling cassette regulation of cell communication cellular process signal transduction protein localization protein localization to M-band localization cellular localization protein localization to organelle cellular macromolecule localization macromolecule localization cellular developmental process cellular component assembly involved in morphogenesis cell development membraneless organelle assembly muscle cell differentiation cellular component organization cellular component biogenesis muscle structure development striated muscle cell development cellular anatomical entity morphogenesis cellular component assembly muscle cell development cell differentiation sarcomere organization anatomical structure development actin filament-based process cellular component organization or biogenesis developmental process actomyosin structure organization actin cytoskeleton organization organelle assembly anatomical structure morphogenesis myofibril assembly organelle organization anatomical structure formation involved in morphogenesis striated muscle cell differentiation supramolecular fiber organization cytoskeleton organization	M band intracellular anatomical structure intracellular membraneless organelle sarcomere intracellular organelle cellular anatomical structure organelle membraneless organelle contractile muscle fiber A band cytoplasm supramolecular fiber myofibril supramolecular polymer M band intracellular anatomical structure intracellular membraneless organelle sarcomere intracellular organelle cellular anatomical structure organelle membraneless organelle contractile muscle fiber A band cytoplasm supramolecular fiber myofibril supramolecular polymer supramolecular complex Z disc I band cytosol cell periphery sarcolemma plasma membrane membrane membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nuclear body nucleoplasm organelle lumen nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
A	IPR008266	Tyrosine-protein kinase, active site	Active Site
A	IPR000219	Dbl homology domain	Domain
A	IPR036028	SH3-like domain superfamily	Homologous Superfamily
A	IPR035526	Obscurin, SH3 domain	Domain
A	IPR000719	Protein kinase domain	Domain
A	IPR013106	Immunoglobulin V-set domain	Domain
A	IPR003599	Immunoglobulin domain subtype	Domain
A	IPR000048	IQ motif, EF-hand binding site	Binding Site
A	IPR001452	SH3 domain	Domain
A	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A	IPR035899	Dbl homology (DH) domain superfamily	Homologous Superfamily
A	IPR007110	Immunoglobulin-like domain	Domain
A	IPR055251	SOS1/NGEF-like, PH domain	Domain
A	IPR017441	Protein kinase, ATP binding site	Binding Site
A	IPR001849	Pleckstrin homology domain	Domain
A	IPR003598	Immunoglobulin subtype 2	Domain
A	IPR011993	PH-like domain superfamily	Homologous Superfamily
A	IPR013098	Immunoglobulin I-set	Domain
A	IPR052385	Obscurin and Obscurin-like Regulators	Family
A	IPR003961	Fibronectin type III	Domain
A	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
A	IPR008271	Serine/threonine-protein kinase, active site	Active Site
A	IPR036116	Fibronectin type III superfamily	Homologous Superfamily